Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes

Biochemical Pharmacology

Volumn 70, Issue 2, 2005, Pages 200-208

  Ho, Ling Jun ^a   Lin, Leou Chyr ^b   Hung, Li Feng ^a   Wang, Shyu Jye ^b   Lee, Chian Her ^b   Chang, Deh Ming ^b   Lai, Jenn Haung ^b   Tai, Tong Yuan ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Activator protein 1; C Jun N terminal kinase; Chondrocytes; Cytokines; Matrix metalloproteinases; Osteoarthritis

Indexed keywords

ALITRETINOIN; COLLAGENASE 3; CYTOKINE; DNA; FENRETINIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; ISOTRETINOIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; RETINOIC ACID; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; CARTILAGE CELL; CELL DAMAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT; WESTERN BLOTTING;

CHONDROCYTES; CYTOKINES; DOWN-REGULATION; HUMANS; INFLAMMATION MEDIATORS; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASE 8; PROTEASE INHIBITORS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRETINOIN;

EID: 20444441141     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.04.039     Document Type: Article

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