Parathyroid hormone receptor recycling: Role of receptor dephosphorylation and β-arrestin

Molecular Endocrinology

Volumn 16, Issue 12, 2002, Pages 2720-2732

  Chauvin, Stephanie ^a   Bencsik, Margaret ^a   Bambino, Tom ^a   Nissenson, Robert A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; PARATHYROID HORMONE RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A;

ARTICLE; BONE CELL; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEPHOSPHORYLATION; DISSOCIATION; ENZYME KINETICS; HUMAN; HUMAN CELL; INTERNALIZATION; KIDNEY CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; SEQUENCE HOMOLOGY;

ANIMALS; ARRESTINS; CELL LINE; CELL MEMBRANE; DOWN-REGULATION; EMBRYO; ENDOCYTOSIS; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HUMANS; KIDNEY; KINETICS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MUTAGENESIS, SITE-DIRECTED; OKADAIC ACID; OPOSSUMS; OXAZOLES; PARATHYROID HORMONE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; RATS; RECEPTORS, PARATHYROID HORMONE; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0036908641     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0049     Document Type: Article

References (43)

1. Nissenson R 2000 Parathyroid hormone-related protein. Endocr Metab Disord 1:343-352
2. Blind E, Bambino T, Huang Z, Bliziotes M, Nissenson RA 1996 Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor. J Bone Miner Res 11:578-586
3. Qian F, Leung A, Abou-Samra A 1998 Agonist-dependent phosphorylation of the parathyroid hormone/parathyroid hormone-related peptide receptor. Biochemistry 37:6240-6246
4. Lee SK, Stern PH 1994 Studies on the mechanism of desensitization of the parathyroid hormone-stimulated calcium signal in UMR-106 cells: Reversal of desensitization by alkaline phosphatase but not by protein kinase C downregulation. J Bone Miner Res 9:781-789
5. Malecz N, Bambino T, Bencsik M, Nissenson RA 1998 Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization. Mol Endocrinol 12:1846-1856
6. Ferrari SL, Behar V, Chorev M, Rosenblatt M, Bisello A 1999 Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves β-arrestin2. Real-time monitoring by fluorescence microscopy. J Biol Chem 274:29968-29975
7. Bergwitz C, Abou-Samra A, Hesch RD, Juppner H 1994 Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SAOS-2). Biochim Biophys Acta 1222:447-456
8. Teitelbaum AP, Silve CM, Nyiredy KO, Arnaud CD 1986 Down-regulation of parathyroid hormone (PTH) receptors in cultured bone cells is associated with agonist-specific intracellular processing of PTH-receptor complexes. Endocrinology 118:595-602
9. Lefkowitz RJ, Pitcher J, Krueger K, Daaka Y 1998 Mechanisms of β-adrenergic receptor desensitization and resensitization. Adv Pharmacol 42:416-420
10. Pippig S, Andexinger S, Lohse MJ 1995 Sequestration and recycling of β2-adrenergic receptors permit receptor resensitization. Mol Pharmacol 47:666-676
11. Garland AM, Grady EF, Lovett M, Vigna SR, Frucht MM, Krause JE, Bunnett NW 1996 Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors. Mol Pharmacol 49:438-446
12. Sibley DR, Strasser RH, Benovic JL, Daniel K, Lefkowitz RJ 1986 Phosphorylation/dephosphorylation of the β-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. Proc Natl Acad Sci USA 83:9408-9412
13. Krueger KM, Daaka Y, Pitcher JA, Lefkowitz RJ 1997 The role of sequestration in G protein-coupled receptor resensitization. Regulation of β2-adrenergic receptor dephosphorylation by vesicular acidification. J Biol Chem 272:5-8
14. Innamorati G, Sadeghi HM, Tran NT, Birnbaumer M 1998 A serine cluster prevents recycling of the V2 vasopressin receptor. Proc Natl Acad Sci USA 95:2222-2226
15. Barak LS, Fergusson SS, Zhang J, Caron MG 1997 A β-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. J Biol Chem 272:27497-27500
16. Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG 2001 Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-β-arrestin complexes after receptor endocytosis. J Biol Chem 276:19452-19460
17. Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG 1999 Association of β-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J Biol Chem 274:32248-32257
18. Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA 2002 Internalization determinants of the parathyroid hormone receptor differentially regulate β-arrestin/receptor association. J Biol Chem 277:8121-8129
