Chronic regulation of the renal Na+/H+ exchanger NHE3 by dopamine: Translational and posttranslational mechanisms

American Journal of Physiology - Renal Physiology

Volumn 304, Issue 9, 2013, Pages

  Hu, Ming Chang ^a,b   Di Sole, Francesca ^a,b   Zhang, Jianning ^a   McLeroy, Paul ^a   Moe, Orson W ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

5' untranslated region; Dopamine; Natriuresis; NHE3; Ubiquitylation

Indexed keywords

DOPAMINE; GAMMA GLUTAMYLDOPA; LACTACYSTIN; LEUPEPTIN; SODIUM PROTON EXCHANGE PROTEIN 3;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; BRUSH BORDER; CELL SURFACE; ENDOCYTOSIS; HALF LIFE TIME; KIDNEY CORTEX; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; REGULATORY MECHANISM; UBIQUITINATION;

EID: 84878563444     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00630.2012     Document Type: Article

References (120)

1. Albrecht FE, Drago J, Felder RA, Printz MP, Eisner GM, Robillard JE, Sibley DR, Westphal HJ, Jose PA. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. J Clin Invest 97: 2283-2288, 1996.
2. Albrecht FE, Xu J, Moe OW, Hopfer U, Simonds WF, Orlowski J, Jose PA. Regulation of NHE3 activity by G protein subunits in renal brush-border membranes. Am J Physiol Regul Integr Comp Physiol 278: R1064-R1073, 2000.
3. Alexander RT, Grinstein S. Tethering, recycling and activation of the epithelial sodium-proton exchanger, NHE3. J Exp Biol 212: 1630-1637, 2009.
4. Ambuhl PM, Amemiya M, Danczkay M, Lotscher M, Kaissling B, Moe OW, Preisig PA, Alpern RJ. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 271: F917-F925, 1996.
5. Ambuhl PM, Yang X, Peng Y, Preisig PA, Moe OW, Alpern RJ. Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3). J Clin Invest 103: 429-435, 1999.
6. Amemiya M, Loffing J, Lotscher M, Kaissling B, Alpern RJ, Moe OW. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int 48: 1206-1215, 1995.
7. Amemiya M, Yamaji Y, Cano A, Moe OW, Alpern RJ. Acid incubation increases NHE-3 mRNA abundance in OKP cells. Am J Physiol Cell Physiol 269: C126-C133, 1995.
8. +-ATPase activity in rat proximal convoluted tubule segments. Am J Physiol Renal Fluid Electrolyte Physiol 252: F39-F45, 1987.
9. Aperia AC. Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolism. Annu Rev Physiol 62: 621-647, 2000.
10. Asico LD, Ladines C, Fuchs S, Accili D, Carey RM, Semeraro C, Pocchiari F, Felder RA, Eisner GM, Jose PA. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. J Clin Invest 102: 493-498, 1998.
11. +/phosphate cotransporter NaPi-IIa in mouse kidney and OK cells. Am J Physiol Renal Physiol 288: F740-F747, 2005.
12. Bacic D, Kaissling B, McLeroy P, Zou L, Baum M, Moe OW. Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule. Kidney Int 64: 2133-2141, 2003.
13. Baines AD, Drangova R. Does dopamine use several signal pathways to inhibit Na-Pi transport in OK cells? J Am Soc Nephrol 9: 1604-1612, 1998.
14. Ball SG, Lee MR. The effect of carbidopa administration on urinary sodium excretion in man. Is dopamine an intrarenal natriuretic hormone? Br J Clin Pharmacol 4: 115-119, 1977.
15. Baum M, Amemiya M, Dwarakanath V, Alpern RJ, Moe OW. Glucocorticoids regulate NHE-3 transcription in OKP cells. Am J Physiol Renal Fluid Electrolyte Physiol 270: F164-F169, 1996.
16. + antiporter. Kidney Int 53: 1254-1258, 1998.
