Essential role of interleukin-15 receptor in normal anxiety behavior

Brain, Behavior, and Immunity

Volumn 24, Issue 8, 2010, Pages 1340-1346

  Wu, Xiaojun ^a   He, Yi ^a   Hsuchou, Hung ^a   Kastin, Abba J ^a   Rood, Jennifer C ^a   Pan, Weihong ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Anxiety; Astrogliosis; Cytokine receptor; Hippocampus; IL15; Microgliosis; Neuroinflammation; Open field

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 4; INTERLEUKIN 6; MINOCYCLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; ASTROCYTOSIS; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MAZE TEST; MICROGLIA; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; TASK PERFORMANCE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANXIETY; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CYTOKINES; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-15; INTERLEUKIN-15 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MINOCYCLINE; MOTOR ACTIVITY; RECEPTORS, INTERLEUKIN-15; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77957234818     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2010.06.012     Document Type: Article

References (39)

1. Aihara N., Tanno H., Hall J.J., Pitts L.H., Noble L.J. Immunocytochemical localization of imunoglobulins in the rat brain: relationship to the blood-brain barrier. J. Comp. Neurol. 1994, 342:481-496.
2. Banks W.A., Ortiz L., Plotkin S.R., Kastin A.J. Human interleukin (IL)1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 1991, 259:988-996.
3. Breese G.R., Knapp D.J., Overstreet D.H., Navarro M., Wills T.A., Angel R.A. Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior. Neuropsychopharmacology 2008, 33:867-876.
4. Cragnolini A.B., Schioth H.B., Scimonelli T.N. Anxiety-like behavior induced by IL-1beta is modulated by alpha-MSH through central melanocortin-4 receptors. Peptides 2006, 27:1451-1456.
5. Dantzer R., Wollman E., Vitkovic L., Yirmiya R. Cytokines and depression: fortuitous or causative association?. Mol. Psychiatry 1999, 4:328-332.
6. Fahey B., Hickey B., Kelleher D., O'Dwyer A.M., O'Mara S.M. The widely-used anti-viral drug interferon-alpha induces depressive- and anxiogenic-like effects in healthy rats. Behav. Brain Res. 2007, 182:80-87.
7. Giron-Michel J., Caignard A., Fogli M., Brouty-Boye D., Briard D., van Dijk M., Meazza R., Ferrini S., Lebousse-Kerdiles C., Clay D., Bompais H., Chouaib S., Peault B., Azzarone B. Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules. Blood 2003, 102:109-117.
8. Goshen I., Kreisel T., Ounallah-Saad H., Renbaum P., Zalzstein Y., Ben-Hur T., Levy-Lahad E., Yirmiya R. A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology 2007, 32:1106-1115.
9. Hanisch U.K., Lyons S.A., Prinz M., Nolte C., Weber J.R., Kettenmann H., Kirchhoff F. Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J. Biol. Chem. 1997, 272:28853-28860.
10. He Y., Hsuchou H., Wu X., Kastin A.J., Khan R.S., Pistell P.J., Wang W.-H., Feng J., Li Z., Guo X., Pan W. Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal dependent memory. J. Neurosci. 2010, 30:4725-4734.
11. He Y., Wu X., Khan R.S., Kastin A.J., Cornélissen G.G., Hsuchou H., Robert B., Halberg F., Pan W. IL15 receptor deletion results in circadian changes of locomotor and metabolic activity. J. Mol. Neurosci. 2010, 41:315-321.
12. Henry C.J., Huang Y., Wynne A., Hanke M., Himler J., Bailey M.T., Sheridan J.F., Godbout J.P. Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J. Neuroinflamm. 2008, 5:15.
13. Hsuchou H., Pan W., Wu X., Kastin A.J. Cessation of blood-to-brain influx of interleukin-15 during development of EAE. J. Cereb. Blood Flow Metab. 2009, 29:1568-1578.
14. Huang Z., Ha G.K., Petitto J.M. IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy. Neurosci. Lett. 2007, 417:160-164.
