Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity

Journal of Applied Physiology

Volumn 112, Issue 8, 2012, Pages 1410-1418

  Pan, Weihong ^a   Hsuchou, Hung ^a   Cornelissen Guillaume, Germaine G ^b   Jayaram, Bhavvani ^a   Wang, Yuping ^a   Tu, Hong ^a   Halberg, Franz ^b   Wu, Xiaojun ^a   Chua, Streamson C ^c   Kastin, Abba J ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Endothelium; Leptin; Metabolic phenotype; Obesity; Receptor

Indexed keywords

EID: 84860348567     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00590.2011     Document Type: Article

References (32)

1. Akasaka Y, Tsunoda M, Ogata T, Ide T, Murakami K. Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor. Biochim Biophys Acta 1801: 1115-1122, 2010.
2. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 17: 305-311, 1996.
3. Bingham C, Arbogast B, Guillaume GC, Lee JK, Halberg F. Inferential statistical methods for estimating and comparing cosinor parameters. Chronobiologia 9: 397-439, 1982.
4. Bjørbæk C, Elmquist JK, Michl P, Ahima RS, van Bueren A, McCall AL, Flier JS. Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 139: 3485-3491, 1998.
5. Boado RJ, Golden PL, Levin N, Pardridge WM. Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet. J Neurochem 71: 1761-1764, 1998.
6. Buettner C, Muse ED, Cheng A, Chen L, Scherer T, Pocai A, Su K, Cheng B, Li X, Harvey-White J, Schwartz GJ, Kunos G, Rossetti L, Buettner C. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med 14: 667-675, 2008.
7. Ceccarini G, Flavell RR, Butelman ER, Synan M, Willnow TE, Bar-Dagan M, Goldsmith SJ, Kreek MJ, Kothari P, Vallabhajosula S, Muir TW, Friedman JM. PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metab 10: 148-159, 2009.
8. de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 115: 3484-3493, 2005.
9. Fogteloo AJ, Meinders AE, Pijl H, Kroon AA, Frolich M, De Leeuw PW. Renal clearance of endogenous leptin in hypertensive humans with or without renal artery stenosis. Am J Physiol Endocrinol Metab 281: E400-E404, 2001.
10. Hama H, Saito A, Takeda T, Tanuma A, Xie Y, Sato K, Kazama JJ, Gejyo F. Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Endocrinology 145: 3935-3940, 2004.
11. Hartz AM, Madole EK, Miller DS, Bauer B. Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/ Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. J Pharmacol Exp Ther 334: 467-476, 2010.
12. He Y, Wu X, Khan RS, Kastin AJ, Cornélissen GG, Hsuchou H, Robert B, Halberg F, Pan W. IL15 receptor deletion results in circadian changes of locomotor and metabolic activity. J Mol Neurosci 41: 315-321, 2010.
13. Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El Haschimi K, Banks WA, Flier JS. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143: 775-783, 2002.
14. Hsuchou H, He Y, Kastin AJ, Tu H, Markadakis EN, Rogers RC, Fossier PB, Pan W. Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain 132: 889-902, 2009.
15. Hsuchou H, Kastin AJ, Tu H, Markadakis EN, Stone KP, Wang Y, Heymsfield SB, Chua SC Jr, Obici S, Magrisso IJ, Pan W. Effects of cell type-specific leptin receptor mutation on leptin transport across the BBB. Peptides 32: 1392-1399, 2011.
16. Hsuchou H, Pan W, Barnes MJ, Kastin AJ. Leptin receptor mRNA in rat brain astrocytes. Peptides 30: 2275-2280, 2009.
17. Jameson JL. Molecular mechanisms of end-organ resistance. Growth Horm IGF Res 14, Suppl A: S45-S50, 2004.
18. Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberger P. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 20: 1449-1453, 1999.
19. McMinn JE, Liu SM, Liu H, Dragatsis I, Dietrich P, Ludwig T, Boozer CN, Chua SC Jr. Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility. Am J Physiol Endocrinol Metab 289: E403-E411, 2005.
20. Meyer C, Robson D, Rackovsky N, Nadkarni V, Gerich J. Role of the kidney in human leptin metabolism. Am J Physiol Endocrinol Metab 273: E903-E907, 1997.
21. Pan W, Hsuchou H, He Y, Kastin AJ. Glial leptin receptors and obesity. In: Modern Insights into Disease-from Molecules to Man: Adipokines, edited by Preedy VR. Enfield, NH: Science Publishers, 2011, p. 185-196.
22. Pan W, Hsuchou H, He Y, Sakharkar A, Cain C, Yu C, Kastin AJ. Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology 149: 2798-2806, 2008.
23. Pan W, Hsuchou H, Tu H, Kastin AJ. Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport. Endocrinology 149: 877-885, 2008.
24. Pan W, Hsuchou H, Xu CL, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese Avy mice. J Mol Neurosci 43: 478-484, 2011.
25. Pan W, Kastin AJ. Mahogany, blood-brain barrier, and fat mass surge in Avy mice. Int J Obesity 31: 1030-1032, 2007.
26. Pan W, Tu H, Hsuchou H, Daniel J, Kastin AJ. Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity. J Mol Neurosci 33: 232-238, 2007.
27. Pan W, Wu X, Kastin AJ, Zhang Y, Hsuchou H, Halberg F, Chatu F, Khan RS, Robert B, Kastin AJ. Potential protective role of IL15Rα during inflammation. J Mol Neurosci 43: 412-423, 2011.
28. Tu H, Hsuchou H, Kastin AJ, Wu X, Pan W. Unique leptin trafficking by a tailless receptor. FASEB J 24: 2281-2291, 2010.
29. Tu H, Kastin AJ, Hsuchou H, Pan W. Soluble receptor inhibits leptin transport. J Cell Physiol 214: 301-305, 2008.
30. Tu H, Pan W, Feucht L, Kastin AJ. Convergent trafficking pattern of leptin after endocytosis mediated by ObRa-ObRd. J Cell Physiol 212: 215-222, 2007.
31. Uotani S, Bjorbaek C, Tornoe J, Flier JS. Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48: 279-286, 1999.
32. Zhang Y, Wu X, He Y, Kastin AJ, Hsuchou H, Rosenblum CI, Pan W. Melanocortin potentiates leptin-induced STAT3 signaling via MAPK pathway. J Neurochem 110: 390-399, 2009.