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0001013917
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Ligand 8 is commercially available but can be prepared in 2 steps (by coupling L-proline methyl ester with L-N-Cbz-proline followed by reduction) according to T. Mukaiyama, Tetrahedron, 1981, 37, 4111; see also ref. 4. Ligand 9 can be prepared in the same way, but using D-proline methyl ester and L-N-Cbz-proline.
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Mukaiyama, T.1
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24
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32644460614
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note
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The product (S)-10 does not lose enantiopurity when treated with excess BuLi under the reaction conditions.
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