Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity

Biology of Reproduction

Volumn 82, Issue 1, 2010, Pages 96-104

  Ghanayem, Burhan I ^a   Bai, Re ^a   Kissling, Grace E ^a   Travlos, Greg ^a   Hoffler, Undi ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Acrylamide; Diet induced obesity; Dominant lethal mutations; Hyperinsulinemia; Insulin; Leptin; Male mice infertility

Indexed keywords

ACRYLAMIDE; CARRIER PROTEINS AND BINDING PROTEINS; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; INSULIN; LARD; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SOMATOMEDIN BINDING PROTEIN 1; SONIC HEDGEHOG PROTEIN; SRC HOMOLOGY 2 ADAPTOR PROTEIN 1; UNCLASSIFIED DRUG; CHOLESTEROL; CYTOCHROME P450 2E1; TRIACYLGLYCEROL;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; DISEASE EXACERBATION; FEMALE; GENE EXPRESSION REGULATION; HORMONE BLOOD LEVEL; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; LEPTIN BLOOD LEVEL; LIPID DIET; MALE; MALE FERTILITY; MALE INFERTILITY; MATING; MOUSE; NONHUMAN; OBESITY; PREGNANCY; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SPERMATOZOON MOTILITY; ADIPOSE TISSUE; ANIMAL; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; COPULATION; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; FAT INTAKE; GLUCOSE BLOOD LEVEL; METABOLISM; MUTATION; PREGNANCY RATE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOZOON COUNT; TESTIS;

MUS;

ACRYLAMIDE; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; COPULATION; CYTOCHROME P-450 CYP2E1; DIETARY FATS; FEMALE; GERM-LINE MUTATION; INFERTILITY, MALE; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; OBESITY; PATERNAL EXPOSURE; PREGNANCY; PREGNANCY RATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPERM COUNT; SPERM MOTILITY; TESTIS; TRIGLYCERIDES;

EID: 77950353938     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.109.078915     Document Type: Article

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