메뉴 건너뛰기




Volumn 41, Issue 4, 2012, Pages 781-803

Fecal Microbiota Transplantation. Techniques, Applications, and Issues

Author keywords

Clostridium difficile; Fecal microbiota transplantation; Microbiome; Microbiota; Probiotics; Ulcerative colitis

Indexed keywords

ANTIBIOTIC AGENT; COLCHICINE; ENEMA; FIDAXOMICIN; METRONIDAZOLE; PENICILLIN G; RIFAXIMIN; STREPTOMYCIN; SUCCINYLSULFATHIAZOLE; TETRACYCLINE; VANCOMYCIN;

EID: 84867959193     PISSN: 08898553     EISSN: 15581942     Source Type: Journal    
DOI: 10.1016/j.gtc.2012.08.008     Document Type: Review
Times cited : (122)

References (103)
  • 1
    • 67349265209 scopus 로고    scopus 로고
    • National point prevalence of Clostridium difficile in US health care facility inpatient
    • Jarvis W.R., Schlosser J.A., Jarvis A.A., et al. National point prevalence of Clostridium difficile in US health care facility inpatient. Am J Infect Control 2008, 37:263-270.
    • (2008) Am J Infect Control , vol.37 , pp. 263-270
    • Jarvis, W.R.1    Schlosser, J.A.2    Jarvis, A.A.3
  • 2
    • 84856959355 scopus 로고
    • Bacteriotherapy for chronic constipation-long term follow-up
    • Andrews P., Borody T.J., Shortis N.P., et al. Bacteriotherapy for chronic constipation-long term follow-up. Gastroenterology 1995, 108:A563.
    • (1995) Gastroenterology , vol.108
    • Andrews, P.1    Borody, T.J.2    Shortis, N.P.3
  • 3
    • 84856966182 scopus 로고    scopus 로고
    • Fecal microbiota transplantation (FMT) in multiple sclerosis (MS)
    • Borody T.J., Leis S., Campbell J., et al. Fecal microbiota transplantation (FMT) in multiple sclerosis (MS). Am J Gastroenterol 2011, 106:S352.
    • (2011) Am J Gastroenterol , vol.106
    • Borody, T.J.1    Leis, S.2    Campbell, J.3
  • 4
    • 84856971587 scopus 로고    scopus 로고
    • Reversal of idiopathic thrombocytopenia purpura (ITP) with fecal microbiota transplantation (FMT)
    • Borody T.J., Campbell J., Torres M., et al. Reversal of idiopathic thrombocytopenia purpura (ITP) with fecal microbiota transplantation (FMT). Am J Gastroenterol 2011, 106:S352.
    • (2011) Am J Gastroenterol , vol.106
    • Borody, T.J.1    Campbell, J.2    Torres, M.3
  • 5
    • 0038613653 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis using fecal bacteriotherapy
    • Borody T.J., Warren E.F., Leis S., et al. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol 2003, 37(1):42-47.
    • (2003) J Clin Gastroenterol , vol.37 , Issue.1 , pp. 42-47
    • Borody, T.J.1    Warren, E.F.2    Leis, S.3
  • 6
    • 0024498413 scopus 로고
    • Treatment of ulcerative colitis by implantation of normal colonic flora
    • Bennet J.D., Brinkman M. Treatment of ulcerative colitis by implantation of normal colonic flora. Lancet 1989, 1:164.
    • (1989) Lancet , vol.1 , pp. 164
    • Bennet, J.D.1    Brinkman, M.2
  • 7
    • 82955233474 scopus 로고    scopus 로고
    • Treating Clostridium difficile infection with fecal microbiota transplantation
    • Bakken J.S., Borody T.J., Brandt L.J., et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 2011, 9:1044-1049.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 1044-1049
    • Bakken, J.S.1    Borody, T.J.2    Brandt, L.J.3
  • 8
    • 3042511702 scopus 로고    scopus 로고
    • Bacteriotherapy using fecal flora: toying with human motions
    • Borody T.J., Warren E.F., Leis S.M., et al. Bacteriotherapy using fecal flora: toying with human motions. J Clin Gastroenterol 2004, 38:475-483.
    • (2004) J Clin Gastroenterol , vol.38 , pp. 475-483
    • Borody, T.J.1    Warren, E.F.2    Leis, S.M.3
  • 9
    • 0001412472 scopus 로고
    • Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis
    • Eiseman B., Silen W., Bascom G.S., et al. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 1958, 44:854-859.
    • (1958) Surgery , vol.44 , pp. 854-859
    • Eiseman, B.1    Silen, W.2    Bascom, G.S.3
  • 10
    • 70449273590 scopus 로고
    • Fecal feedings as a therapy in Staphylococcus enterocolitis
    • Cutolo L.C., Kleppel N.H., Freund R.H., et al. Fecal feedings as a therapy in Staphylococcus enterocolitis. N Y State J Med 1959, 59:3831-3833.
    • (1959) N Y State J Med , vol.59 , pp. 3831-3833
    • Cutolo, L.C.1    Kleppel, N.H.2    Freund, R.H.3
  • 11
    • 0016395244 scopus 로고
    • Pseudomembranous colitis associated with antibiotic therapy-an emerging entity
    • Fenton S., Stephenson D., Weder C., et al. Pseudomembranous colitis associated with antibiotic therapy-an emerging entity. Can Med Assoc J 1974, 111:1110-1114.
