Cell-specific transcriptional regulation of follicle-stimulating hormone-β by activin and gonadotropin-releasing hormone in the LβT2 pituitary gonadotrope cell model

Endocrinology

Volumn 142, Issue 6, 2001, Pages 2284-2295

  Pernasetti, Flavia ^a   Vyacheslav, Vasilyev V ^a   Rosenberg, Suzanne B ^a   Bailey, Janice S ^a   Huang, Huey Jing ^b   Miller, William L ^b   Mellon, Pamela L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; FOLLISTATIN; FOLLITROPIN; GONADORELIN; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HORMONAL REGULATION; HYPOPHYSIS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

EID: 0035020036     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.6.8185     Document Type: Article

References (63)

1. 1. Pierce JG, Parsons TF 1981 Glycoprotein hormones: structure and function. Annu Rev Biochem 50:465-495
2. 2. Vale W, Rivier C, Brown M 1977 Regulatory peptides of the hypothalamus. Annu Rev Physiol 39:473-527
3. 3. Shupnik MA 1996 Gonadotropin gene modulation by steroids and gonadotropin-releasing hormone. Biol Reprod 54:279-286
4. 4. Gregg DW, Schwall RH, Nett TM 1991 Regulation of gonadotropin secretion and number of gonadotropin-releasing hormone receptors by inhibin, activin-A, and estradiol. Biol Reprod 44:725-732
5. 5. Braden TD, Conn PM 1992 Activin-A stimulates the synthesis of gonadotropin-releasing hormone receptors. Endocrinology 130:2101-2105
6. 6. Ling N, Ying S-Y, Ueno N, Shimasaki S, Esch F, Hotta O, Guillemin R 1986 Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin. Nature 321:779-782
7. 7. Carroll RS, Corrigan AZ, Gharib SD, Vale W, Chin WW 1989 Inhibin, activin, and follistatin: regulation of follicle-stimulating hormone messenger ribonucleic acid levels. Mol Endocrinol 3:1969-1976
8. 8. Vale W, Hseuh A, Rivier C, Yu J 1990 The inhibin/activin family of hormones and growth factors. In: Sporn M, Roberts A (eds) Peptide Growth Factors and Their Receptors: Handbook of Experimental Pharmacology. Springer-Verlag, Berlin, vol 95:211-248.
9. 9. Mathews LS 1994 Activin receptors and cellular signaling by the receptor serine kinase family. Endocr Rev 15:310-324
10. 10. Meunier H, Rivier C, Evans RM, Vale W 1988 Gonadal and extragonadal expression of inhibin α, βA, and βB subunits in various tissues predicts diverse functions. Proc Natl Acad Sci USA 85:247-51
11. 11. Yins S-Y 1988 Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicule-stimulating hormone. Endocr Rev 9:267-293
12. 12. Shimasaki S, Koga M, Esch F, Cooksey K, Mercado M, Koba A, Ueno N, Ying S-Y, Ling N, Guillemin R 1988 Primary structure of the human follistatin precursor and its genomic organization. Proc Natl Acad Sci USA 85:4218-4222
13. 13. Strahl BD, Huang HJ, Pedersen NR, Wu JC, Ghosh BR, Miller WL 1997 Two proximal activating protein-1-binding sites are sufficient to stimulate transcription of the ovine follicle-stimulating hormone-beta gene. Endocrinology 138:2621-2631
14. 14. Strahl BD, Huang HJ, Sebastian J, Ghosh BR, Miller WL 1998 Transcriptional activation of the ovine follicle-stimulating hormone β-subunit gene by gonadotropin-releasing hormone: involvement of two activating protein-1-binding sites and protein kinase C. Endocrinology 139:4455-4465
15. 15. Kumar TR, Low MJ 1995 Hormonal regulation of human follicle-stimulating hormone-β subunit gene expression: GnRH stimulation and GnRH-independent androgen inhibition. Neuroendocrinology 61:628-637
16. 16. Alarid ET, Windle JJ, Whyte DB, Mellon PL 1996 Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development 122:3319-3329
17. 17. Turgeon JL, Kimura Y, Waring DW, Mellon PL 1996 Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol 10:439-450
18. 18. Webster JC, Pedersen NR, Edwards DP, Beck CA, Miller WL 1995 The 5′-flanking region of the ovine follicle-stimulating hormone-β gene contains six progesterone response elements: three proximal elements are sufficient to increase transcription in the presence of progesterone. Endocrinology 136:1049-1058
