메뉴 건너뛰기




Volumn 23, Issue 2, 2009, Pages 147-156

Dscam and DSCAM: Complex genes in simple animals, complex animals yet simple genes

Author keywords

Alternative splicing; Dscam; Immunoglobulin receptor; Neural circuit formation

Indexed keywords

CELL ADHESION MOLECULE; DOWN SYNDROME CELL ADHESION MOLECULE; DSCAM RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG;

EID: 58849147630     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1752909     Document Type: Review
Times cited : (144)

References (53)
  • 1
    • 0034811349 scopus 로고    scopus 로고
    • Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion
    • Agarwala, K. 2001. Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion. Biochem. Biophys. Res. Commun. 285: 760-772.
    • (2001) Biochem. Biophys. Res. Commun , vol.285 , pp. 760-772
    • Agarwala, K.1
  • 2
    • 0034705561 scopus 로고    scopus 로고
    • Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion
    • Agarwala, K.L., Nakamura, S., Tsutsumi, Y., and Yamakawa, K. 2000. Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion. Brain Res. Mol. Brain Res. 79: 118-126.
    • (2000) Brain Res. Mol. Brain Res , vol.79 , pp. 118-126
    • Agarwala, K.L.1    Nakamura, S.2    Tsutsumi, Y.3    Yamakawa, K.4
  • 3
    • 0036298195 scopus 로고    scopus 로고
    • Mammalian DSCAMs: Roles in the development of the spinal cord, cortex, and cerebellum?
    • Barlow, G., Micales, B., Chen, X., Lyons, G.E., and Korenberg, J. 2002. Mammalian DSCAMs: Roles in the development of the spinal cord, cortex, and cerebellum? Biochem. Biophys. Res. Commun. 293: 881-891.
    • (2002) Biochem. Biophys. Res. Commun , vol.293 , pp. 881-891
    • Barlow, G.1    Micales, B.2    Chen, X.3    Lyons, G.E.4    Korenberg, J.5
  • 4
    • 0035477393 scopus 로고    scopus 로고
    • Neuronal plasticity and cellular immunity: Shared molecular mechanisms
    • Boulanger, L.M., Huh, G.S., and Shatz, C.J. 2001. Neuronal plasticity and cellular immunity: Shared molecular mechanisms. Curr. Opin. Neurobiol. 11: 568-578.
    • (2001) Curr. Opin. Neurobiol , vol.11 , pp. 568-578
    • Boulanger, L.M.1    Huh, G.S.2    Shatz, C.J.3
  • 6
    • 0030592485 scopus 로고    scopus 로고
    • UNC-40, a C. elegans homolog of DCC (deleted in colorectal cancer), is required in motile cells responding to UNC-6 netrin cues
    • Chan, S.S., Zheng, H., Su, M.W., Wilk, R., Killeen, M.T., Hedgecock, E.M., and Culotti, J.G. 1996. UNC-40, a C. elegans homolog of DCC (deleted in colorectal cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87: 187-195.
    • (1996) Cell , vol.87 , pp. 187-195
    • Chan, S.S.1    Zheng, H.2    Su, M.W.3    Wilk, R.4    Killeen, M.T.5    Hedgecock, E.M.6    Culotti, J.G.7
  • 7
    • 33646131607 scopus 로고    scopus 로고
    • The molecular diversity of dscam is functionally required for neuronal wiring specificity in Drosophila
    • Chen, B., Kondo, M., Garnier, A., Watson, F., Puettmannholgado, R., Lamar, D., and Schmucker, D. 2006. The molecular diversity of dscam is functionally required for neuronal wiring specificity in Drosophila. Cell 125: 607-620.
    • (2006) Cell , vol.125 , pp. 607-620
    • Chen, B.1    Kondo, M.2    Garnier, A.3    Watson, F.4    Puettmannholgado, R.5    Lamar, D.6    Schmucker, D.7
  • 8
    • 2642648459 scopus 로고
    • The outline structure of the T-cell α β receptor
    • Chothia, C., Boswell, D.R., and Lesk, A.M. 1988. The outline structure of the T-cell α β receptor. EMBO J. 7: 3745-3755.
    • (1988) EMBO J , vol.7 , pp. 3745-3755
    • Chothia, C.1    Boswell, D.R.2    Lesk, A.M.3
  • 9
    • 33845731203 scopus 로고    scopus 로고
    • Tracking the evolution of alternatively spliced exons within the Dscam family
    • doi:10.1186/1471-2148-6-16
    • Crayton, M.E., Powell, B.C., Vision, T.J., and Giddings, M.C. 2006. Tracking the evolution of alternatively spliced exons within the Dscam family. BMC Evol. Biol. 6: 16. doi:10.1186/1471-2148-6-16.
    • (2006) BMC Evol. Biol , vol.6 , pp. 16
    • Crayton, M.E.1    Powell, B.C.2    Vision, T.J.3    Giddings, M.C.4
  • 10
    • 0037032812 scopus 로고    scopus 로고
    • Molecular mechanisms of axon guidance
    • Dickson, B.J. 2000. Molecular mechanisms of axon guidance. Science 298: 1959-1964.