    • (1974) Can Med Assoc J , vol.111 , pp. 1110-1114
    • Fenton, S.1    Stephenson, D.2    Weder, C.3
  • 12
    • 0019454759 scopus 로고
    • Pseudomembranous enterocolitis: mechanism for restoring floral homeostasis
    • Bowden T.A., Mansberger A.R., Lykins L.E. Pseudomembranous enterocolitis: mechanism for restoring floral homeostasis. Am Surg 1981, 47:178-183.
    • (1981) Am Surg , vol.47 , pp. 178-183
    • Bowden, T.A.1    Mansberger, A.R.2    Lykins, L.E.3
  • 13
    • 0021238491 scopus 로고
    • Relapsing Clostridium difficile enterocolitis cured by rectal infusion of normal faeces
    • Schwan A., Sjölin S., Trottestam U., et al. Relapsing Clostridium difficile enterocolitis cured by rectal infusion of normal faeces. Scand J Infect Dis 1984, 16:211-215.
    • (1984) Scand J Infect Dis , vol.16 , pp. 211-215
    • Schwan, A.1    Sjölin, S.2    Trottestam, U.3
  • 14
    • 0024312284 scopus 로고
    • Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients
    • Tvede M., Rask-Madsen J. Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients. Lancet 1989, 1:1156-1160.
    • (1989) Lancet , vol.1 , pp. 1156-1160
    • Tvede, M.1    Rask-Madsen, J.2
  • 15
    • 0025733220 scopus 로고
    • Refractory Clostridium difficile infection. Untraditional treatment for antibiotic-induced colitis
    • [in Norwegian]
    • Flotterod O., Hopen G. Tidsskr Nor Laegeforen 1991, 111:1364-1365. [in Norwegian].
    • (1991) Tidsskr Nor Laegeforen , vol.111 , pp. 1364-1365
    • Flotterod, O.1    Hopen, G.2
  • 16
    • 0027982847 scopus 로고
    • Putting back the bugs: bacterial treatment relieves chronic diarrhoea
    • Paterson D.L., Iredell J., Whitby M. Putting back the bugs: bacterial treatment relieves chronic diarrhoea. Med J Aust 1994, 160:232-233.
    • (1994) Med J Aust , vol.160 , pp. 232-233
    • Paterson, D.L.1    Iredell, J.2    Whitby, M.3
  • 17
    • 0030307785 scopus 로고    scopus 로고
    • Recurrent pseudomembranous colitis treated with the donor feces
    • Harkonen N. Recurrent pseudomembranous colitis treated with the donor feces. Duodecim 1996, 112:1803-1804.
    • (1996) Duodecim , vol.112 , pp. 1803-1804
    • Harkonen, N.1
  • 19
    • 0033766160 scopus 로고    scopus 로고
    • Treatment of recurrent Clostridium difficile-associated diarrhoea by administration of donated stool directly through a colonoscope
    • Persky S.E., Brandt L.J. Treatment of recurrent Clostridium difficile-associated diarrhoea by administration of donated stool directly through a colonoscope. Am J Gastroenterol 2000, 95:3283-3285.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3283-3285
    • Persky, S.E.1    Brandt, L.J.2
  • 20
    • 0038207477 scopus 로고    scopus 로고
    • Treatment of recurrent pseudomembranous colitis (RPMC) with stool transplantation (ST): report of six (6) cases
    • Faust G., Langelier D., Haddad H., et al. Treatment of recurrent pseudomembranous colitis (RPMC) with stool transplantation (ST): report of six (6) cases. Can J Gastroenterol 2002, a002.
    • (2002) Can J Gastroenterol
    • Faust, G.1    Langelier, D.2    Haddad, H.3
  • 21
    • 0037373020 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube
    • Aas J., Gessert C.E., Bakken J.S. Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis 2003, 36:580-585.
    • (2003) Clin Infect Dis , vol.36 , pp. 580-585
    • Aas, J.1    Gessert, C.E.2    Bakken, J.S.3
  • 22
    • 33751419472 scopus 로고    scopus 로고
    • Feces culture successful therapy in Clostridium difficile diarrhoea
    • [abstract], [in Swedish]
    • Jorup-Rönström C., Hakanson A., Persoon A.K. Larkartidningen 2006, 103:3603-3605. [abstract], [in Swedish].
    • (2006) Larkartidningen , vol.103 , pp. 3603-3605
    • Jorup-Rönström, C.1    Hakanson, A.2    Persoon, A.K.3
  • 23
    • 84867933310 scopus 로고    scopus 로고
    • Fecal bacteriotherapy-an effective treatment for relapsing symptomatic Clostridium difficile infection [abstract G67]. Presented at the 15th United European Gastroenterology Week
    • Wettstein A, Borody TJ, Leis S. Fecal bacteriotherapy-an effective treatment for relapsing symptomatic Clostridium difficile infection [abstract G67]. Presented at the 15th United European Gastroenterology Week. 2007.
