Anti-aging molecule, Sirt1: A novel therapeutic target for diabetic nephropathy

Archives of Pharmacal Research

Volumn 36, Issue 2, 2013, Pages 230-236

  Kume, Shinji ^a   Kitada, Munehiro ^b   Kanasaki, Keizo ^b   Maegawa, Hiroshi ^a   Koya, Daisuke ^b  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Autophagy; Calorie restriction; Diabetic nephropathy; Sirt1; Sirtuin

Indexed keywords

SIRTUIN 1;

AGING; AUTOPHAGY; BLOOD PRESSURE REGULATION; CALORIC RESTRICTION; CELL HYPOXIA; CHRONIC KIDNEY DISEASE; CONCENTRATION (PARAMETERS); DIABETIC NEPHROPATHY; GENETIC ASSOCIATION; GLOMERULUS; HUMAN; IN VIVO STUDY; KIDNEY; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LIFESPAN; MOLECULARLY TARGETED THERAPY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW;

EID: 84878531104     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0019-4     Document Type: Review

References (38)

1. Brenner, B.M.; M.E. Cooper, D. De Zeeuw, W.F. Keane, W.E. Mitch, H.H. Parving, G. Remuzzi, S.M. Snapinn, Z. Zhang, and S. Shahinfar. 2001. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. New England Journal of Medicine 345: 861-869.
2. Brownlee, M. 2005. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615-1625.
3. Cherry, Engelman. 1998. R. W.; Wang, B. Y.; Kinjoh, K.; El-Badri, N. S.; and Good, R. A. Calorie restriction delays the crescentic glomerulonephritis of SCG/Kj mice. Proceedings of the Society for Experimental Biology and Medicine 218: 218-222.
4. Chuang, P.Y.; Y. Dai, R. Liu, H. He, M. Kretzler, B. Jim, C.D. Cohen, and J.C. He. 2011. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PLoS One 6: e23566.
5. Cohen, H.Y.; C. Miller, K.J. Bitterman, N.R. Wall, B. Hekking, B. Kessler, K.T. Howitz, M. Gorospe, R. De Cabo, and D.A. Sinclair. 2004. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392.
6. Colman, R.J.; R.M. Anderson, S.C. Johnson, E.K. Kastman, K.J. Kosmatka, T.M. Beasley, D.B. Allison, C. Cruzen, H.A. Simmons, J.W. Kemnitz, and R. Weindruch. 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204.
7. DCCT Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. The New England Journal of Medicine 329: 977-986.
8. Dioum, E.M.; R. Chen, M.S. Alexander, Q. Zhang, R.T. Hogg, R.D. Gerard, and J.A. Garcia. 2009. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324: 1289-1293.
9. Fan, Y.Y.; M. Kohno, H. Hitomi, K. Kitada, Y. Fujisawa, J. Yatabe, M. Yatabe, R.A. Felder, H. Ohsaki, K. Rafiq, S.J. Sherajee, T. Noma, A. Nishiyama, and D. Nakano. 2011. Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney. Endocrinology 152: 680-688.
10. Fontana, L.; L. Partridge, and V.D. Longo. 2010. Extending healthy life span-from yeast to humans. Science 328: 321-326.
11. Hasegawa, K.; S. Wakino, K. Yoshioka, S. Tatematsu, Y. Hara, H. Minakuchi, K. Sueyasu, N. Washida, H. Tokuyama, M. Tzukerman, K. Skorecki, K. Hayashi, and H. Itoh. 2010. Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. Journal of Biological Chemistry 285: 13045-13056.
12. Hasegawa, K.; S. Wakino, K. Yoshioka, S. Tatematsu, Y. Hara, H. Minakuchi, N. Washida, H. Tokuyama, K. Hayashi, and H. Itoh. 2008. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochemical and Biophysical Research Communications 372: 51-56.
13. He, W.; Y. Wang, M.Z. Zhang, L. You, L.S. Davis, H. Fan, H.C. Yang, A.B. Fogo, R. Zent, R.C. Harris, M.D. Breyer, and C.M. Hao. 2010. Sirt1 activation protects the mouse renal medulla from oxidative injury. The Journal of Clinical Investigation 120: 1056-1068.
14. Hwang, I.; J. Lee, J.Y. Huh, J. Park, H.B. Lee, Y.S. Ho, and H. Ha. 2012. Catalase deficiency accelerates diabetic renal injury through peroxisomal dysfunction. Diabetes 61: 728-738.
15. Kitada, M.; A. Takeda, T. Nagai, H. Ito, K. Kanasaki, and D. Koya. 2011. Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes. Experimental Diabetes Research 2011: 908185.
16. Koya, D.; and G.L. King. 1998. Protein kinase C activation and the development of diabetic complications. Diabetes 47: 859-866.
