Suppression of pulsatile luteinizing hormone secretion but not luteinizing hormone surge in leptin resistant obese Zucker rats

Journal of Neuroendocrinology

Volumn 15, Issue 1, 2003, Pages 61-68

  Todd, B J ^a   Ladyman, S R ^a   Grattan, David R ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Leptin; LH surge; Pulsatile LH secretion; Zucker rats

Indexed keywords

ESTROGEN; LEPTIN; LUTEINIZING HORMONE; NALOXONE; OPIATE ANTAGONIST; OPIATE RECEPTOR; PROGESTERONE; STEROID;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD ANALYSIS; CATHETERIZATION; CONTROLLED STUDY; FEMALE; HORMONE RESISTANCE; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; NONHUMAN; OBESITY; OVARIECTOMY; PHENOTYPE; PRIORITY JOURNAL; PROESTRUS; PULSATILE HORMONE RELEASE; PULSE RATE; RADIOIMMUNOASSAY; RAT; RAT STRAIN; REVIEW; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ANIMALS; BODY WEIGHT; ESTROGENS; FEMALE; LEPTIN; LUTEINIZING HORMONE; NALOXONE; NARCOTIC ANTAGONISTS; OBESITY; OPIOID PEPTIDES; PULSATILE FLOW; RATS; RATS, ZUCKER;

EID: 0037246921     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2003.00871.x     Document Type: Review

References (55)