    • (2007)
    • Wettstein, A.1    Borody, T.J.2    Leis, S.3
  • 24
    • 80054111727 scopus 로고    scopus 로고
    • Home-based fecal flora infusion to arrest multiple-recurrent Clostridium difficile infection (CDI)
    • Chemotherapy in conjunction with the Infectious Disease Society of America
    • Louie TJ. Home-based fecal flora infusion to arrest multiple-recurrent Clostridium difficile infection (CDI). Presented at the 48th Interscience Conference on Antimicrobial Agents, Chemotherapy in conjunction with the Infectious Disease Society of America. 2008.
    • (2008) Presented at the 48th Interscience Conference on Antimicrobial Agents
    • Louie, T.J.1
  • 25
    • 51849160474 scopus 로고    scopus 로고
    • Treatment of recurrent Clostridium difficile-associated diarrhoea with a suspension of donor faeces
    • [in dutch]
    • Niewdorp M., Van Nood E., Speelman P., et al. Ned Tijdschr Geneeskd 2008, 152:1927-1932. [in dutch].
    • (2008) Ned Tijdschr Geneeskd , vol.152 , pp. 1927-1932
    • Niewdorp, M.1    Van Nood, E.2    Speelman, P.3
  • 26
    • 43049091604 scopus 로고    scopus 로고
    • Successful treatment of fulminant Clostridium difficile infection with fecal bacteriotherapy
    • You D.M., Franzos M.A., Holman R.P. Successful treatment of fulminant Clostridium difficile infection with fecal bacteriotherapy. Ann Intern Med 2008, 148:632-633.
    • (2008) Ann Intern Med , vol.148 , pp. 632-633
    • You, D.M.1    Franzos, M.A.2    Holman, R.P.3
  • 27
    • 67650822195 scopus 로고    scopus 로고
    • Faecal transplantation for recurrent Clostridium difficile colitis, an underused treatment modality
    • Hellemans R., Naegels S., Holvoet J. Faecal transplantation for recurrent Clostridium difficile colitis, an underused treatment modality. Acta Gastroenterol Belg 2009, 72:269-270.
    • (2009) Acta Gastroenterol Belg , vol.72 , pp. 269-270
    • Hellemans, R.1    Naegels, S.2    Holvoet, J.3
  • 28
    • 70649100022 scopus 로고    scopus 로고
    • Faecal transplant for recurrent Clostridium difficile-associated diarrhoea: a UK case series
    • MacConachie A.A., Fox R., Kennedy D.R., et al. Faecal transplant for recurrent Clostridium difficile-associated diarrhoea: a UK case series. QJM 2009, 102:781-784.
    • (2009) QJM , vol.102 , pp. 781-784
    • MacConachie, A.A.1    Fox, R.2    Kennedy, D.R.3
  • 29
    • 84856965381 scopus 로고    scopus 로고
    • Fecal bacteriotherapy for recurrent Clostridium difficile infection
    • Arkkila P.E., Uusitalo-Seppälä R., Lehtola L., et al. Fecal bacteriotherapy for recurrent Clostridium difficile infection. Gastroenterology 2010, 138:S5.
    • (2010) Gastroenterology , vol.138
    • Arkkila, P.E.1    Uusitalo-Seppälä, R.2    Lehtola, L.3
  • 30
    • 77951700268 scopus 로고    scopus 로고
    • Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea
    • Khoruts A., Dicksved J., Jansson J.K., et al. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol 2010, 44:354-360.
    • (2010) J Clin Gastroenterol , vol.44 , pp. 354-360
    • Khoruts, A.1    Dicksved, J.2    Jansson, J.K.3
  • 31
    • 77955982119 scopus 로고    scopus 로고
    • Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients
    • Yoon S.S., Brandt L.J. Treatment of refractory/recurrent C. difficile-associated disease by donated stool transplanted via colonoscopy: a case series of 12 patients. J Clin Gastroenterol 2010, 44:562-566.
    • (2010) J Clin Gastroenterol , vol.44 , pp. 562-566
    • Yoon, S.S.1    Brandt, L.J.2
  • 32
    • 77955985109 scopus 로고    scopus 로고
    • Fecal flora reconstitution for recurrent Clostridium difficile infection: results and methodology
    • Rohlke F., SUrawicz C.M., Stollman N. Fecal flora reconstitution for recurrent Clostridium difficile infection: results and methodology. J Clin Gastroenterol 2010, 44:567-570.
    • (2010) J Clin Gastroenterol , vol.44 , pp. 567-570
    • Rohlke, F.1    SUrawicz, C.M.2    Stollman, N.3
  • 33
    • 77950861655 scopus 로고    scopus 로고
    • Success of self-administered home fecal transplantation for chronic Clostridium difficile infection
    • Silverman M.S., Davis I., Pillai D.R. Success of self-administered home fecal transplantation for chronic Clostridium difficile infection. Clin Gastroenterol Hepatol 2010, 5:471-473.
    • (2010) Clin Gastroenterol Hepatol , vol.5 , pp. 471-473
    • Silverman, M.S.1    Davis, I.2    Pillai, D.R.3
  • 34
    • 78549241710 scopus 로고    scopus 로고
    • Results of faecal donor instillation therapy for recurrent Clostridium difficile-associated diarrhoea
    • Garborg K., Waagsbó B., Stallemo A., et al. Results of faecal donor instillation therapy for recurrent Clostridium difficile-associated diarrhoea. Scand J Infect Dis 2010, 42:857-861.
