Mitochondrial uncoupling proteins and obesity: Molecular and genetic aspects of UCP1

International Journal of Obesity

Volumn 23, Issue , 1999, Pages S33-S37

  Kozak, Leslie P ^a   Koza, R A ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Ap2 UCP1; Brown adipose tissue; PGC1; Transgene; UCP DTA; UCP1 KO

Indexed keywords

LEPTIN; UNCOUPLING PROTEIN; CARRIER PROTEIN; ION CHANNEL; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BODY WEIGHT; BRAIN; BROWN ADIPOSE TISSUE; CELL STRUCTURE; CONFERENCE PAPER; GENE TARGETING; GENETIC MANIPULATION; GENETIC VARIABILITY; HYPERPHAGIA; MITOCHONDRION; MOUSE; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RETINOPATHY; TRANSGENIC ANIMAL; ADIPOSE TISSUE; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; THERMOREGULATION;

ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE REGULATION; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HUMANS; ION CHANNELS; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OBESITY;

EID: 0033042173     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800941     Document Type: Article

References (28)

1. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwitt R. RicquierWarden CH. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 1997, 15: 269-272.
2. Gimeno RE, Demski M, Weng X, Deng N, Shyjan AW, Giameno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LA. Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis. Diabetes 1997, 46: 900-906.
3. Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue- specific expression. FEBS Lett 1997, 408: 39-42.
4. Vidal-Puig A, Solanes G, Grujic D, Flier JS. Lowell BB. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 1997, 235: 79-82.
5. Gong DW, He Y, Karas M, Reitman M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, /?3-adrenergic agonists and leptin. J Biol Chem 1997, 272: 24129-24132.
6. Enerbäck S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 1997, 387: 90- 94.
7. Surw'it RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL/6J mice. Diabetes 1988, 37: 1163-1167.
8. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, Himms- Hagen J, Boyer BB, Kozak LP, Flier JS. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993, 366: 740-742.
9. Melnyk A, Harper ME, Himms-Hagen J. Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice. Am J Physiol (Regulatory Integrative Comp Physiol 41) 1997, 272: RÍ088-R1093.
10. Hamann A, Flier JS, Lowell BB. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 1996, 137: 21-29.
11. Mantzoros CS, Frederich RC, Qu D. Lowell BB. Maratos-FlierFlier JS. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentations. Diabetes 1998, 47: 230-238.
12. Kopecky J, Clarke G, Enerbäck S, Speigelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 promoter prevents genetic obesity. J Clin Invest 1995, 96: 2914-2923.
13. Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda RL. McKnight OS. Genetically lean mice result from targeted disruption of the RII/? subunit of protein kinase A. Nature 1996, 382: 622-626.
14. Stafl B, Janovská A, Hodny Z, Rossmeisl M, Horáková M, Syrovy I, Bémová J, Bendlová B, Kopecky J. Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in a P2-UCP mice. Am J Physiol 1998, 274: E527- E533.
15. Kozak LP, Kozak UC, Clarke GT. Abnormal brown and white fat development in transgenic mice overexpressing glycerol 3-phosphate dehydrogenase. Genes Dev 1991, 5: 2256- 2264.
16. Young P, Arch JRS, Ashwell M. Brown adipose tissue in the parametrial fat pad of mouse. FEBS Lett 1984, 167: 10-14.
17. Loncar D. Development of thermogenic adipose tissue. Int J Dev Biol 1991, 35: 321-333.
18. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Pénicaud L, Casteilla L. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 1992, 103: 931 -942.
19. Champigny O, Ricquier D, Blondel O, Mayer RM, Briscoe MG, Halloway BR. b3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs. Proc Natl Acad Sci USA 1991,88:10774-10777.
20. Himms-Hagen J, Cui J, Danforth E, Taatjes DJ, Lang SS, Waters BL, Claus TH. Effect of CL-316,243, a thermogenic /?3-agonist, on energy balance and brown and white adipose tissues in rat. Am J Physiol 1994, 266: R1371 -R1382.
21. Champigny O, Ricquier D. Evidence from in vitro differentiating cells that adrenoreceptor agonists can increase uncoupling protein mRNA levels in adipocytes of adult humaas: an RT-PCR study. J Lipid Äes 1996, 37: 1907-1914.
22. Nedergaard J, Connolly E, Cannon B. Brown adipose tissue n the mammalian neonate. In: Trayhum P, Nicholls DG (eds). Brown Adipose Tissue. Arnold: London, 1986, pp: 153 - 213.
23. Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. J Clin Invest 1998, 102: 412 -420.
24. Surwit RS, Wang S, Petro AE, Sanchis D, Raimbault S, Ricquier D, Collins S. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. Proc Natl Acad Sci USA 1998, 95: 4061-4065.
25. Boyer BB, Kozak LP. The mitochondrial uncoupling protein gene in brown fat: correlation between DNAse hypersensitivity and expression in transgenic mice. Mol Cell Biol 1991, 11: 4147-4156.
26. Larose M, Cassard-Doulcier A-M, Fleury C, Serra F, Champigny O, Bouillaud F, Ricquier D. Essential cw-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain. J Biol Chem 1996, 271: 31533-31542.
27. Kozak UC, Kopecky J, Teisinger J, Enerback S, Boyer B, Kozak LP. An upstream enhancer regulating brown-fat-speci- fic expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 1994, 14: 59-67.
28. Puigserver P, Wu Z, Park CW, Graves R, Wright R, Wright M, Speigelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92: 829-839.