Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice

Endocrinology

Volumn 154, Issue 6, 2013, Pages 2188-2199

  Sharma, Shweta ^a,b,e   Morinaga, Hidetaka ^b   Hwang, Vicky ^a,b   Fan, WuQiang ^b   Fernandez, Marina O ^a,b   Varki, Nissi ^c,d   Olefsky, Jerrold M ^b   Webster, Nicholas J G ^a,b,d  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Roche Diagnostics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FOLLITROPIN; GONADORELIN; LIPOPOLYSACCHARIDE; LUTEINIZING HORMONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; OVARY; PHOSPHORYLATION; PRIORITY JOURNAL; SEMINIFEROUS TUBULE;

ANIMALS; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS, NONESTERIFIED; FEMALE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; GENE EXPRESSION; GONADOTROPHS; IMMUNOBLOTTING; LUTEINIZING HORMONE, BETA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; OBESITY; OVARY; PITUITARY GLAND; PROESTRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84878431420     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2218     Document Type: Article

References (51)

1. World Health Organization. Obesity and overweight - fact sheet number 311. Washington, DC: World Health Organization; 2012.
2. Bjercke S, Dale PO, Tanbo T, Storeng R, Ertzeid G, Abyholm T. Impact of insulin resistance on pregnancy complications and outcome in women with polycystic ovary syndrome. Gynecol Obstet Invest. 2002;54:94-98. (Pubitemid 36164639)
3. Chang RJ. The reproductive phenotype in polycystic ovary syndrome. Nat Clin Pract Endocrinol Metab. 2007;3:688-695. (Pubitemid 47463708)
4. Norman JE. The adverse effects of obesity on reproduction. Reproduction. 2010;140:343-345.
5. Ramsay JE, Greer I, Sattar N. ABCs of obesity. Obesity and reproduction. BMJ. 2006;333:1159-1162.
6. Niederberger C. Re: Functional relationship between obesity and male reproduction: from humans to animal models. J Urol. 2012;188:553-554.
7. Teerds KJ, de Rooij DG, Keijer J. Functional relationship between obesity and male reproduction: from humans to animal models. Hum Reprod Update. 2011;17:667-683.
8. Cabler S, Agarwal A, Flint M, du Plessis SS. Obesity: modern man's fertility nemesis. Asian J Androl. 2010;12:480-489.
9. Shayeb AG, Harrild K, Mathers E, Bhattacharya S. An exploration of the association between male body mass index and semen quality. Reprod Biomed Online. 2011;23:717-723.
10. Du Plessis SS, Cabler S, McAlister DA, Sabanegh E, Agarwal A. The effect of obesity on sperm disorders and male infertility. Nat Rev Urol. 2010;7:153-161.
11. Ghanayem BI, Bai R, Kissling GE, Travlos G, Hoffler U. Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod. 2010;82:96-104.
12. Chang AS, Dale AN, Moley KH. Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis. Endocrinology. 2005;146:2445-2453. (Pubitemid 40577532)
13. Elmes MJ, Tan DS, Cheng Z, Wathes DC, McMullen S. The effects of a high-fat, high-cholesterol diet on markers of uterine contractility during parturition in the rat. Reproduction. 2011;141:283-290.
14. Jungheim ES, Schoeller EL, Marquard KL, Louden ED, Schaffer JE, Moley KH. Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology. 2010;151:4039-4046.
15. McKnight JR, Satterfield MC, Li X, et al. Obesity in pregnancy: problems and potential solutions. Front Biosci (Elite Ed). 2011;3:442-452.
16. Oben JA, Mouralidarane A, Samuelsson AM, et al. Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol. 2010;52:913-920.
17. Shalev U, Tylor A, Schuster K, Frate C, Tobin S, Woodside B. Long-term physiological and behavioral effects of exposure to a highly palatable diet during the perinatal and post-weaning periods. Physiol Behav. 2010;101:494-502.
18. Shankar K, Kang P, Harrell A, et al. Maternal overweight programs insulin and adiponectin signaling in the offspring. Endocrinology. 2010;151:2577-2589.
19. Bakos HW, Mitchell M, Setchell BP, Lane M. The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. Int J Androl. 2011;34:402-410.
20. Mitchell M, Bakos HW, Lane M. Paternal diet-induced obesity impairs embryo development and implantation in the mouse. Fertil Steril. 2011;95:1349-1353.
21. Delarue J, Magnan C. Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care. 2007;10:142-148. (Pubitemid 46220305)
22. Macut D, Panidis D, Glisic B, et al. Lipid and lipoprotein profile in women with polycystic ovary syndrome. Can J Physiol Pharmacol. 2008;86:199-204. (Pubitemid 351536451)