    • (2010) Scand J Infect Dis , vol.42 , pp. 857-861
    • Garborg, K.1    Waagsbó, B.2    Stallemo, A.3
  • 35
    • 77954370913 scopus 로고    scopus 로고
    • Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol
    • Russel G., Kaplan J., Ferraro M.J., et al. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics 2010, 126:e239-e242.
    • (2010) Pediatrics , vol.126
    • Russel, G.1    Kaplan, J.2    Ferraro, M.J.3
  • 36
    • 84856960948 scopus 로고    scopus 로고
    • Successful treatment of recurrent Clostridium difficile infection with donor stool administered at colonoscopy: a case series
    • [abstract 366]
    • Kelly C., De Leon L. Successful treatment of recurrent Clostridium difficile infection with donor stool administered at colonoscopy: a case series. Am J Gastroenterol 2010, 105:S135. [abstract 366].
    • (2010) Am J Gastroenterol , vol.105
    • Kelly, C.1    De Leon, L.2
  • 37
    • 84856957445 scopus 로고    scopus 로고
    • Colonoscopic fecal bacteriotherapy in the treatment of recurrent Clostridium difficile infection
    • [abstract]
    • Mellow M., Kanatzar A. Colonoscopic fecal bacteriotherapy in the treatment of recurrent Clostridium difficile infection. Am J Gastroenterol 2010, 105:S135. [abstract].
    • (2010) Am J Gastroenterol , vol.105
    • Mellow, M.1    Kanatzar, A.2
  • 38
    • 84856968600 scopus 로고    scopus 로고
    • Fecal transplantation via retention enemas is effective for recurrent or refractory Clostridium difficile-associated diarrhea
    • Kassam Z., Hundal R., Marshall J.K., et al. Fecal transplantation via retention enemas is effective for recurrent or refractory Clostridium difficile-associated diarrhea. Gastroenterology 2010, 138:S207-S208.
    • (2010) Gastroenterology , vol.138
    • Kassam, Z.1    Hundal, R.2    Marshall, J.K.3
  • 39
    • 84855772543 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for relapsing Clostridium difficile infection in 26 patients: methodology and results
    • Kelly C.R., de Leon L., Jasutkar N. Fecal microbiota transplantation for relapsing Clostridium difficile infection in 26 patients: methodology and results. J Clin Gastroenterol 2012, 46(2):145-149.
    • (2012) J Clin Gastroenterol , vol.46 , Issue.2 , pp. 145-149
    • Kelly, C.R.1    de Leon, L.2    Jasutkar, N.3
  • 40
    • 84862309942 scopus 로고    scopus 로고
    • Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection
    • Hamilton M.J., Weingarden A.R., Sadowsky M.J., et al. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am J Gastroenterol 2012, 107(5):761-767.
    • (2012) Am J Gastroenterol , vol.107 , Issue.5 , pp. 761-767
    • Hamilton, M.J.1    Weingarden, A.R.2    Sadowsky, M.J.3
  • 41
    • 84857640098 scopus 로고    scopus 로고
    • Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection
    • Mattila E., Uusitalo-Seppälä R., Wuorela M., et al. Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection. Gastroenterology 2012, 142(3):490-496.
    • (2012) Gastroenterology , vol.142 , Issue.3 , pp. 490-496
    • Mattila, E.1    Uusitalo-Seppälä, R.2    Wuorela, M.3
  • 42
    • 84863719891 scopus 로고    scopus 로고
    • Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection
    • Brandt L.J., Aroniadis O.C., Mellow M., et al. Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection. Am J Gastroenterol 2012, 107(7):1079-1087.
    • (2012) Am J Gastroenterol , vol.107 , Issue.7 , pp. 1079-1087
    • Brandt, L.J.1    Aroniadis, O.C.2    Mellow, M.3
  • 43
    • 4444382260 scopus 로고    scopus 로고
    • Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity
    • Pepin J., Valiquette L., Alary M.E., et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004, 171:466-472.
    • (2004) CMAJ , vol.171 , pp. 466-472
    • Pepin, J.1    Valiquette, L.2    Alary, M.E.3
  • 44
    • 84877874614 scopus 로고    scopus 로고
    • Niagara System Faces Government Control. CBC news. Available at:
    • Niagara System Faces Government Control. CBC news. Available at: http://www.cbc.ca/news/health/story/2011/08/15/c-difficile-niagara-supervisor.html.
  • 45
    • 66249121680 scopus 로고    scopus 로고
    • Fulminant Clostridium difficile colitis
    • Sailhamer E.A., Carson K., Chang Y., et al. Fulminant Clostridium difficile colitis. Arch Surg 2009, 144(5):433-439.
    • (2009) Arch Surg , vol.144 , Issue.5 , pp. 433-439
    • Sailhamer, E.A.1    Carson, K.2    Chang, Y.3
  • 46
    • 33747599197 scopus 로고    scopus 로고
    • Improving the treatment of Clostridium difficile-associated disease: where should we start?
    • Pepin J. Improving the treatment of Clostridium difficile-associated disease: where should we start?. Clin Infect Dis 2006, 43:553-555.