17. Baum M, Moe OW, Gentry DL, Alpern RJ. Effect of glucocorticoids on renal cortical NHE-3 and NHE-1 mRNA. Am J Physiol Renal Fluid Electrolyte Physiol 267: F437-F442, 1994.
18. Baum M, Quigley R. Inhibition of proximal convoluted tubule transport by dopamine. Kidney Int 54: 1593-1600, 1998.
19. Bek MJ, Wang X, Asico LD, Jones JE, Zheng S, Li X, Eisner GM, Grandy DK, Carey RM, Soares-da-Silva P, Jose PA. Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice. Hypertension 47: 288-295, 2006.
20. Bello-Reuss E, Higashi Y, Kaneda Y. Dopamine decreases fluid reab-sorption in straight portions of rabbit proximal tubule. Am J Physiol Renal Fluid Electrolyte Physiol 242: F634-F640, 1982.
21. +-ATPase activity requires simultaneous activation of DA1 and DA2 receptors. Am J Physiol Renal Fluid Electrolyte Physiol 259: F924-F928, 1990.
22. Bertorello A, Hokfelt T, Goldstein M, Aperia A. Proximal tubule Na+-K+-ATPase activity is inhibited during high-salt diet: evidence for DA-mediated effect. Am J Physiol Renal Fluid Electrolyte Physiol 254: F795-F801, 1988.
23. + exchanger-3 (NHE3) by activation of NHE3 exocytosis. Am J Physiol Renal Physiol 289: F685-F691, 2005.
24. + exchangers in renal regulation of acid-base balance. Semin Nephrol 26: 334-344, 2006.
25. + exchange in the proximal tubule. Pflügers Arch 458: 5-21, 2009.
26. + exchanger NHE3 by dopamine: role of protein phosphatase 2A. Am J Physiol Renal Physiol 298: F1205-F1213, 2010.
27. Cano A. Characterization of the rat NHE3 promoter. Am J Physiol Renal Fluid Electrolyte Physiol 271: F629-F636, 1996.
28. Cano A, Baum M, Moe OW. Thyroid hormone stimulates the renal Na/H exchanger NHE3 by transcriptional activation. Am J Physiol Cell Physiol 276: C102-C108, 1999.
29. Chan YL. Cellular mechanisms of renal tubular transport of I-dopa and its derivatives in the rat: microperfusion studies. J Pharmacol Exp Ther 199: 17-24, 1976.
30. Clark BA, Rosa RM, Epstein FH, Young JB, Landsberg L. Altered dopaminergic responses in hypertension. Hypertension 19: 589-594, 1992.
31. Damasceno A, Santos A, Serrao P, Caupers P, Soares-da-Silva P, Polonia J. Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects. J Hypertens 17: 1995-2001, 1999.
32. +-exchanger 3 trafficking via ezrin phosphorylation. J Am Soc Nephrol 20: 1776-1786, 2009.
33. + exchanger NHE3 activity and expression in opossum kidney cells. J Cell Physiol 216: 221-233, 2008.
34. Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X. NHE3 regulatory complexes. J Exp Biol 212: 1638-1646, 2009.
35. Fehr C, Conrad KD, Niepmann M. Differential stimulation of hepatitis C virus RNA translation by microRNA-122 in different cell cycle phases. Cell Cycle 11: 277-285, 2012.
36. + exchange in renal brush border by D1 dopamine agonists. Am J Physiol Renal Fluid Electrolyte Physiol 264: F1032-F1037, 1993.
37. Freestone S, Ellis R, MacDonald TM, Lee MR. Effect of prolonged intravenous infusion of gludopa in humans and a preliminary study of its oral bioavailability. Am J Hypertens 3: 126S-129S, 1990.
38. Gentzsch M, Chang XB, Cui L, Wu Y, Ozols VV, Choudhury A, Pagano RE, Riordan JR. Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator. Mol Biol Cell 15: 2684-2696, 2004.
