Anti-inflammatory and anti-hyperalgesic effect of all-trans retinoic acid in carrageenan-induced paw edema in Wistar rats: Involvement of peroxisome proliferator-activated receptor-β/δ receptors

Indian Journal of Pharmacology

Volumn 45, Issue 3, 2013, Pages 278-282

  Gill, Navneet ^a   Bijjem, Krishna Reddy V ^a   Sharma, Pyare L ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

GSK0660; GW0742; inflammatory pain; peroxisome proliferator activated receptor receptors; retinoic acid

Indexed keywords

3 [(4 ANILINO 2 METHOXYPHENYL)SULFAMOYL] 2 THENOIC ACID METHYL ESTER; [4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; CARRAGEENAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; RETINOIC ACID;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; INFLAMMATORY PAIN; MALE; MECHANICAL HYPERALGESIA; NITROSATIVE STRESS; NONHUMAN; PAW EDEMA; PEROXISOME; PLETHYSMOGRAPHY; RAT; THERMAL HYPERALGESIA; TREATMENT DURATION;

GSK0660; GW0742; INFLAMMATORY PAIN; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-Β/Δ-RECEPTORS; RETINOIC ACID;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; EDEMA; FOOT; HYPERALGESIA; MALE; MALONDIALDEHYDE; PEROXIDASE; PPAR GAMMA; PPAR-BETA; RATS; RATS, WISTAR; SULFONES; THIAZOLES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THIOPHENES; TRETINOIN;

EID: 84878477442     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.111944     Document Type: Article

References (30)

1. Bishop-Bailey D, Bystrom J. Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation. Pharmacol Ther 2009;124:141-50.
2. Graham TL, Mookherjee C, Suckling KE, Palmer CN, Patel L. The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice. Atherosclerosis 2005;181:29-37.
3. Polak PE, Kalinin S, Dello Russo C, Gavrilyuk V, Sharp A, Peters JM, et al. Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis. J Neuroimmunol 2005;168:65-75.
4. Collino M, Benetti E, Miglio G, Castiglia S, Rosa AC, Aragno M, et al. Peroxisome proliferator-activated receptor ®/™ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats. Free Radic Biol Med 2011;50:345-53.
5. Shearer BG, Steger DJ, Way JM, Stanley TB, Lobe DC, Grillot DA, et al. Identification and characterization of a selective peroxisome proliferatoractivated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol 2008;22:523-9.
6. Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NS, et al. Protective role of peroxisome proliferator-activated receptor-®/™ in septic shock. Am J Respir Crit Care Med 2010;182:1506-15.
7. Romero-Sandoval EA, Molina C, Alique M, Moreno-Manzano V, Lucio FJ, Herrero JF. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration. Br J Pharmacol 2006;149:56-64.
8. Dheen ST, Jun Y, Yan Z, Tay SS, Ling EA. Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. Glia 2005;50:21-31.
9. Ho LJ, Lin LC, Hung LF, Wang SJ, Lee CH, Chang DM, et al. Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes. Biochem Pharmacol 2005;70:200-8.
10. Bijjem KR, Padi SS, Sharma PL. Ameliorative effects of all-trans retinoic acid on behavioural symptoms of mononeuropathic pain in wistar rat. Int J Recent Adv Pharm Res 2012;2:56-64.
11. Shaw N, Elholm M, Noy N. Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem 2003;278:41589-92.
12. Dirig DM, Isakson PC, Yaksh TL. Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J Pharmacol Exp Ther 1998;285:1031-8.
13. Kaur S, Bijjem KR, Sharma PL. Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. Inflammopharmacology 2011;19:265-72.
14. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and 15N nitrate in biological fluids. Anal Biochem 1982;126:131-8.
15. Cuzzocrea S, Di Paola R, Mazzon E, Genovese T, Muià C, Centorrino T, et al. Cite this article as: Gill N, Bijjem KR, Sharma PL. Anti-inflammatory and antihyperalgesic effect of all-trans retinoic acid in carrageenan-induced paw edema in Wistar rats: Involvement of peroxisome proliferator-activated receptor-β/δ receptors. Indian J Pharmacol 2013;45:278-82.
16. Panthong A, Kanjanapothi D, Taesotikul T, Phankummoon A, Panthong K, Reutrakul V. Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre. J Ethnopharmacol 2004;91:237-42.
17. Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM. Kinin B1 receptors: Key G-protein-coupled receptors and their role in inflammatory and painful processes. Br J Pharmacol 2004;143:803-18.
18. Napimoga MH, Souza GR, Cunha TM, Ferrari LF, Clemente-Napimoga JT, Parada CA, et al. 15d-prostaglandin J2 inhibits inflammatory hypernociception: Involvement of peripheral opioid receptor. J Pharmacol Exp Ther 2008;324: 313-21.
19. Cunha TM, Verri WA Jr, Silva JS, Poole S, Cunha FQ, Ferreira SH. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci U S A 2005;102:1755-60.
20. Verri WA Jr, Cunha TM, Parada CA, Poole S, Cunha FQ, Ferreira SH. Hypernociceptive role of cytokines and chemokines: Targets for analgesic drug development? Pharmacol Ther 2006;112:116-38.
21. Salvemini D, Wang ZQ, Wyatt PS, Bourdon DM, Marino MH, Manning PT, et al. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 1996;118:829-38.
22. Beloeil H, Asehnoune K, Moine P, Benhamou D, Mazoit JX. Bupivacaine's action on the carrageenan-induced inflammatory response in mice: Cytokine production by leukocytes after ex-vivo stimulation. Anesth Analg 2005;100:1081-6.
23. Di Paola R, Esposito E, Mazzon E, Paterniti I, Galuppo M, Cuzzocrea S. GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. J Leukoc Biol 2010;88:291-301.
24. Paterniti I, Esposito E, Mazzon E, Galuppo M, Di Paola R, Bramanti P, et al. Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury. J Pharmacol Exp Ther 2010;333:465-77.
25. Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, et al. Transcriptional repression of atherogenic inflammation: Modulation by PPARdelta. Science 2003;302:453-7.
26. Barish GD, Atkins AR, Downes M, Olson P, Chong LW, Nelson M, et al. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc Natl Acad Sci U S A 2008;105:4271-6.
27. Takata Y, Liu J, Yin F, Collins AR, Lyon CJ, Lee CH, et al. PPARdeltamediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc Natl Acad Sci U S A 2008;105:4277-82.
28. Liu PT, Krutzik SR, Kim J, Modlin RL. Cutting edge: All-trans retinoic acid down-regulates TLR2 expression and function. J Immunol 2005;174:2467-70.
29. Berry DC, Noy N. All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor. Mol Cell Biol 2009;29:3286-96.
30. Handy RL, Moore PK. Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia. Neuropharmacology 1998;37:37-43.