    • (2000) Science , vol.298 , pp. 1959-1964
    • Dickson, B.J.1
  • 12
    • 33745874084 scopus 로고    scopus 로고
    • AgDscam, a hypervariable immunoglobulin domain-containing receptor of the anopheles gambiae innate immune system
    • doi:10.1371/journal.pbio.0040229
    • Dong, Y., Taylor, H., and Dimopoulos, G. 2006. AgDscam, a hypervariable immunoglobulin domain-containing receptor of the anopheles gambiae innate immune system. PLoS Biol. 4: e229. doi:10.1371/journal.pbio.0040229.
    • (2006) PLoS Biol , vol.4
    • Dong, Y.1    Taylor, H.2    Dimopoulos, G.3
  • 13
    • 38549102494 scopus 로고    scopus 로고
    • Neurite arborization and mosaic spacing in the mouse retina require DSCAM
    • Fuerst, P., Koizumi, A., Masland, R., and Burgess, R. 2008. Neurite arborization and mosaic spacing in the mouse retina require DSCAM. Nature 451: 470-474.
    • (2008) Nature , vol.451 , pp. 470-474
    • Fuerst, P.1    Koizumi, A.2    Masland, R.3    Burgess, R.4
  • 14
    • 33645798856 scopus 로고    scopus 로고
    • Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: A lesson from studies on planarian
    • Fusaoka, E., Inoue, T., Mineta, K., Agata, K., and Takeuchi, K. 2006. Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: A lesson from studies on planarian. Genes Cells 11: 541-555.
    • (2006) Genes Cells , vol.11 , pp. 541-555
    • Fusaoka, E.1    Inoue, T.2    Mineta, K.3    Agata, K.4    Takeuchi, K.5
  • 15
    • 26244435561 scopus 로고    scopus 로고
    • Mutually exclusive splicing of the insect premRNA directed by competing intronic RNA secondary structures
    • Graveley, B. 2005. Mutually exclusive splicing of the insect premRNA directed by competing intronic RNA secondary structures. Cell 123: 65-73.
    • (2005) Cell , vol.123 , pp. 65-73
    • Graveley, B.1
  • 16
    • 4644353346 scopus 로고    scopus 로고
    • The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes
    • Graveley, B., Kaur, A., Gunning, D., Zipursky, S., Rowen, L., and Clemens, J. 2004. The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes. RNA 10: 1499-1506.
    • (2004) RNA , vol.10 , pp. 1499-1506
    • Graveley, B.1    Kaur, A.2    Gunning, D.3    Zipursky, S.4    Rowen, L.5    Clemens, J.6
  • 17
    • 0036333568 scopus 로고    scopus 로고
    • Tiling of the Drosophila epidermis by multidendritic sensory neurons
    • Grueber, W.B., Jan, L.Y., and Jan, Y.N. 2002. Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development 129: 2867-2878.
    • (2002) Development , vol.129 , pp. 2867-2878
    • Grueber, W.B.1    Jan, L.Y.2    Jan, Y.N.3
  • 18
    • 0028361540 scopus 로고
    • Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains
    • Harpaz, Y. and Chothia, C. 1994. Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. J. Mol. Biol. 238: 528-539.
    • (1994) J. Mol. Biol , vol.238 , pp. 528-539
    • Harpaz, Y.1    Chothia, C.2
  • 19
    • 34548612755 scopus 로고    scopus 로고
    • Dscam diversity is essential for neuronal wiring and self-recognition
    • Hattori, D., Demir, E., Kim, H., Viragh, E., Zipursky, S., and Dickson, B. 2007. Dscam diversity is essential for neuronal wiring and self-recognition. Nature 449: 223-227.
    • (2007) Nature , vol.449 , pp. 223-227
    • Hattori, D.1    Demir, E.2    Kim, H.3    Viragh, E.4    Zipursky, S.5    Dickson, B.6
  • 20
    • 0034721728 scopus 로고    scopus 로고
    • Diversity and dynamics of dendritic signaling
    • Häusser, M., Spruston, N., and Stuart, G.J. 2000. Diversity and dynamics of dendritic signaling. Science 290: 739-744.
    • (2000) Science , vol.290 , pp. 739-744
    • Häusser, M.1    Spruston, N.2    Stuart, G.J.3
  • 21
    • 0025332245 scopus 로고
    • The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
    • Hedgecock, E. 1990. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4: 61-85.
    • (1990) Neuron , vol.4 , pp. 61-85
    • Hedgecock, E.1
  • 24
    • 0031030360 scopus 로고    scopus 로고
    • The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells
    • Ito, K., Awano, W., Suzuki, K., Hiromi, Y., and Yamamoto, D. 1997. The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells. Development 124: 761-771.
