Immunology: Extensive diversity of Ig-superfamily proteins in the immune system of insects

Science

Volumn 309, Issue 5742, 2005, Pages 1874-1878

  Watson, Fiona L ^a   Püttmann Holgado, Roland ^a   Thomas, Franziska ^a,b   Lamar, David L ^a,c   Hughes, Michael ^a   Kondo, Masahiro ^a   Rebel, Vivienne I ^a,d   Schmucker, Dietmar ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; BACTERIA; CELLS; INSECT CONTROL; PROTEINS;

BACTERIAL BINDING; HEMOLYMPH; IMMUNE RECEPTORS; SOMATIC DIVERSIFICATION;

IMMUNOLOGY;

CELL ADHESION MOLECULE; IMMUNOGLOBULIN RECEPTOR; ISOPROTEIN; DROSOPHILA PROTEIN; DSCAM PROTEIN, DROSOPHILA; IMMUNOGLOBULIN;

MEDICINE;

ARTICLE; BIODIVERSITY; CONTROLLED STUDY; DROSOPHILA; DSCAM GENE; GENE; HEMOLYMPH; IMMUNOGENETICS; INNATE IMMUNITY; LYMPHOCYTE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL; BLOOD CELL; BRAIN; CELL LINE; CHEMISTRY; DNA MICROARRAY; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FAT BODY; GENETICS; IMMUNOLOGY; INSECT; METABOLISM; MOLECULAR GENETICS; NERVE CELL; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE; TRANSGENIC ANIMAL;

BACTERIA (MICROORGANISMS); HEXAPODA; INSECTA; INVERTEBRATA; VERTEBRATA;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ESCHERICHIA COLI; FAT BODY; HEMOCYTES; HEMOLYMPH; IMMUNITY, NATURAL; IMMUNOGLOBULINS; INSECTS; MOLECULAR SEQUENCE DATA; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHAGOCYTOSIS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IMMUNOLOGIC; RNA INTERFERENCE;

EID: 24944454976     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1116887     Document Type: Article

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25. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
26. We thank S. Sinenko and B. Mathey-Prevot for Hml-GAL4 flies and important advice; H. Agaisse and N. Perrimon for S2 cells, UAS-dslacZ flies, and insightful discussions; S. Brown, Kansas State University, for embryonic RNA from Tribolium; and S. Lewis, Tufts University, for Tribolium animals; members of Dana-Farber Core Facility and the Mass-Spec Facility at Harvard Medical School (Boston, MA) for the help during LC-MS/MS analysis; W. Wojtowicz, J. Clemens, and L. Zipursky for kindly providing the Dscam-Fc expression constructs; E. Tanner, A. Wakabayashi, and M. Sackal for excellent technical assistance; and C. Weitz, C. Stiles, N. Perrimon, H. Agaisse, B. Mathey-Prevot J. Green, Q. Ma, and B. Chen for critical reading of the manuscript This research was supported by a Medical Foundation Award (D.S.), a Pew Scholars Program Award (D.S.), and a John Merck Fund Award (D.S.). Work on the Dscam expression analysis was supported by NIH grant 1RO1-NS46747-01 (D.S.). Sequences have been deposited at GenBank (accession number DQ157471).