Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension

Journal of Clinical Investigation

Volumn 102, Issue 3, 1998, Pages 493-498

  Asico, Laureano D ^a   Ladines, Cecilia ^a   Fuchs, Sara ^b   Accili, Domenico ^c   Carey, Robert M ^e   Semeraro, Claudio ^d   Pocchiari, Felice ^d   Felder, Robin A ^e   Eisner, Gilbert M ^a   Jose, Pedro A ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d Zambon Group SpA   (Italy)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Catecholamines; D3 receptor gene; Dopamine receptor; Renin

Indexed keywords

ALDOSTERONE; DOPAMINE 3 RECEPTOR; RENIN; ANGIOTENSIN I; ANGIOTENSIN RECEPTOR; DOPAMINE 2 RECEPTOR; DRD3 PROTEIN, MOUSE; SODIUM CHLORIDE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; GENE MUTATION; HYPERTENSION; MOUSE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RECEPTOR GENE; SODIUM BALANCE; ANIMAL; BLOOD; BLOOD PRESSURE; COMPARATIVE STUDY; DISEASE MODEL; DIURESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GENOTYPE; JUXTAGLOMERULAR APPARATUS; KIDNEY PROXIMAL TUBULE; MOUSE MUTANT; NATRIURESIS; PATHOPHYSIOLOGY; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANGIOTENSIN I; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DIURESIS; GENOTYPE; HYPERTENSION; JUXTAGLOMERULAR APPARATUS; KIDNEY TUBULES, PROXIMAL; MICE; MICE, KNOCKOUT; NATRIURESIS; RECEPTORS, ANGIOTENSIN; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RENIN; RENIN-ANGIOTENSIN SYSTEM; SODIUM CHLORIDE;

EID: 0032129201     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3685     Document Type: Article

References (39)