23. Norman RJ, Noakes M, Wu R, Davies MJ, Moran L, Wang JX. Improving reproductive performance in overweight/obese women with effective weight management. Hum Reprod Update. 2004;10:267-280. (Pubitemid 38744871)
24. Quennell JH, Howell CS, Roa J, Augustine RA, Grattan DR, Anderson GM. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology. 2011;152:1541-1550.
25. Tortoriello DV, McMinn J, Chua SC. Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology. 2004;145:1238-1247. (Pubitemid 38281005)
26. Brothers KJ, Wu S, DiVall SA, et al. Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor. Cell Metab. 2010;12:295-305.
27. Fresno M, Alvarez R, Cuesta N. Toll-like receptors, inflammation, metabolism and obesity. Arch Physiol Biochem. 2011;117:151-164.
28. Kanczkowski W, Ziegler CG, Zacharowski K, Bornstein SR. Toll-like receptors in endocrine disease and diabetes. Neuroimmunomodulation. 2008;15:54-60.
29. Kannaki TR, Shanmugam M, Verma PC. Toll-like receptors and their role in animal reproduction. Anim Reprod Sci. 2011;125:1-12.
30. Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420:333-336. (Pubitemid 35398190)
31. Nguyen MT, Satoh H, Favelyukis S, et al. JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005;280:35361-35371. (Pubitemid 41532725)
32. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115:1111-1119. (Pubitemid 40629025)
33. Yuan M, Konstantopoulos N, Lee J, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkß. Science. 2001;293:1673-1677. (Pubitemid 32807849)
34. Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab. 2002;87:226-234. (Pubitemid 34084695)
35. Mistry DS, Tsutsumi R, Fernandez M, et al. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-β gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011;25:1387-1403.
36. Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science. 1999;284:321-325.
37. Tanaka M, Fuentes ME, Yamaguchi K, et al. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice. Immunity. 1999;10:421-429. (Pubitemid 29205478)
38. Zhang H, Bailey JS, Coss D, et al. Activin modulates the transcriptional response of LßT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006;20:2909-2930. (Pubitemid 44833545)
39. Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebah AH. Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab. 1983;57:304-310. (Pubitemid 13032480)
40. Holte J, Bergh T, Berne C, Lithell H. Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables. Clin Endocrinol (Oxf). 1994;41:463-471. (Pubitemid 24301279)
41. Pernasetti F, Vasilyev VV, Rosenberg SB, et al. Cell-specific transcriptional regulation of follicle-stimulating hormone-β by activin and gonadotropin-releasing hormone in the LßT2 pituitary gonadotrope cell model. Endocrinology. 2001;142:2284-2295. (Pubitemid 32473082)
42. Shetty J, Marathe GK, Dighe RR. Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat. Endocrinology. 1996;137:2179-2182. (Pubitemid 26133993)
43. Grover A, Sairam MR, Smith CE, Hermo L. Structural and functional modifications of Sertoli cells in the testis of adult follicle-stimulating hormone receptor knockout mice. Biol Reprod. 2004;71:117-129. (Pubitemid 38915316)
44. Sairam MR, Krishnamurthy H. The role of follicle-stimulating hormone in spermatogenesis: lessons from knockout animal models. Arch Med Res. 2001;32:601-608. (Pubitemid 34031753)
45. Wreford NG, Rajendra Kumar T, Matzuk MM, de Kretser DM. Analysis of the testicular phenotype of the follicle-stimulating hormone β-subunit knockout and the activin type II receptor knockout mice by stereological analysis. Endocrinology. 2001;142:2916-2920. (Pubitemid 32575528)
46. Townsend KL, Lorenzi MM, Widmaier EP. High-fat diet-induced changes in body mass and hypothalamic gene expression in wildtype and leptin-deficient mice. Endocrine. 2008;33:176-188.
47. Quennell JH, Mulligan AC, Tups A, et al. Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology. 2009;150:2805-2812.
48. Donato J Jr, Cravo RM, Frazao R, et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest. 2011;121:355-368.
49. Donato J Jr, Frazao R, Fukuda M, Vianna CR, Elias CF. Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology. 2011;151:5415-5427.
50. Todd BJ, Ladyman SR, Grattan DR. Suppression of pulsatile luteinizing hormone secretion but not luteinizing hormone surge in leptin resistant obese Zucker rats. J Neuroendocrinol. 2003;15:61- 68.
51. Garrel G, Simon V, Denoyelle C, et al. Unsaturated fatty acids stimulate LH secretion via novel PKCε and -θ in gonadotrope cells and inhibit GnRH-induced LH release. Endocrinology. 2011;152:3905-3916