39. + exchanger. Am J Physiol Renal Fluid Electrolyte Physiol 258: F514-F521, 1990.
40. Gill JR Jr, Grossman E, Goldstein DS. High urinary dopa and low urinary dopamine-to-dopa ratio in salt-sensitive hypertension. Hypertension 18: 614-621, 1991.
41. + exchanger isoform NHE3 in proximal tubule cells. Am J Physiol Cell Physiol 287: C1238-C1245, 2004.
42. +-phosphate cotransport by dopamine. Am J Physiol Renal Fluid Electrolyte Physiol 264: F618-F622, 1993.
43. Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82: 373-428, 2002.
44. Goldstein DS, Stull R, Eisenhofer G, Gill JR Jr. Urinary excretion of dihydroxyphenylalanine and dopamine during alterations of dietary salt intake in humans. Clin Sci (Lond) 76: 517-522, 1989.
45. Goossen B, Caughman SW, Harford JB, Klausner RD, Hentze MW. Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo. EMBO J 9: 4127-4133, 1990.
46. Grider J, Kilpatrick E, Ott C, Jackson B. Effect of dopamine on NaCl transport in the medullary thick ascending limb of the rat. Eur J Pharmacol 342: 281-284, 1998.
47. Grider JS, Ott CE, Jackson BA. Dopamine D1 receptor-dependent inhibition of NaCl transport in the rat thick ascending limb: mechanism of action. Eur J Pharmacol 473: 185-190, 2003.
48. Grossman E, Hoffman A, Tamrat M, Armando I, Keiser HR, Goldstein DS. Endogenous dopa and dopamine responses to dietary salt loading in salt-sensitive rats. J Hypertens 9: 259-263, 1991.
49. + antiporter (NHE3) in the proximal tubule of the hypothyroid adrenalec-tomized rat. Am J Physiol Renal Physiol 287: F521-F527, 2004.
50. Hagiwara N, Kubota T, Kubokawa M, Fujimoto M. Effects of dopamine on the transport of Na, H, and Ca in the bullfrog proximal tubule. Jpn J Physiol 40: 351-368, 1990.
51. Hansell P, Fasching A. The effect of dopamine receptor blockade on natriuresis is dependent on the degree of hypervolemia. Kidney Int 39: 253-258, 1991.
52. Hayashi M, Yamaji Y, Kitajima W, Saruta T. Aromatic L-amino acid decarboxylase activity along the rat nephron. Am J Physiol Renal Fluid Electrolyte Physiol 258: F28-F33, 1990.
53. Hebert SC. Bartter syndrome. Curr Opin Nephrol Hypertens 12: 527-532, 2003.
54. Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl~ cotransport: the SLC12 family. Pflügers Arch 447: 580-593, 2004.
55. Hegde SS, Jadhav AL, Lokhandwala MF. Role of kidney dopamine in the natriuretic response to volume expansion in rats. Hypertension 13: 828-834, 1989.
56. Hegde SS, Lokhandwala MF. Renal dopamine and sodium excretion. Am J Hypertens 3: 78S-81S, 1990.
57. Hollenberg NK, Adams DF, Mendell P, Abrams HL, Merrill JP. Renal vascular responses to dopamine: haemodynamic and angiographic observations in normal man. Clin Sci Mol Med 45: 733-742, 1973.
58. Hollon TR, Bek MJ, Lachowicz JE, Ariano MA, Mezey E, Ram-achandran R, Wersinger SR, Soares-da-Silva P, Liu ZF, Grinberg A, Drago J, Young WS 3rd, Westphal H, Jose PA, Sibley DR. Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci 22: 10801-10810, 2002.
59. + exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation. J Biol Chem 276: 26906-26915, 2001.