17. Kume, S.; M. Haneda, K. Kanasaki, T. Sugimoto, S. Araki, M. Isono, K. Isshiki, T. Uzu, A. Kashiwagi, and D. Koya. 2006. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation. Free Radical Biology and Medicine 40: 2175-2182.
18. Kume, S.; M. Haneda, K. Kanasaki, T. Sugimoto, S. Araki, K. Isshiki, M. Isono, T. Uzu, L. Guarente, A. Kashiwagi, and D. Koya. 2007. SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. Journal of Biological Chemistry 282: 151-158.
19. Kume, S.; T. Uzu, K. Horiike, M. Chin-Kanasaki, K. Isshiki, S. Araki, T. Sugimoto, M. Haneda, A. Kashiwagi, and D. Koya. 2010. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. The Journal of Clinical Investigation 120: 1043-1055.
20. Li, J.; X. Qu, S.D. Ricardo, J.F. Bertram, and D.J. Nikolic-Paterson. 2010. Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3. American Journal of Pathology 177: 1065-1071.
21. Liang, F.; S. Kume, and D. Koya. 2009. SIRT1 and insulin resistance. Nature Reviews Endocrinology 5: 367-373.
22. Lin, S.J.; P.A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
23. McCay, C.M.; and M.F. Crowell. 1934. Prolonging the life span. The Scientific Monthly 39: 405-414.
24. Maeda, S.; D. Koya, S. Araki, T. Babazono, T. Umezono, M. Toyoda, K. Kawai, M. Imanishi, T. Uzu, D. Suzuki, H. Maegawa, A. Kashiwagi, Y. Iwamoto, and Y. Nakamura. 2011. Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clinical and Experimental Nephrology 15: 381-390.
25. Mattagajasingh, I.; C.S. Kim, A. Naqvi, T. Yamamori, T.A. Hoffman, S.B. Jung, J. Dericco, K. Kasuno, and K. Irani. 2007. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences USA 104: 14855-14860.
26. Mckiernan, S.H.; V.C. Tuen, K. Baldwin, J. Wanagat, A. Djamali, and J.M. Aiken. 2007. Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells. American Journal of Physiology - Renal Physiology 292: F1751-F1760.
27. Mimura, I.; and M. Nangaku. 2010. The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease. Nature Reviews Nephrology 6: 667-678.
28. Miyazaki, R.; T. Ichiki, T. Hashimoto, K. Inanaga, I. Imayama, J. Sadoshima, and K. Sunagawa. 2008. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology 28: 1263-1269.
29. Nisoli, E.; C. Tonello, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, S. Falcone, A. Valerio, O. Cantoni, E. Clementi, S. Moncada, and M.O. Carruba. 2005. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310: 314-317.
30. Ohkubo, Y.; H. Kishikawa, E. Araki, T. Miyata, S. Isami, S. Motoyoshi, Y. Kojima, N. Furuyoshi, and M. Shichiri. 1995. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Research and Clinical Practice 28: 103-117.
31. Shikata, K. 2007. Microinflammation in the pathogenesis of diabetic nephropathy. Nippon Jinzo Gakkai Shi 49: 474-480.
32. Tikoo, K.; K. Singh, D. Kabra, V. Sharma, and A. Gaikwad. 2008. Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy. Free Radical Research 42: 397-404.
33. UKPDS Group. 1998. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352: 837-853.
34. Uzu, T.; G. Kimura, A. Yamauchi, M. Kanasaki, K. Isshiki, S. Araki, T. Sugiomoto, Y. Nishio, H. Maegawa, D. Koya, M. Haneda, and A. Kashiwagi. 2006. Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension. Journal of Hypertension 24: 1627-1632.
35. Yeung, F.; J.E. Hoberg, C.S. Ramsey, M.D. Keller, D.R. Jones, R.A. Frye, and M.W. Mayo. 2004. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO Journal 23: 2369-2380.
36. Yoshizaki, T.; S. Schenk, T. Imamura, J.L. Babendure, N. Sonoda, E.J. Bae, D.Y. Oh, M. Lu, J.C. Milne, C. Westphal, G. Bandyopadhyay, and J.M. Olefsky. 2010. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. American Journal of Physiology - Endocrinology and Metabolism 298: E419-E428.
37. Zhang, D.; S. Li, P. Cruz, and B.C. Kone. 2009. Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct. Journal of Biological Chemistry 284: 20917-20926.
38. Zhuo, L.; B. Fu, X. Bai, B. Zhang, L. Wu, J. Cui, S. Cui, R. Wei, X. Chen, and G. Cai. 2011. NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway. Cellular Physiology and Biochemistry 27: 681-690.