    • (2006) Clin Infect Dis , vol.43 , pp. 553-555
    • Pepin, J.1
  • 47
    • 0036311186 scopus 로고    scopus 로고
    • Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease
    • McFarland L.V., Elmer G.W., Surawicz C.M. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol 2002, 97:1769-1775.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1769-1775
    • McFarland, L.V.1    Elmer, G.W.2    Surawicz, C.M.3
  • 48
    • 33847618667 scopus 로고    scopus 로고
    • Narrative review: the new epidemic of Clostridium difficile-associated enteric disease
    • Bartlett J.G. Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Ann Intern Med 2006, 145(10):758-764.
    • (2006) Ann Intern Med , vol.145 , Issue.10 , pp. 758-764
    • Bartlett, J.G.1
  • 49
    • 79551527297 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for Clostridium difficile infection
    • Louie T.J., Miller M.A., Mullane K.M., et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med 2011, 364(5):422-431.
    • (2011) N Engl J Med , vol.364 , Issue.5 , pp. 422-431
    • Louie, T.J.1    Miller, M.A.2    Mullane, K.M.3
  • 50
    • 33747603490 scopus 로고    scopus 로고
    • Prospective, randomized inpatient study of oral metronidazole versus oral metronidazole and rifampin for treatment of primary episode of Clostridium difficile-associated diarrhea
    • Lagrotteria D., Holmes S., Smieja M., et al. Prospective, randomized inpatient study of oral metronidazole versus oral metronidazole and rifampin for treatment of primary episode of Clostridium difficile-associated diarrhea. Clin Infect Dis 2006, 43(5):547-552.
    • (2006) Clin Infect Dis , vol.43 , Issue.5 , pp. 547-552
    • Lagrotteria, D.1    Holmes, S.2    Smieja, M.3
  • 51
    • 60249098134 scopus 로고    scopus 로고
    • Intracolonic vancomycin for adjunctive treatment of severe clostridium difficile colitis: indications and precautions
    • Apisarnthanarak A., Mundy L.M. Intracolonic vancomycin for adjunctive treatment of severe clostridium difficile colitis: indications and precautions. J Infect Dis Antimicrob Agents 2005, 22:21-26.
    • (2005) J Infect Dis Antimicrob Agents , vol.22 , pp. 21-26
    • Apisarnthanarak, A.1    Mundy, L.M.2
  • 52
    • 15544372997 scopus 로고    scopus 로고
    • Alternative treatments for Clostridium difficile disease: what really works?
    • McFarland L.V. Alternative treatments for Clostridium difficile disease: what really works?. J Med Microbiol 2005, 54(2):101-111.
    • (2005) J Med Microbiol , vol.54 , Issue.2 , pp. 101-111
    • McFarland, L.V.1
  • 53
    • 84877874068 scopus 로고    scopus 로고
    • Tolevamer: a novel, non-antibiotic drug being investigated for the treatment of the most common cause of nosocomial diarrhea. Available at:
    • Tolevamer: a novel, non-antibiotic drug being investigated for the treatment of the most common cause of nosocomial diarrhea. Available at: http://www.genzyme.com/corp/./genz_pdf_tolevamer_nonconfidential.pdf.
  • 54
    • 68349106978 scopus 로고    scopus 로고
    • First Australian isolation of epidemic Clostridium difficile PCR ribotype 027
    • Riley T.V., Thean S., Hool G., et al. First Australian isolation of epidemic Clostridium difficile PCR ribotype 027. Med J Aust 2009, 190(12):706-708.
    • (2009) Med J Aust , vol.190 , Issue.12 , pp. 706-708
    • Riley, T.V.1    Thean, S.2    Hool, G.3
  • 55
    • 79955493719 scopus 로고    scopus 로고
    • Severe infection with Clostridium difficile PCR ribotype 027 acquired in Melbourne, Australia
    • Richards M., Knox J., Elliott B., et al. Severe infection with Clostridium difficile PCR ribotype 027 acquired in Melbourne, Australia. Med J Aust 2011, 194(7):369-371.
    • (2011) Med J Aust , vol.194 , Issue.7 , pp. 369-371
    • Richards, M.1    Knox, J.2    Elliott, B.3
  • 56
    • 84877873916 scopus 로고    scopus 로고
    • State hospitals fall prey to a different superbug. Available at:
    • State hospitals fall prey to a different superbug. Available at: http://www.theage.com.au/victoria/state-hospitals-fall-prey-to-a-difficult-superbug-20120525-1zads.html.
  • 57
    • 77955961892 scopus 로고    scopus 로고
    • Durable alteration of the colonic microbiota by the administration of donor fecal flora
    • Grehan M.J., Leis S.M., Campbell J., et al. Durable alteration of the colonic microbiota by the administration of donor fecal flora. J Clin Gastroenterol 2010, 44:551-561.
    • (2010) J Clin Gastroenterol , vol.44 , pp. 551-561
    • Grehan, M.J.1    Leis, S.M.2    Campbell, J.3
  • 58
    • 80052024909 scopus 로고    scopus 로고
    • Endoscopic fecal microbiota transplantation ''first-line'' treatment for severe Clostridium difficile Infection?
    • Brandt L.J., Borody T.J., Campbell J. Endoscopic fecal microbiota transplantation ''first-line'' treatment for severe Clostridium difficile Infection?. J Clin Gastroenterol 2011, 45(8):655-657.