60. Huang CL, Kuo E, Toto RD. WNK kinases and essential hypertension. Curr Opin Nephrol Hypertens 17: 133-137, 2008.
61. Jackson RJ, Hellen CU, Pestova TV. The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol 11: 113-127, 2010.
62. Jose PA, Eisner GM, Drago J, Carey RM, Felder RA. Dopamine receptor signaling defects in spontaneous hypertension. Am J Hypertens 9: 400-405, 1996.
63. Jose PA, Eisner GM, Felder RA. Renal dopamine receptors in health and hypertension. Pharmacol Ther 80: 149-182, 1998.
64. Jose PA, Eisner GM, Felder RA. Renal dopamine and sodium homeostasis. Curr Hypertens Rep 2: 174-183, 2000.
65. Kiwull-Schone H, Kiwull P, Frede S, Wiemann M. Role of brainstem sodium/proton exchanger 3 for breathing control during chronic acid base imbalance. Am J Respir Crit Care Med 176: 513-519, 2007.
66. + exchanger 3: biphasic response and glucocorticoid dependence. Am J Physiol Renal Physiol 283: F532-F539, 2002.
67. + exchanger 3 in OKP cells. J Am Soc Nephrol 14: 3008-3016, 2003.
68. + exchanger NHE3 at PKA consensus sites. Am J Physiol Renal Physiol 289: F249-F258, 2005.
69. Kozak M. Interpreting cDNA sequences: some insights from studies on translation. Mamm Genome 7: 563-574, 1996.
70. Krishna GG, Danovitch GM, Beck FW, Sowers JR. Dopaminergic mediation of the natriuretic response to volume expansion. J Lab Clin Med 105: 214-218, 1985.
71. Kuchel OG, Kuchel GA. Peripheral dopamine in pathophysiology of hypertension. Interaction with aging and lifestyle. Hypertension 18: 709-721, 1991.
72. Lederer ED, Sohi SS, McLeish KR. Dopamine regulates phosphate uptake by opossum kidney cells through multiple counter-regulatory receptors. J Am Soc Nephrol 9: 975-985, 1998.
73. + exchanger but not in mice lacking NHE2. Am J Physiol Renal Physiol 281: F718-F727, 2001.
74. Lee MR. Five years' experience with gamma-L-glutamyl-L-dopa: a relatively renally specific dopaminergic prodrug in man. J Auton Pharmacol 10, Suppl 1: s103-s108, 1990.
75. Li XX, Bek M, Asico LD, Yang Z, Grandy DK, Goldstein DS, Rubinstein M, Eisner GM, Jose PA. Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice. Hypertension 38: 303-308, 2001.
76. Lin DH, Sterling H, Wang Z, Babilonia E, Yang B, Dong K, Hebert SC, Giebisch G, Wang WH. ROMK1 channel activity is regulated by monoubiquitination. Proc Natl Acad Sci USA 102: 4306-4311, 2005.
77. Loffing J, Lotscher M, Kaissling B, Biber J, Murer H, Seikaly M, Alpern RJ, Levi M, Baum M, Moe OW. Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states. J Am Soc Nephrol 9: 1560-1567, 1998.
78. McDonald RH Jr, Goldberg LI, McNay JL, Tuttle EP Jr. Effect of dopamine in man: augmentation of sodium excretion, glomerular filtration rate, and renal plasma flow. J Clin Invest 43: 1116-1124, 1964.
79. Min H, Yoon S. Got target? Computational methods for microRNA target prediction and their extension. Exp Mol Med 42: 233-244, 2010.
80. Moe OW, Miller RT, Horie S, Cano A, Preisig PA, Alpern RJ. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. J Clin Invest 88: 1703-1708, 1991.
81. Moe OW, Preisig PA, Alpern RJ. Cellular model of proximal tubule NaCl and NaHCO3 absorption. Kidney Int 38: 605-611, 1990.
82. Olsen NV, Fogh-Andersen N, Strandgaard S, Leyssac PP. Endogenous versus exogenous lithium clearance for evaluation of dopamine-induced changes in renal tubular function. Clin Sci (Lond) 90: 511-515, 1996.