    • (1997) Development , vol.124 , pp. 761-771
    • Ito, K.1    Awano, W.2    Suzuki, K.3    Hiromi, Y.4    Yamamoto, D.5
  • 26
    • 0028061313 scopus 로고
    • Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
    • Kennedy, T.E., Serafini, T., de la Torre, J.R., and Tessier-Lavigne, M. 1994. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78: 425-435.
    • (1994) Cell , vol.78 , pp. 425-435
    • Kennedy, T.E.1    Serafini, T.2    de la Torre, J.R.3    Tessier-Lavigne, M.4
  • 27
    • 0037962406 scopus 로고    scopus 로고
    • Evolution of key cell signaling and adhesion protein families predates animal origins
    • King, N., Hittinger, C.T., and Carroll, S.B. 2003. Evolution of key cell signaling and adhesion protein families predates animal origins. Science 301: 361-363.
    • (2003) Science , vol.301 , pp. 361-363
    • King, N.1    Hittinger, C.T.2    Carroll, S.B.3
  • 28
    • 27944461704 scopus 로고    scopus 로고
    • The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA
    • Kreahling, J.M. and Graveley, B. 2005. The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA. Mol. Cell. Biol. 25: 10251-10260.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 10251-10260
    • Kreahling, J.M.1    Graveley, B.2
  • 29
  • 30
    • 45449083263 scopus 로고    scopus 로고
    • DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1
    • Ly, A., Nikolaev, A., Suresh, G., Zheng, Y., Tessier-Lavigne, M., and Stein, E. 2008. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell 133: 1241-1254.
    • (2008) Cell , vol.133 , pp. 1241-1254
    • Ly, A.1    Nikolaev, A.2    Suresh, G.3    Zheng, Y.4    Tessier-Lavigne, M.5    Stein, E.6
  • 33
    • 1442311559 scopus 로고    scopus 로고
    • Stochastic yet biased expression of multiple Dscam splice variants by individual cells
    • Neves, G., Zucker, J., Daly, M., and Chess, A. 2004. Stochastic yet biased expression of multiple Dscam splice variants by individual cells. Nat. Genet. 36: 240-246.
    • (2004) Nat. Genet , vol.36 , pp. 240-246
    • Neves, G.1    Zucker, J.2    Daly, M.3    Chess, A.4
  • 35
    • 51549115043 scopus 로고    scopus 로고
    • A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms
    • Sawaya, M.R., Wojtowicz, W.M., Andre, I., Qian, B., Wu, W., Baker, D., Eisenberg, D., and Zipursky, S. 2008. A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell 134: 1007-1018.
    • (2008) Cell , vol.134 , pp. 1007-1018
    • Sawaya, M.R.1    Wojtowicz, W.M.2    Andre, I.3    Qian, B.4    Wu, W.5    Baker, D.6    Eisenberg, D.7    Zipursky, S.8
  • 36
    • 36348949179 scopus 로고    scopus 로고
    • Molecular diversity of Dscam: Recognition of molecular identity in neuronal wiring
    • Schmucker, D. 2007. Molecular diversity of Dscam: Recognition of molecular identity in neuronal wiring. Nat. Rev. Neurosci. 8: 915-920.
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 915-920
    • Schmucker, D.1
  • 37
    • 0034625260 scopus 로고    scopus 로고
    • Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
    • Schmucker, D., Clemens, J.C., Shu, H., Worby, C.A., Xiao, J., Muda, M., Dixon, J.E., and Zipursky, S.L. 2000. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101: 671-684.
    • (2000) Cell , vol.101 , pp. 671-684
    • Schmucker, D.1    Clemens, J.C.2    Shu, H.3    Worby, C.A.4    Xiao, J.5    Muda, M.6    Dixon, J.E.7    Zipursky, S.L.8
  • 38
    • 0028138219 scopus 로고
    • The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
    • Serafini, T., Kennedy, T.E., Galko, M.J., Mirzayan, C., Jessell, T.M., and Tessier-Lavigne, M. 1994. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78: 409-424.
    • (1994) Cell , vol.78 , pp. 409-424
    • Serafini, T.1    Kennedy, T.E.2    Galko, M.J.3    Mirzayan, C.4    Jessell, T.M.5    Tessier-Lavigne, M.6
  • 39
    • 34748821804 scopus 로고    scopus 로고
    • Self-recognition at the atomic level: Understanding the astonishing molecular diversity of homophilic Dscams
    • Shapiro, L. 2007. Self-recognition at the atomic level: Understanding the astonishing molecular diversity of homophilic Dscams. Neuron 56: 10-13.
    • (2007) Neuron , vol.56 , pp. 10-13
    • Shapiro, L.1
  • 40
    • 34247539553 scopus 로고    scopus 로고