    • (2011) J Clin Gastroenterol , vol.45 , Issue.8 , pp. 655-657
    • Brandt, L.J.1    Borody, T.J.2    Campbell, J.3
  • 60
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J., Ruiqiang L., Raes J., et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464:59-65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Ruiqiang, L.2    Raes, J.3
  • 61
    • 15544369658 scopus 로고    scopus 로고
    • Host-bacterial mutualism in the human intestine
    • Backhed F., Ley R.E., Sonnenburg J.L., et al. Host-bacterial mutualism in the human intestine. Science 2005, 307(5717):1915-1920.
    • (2005) Science , vol.307 , Issue.5717 , pp. 1915-1920
    • Backhed, F.1    Ley, R.E.2    Sonnenburg, J.L.3
  • 62
    • 77955647582 scopus 로고    scopus 로고
    • Gut microbiota in health and disease
    • Sekirov I., Russell S.L., Antunes C.M., et al. Gut microbiota in health and disease. Physiol Rev 2010, 90(3):859-904.
    • (2010) Physiol Rev , vol.90 , Issue.3 , pp. 859-904
    • Sekirov, I.1    Russell, S.L.2    Antunes, C.M.3
  • 63
    • 0020380906 scopus 로고
    • Colonization resistance of the digestive tract: clinical consequences and implications
    • Van Der Waaj D. Colonization resistance of the digestive tract: clinical consequences and implications. J Antimicrob Chemother 1982, 10:263-270.
    • (1982) J Antimicrob Chemother , vol.10 , pp. 263-270
    • Van Der Waaj, D.1
  • 64
    • 0021154432 scopus 로고
    • The structure and mode of action of glycopeptide antibiotics of the vancomycin group
    • Barna J.C., Williams D.H. The structure and mode of action of glycopeptide antibiotics of the vancomycin group. Annu Rev Microbiol 1984, 38:339-357.
    • (1984) Annu Rev Microbiol , vol.38 , pp. 339-357
    • Barna, J.C.1    Williams, D.H.2
  • 65
    • 34548061219 scopus 로고    scopus 로고
    • In vitro inhibition activity of nisin A, nisin Z, pediocin PA-1 and antibiotics against common intestinal bacteria
    • Le Blay G., Lacroix C., Zihler A., et al. In vitro inhibition activity of nisin A, nisin Z, pediocin PA-1 and antibiotics against common intestinal bacteria. Lett Appl Microbiol 2007, 45(3):252-257.
    • (2007) Lett Appl Microbiol , vol.45 , Issue.3 , pp. 252-257
    • Le Blay, G.1    Lacroix, C.2    Zihler, A.3
  • 66
    • 33751556362 scopus 로고    scopus 로고
    • Abnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis
    • Martinez-Medina M., Aldeguer X., Gonzalez-Huix F., et al. Abnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis. Inflamm Bowel Dis 2006, 12(12):1136-1145.
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.12 , pp. 1136-1145
    • Martinez-Medina, M.1    Aldeguer, X.2    Gonzalez-Huix, F.3
  • 67
    • 79955935457 scopus 로고    scopus 로고
    • Intestinal microbiota in inflammatory bowel disease: friend or foe?
    • Fava F., Danese S. Intestinal microbiota in inflammatory bowel disease: friend or foe?. World J Gastroenterol 2011, 17(5):557-566.
    • (2011) World J Gastroenterol , vol.17 , Issue.5 , pp. 557-566
    • Fava, F.1    Danese, S.2
  • 68
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn's disease patients
    • Sokol H., Pigneur B., Watterlot L., et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn's disease patients. Proc Natl Acad Sci U S A 2008, 105(43):16731-16736.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.43 , pp. 16731-16736
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3
  • 69
    • 34548399000 scopus 로고    scopus 로고
    • Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae
    • Lupp C., Robertson M.L., Wickham M.E., et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe 2007, 2(3):204.
    • (2007) Cell Host Microbe , vol.2 , Issue.3 , pp. 204
    • Lupp, C.1    Robertson, M.L.2    Wickham, M.E.3
  • 70
    • 40749084834 scopus 로고    scopus 로고
    • Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract
    • Barman M., Unold D., Shifley K., et al. Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract. Infect Immun 2008, 76(3):907-915.
    • (2008) Infect Immun , vol.76 , Issue.3 , pp. 907-915
    • Barman, M.1    Unold, D.2    Shifley, K.3
  • 71
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky D.K. Inflammatory bowel disease. N Engl J Med 2002, 347:417-429.
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 72
    • 84865489065 scopus 로고    scopus 로고
    • The many faces of Crohn's Disease: latest concepts in etiology
    • [Epub ahead of print]
    • Campbell J., Borody T.J., Leis S. The many faces of Crohn's Disease: latest concepts in etiology. Open J Intern Med 2012, [Epub ahead of print].
    • (2012) Open J Intern Med
    • Campbell, J.1    Borody, T.J.2    Leis, S.3
  • 73
    • 0024970366 scopus 로고
    • Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?
    • Borody T.J., George L., Andrews P., et al. Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?. Med J Aust 1989, 150:604.
    • (1989) Med J Aust , vol.150 , pp. 604
    • Borody, T.J.1    George, L.2    Andrews, P.3
  • 74
    • 78651244721 scopus 로고    scopus 로고
    • Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo
    • Moussata D., Goetz M., Gloeckner A., et al. Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo. Gut 2011, 60:26-33.