19. Ferrari SL, Bisello A 2001 Cellular distribution of constitutively active mutant parathyroid hormone (PTH)/PTH-related protein receptors and regulation of cyclic adenosine 3′,5′-monophosphate signaling by β-arrestin2. Mol Endocrinol 15:149-163
20. Huang Z, Bambino T, Chen Y, Lameh J, Nissenson RA 1999 Role of signal transduction in internalization of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein. Endocrinology 140:1294-1300
21. Blind E, Bambino T, Nissenson RA 1995 Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein. Endocrinology 136:4271-4277
22. Trejo J, Coughlin SR 1999 The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes vs. recycling. J Biol Chem 274:2216-2224
23. Anborgh PH, Seachrist JL, Dale LB, Ferguson SS 2000 Receptor/β-arrestin complex formation and the differential trafficking and resensitization of β2-adrenergic and angiotensin II type 1A receptors. Mol Endocrinol 14:2040-2053
24. Tsao PI, von Zastrow M 2000 Type-specific sorting of G protein-coupled receptors after endocytosis. J Biol Chem 275:11130-11140
25. Cohen PT, Brewis ND, Hughes V, Mann DJ 1990 Protein serine/threonine phosphatases; an expanding family. FEBS Lett 268:355-359
26. Pitcher JA, Payne ES, Csortos C, DePaoli-Roach AA, Lefkowitz RJ 1995 The G-protein-coupled receptor phosphatase: A protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc Natl Acad Sci USA 92:8343-8347
27. Huang W, Erickson RL 1994 Constitutive activation of Mek1 by mutation of serine phosphorylation sites. Proc Natl Acad Sci USA 91:8960-8963
28. Hinchliffe KA, Ciruela A, Letcher AJ, Divecha N, Irvine RF 1999 Regulation of type IIα phosphatidylinositol phosphate kinase localisation by the protein kinase CK2. Curr Biol 9:983-986
29. Rao RV, Holicky EL, Kuntz SM, Miller LJ 2000 CCK receptor phosphorylation exposes regulatory domains affecting phosphorylation and receptor trafficking. Am J Physiol Cell Physiol 279:C1986-C1992
30. Zhang J, Barak LS, Anborgh PH, Laporte SA, Caron MG, Ferguson SS 1999 Cellular trafficking of G protein-coupled receptor/β-arrestin endocytic complexes. J Biol Chem 274:10999-1006
31. Ferguson SS, Downey 3rd WE, Colapietro AM, Barak LS, Menard L, Caron MG 1996 Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271:363-366
32. Bremnes T, Paasche JD, Mehlum A, Sandberg C, Bremnes B, Attramadal H 2000 Regulation and intracellular trafficking pathways of the endothelin receptors. J Biol Chem 275:17596-17604
33. Xiang B, Yu GH, Guo J, Chen L, Hu W, Pei G, Ma L 2001 Heterologous activation of protein kinase C stimulates phosphorylation of δ-opioid receptor at serine 344, resuiting in β-arrestin- and clathrin-mediated receptor internalization. J Biol Chem 276:4709-4716
34. Ferguson SS, Zhang J, Barak LS, Caron MG 1998 Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. Life Sci 62:1561-1565
35. Gardner B, Liu ZF, Jiang D, Sibley DR 2001 The role of phosphorylation/dephosphorylation in agonist-induced desensitization of D1 dopamine receptor function: Evidence for a novel pathway for receptor dephosphorylation. Mol Pharmacol 59:310-321
36. Innamorati G, Sadeghi HM, Birnbaumer M 1998 Transient phosphorylation of the V1a vasopressin receptor. J Biol Chem 273:7155-7161
37. Luttrell LM, Fergusson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ 1999 β-arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes. Science 283:655-661
38. Cole J 1999 Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells. Endocrinology 140:5771-5779
39. Baratti-Elbaz C, Ghinea N, Lahuna O, Loosfelt H, Pichon C, Milgrom E 1999 Internalization and recycling pathways of the thyrotropin receptor. Mol Endocrinol 13:1751-1765
40. Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M 1999 A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor. Nature 401:286-290
41. Kishi M, Liu X, Hirakawa T, Reczek D, Bretscher A, Ascoli M 2001 Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat LH receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway. Mol Endocrinol 15:1624-1635
42. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K 1997 Current Protocols in Molecular Biology. New York: John Wiley & Sons, Inc.
43. Huang Z, Chen Y, Nissenson RA 1995 The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J Biol Chem 270:151-156