1. Wade GM, Schneider JE, Li HY. Control of fertility by metabolic cues. Am J Physiol Endocrinol Met 1996; 33: E1-E19.
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
3. Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996; 271: 994-996.
4. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ, Hess JF. Leptin receptor missense mutation in the fatty Zucker rat [letter]. Nature Genet 1996; 13: 18-19.
5. Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet 1996; 12: 318-320.
6. Barash IA, Cheung CC, Weigle DS, Ren H, Kabigting EB, Kuijper JL, Clifton DK, Steiner RA. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996; 137: 3144-3147.
7. Carro E, Pinilla L, Scene LM, Considine RV, Aguilar E, Casanueva FF, Dieguez C. Influence of endogenous leptin tone on the estrous cycle and luteinizing hormone pulsatility in female rats. Neuroendocrinology 1997; 66: 375-376.
8. Nagatani S, Guthikonda P, Thompson RC, Tsukamura H, Maeda KI, Foster DL. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 1998; 67: 370-376.
9. Finn PD, Cunningham MJ, Pau KY, Spies HG, Clifton DK, Steiner RA. The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey. Endocrinology 1998; 139: 4652-4662.
10. Nagatani S, Zeng Y, Keisler DH, Foster DL, Jaffe CA. Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep. Endocrinology 2000; 141: 3965-3975.
11. Kohsaka A, Watanobe H, Kakizaki Y, Habu S, Suda T. A significant role of leptin in the generation of steroid-induced luteinizing hormone and prolactin surges in female rats. Biochem Biophys Res Comm 1999; 254: 578-581.
12. Gonzalez LC, Pinilla L, Tena-Sempere M, Dieguez C, Casanueva FF, Aguilar E. Effect of acute immunoneutralization of endogenous leptin on prolactin and LH secretion during the afternoon of pro-oestrous or in steroid-treated ovariectomized female rats. J Reprod Fertil 2000; 118: 39-45.
13. Zucker LM, Zucker TF. Fatty, a new mutation in the rat. J Heredity 1961; 52: 275-278.
14. Saiduddin S, Bray GA, York DA, Swerdloff RS. Reproductive function in the genetically obese 'fatty' rat. Endocrinology 1973; 93: 1251-1256.
15. Bivens CL, Olster DH. Abormal estrous cyclicity and behavioural hyporesponsiveness to ovarian hormones in genetically obese Zucker female rats. Endocrinology 1997; 138: 143-148.
16. Whitaker EM, Robinson AC. Circulating reproductive hormones and hypothalamic oestradiol and progestin receptors in infertile Zucker rats. J Endocrinol 1989; 120: 331-336.
17. Blank MS, Roberts DL. Antagonist of gonadotrophin-releasing hormone blocks naloxone-induced elevations in serum luteinizing hormone. Neuroendocrinology 1982; 35: 309-312.
18. Bruni JF, Van Vugt D, Marshall S, Meites J. Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone. Life Sci 1977; 21: 461-466.
19. Petraglia F, Locatelli V, Penalva A, Cocchi D, Genazzani AR, Muller EE. Gonadal steroid modulation of naloxone-induced LH secretion in the rat. J Endocrinol 1984; 101: 33-39.
20. Cagampang FR, Maeda KI, Tsukamura H, Ohkura S, Ota K. Involvement of ovarian steroids and endogenous opioids in the fasting-induced suppression of pulsatile LH release in ovariectomized rats. J Endocrinol 1991; 129: 321-328.
21. Roane DS, Iadarola MJ, Porter JR. Decreased [3H]-naloxone binding and elevated dynorphin-A (1-8) content in Zucker rat brain. Physiol Behav 1988; 43: 371-374.
22. Margules DL, Moisset B, Lewis MJ, Shibuya H, Pert CB. Beta-endorphin in associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa). Science 1978; 202: 988-991.
23. Marin-Bivens CL, Olster DH. Opioid receptor blockade promotes weight loss and improves the display of sexual behaviours in obese Zucker female rats. Pharmacol Biochem Behav 1999; 63: 515-520.
24. Cagampang FR, Maeda K, Yokoyama A, Ota K. Effect of food deprivation on the pulsatile LH release in the cycling and ovariectomized female rat. Horm Metab Res 1990; 22: 269-272.
25. Caligaris L, Astrada JJ, Taleisnik S. Biphasic effect of progesterone on the release of gonadotropin in rats. Endocrinology 1971; 89: 331-337.
26. Caligaris L, Astrada JJ, Taliesnik S. Stimulating and inhibiting effects of progesterone on the release of luteinizing hormone. Acta Endocrinol 1968; 59: 177-185.
27. Freeman MC, Dupke KC, Croteau CM. Extinction of the estrogen-induced daily signal for LH release in the rat. a role for the proestrous surge of progesterone. Endocrinology 1976; 99: 223-229.
28. Legan SJ, Coon GA, Karsch FJ. Role of estrogen as initiator of daily LH surges in the ovariectomized rat. Endocrinology 1975; 96: 50-56.
29. Taleisnik S, Caligaris L, Astrada JJ. Sex difference in the release of luteinizing hormone evoked by progesterone. J Endocrinol 1969; 44: 313-321.
30. Kornblatt JJ, Grattan DR. Lactation alters gamma-aminobutyric acid neuronal activity in the hypothalamus and cerebral cortex in the rat. Neuroendocrinology 2001; 73: 175-184.
31. Zamorano PL, Mahesh VB, De Sevilla LM, Chorich LP, Bhat GK, Brann DW. Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat. Neuroendocrinology 1997; 65: 223-228.
32. Young RA, Frink R, Longcope C. Serum testosterone and gonadotropins in the genetically obese male Zucker rat. Endocrinology 1982; 111: 977-978.
33. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Med 1996; 2: 589-593.
34. Bedran de Castro JC, Khorram O, Petrovic SL, McCann S. Role of opioid peptides in pulsatile release of gonadotropins and prolactin in the rat. Brain Res Bull 1987; 19: 539-544.
35. Ropert JF, Quigley ME, Yen SS. Endogenous opiates modulate pulsatile luteinizing hormone release in humans. J Clin Endocrinol Metab 1981; 52: 583-585.
36. Cunningham MJ, Clifton DK, Steiner RA. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 1999; 60: 216-222.
37. Hakansson ML, Hulting AL, Meister B. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurones. Neuroreport 1996; 7: 3087-3092.
38. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate neucleus of mouse hypothalamus. J Neuroendocrinol 1996; 8: 733-735.
39. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999; 23: 775-786.
40. Ahima RS, Kelly J, Emquist JK, Flier JS. Distinct physiologic and neuronal responses to decreased letpin and mild hyperleptinemia. Endocrinology 1999; 140: 4923-4931.
41. Kim EM, O'Hare E, Grace MK, Welch CC, Billington CJ, Levine AS. ARC POMC mRNA and PVN alpha-MSH are lower in obese relative to lean Zucker rats. Brain Res 2000; 862: 11-16.
42. Sanacora G, Kershaw M, Finkelstein JA, White JD. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 1990; 127: 730-737.
43. Kalra SP, Crowley WR. Norepinephrine-like effects of neuropeptide Y on LH release in the rat. Life Sci 1984; 35: 1173-1176.
44. Kaynard AH, Pau KY, Hess DL, Spies HG. Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus macaques. Endocrinology 1990; 127: 2437-2444.
45. McDonald JK, Lumpkin MD, Samson WK, McCann SM. Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats. Proc Natl Acad Sci USA 1985; 82: 561-564.
46. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411: 480-484.
47. Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 1997; 756: 283-286.
48. Pu S, Jain MR, Horvath TL, Diano S, Kalra PS, Kalra SP. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 1999; 140: 933-940.
49. Ovesjo ML, Gamstedt M, Collin M, Meister B. GABAergic nature of hypothalamic leptin target neurones in the ventromedial arcuate nucleus. J Neuroendocrinol 2001; 13: 505-516.
50. Akema T, Chiba A, Kimura F. On the relationship between noradrenergic stimulatory and GABAergic inhibitory systems in the control of lueinizing hormone secretion in female rats. Neuroendocrinology 1990; 52: 566-572.
51. Donoso AO, Banzan AM. Effects of increase of brain GABA levels on the hypothalamic-pituitary-luteinizing hormone axis in rats. Acta Endocrinol 1984; 106: 298-304.
52. Hiruma H, Sano A, Kimura F. Injection of bicuculline elicits firing of luteinizing hormone releasing hormone pulse generator in muscimol-treated ovariectomized rats. Brain Res 1994; 641: 191-197.
53. Lamberts R, Vijayan E, Graf M, Mansky T, Wuttke W. Involvement of preoptic-anterior hypothalamic GABA neurons in the regulation of pituitary LH and prolactin release. Exp Brain Res 1983; 52: 356-362.
54. Whitaker EM, Shaw MA, Hervey GR. Plasma oestradiol-17 beta and testosterone concentrations as possible causes of the infertility of congenitally obese Zucker rats. J Endocrinol 1983; 99: 485-490.
55. van der Schoot P, de Greef WJ. Dioestrous progesterone and pro-estrous luteinizing hormone in 4- and 5-day cycles of female rats. J Endocrinol 1976; 70: 61-68.