    • (2011) Gut , vol.60 , pp. 26-33
    • Moussata, D.1    Goetz, M.2    Gloeckner, A.3
  • 75
    • 0026549865 scopus 로고
    • Chronic constipation reversed by restoration of bowel flora. A case and a hypothesis
    • Andrews P.J., Barnes P., Borody T.J. Chronic constipation reversed by restoration of bowel flora. A case and a hypothesis. Eur J Gastroenterol Hepatol 1992, 4:245-247.
    • (1992) Eur J Gastroenterol Hepatol , vol.4 , pp. 245-247
    • Andrews, P.J.1    Barnes, P.2    Borody, T.J.3
  • 76
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh P.J., Ley R.E., Mahowald M.A., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3
  • 77
    • 77949393654 scopus 로고    scopus 로고
    • Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    • Larsen N., Vogensen F.K., Van Den Berg F.W., et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 2010, 5(2):e9085.
    • (2010) PLoS One , vol.5 , Issue.2
    • Larsen, N.1    Vogensen, F.K.2    Van Den Berg, F.W.3
  • 78
    • 25844467765 scopus 로고    scopus 로고
    • Differences between the gut microflora of children with autism spectrum disorders and that of healthy children
    • Parracho H., Bingham M.O., Gibson G.R., et al. Differences between the gut microflora of children with autism spectrum disorders and that of healthy children. J Med Microbiol 2005, 54(10):987-991.
    • (2005) J Med Microbiol , vol.54 , Issue.10 , pp. 987-991
    • Parracho, H.1    Bingham, M.O.2    Gibson, G.R.3
  • 79
    • 0027264811 scopus 로고
    • Remission of myasthenia gravis after proctocolectomy in a patient with ulcerative colitis
    • Gower-Rousseau C., Reumaux D., Bellard M., et al. Remission of myasthenia gravis after proctocolectomy in a patient with ulcerative colitis. Am J Gastroenterol 1993, 88(7):1136-1138.
    • (1993) Am J Gastroenterol , vol.88 , Issue.7 , pp. 1136-1138
    • Gower-Rousseau, C.1    Reumaux, D.2    Bellard, M.3
  • 80
    • 49049110038 scopus 로고    scopus 로고
    • Commensal gut bacteria and the etiopathogenesis of rheumatoid arthritis
    • Edwards C.J. Commensal gut bacteria and the etiopathogenesis of rheumatoid arthritis. J Rheumatol 2008, 35:1477-1479.
    • (2008) J Rheumatol , vol.35 , pp. 1477-1479
    • Edwards, C.J.1
  • 81
    • 70349631208 scopus 로고    scopus 로고
    • Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and methanogens in anorexic patients
    • Armougom F., Henry M., Vialettes B., et al. Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and methanogens in anorexic patients. PLoS One 2009, 4(9):e7125.
    • (2009) PLoS One , vol.4 , Issue.9
    • Armougom, F.1    Henry, M.2    Vialettes, B.3
  • 82
  • 83
    • 79957883062 scopus 로고    scopus 로고
    • Metabolic effects of transplanting gut microbiota from lean donors to subjects with metabolic syndrome
    • Vrieze A., Holleman F., Serlie M.J., et al. Metabolic effects of transplanting gut microbiota from lean donors to subjects with metabolic syndrome. EASD 2010, A90.
    • (2010) EASD
    • Vrieze, A.1    Holleman, F.2    Serlie, M.J.3
  • 84
    • 8644259908 scopus 로고    scopus 로고
    • Life style risks of Parkinson's disease: association between decreased water intake and constipation
    • Ueki A., Otsuka M. Life style risks of Parkinson's disease: association between decreased water intake and constipation. J Neurol 2004, 251(7):18-23.
    • (2004) J Neurol , vol.251 , Issue.7 , pp. 18-23
    • Ueki, A.1    Otsuka, M.2
  • 85
    • 0035859865 scopus 로고    scopus 로고
    • Frequency of bowel movements and the future risk of Parkinson's disease
    • Abbott R.D., Petrovich H., White L.R., et al. Frequency of bowel movements and the future risk of Parkinson's disease. Neurology 2001, 57:456-462.
    • (2001) Neurology , vol.57 , pp. 456-462
    • Abbott, R.D.1    Petrovich, H.2    White, L.R.3
  • 86
    • 84877875139 scopus 로고    scopus 로고
    • Treatment of severe constipation improves Parkinson's Disease (PD) symptoms
    • Borody T.J., Torres M., Campbell J., et al. Treatment of severe constipation improves Parkinson's Disease (PD) symptoms. Am J Gastroenterol 2009, S999.
    • (2009) Am J Gastroenterol
    • Borody, T.J.1    Torres, M.2    Campbell, J.3
  • 87
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak H., Del Tredechi K., Rüb U., et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003, 24:197-211.
    • (2003) Neurobiol Aging , vol.24 , pp. 197-211
    • Braak, H.1    Del Tredechi, K.2    Rüb, U.3
  • 89
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian S.K., Liu C.H., Tzianabos A.O., et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122:107-118.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3
  • 90
    • 0036061028 scopus 로고    scopus 로고
    • Gastrointestinal microflora studies in late-onset autism
    • Finegold S., Molitoris D., Song Y., et al. Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 2002, 35:S6-16.