83. Orlowski J, Kandasamy RA, Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 267: 9331-9339, 1992.
84. Pelayo JC, Fildes RD, Eisner GM, Jose PA. Effects of dopamine blockade on renal sodium excretion. Am J Physiol Renal Fluid Electrolyte Physiol 245: F247-F253, 1983.
85. Perrichot R, Garcia-Ocana A, Couette S, Comoy E, Amiel C, Fried-lander G. Locally formed dopamine modulates renal Na-Pi co-transport through DA1 and DA2 receptors. Biochem J 312: 433-437, 1995.
86. Quinones H, Collazo R, Moe OW. The dopamine precursor L-dihy-droxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex. Am J Physiol Renal Physiol 287: F74-F80, 2004.
87. Riveira-Munoz E, Chang Q, Bindels RJ, Devuyst O. Gitelman's syndrome: towards genotype-phenotype correlations? Pediatr Nephrol 22: 326-332, 2007.
88. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78: 761-771, 1994.
89. Romero-Vecchione E, Vasquez J, Lema G, Guerrero H, Rosa F, Bermudez M. Low urinary dopamine excretion associated to low sodium excretion in normotensive Piaroa Amazonian ethnia compared to urban subjects. Invest Clin 36: 61-71, 1995.
90. Schultheis PJ, Clarke LL, Meneton P, Miller ML, Soleimani M, Gawenis LR, Riddle TM, Duffy JJ, Doetschman T, Wang T, Giebisch G, Aronson PS, Lorenz JN, Shull GE. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet 19: 282-285, 1998.
91. Schwake M, Friedrich T, Jentsch TJ. An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease. J Biol Chem 276: 12049-12054, 2001.
92. Sheikh-Hamad D, Wang YP, Jo OD, Yanagawa N. Dopamine antagonizes the actions of angiotensin II in renal brush-border membrane. Am J Physiol Renal Fluid Electrolyte Physiol 264: F737-F743, 1993.
93. + exchanger 1 ubiquitylation, endocytosis, and function. J Biol Chem 285: 38293-38303, 2010.
94. Siragy HM, Felder RA, Howell NL, Chevalier RL, Peach MJ, Carey RM. Evidence that intrarenal dopamine acts as a paracrine substance at the renal tubule. Am J Physiol Renal Fluid Electrolyte Physiol 257: F469-F477, 1989.
95. Sowers JR, Crane PD, Beck FW, McClanahan M, King ME, Mo-hanty PK. Relationship between urinary dopamine production and natriuresis after acute intravascular volume expansion with sodium chloride in dogs. Endocrinology 115: 2085-2090, 1984.
96. + channel (ENaC) by ubiquitination. EMBO J 16: 6325-36, 1997.
97. Staub O, Rotin D. Role of ubiquitylation in cellular membrane transport. Physiol Rev 86: 669-707, 2006.
98. Staudacher T, Pech B, Tappe M, Gross G, Muhlbauer B, Luippold G. Arterial blood pressure and renal sodium excretion in dopamine D3 receptor knockout mice. Hypertens Res 30: 93-101, 2007.
99. Stier CT Jr, Itskovitz HD, Chen YH. Urinary dopamine and sodium excretion in spontaneously hypertensive rats. Clin Exp Hypertens 15: 105-123, 1993.
100. Suzuki H, Nakane H, Kawamura M, Yoshizawa M, Takeshita E, Saruta T. Excretion and metabolism of dopa and dopamine by isolated perfused rat kidney. Am J Physiol Endocrinol Metab 247: E285-E290, 1984.
101. Takemoto F, Cohen HT, Satoh T, Katz AI. Dopamine inhibits Na/K-ATPase in single tubules and cultured cells from distal nephron. Pflügers Arch 421: 302-306, 1992.