1. Lifton, R.P. 1996. Molecular genetics of human blood pressure variation. Science. 272:676-680.
2. Sealy, J.E., J.D. Blumenfeld, G.M. Bell, M.S. Pecker, S.C. Sommers, and J.H. Laragh. 1996. Nephron heterogeneity with unsuppressible renin secretion: a cause of essential hypertension. In Hypertension. Pathophysiology, Diagnosis, and Management, 2nd ed. J.H. Laragh, and B.M. Brenner, editors, Raven Press, Ltd., New York. 1405-1421.
3. Jeunemaitre, X., F. Soubrier, Y.V. Kotelevtsev, R.P. Lifton, C.S. Williams, A. Charru, S.C. Hunt, P.N. Hopkins, R.R. Williams, J. Lalouel, and P. Corvol. 1992. Molecular basis of human hypertension: role of angiotensinogen. Cell. 71:169-180.
4. Hopkins, P.N., R.P. Lifton, N.K. Hollenberg, X. Jeunemaitre, M.C. Hallouin, J. Skuppin, C.S. Williams, R.G. Dluhy, J.M. Lalouel, R.R. Williams, and G.H. Williams. 1996. Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity. J. Hypertens. 14:199-207.
5. Brand, E., N. Chatelain, B. Keavney, M. Caulfield, L. Citterio, J. Connell, D. Grobbee, S. Schmidt, H. Schunkert, H. Schuster, et al. Evaluation of the angiotensinogen locus in human essential hypertension. A European study. 1998. Hypertension (Dallas). 31:725-729.
6. Antonipillai, I., M.I. Broers, and D. Lang. 1989. Evidence that specific dopamine-1 receptor activation is involved in dopamine-induced renin release. Hypertension (Dallas). 13:463-468.
7. Kurtz, A., R. Della Bruna, J. Pratz, and I. Cavero. 1988. Rat juxtaglomerular cells are endowed with DA-1 dopamine receptors mediating renin release. J. Cardiovasc. Pharmacol. 12:658-663.
8. 1A receptors in rat juxtaglomerular cells. Hypertension (Dallas). 29:962-968.
9. Wang, T.T., S. Lachance, A. Delalandre, S. Carriere, and J.S. Chan. 1996. Dopaminergic receptors and angiotensinogen gene expression in opossum kidney cells. Am. J. Physiol. 271:R519-R527.
10. Jose, P.A., and R.A. Felder. 1996. What we can learn from the selective manipulation of dopaminergic receptors about pathogenesis and treatment of hypertension? Curr. Opin. Nephrol. Hypertens. 5:447-451.
11. Jeffrey, R.F., T.M. MacDonald, K. Marwick, and M.R. Lee. 1988. The effect of carbidopa and indomethacin on the renal response to γ-L-glutamyl-L-dopa in normal man. Br. J. Clin. Pharmacol. 25:195-201.
12. MacDonald, T.M., R.F. Jeffrey, S. Freestone, and M.R. Lee. 1988. (+)-sulpiride antagonizes the renal effects of L-glutamyl-L-dopa in man. Br. J. Clin. Pharmacol. 25:203-212.
13. Worth, D.P., J.N. Harvey, J. Brown, A. Worral, and M.R. Lee. 1986. Domperidone treatment in man inhibits the fall in plasma renin activity induced by intravenous L-glutamyl-L-dopa. Br. J Clin. Pharmacol. 21:497-502.
14. 3 receptors in rat juxtaglomerular cells. Clin. Exp. Hypertens. 19: 93-105.
15. Jose, P.A., L.D. Asico, G.M. Eisner, F. Pocchiari, C. Semeraro, R.M. Carey, and R.A. Felder. 1997. Z1046, a novel dopaminergic agonist: vasodilator and natriuretic and inhibitory of renin secretion. J. Investig. Med. 45:277A. (Abstr.)
16. Kim, H.S., J.H. Krege, K.D. Kluckman, J.R. Hagaman, J.B. Hodgin, C.F. Best, J.C. Jennette, T.M. Coffman, N. Maeda, and O. Smithies. 1995. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. USA. 92:2735-2739.
17. Merrill, D.C., M.W. Thompson, C.L. Carney, B.P. Granwehr, G. Schlager, J.E. Robillard, and C.D. Sigmund. 1996. Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J. Clin. Invest. 97:1047-1055.
18. Mullins, J.J., J. Peters, and D. Ganten. 1990. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature. 344:541-544.
19. 3 dopamine receptor gene is associated with hyperactivity in mice. Proc. Natl. Acad. Sci. USA. 93:1945-1949.
20. 3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron. 19:838-848.
21. 1A dopamine receptor in the pathogenesis of genetic hypertension. J. Clin. Invest. 97:2283-2288.
22. 3 subtypes. Brain Res. 649:95-110.
23. Yu, P.-Y., L. D. Asico, G.M. Eisner, and P.A. Jose. 1995. Differential regulation of renal phospholipase C isoforms by catecholamines. J. Clin. Invest. 95:304-308.
24. Norwood, V.F., R.M. Carey, K. Geary, P.A. Jose, R.A. Gomez, and R.L. Chevalier. 1994. Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells. Kidney Int. 45:1333-1339.
25. 3 receptor-preferring agonist: comparison to other dopamine receptor agonists. Eur. J. Pharmacol. 312:35-44.
26. 2 receptors. Am. J. Physiol. 259:F924-F928.
27. Satoh, T., H.T. Cohen, and A.I. Katz. Different mechanisms of renal Na-K-ATPase regulation by protein kinases in proximal and distal nephron. Am. J. Physiol. 265:F399-F405.
28. Sheikh-Hamad, D., Y.-P. Wang, O.D. Jo, and N. Yanagawa. 1993. Dopamine antagonizes the actions of angiotensin II in renal brush-border membrane. Am. J. Physiol. 264:F737-F743.
29. Ferguson, M., and C. Bell. 1991. Two patterns of dopa decarboxylase immunoreactivity in sympathetic axons supplying rat renal cortex. Renal Physiol. Biochem. 14:55-62.
30. Ozono, R., D.P. O'Connell, C. Vaughan, S.J. Botkin, S.F. Walk, R.A. Felder, and R.M. Carey. 1996. Expression of the subtype 1A dopamine receptor in the rat heart. Hypertension (Dallas). 27:693-703.
31. Williams, B.C., A. Eglen, F.M. Duncan, and C.R. Edwards. 1985. The effect of sodium intake on the renin response to dopamine in superfused rat cortical cells. J. Hypertens. 3(Suppl. 3):S267-S268.
32. Smithies, O., and N. Maeda. 1995. Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension. Proc. Natl. Acad. Sci. USA. 92:5266-5272.
33. Shesely, E.G., N. Maeda, H.S. Kim, K.M. Desai, J.H. Krege, V.E. Laubach, P.A. Sherman, W.C. Sessa, and O. Smithies. 1996. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA. 93:13176-13181.
34. Tsuda, K., S. Tsuda, and Y. Masuyama. 1988. The role of dopamine in the regulation of neurotransmitter release in spontaneously hypertensive rats. Jpn. Heart J. 29:215-222.
35. Jose, P.A., G.M. Eisner, J. Drago, R.M. Carey, R.A. Felder. 1996. Dopamine receptor signaling defects in spontaneous hypertension. Am. J. Hypertens. 9:400-405.
36. Kinoshita, S., A. Sidhu, and R.A. Felder. 1989. Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat. J. Clin. Invest. 84:1849-1856.
37. Chen, C., R.E. Beach, and M.F. Lokhandwala. 1993. Dopamine fails to inhibit renal tubular sodium pump in hypertensive rats. Hypertension (Dallas). 21:364-372.
38. Williams, G.H., and N.D.L. Fisher. 1997. Genetic approach to diagnostic and therapeutic decisions in human hypertension. Curr. Opin. Nephrol. Hypertens. 6:199-204.
39. 3 receptor in peripheral mononuclear cells of essential hypertensives. Hypertension (Dallas). 30:1566-1571.