19. 19. Fernandez-Vazquez G, Kaiser UB, Albarracin CT, Chin WW 1996 Transcriptional activation of the gonadotropin-releasing hormone receptor gene by activin A. Mol Endocrinol 10:356-366
20. 20. Attardi B, Klatt B, Little G 1995 Repression of glycoprotein hormone α-subunit gene expression and secretion by activin in αT3-I cells. Mol Endocrinol 9:1737-1749
21. 21. Schoderbek WE, Kim KE, Ridgway EC, Mellon PL, Maurer RA 1992 Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone α-subunit gene. Mol Endocrinol 6:893-903
22. 22. Nordeen SK 1988 Luciferase reporter gene vectors for analysis of promoters and enhancers. BioTechniques 6:454-458
23. 23. Sambrook J, Fritsch EF, Maniatis T 1989 Molecular Cloning: A Laboratory Manual, Ed 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
24. 24. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
25. 25. Kumar TR, Kelly M, Mortrud M, Low MJ, Matzuk MM 1995 Cloning of the mouse gonadotropin β-subunit-encoding genes. I. Structure of the follicle-stimulating hormone β-subunit-encoding gene. Gene 166:333-334
26. 26. Maurer RA 1987 Molecular cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for the β-subunit of rat follicle stimulating hormone. Mol Endocrinol 1:717-723
27. 27. Feinberg AP, Vogelstein B 1983 A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6-13
28. 28. Alarid ET, Holley S, Hayakawa M, Mellon PL 1998 Discrete stages of anterior pituitary differentiation recapitulated in immortalized cell lines. Mol Cell Endocrinol 140:25-30
29. 29. Windle JJ, Weiner RI, Mellon PL 1990 Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol 4:597-603
30. 30. Mellon PL, Windle JJ, Goldsmith P, Pedula C, Roberts J, Weiner RI 1990 Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10
31. 31. Attardi B, Winters SJ 1993 Decay of follicle-stimulating hormone-β messenger RNA in the presence of transcriptional inhibitors and/or inhibin, activin, or follistatin. Mol Endocrinol 7:668-680
32. 32. Feng Z-M, Bardin CW, Chen C-LC 1989 Characterization and regulation of testicular inhibin β-subunit mRNA. Mol Endo 3:939-948
33. 33. Roberts V, Meunier H, Vaughan J, Rivier J, Rivier C, Vale W, Sawchenko P 1989 Production and regulation of inhibin subunits in pituitary gonadotropes. Endocrinology 124:552-554
34. 34. Michel U, Farnworth P, Findlay JK 1993 Follistatins: more than follicle-stimulating hormone suppressing proteins. Mol Cell Endocrinol 91:1-11
35. 35. Roberts VJ, Barth SL 1994 Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid-and late-gestation rat embryogenesis. Endocrinology 134:914-923
36. 36. De Paolo LV, Bicsak TA, Erickson GF, Shimasaki S, Ling N 1991 Follistatin and activin: a potential intrinsic regulatory system within diverse tissues. Proc Soc Exp Biol Med 198:500-512
37. 37. Mather JP, Moore A, Li R-H 1997 Activin, inhibin, and follistatin: further thoughts on a growing family of regulators. Proc Soc Exp Biol Med 215:209 -222
38. 38. Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S, Vandi Spiegle K, ten Dijke P, Morén A, Vanscheeuwijck P, Heldin CH, Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J, Huylebroeck D 1995 Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech Dev 52:109-123
39. 39. Feijen A, Goumans MJ, Van Den Eijnden-van Raaij AJM 1994 Expression of activin subunits, activin receptors, and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development 120:3621-3637
40. 40. Sakurai T, Abe Y, Kasuya Y, Takuwa N, Shiba R, Yamashita T, Endo T, Goto K 1994 Activin A stimulates mitogenesis in Swiss 3T3 fibroblasts without activation of mitogen-activated protein kinases. J Biol Chem 269:14118-14122
41. 41. Horn F, Bilezlkjian LM, Perrin MH, Bosma MM, Windle JJ, Huber KS, Bount AL, Hille B, Vale W, Mellon PL 1991 Intracellular responses to GnRH in a clonal cell line of the gonadotrope lineage. Mol Endocrinol 5:347-355