102. Tamarapu Parthasarathy P, Galam L, Huynh B, Yunus A, Abuele-nen T, Castillo A, Kollongod Ramanathan G, Cox R Jr, Kolliputi N. MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells. Biochem Biophys Res Commun 426: 203-208, 2012.
103. Treier M, Staszewski LM, Bohmann D. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78: 787-798, 1994.
104. Wahbe F, Hagege J, Loreau N, Ardaillou R. Endogenous dopamine synthesis and dopa-decarboxylase activity in rat renal cortex. Mol Cell Endocrinol 27: 45-54, 1982.
105. Wang ZQ, Siragy HM, Felder RA, Carey RM. Intrarenal dopamine production and distribution in the rat. Physiological control of sodium excretion. Hypertension 29: 228-234, 1997.
106. Wang ZQ, Way D, Trigg L, McGrath BP. DA-1 receptors mediate renal effects of the dopamine prodrug, gludopa, in conscious rabbits. Clin Exp Pharmacol Physiol 19: 369-372, 1992.
107. Warnock DG. The epithelial sodium channel in hypertension. Curr Hypertens Rep 1: 158-163, 1999.
108. Wiederkehr MR, Di Sole F, Collazo R, Quinones H, Fan L, Murer H, Helmle-Kolb C, Moe OW. Characterization of acute inhibition of Na/H exchanger NHE-3 by dopamine in opossum kidney cells. Kidney Int 59: 197-209, 2001.
109. + antiport in proximal tubular brush border membrane: role of dopamine. Kidney Int 38: 1133-1140, 1990.
110. Wolfovitz E, Grossman E, Folio CJ, Keiser HR, Kopin IJ, Goldstein DS. Derivation of urinary dopamine from plasma dihydroxyphenylala-nine in humans. Clin Sci (Lond) 84: 549-557, 1993.
111. Woo AL, Noonan WT, Schultheis PJ, Neumann JC, Manning PA, Lorenz JN, Shull GE. Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect. Am J Physiol Renal Physiol 284: F1190-F1198, 2003.
112. + exchange. Adaptation to metabolic acidosis. J Biol Chem 271: 32749-32752, 1996.
113. Xu G, Rabadan-Diehl C, Nikodemova M, Wynn P, Spiess J, Aguilera G. Inhibition of corticotropin releasing hormone type-1 receptor translation by an upstream AUG triplet in the 5' untranslated region. Mol Pharmacol 59: 485-492, 2001.
114. Yang Z, Asico LD, Yu P, Wang Z, Jones JE, Escano CS, Wang X, Quinn MT, Sibley DR, Romero GG, Felder RA, Jose PA. D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure. Am J Physiol Regul Integr Comp Physiol 290: R96-R104, 2006.
115. Yoshimura M, Kambara S, Okabayashi H, Takahashi H, Ijichi H. Effect of decreased dopamine synthesis on the development of hypertension induced by salt loading in spontaneously hypertensive rats. Clin Exp Hypertens A 9: 1141-1157, 1987.
116. Zeng C, Armando I, Luo Y, Eisner GM, Felder RA, Jose PA. Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Am J Physiol Heart Circ Physiol 294: H551-H569, 2008.
117. Zeng C, Jose PA. Dopamine receptors: important antihypertensive counterbalance against hypertensive factors. Hypertension 57: 11-17, 2011.
118. Zeng C, Yang Z, Asico LD, Jose PA. Regulation of blood pressure by D5 dopamine receptors. Cardiovasc Hematol Agents Med Chem 5: 241-248, 2007.
119. Zhao H, Wiederkehr MR, Fan L, Collazo RL, Crowder LA, Moe OW. Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase a and NHE-3 phosphoserines 552 and 605. J Biol Chem 274: 3978-87, 1999.
120. Zheng S, Yu P, Zeng C, Wang Z, Yang Z, Andrews PM, Felder RA, Jose PA. Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron. Hypertension 41: 604-610, 2003.