    • (2002) Clin Infect Dis , vol.35
    • Finegold, S.1    Molitoris, D.2    Song, Y.3
  • 91
    • 84655167934 scopus 로고    scopus 로고
    • State of the art; microbiology in health and disease. Intestinal bacterial flora in autism
    • Finegold S. State of the art; microbiology in health and disease. Intestinal bacterial flora in autism. Anaerobe 2011, 17:367-368.
    • (2011) Anaerobe , vol.17 , pp. 367-368
    • Finegold, S.1
  • 92
    • 0014972216 scopus 로고
    • Malabsorption and cerebral dysfunction: a multivariate and comparative study of autistic children
    • Goodwin M.S., Goodwin T.C., Cowen M.A. Malabsorption and cerebral dysfunction: a multivariate and comparative study of autistic children. J Autism Child Schizophr 1971, 1(1):48-62.
    • (1971) J Autism Child Schizophr , vol.1 , Issue.1 , pp. 48-62
    • Goodwin, M.S.1    Goodwin, T.C.2    Cowen, M.A.3
  • 93
    • 0036615858 scopus 로고    scopus 로고
    • Autism and gastrointestinal symptoms
    • Horvath K., Perman J.A. Autism and gastrointestinal symptoms. Curr Gastroenterol Rep 2002, 4(3):251-258.
    • (2002) Curr Gastroenterol Rep , vol.4 , Issue.3 , pp. 251-258
    • Horvath, K.1    Perman, J.A.2
  • 94
    • 33750313546 scopus 로고    scopus 로고
    • Frequency of gastrointestinal symptoms in children with autism spectrum disorders and association with family history of autoimmune disease
    • Valicenti-McDermott M., McVicar K., Rapin I., et al. Frequency of gastrointestinal symptoms in children with autism spectrum disorders and association with family history of autoimmune disease. J Dev Behav Pediatr 2006, 27:S128-S136.
    • (2006) J Dev Behav Pediatr , vol.27
    • Valicenti-McDermott, M.1    McVicar, K.2    Rapin, I.3
  • 95
    • 8744264007 scopus 로고    scopus 로고
    • Real-time PCR quanititation of clostridia in feces of autistic children
    • Song Y., Liu C., Finegold S.M. Real-time PCR quanititation of clostridia in feces of autistic children. Appl Environ Microbiol 2004, 70(11):6459-6465.
    • (2004) Appl Environ Microbiol , vol.70 , Issue.11 , pp. 6459-6465
    • Song, Y.1    Liu, C.2    Finegold, S.M.3
  • 96
    • 0033929819 scopus 로고    scopus 로고
    • Short-term benefit from oral vancomycin treatment of regressive-onset autism
    • Sandler R.H., Finegold S.M., Bolte E.R., et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol 2000, 15(7):429-435.
    • (2000) J Child Neurol , vol.15 , Issue.7 , pp. 429-435
    • Sandler, R.H.1    Finegold, S.M.2    Bolte, E.R.3
  • 97
    • 70350247500 scopus 로고    scopus 로고
    • Magnetically induced vagus nerve stimulation and feeding behaviour in rats
    • Ziomber A., Juszczak K., Kaszuba-Zwionska J., et al. Magnetically induced vagus nerve stimulation and feeding behaviour in rats. J Physiol Pharmacol 2009, 60(3):71-77.
    • (2009) J Physiol Pharmacol , vol.60 , Issue.3 , pp. 71-77
    • Ziomber, A.1    Juszczak, K.2    Kaszuba-Zwionska, J.3
  • 98
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of Lactobacillus strain regulates emotional behaviour and central GABA receptor expression in a mouse via the vagus nerve
    • Bravo J.A., Forsythe P., Chew M.V. Ingestion of Lactobacillus strain regulates emotional behaviour and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A 2011, 108(38):16050-16055.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.38 , pp. 16050-16055
    • Bravo, J.A.1    Forsythe, P.2    Chew, M.V.3
  • 99
    • 84856377281 scopus 로고    scopus 로고
    • Targeting the microbiota-gut-brain axis to modulate behaviour: which bacterial strain will translate best to humans?
    • McLean P.G., Bergonzelli G.E., Collins S.M., et al. Targeting the microbiota-gut-brain axis to modulate behaviour: which bacterial strain will translate best to humans?. Proc Natl Acad Sci U S A 2012, 109(4):E174.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.4
    • McLean, P.G.1    Bergonzelli, G.E.2    Collins, S.M.3
  • 100
    • 0031853068 scopus 로고    scopus 로고
    • Autism and clostridium tetani
    • Bolte E.R. Autism and clostridium tetani. Med Hypothesis 1998, 51(2):133-144.
    • (1998) Med Hypothesis , vol.51 , Issue.2 , pp. 133-144
    • Bolte, E.R.1
  • 102
    • 84877875948 scopus 로고    scopus 로고
    • FDA AABB donor history questionnaire documents. Available at:
    • FDA AABB donor history questionnaire documents. Available at: http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/BloodDonorScreening/UCM213552.pdf.
  • 103
    • 80052033909 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube
    • Aas J., Gessert C.E., Bakken J.S. Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis 2002, 34(3):346-353.
    • (2002) Clin Infect Dis , vol.34 , Issue.3 , pp. 346-353
    • Aas, J.1    Gessert, C.E.2    Bakken, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.