42. 42. Weck J, Anderson AC, Jenkins S, Fallest PC, Shupnik MA 2000 Divergent and composite gonadotropin-releasing hormone-responsive elements in the rat luteinizing hormone subunit genes. Mol Endocrinol 14:472-485
43. 43. Jennes L 1990 Prenatal development of gonadotropin-releasing hormone receptors in the rat anterior pituitary. Endocrinology 126:942-947
44. 44. Japon MA, Rubinstein M, Low MJ 1994 In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development. J Histochem Cytochem 42:1117-1125
45. 45. Graham KE, Nusser KD, Low MJ 1999 LβT2 gonadotroph cells secrete follicle stimulating hormone (FSH) in response to activin A. J Endocrinol 162:R1-R5
46. 46. Tremblay JJ, Drouin J 1999 Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone β gene transcription. Mol Cell Biol 19:2567-2576
47. 47. Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G, Milbrandt J 1996 Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273:1219-1221
48. 48. Ingraham HA, Lala DS, Ikeda Y, Luo X, Shen WH, Nachtigal MW, Abbud R, Nilson JH, Parker KL 1994 The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev 8:2302-2312
49. 49. Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisoea-Belmonte JC, Rosenfeld MG 1999 Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev 13:484-494
50. 50. Weiss J, Guendner MJ, Halvorson LM, Jameson JL 1995 Transcriptional activation of the follicle-stimulating hormone beta-subunit gene by activin. Endocrinology 136:1885-1891
51. 51. Macfas-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL 1996 MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87:1215-1224
52. 52. Zawel L, Dai JL, Buckhaults P, Shou S, Kinzler KW, Vogelstein B, Karn SE 1998 Human Smad3 and Smad 4 are sequence-specific transcription activators. Mol Cell 1:611-617
53. 53. Attardi B, Miklos J 1990 Rapid stimulatory effect of activin-A on messenger RNA encoding the follicle-stimulating hormone β-subunit in rat pituitary cell cultures. Mol Endocrinol 4:721-726
54. 54. Schwartz NB 1995 The 1994 Stevenson Award Lecture. Follicle-stimulating hormone and luteinizing hormone: a tale of two gonadotropins. Can J Physiol Pharmacol 73:675-684
55. 55. Katayama T, Shiota K, Takahashi M 1990 Activin A increases the number of follicle-stimulating hormone cells in anterior pituitary cultures. Mol Cell Endocrinol 69:179-185
56. 56. Stouffer RL, Woodruff TK, Dahl KD, Hess DL, Mather JP, Molskness TA 1993 Human recombinant activin-A alters pituitary luteinizing hormone and follicle-stimulating hormone secretion, follicular development, and steroidogenesis, during the menstrual cycle in rhesus monkeys. J Clin Endocrinol Metab 77:241-248
57. 57. McLachlan RI, Dahl KD, Bremner WJ, Schwall R, Schmelzer CH, Mason AJ, Steiner RA 1939 Recombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis. Endocrinology 125:2787-9
58. 58. Weck J, Fallest PC, Pitt LK, Shupnik MA 1998 Differential gonadotropin-releasing hormone stimulation of rat luteinizing hormone subunit gene transcription by calcium influx and mitogen-activated protein kinase-signaling pathways. Mol Endocrinol 12:451-457
59. 59. Bhat G, Mahesh VB, Aguan K, Brann DW 1996 Evidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels. Neuroendocrinology 64:93-102
60. 60. Shimonaka M, Inouye S, Shimasaki S, Ling N 1991 Follistatin binds to both activin and inhibin through the common subunit. Endocrinology 128:3313-3315
61. 61. Iemura S-I, Yamamoto TS, Takagi C, Uchiyama H, Natsume T, Shimasaki S, Sugino H, Ueno N 1998 Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc Natl Acad Sci USA 95:9337-9342
62. 62. Mellon PL, Pernasetti FM, Holley SJ 1999 Gene expression in pituitary cell lines created by oncogenesis in transgenic mice. In: Beck-Peccoz P (ed) Regulation of Pituitary Hormone Secretion. BioScientifica, Bristol, vol 3:29-38
63. 63. Yamashita H, ten Dijke P, Huylebroeck D, Sampath TK, Andries M, Smith JC, Heldin C-H, Miyazono K 1995 Ostoegenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol 130:217-226