15. Jiang F., Liu T., Cheng M., Pang X.Y., Bai Z.T., Zhou J.J., Ji Y.H. Spinal astrocyte and microglial activation contributes to rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch. Eur. J. Pharmacol. 2009, 623:52-64.
16. Johnston J.A., Bacon C.M., Finbloom D.S., Rees R.C., Kaplan D., Shibuya K., Ortaldo J.R., Gupta S., Chen Y.Q., Giri J.D. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc. Natl. Acad. Sci. USA 1995, 92:8705-8709.
17. Karrenbauer B.D., Ho Y.J., Ludwig V., Lohn J., Spanagel R., Schwarting R.K., Pawlak C.R. Time-dependent effects of striatal interleukin-2 on open field behaviour in rats. J. Neuroimmunol. 2009, 208:10-18.
18. Kerr B.J., Patterson P.H. Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse. Exp. Neurol. 2004, 188:391-407.
19. Kim H.S., Suh Y.H. Minocycline and neurodegenerative diseases. Behav. Brain Res. 2009, 196:168-179.
20. Koo J.W., Duman R.S. Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory. Neurosci. Lett. 2009, 456:39-43.
21. Kurowska M., Rudnicka W., Maslinska D., Maslinski W. Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Ann. NY Acad. Sci. 2002, 966:441-445.
22. Montkowski A., Landgraf R., Yassouridis A., Holsboer F., Schobitz B. Central administration of IL-1 reduces anxiety and induces sickness behaviour in rats. Pharmacol. Biochem. Behav. 1997, 58:329-336.
23. Pan W., Cain C., Yu Y., Kastin A.J. Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury. J. Neuroimmunol. 2006, 174:119-125.
24. Pan W., Hsuchou H., He Y., Sakharkar A., Cain C., Yu C., Kastin A.J. Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology 2008, 149:2798-2806.
25. Pan W., Hsuchou H., Tu H., Kastin A.J. Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport. Endocrinology 2008, 149:877-885.
26. Pan W., Hsuchou H., Yu C., Kastin A.J. Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS. J. Neurochem. 2008, 106:313-319.
27. Pan W., Yu C., Hsuhou H., Khan R.S., Kastin A.J. Cerebral microvascular IL15 is a novel mediator of TNF action. J. Neurochem. 2009, 111:819-827.
28. Pawlak C.R., Ho Y.J., Schwarting R.K., Bauhofer A. Relationship between striatal levels of interleukin-2 mRNA and plus-maze behaviour in the rat. Neurosci. Lett. 2003, 341:205-208.
29. Pawlak C.R., Schwarting R.K. Striatal microinjections of interleukin-2 and rat behaviour in the elevated plus-maze. Behav. Brain Res. 2006, 168:339-344.
30. Pellow S., Chopin P., File S.E., Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 1985, 14:149-167.
31. Petitto J.M., Huang Z., Hartemink D.A., Beck R. IL-2/15 receptor-beta gene deletion alters neurobehavioral performance. Brain Res. 2002, 929:218-225.
32. Richwine A.F., Parkin A.O., Buchanan J.B., Chen J., Markham J.A., Juraska J.M., Johnson R.W. Architectural changes to CA1 pyramidal neurons in adult and aged mice after peripheral immune stimulation. Psychoneuroendocrinology 2008, 33:1369-1377.
33. Silverman M.N., Macdougall M.G., Hu F., Pace T.W., Raison C.L., Miller A.H. Endogenous glucocorticoids protect against TNF-alpha-induced increases in anxiety-like behavior in virally infected mice. Mol. Psychiatry 2007, 12:408-417.
34. Takao K., Nagatani T., Kitamura Y., Yamawaki S. Effects of corticosterone on 5-HT1A and 5-HT2 receptor binding and on the receptor-mediated behavioral responses of rats. Eur. J. Pharmacol. 1997, 333:123-128.
35. Tikka T., Fiebich B.L., Goldsteins G., Keinanen R., Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J. Neurosci. 2001, 21:2580-2588.
36. Waldmann T., Tagaya Y., Bamford R. Interleukin-2, interleukin-15, and their receptors. Int. Rev. Immunol. 1998, 16:205-226.
37. Waldmann T.A., Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 1999, 17:19-49.
38. Wu X., Pan W., He Y., Hsuchou H., Kastin A.J. Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2010, 223:65-72.
39. Wu X., Pan W., Stone K.P., Zhang Y., Hsuchou H., Kastin A.J. Expression and signaling of novel IL15Ra splicing variants in cerebral endothelial cells of the blood-brain barrier. J. Neurochem. 2010, (Epub PMID: 20374432).