Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat

Endocrinology

Volumn 137, Issue 5, 1996, Pages 2179-2182

  Shetty, Jagathpal ^a   Marathe, Gopal K ^a,b   Dighe, Rajan R ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; CELL DEATH; DNA STRAND BREAKAGE; FOLLITROPIN BLOOD LEVEL; MALE; NONHUMAN; PACHYTENE; PRIORITY JOURNAL; RAT; SPERMATOCYTE; SPERMATOGENESIS;

EID: 0029923357     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.5.8612566     Document Type: Article

References (10)

1. Zirkin BR, Awoniyi C, Griswold MD, Russell LD, Sharpe R 1994 Is FSH required for adult spermatogenesis? J Androl 15:273-276.
2. Dym M, Raj HGM, Lyn YC, Chems HE, Kotite NJ, Nayfeh SN, French ES 1979 Is FSH required for maintenance of spermatogenesis in adult rats? J Reprod Fertil (suppl) 26:172-181.
3. Marathe GK, Shetty J, Dighe RR 1995 Selective immunoneutralization of luteinizing hormone results in the apoptotic cell death of pachytene spermatocytes and spermatids in the rat testis. Endocrine 3: 705-709.
4. Russell LD, Alger LE, Nequin LG 1987 Hormonal control of pubertal spermatogenesis. Endocrinology 120:1615-1632.
5. Billig H, Furut I, Rivier C, Tapanainen J, Parvinen 2M, Hsueh AJW 1995 Apoptosis in testis germ cells developmental changes in gonadotropin dependence and localization to selective tubule stages Endocrinology 136:512.
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8. Tapanainen JS, Tilly JL, Vihko KK, Hsueh AJW 1993 Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol 7: 643-650.
9. Shetty J, Marathe KM, Suresh R, Dighe RR 1996 Pituitary gonadotropins regulate spermatogonial differentiation and proliferation in the rat. J Biosciences (in press, February/March).
10. Henriksen K, Hakovitra H, Parvinen M 1995 Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specific manner: In situ quantification in squash preparations after administration of ethane dimethane sulfonate. Endocrinology 136:3285-3291.