    • Drosophila sensory neurons require dscam for dendritic self-avoidance and proper dendritic field organization
    • Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S., Yu, H., Lee, T., Jan, L., and Jan, Y. 2007. Drosophila sensory neurons require dscam for dendritic self-avoidance and proper dendritic field organization. Neuron 54: 403-416.
    • (2007) Neuron , vol.54 , pp. 403-416
    • Soba, P.1    Zhu, S.2    Emoto, K.3    Younger, S.4    Yang, S.5    Yu, H.6    Lee, T.7    Jan, L.8    Jan, Y.9
  • 41
    • 0037075181 scopus 로고    scopus 로고
    • Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons
    • Wang, J., Zugates, C., Liang, I.H., Lee, C.H., and Lee, T. 2002. Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron 33: 559-571.
    • (2002) Neuron , vol.33 , pp. 559-571
    • Wang, J.1    Zugates, C.2    Liang, I.H.3    Lee, C.H.4    Lee, T.5
  • 42
    • 4444288626 scopus 로고    scopus 로고
    • Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis
    • Wang, J., Ma, X., Yang, J., Zheng, X., Zugates, C., Lee, C., and Lee, T. 2004. Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis. Neuron 43: 663-672.
    • (2004) Neuron , vol.43 , pp. 663-672
    • Wang, J.1    Ma, X.2    Yang, J.3    Zheng, X.4    Zugates, C.5    Lee, C.6    Lee, T.7
  • 43
    • 5044222028 scopus 로고    scopus 로고
    • Parallel processing in the mammalian retina
    • Wässle, H. 2004. Parallel processing in the mammalian retina. Nat. Rev. Neurosci. 5: 747-757.
    • (2004) Nat. Rev. Neurosci , vol.5 , pp. 747-757
    • Wässle, H.1
  • 45
    • 0024149641 scopus 로고
    • The immunoglobulin superfamily-Domains for cell surface recognition
    • Williams, A.F. and Barclay, A.N. 1988. The immunoglobulin superfamily-Domains for cell surface recognition. Annu. Rev. Immunol. 6: 381-405.
    • (1988) Annu. Rev. Immunol , vol.6 , pp. 381-405
    • Williams, A.F.1    Barclay, A.N.2
  • 46
    • 4444318773 scopus 로고    scopus 로고
    • Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding
    • Wojtowicz, W. 2004. Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell 118: 619-633.
    • (2004) Cell , vol.118 , pp. 619-633
    • Wojtowicz, W.1
  • 47
    • 34548603928 scopus 로고    scopus 로고
    • A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains
    • Wojtowicz, W., Wu, W., Andre, I., Qian, B., Baker, D., and Zipursky, S. 2007. A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell 130: 1134-1145.
    • (2007) Cell , vol.130 , pp. 1134-1145
    • Wojtowicz, W.1    Wu, W.2    Andre, I.3    Qian, B.4    Baker, D.5    Zipursky, S.6
  • 48
    • 38549172807 scopus 로고    scopus 로고
    • Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina
    • Yamagata, M. and Sanes, J. 2008. Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina. Nature 451: 465-469.
    • (2008) Nature , vol.451 , pp. 465-469
    • Yamagata, M.1    Sanes, J.2
  • 49
    • 0031964775 scopus 로고    scopus 로고
    • DSCAM: A novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system
    • Yamakawa, K., Huot, Y.K., Haendelt, M.A., Hubert, R., Chen, X.N., Lyons, G.E., and Korenberg, J.R. 1998. DSCAM: A novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum. Mol. Genet. 7: 227-237.
    • (1998) Hum. Mol. Genet , vol.7 , pp. 227-237
    • Yamakawa, K.1    Huot, Y.K.2    Haendelt, M.A.3    Hubert, R.4    Chen, X.N.5    Lyons, G.E.6    Korenberg, J.R.7
  • 50
    • 13544268491 scopus 로고    scopus 로고
    • The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis
    • Yimlamai, D., Konnikova, L., Moss, L., and Jay, D. 2005. The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis. Dev. Biol. 279: 44-57.
    • (2005) Dev. Biol , vol.279 , pp. 44-57
    • Yimlamai, D.1    Konnikova, L.2    Moss, L.3    Jay, D.4
  • 52
    • 33344477761 scopus 로고    scopus 로고
    • Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe
    • Zhu, H., Hummel, T., Clemens, J., Berdnik, D., Zipursky, S., and Luo, L. 2006. Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nat. Neurosci. 9: 349-355.
    • (2006) Nat. Neurosci , vol.9 , pp. 349-355
    • Zhu, H.1    Hummel, T.2    Clemens, J.3    Berdnik, D.4    Zipursky, S.5    Luo, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.