A life course of adiposity and dementia

European Journal of Pharmacology

Volumn 585, Issue 1, 2008, Pages 163-175

  Gustafson, Deborah ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Adipose; Alzheimer; BMI; Dementia; Obesity; Overweight

Indexed keywords

GHRELIN; HORMONE; LEPTIN; NEUROPEPTIDE;

BODY MASS; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN REGION; COGNITION; DEMENTIA; HUMAN; LEARNING; MEMORY; OBESITY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; RISK FACTOR;

ADIPOSE TISSUE; ADIPOSITY; ADULT; AGE FACTORS; AGED; BODY MASS INDEX; DEMENTIA; HUMANS; MIDDLE AGED; OBESITY; RISK FACTORS;

EID: 42249090877     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.01.052     Document Type: Review

References (142)

1. Adam T.C., and Epel E.S. Stress, eating and the reward system. Physiol Behav 91 (2007) 449-458
2. Aevarsson O., and Skoog I. A population-based study on the incidence of dementia disorders between 85 and 88 years of age. J. Am. Geriatr. Soc. 44 (1996) 1455-1460
3. Albiston A.L., McDowall S.G., Matsacos D., Sim P., Clune E., Mustafa T., Lee J., Mendelsohn F.A., Simpson R.J., Connolly L.M., and Chai S.Y. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. J. Biol. Chem. 276 (2001) 48623-48626
4. Alonso-Alonso M., and Pascual-Leone A. The right brain hypothesis for obesity. JAMA 297 (2007) 1819-1822
5. Ashdown-Lambert J. A review of low birth weight: predictors, precursors and morbidity outcomes. J. R. Soc. Promot. Health 125 (2005) 76-83
6. Ayanian J.Z., Zaslavsky A.M., Weissman J.S., Schneider E.C., and Ginsburg J.A. Undiagnosed hypertension and hypercholesterolemia among uninsured and insured adults in the Third National Health and Nutrition Examination Survey. Am. J. Public Health 93 (2003) 2051-2054
7. Baessler A., Hasinoff M.J., Fischer M., Reinhard W., Sonnenberg G.E., Olivier M., Erdmann J., Schunkert H., Doering A., Jacob H.J., Comuzzie A.G., Kissebah A.H., and Kwitek A.E. Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes 54 (2005) 259-267
8. Banks W. Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations. Curr. Pharm. Des. 9 (2003) 801-809
9. Barker D.J. The fetal and infant origins of adult disease. Br. Med. J. 301 (1990) 1111
10. Barker D.J., and Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1 (1986) 1077-1081
11. Barker D.J., Osmond C., Forsen T.J., Kajantie E., and Eriksson J.G. Trajectories of growth among children who have coronary events as adults. N. Engl. J. Med. 353 (2005) 1802-1809
12. Barrett-Connor E., Edelstein S.L., Corey-Bloom J., and Wiederholt W.C. Weight loss precedes dementia in community-dwelling older adults. J. Am. Geriatr. Soc. 44 (1996) 1147-1152
13. Barton M., Carmona R., Ortmann J., Krieger J.E., and Traupe T. Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Int. J. Biochem. Cell Biol. 35 (2003) 826-837
14. Bateson P., Barker D., Clutton-Brock T., Deb D., D'Udine B., Foley R.A., Gluckman P., Godfrey K., Kirkwood T., Lahr M.M., McNamara J., Metcalfe N.B., Monaghan P., Spencer H.G., and Sultan S.E. Developmental plasticity and human health. Nature 430 (2004) 419-421
15. Batstra L., Neeleman J., Elsinga C., and Hadders-Algra M. Psychiatric morbidity is related to a chain of prenatal and perinatal adversities. Early Hum. Dev. 82 (2006) 721-729
16. Beeri M.S., Davidson M., Silverman J.M., Noy S., Schmeidler J., and Goldbourt U. Relationship between body height and dementia. Am. J. Geriatr. Psychiatry 13 (2005) 116-123
17. Bergvall N., Iliadou A., Tuvemo T., and Cnattingius S. Birth characteristics and risk of low intellectual performance in early adulthood: are the associations confounded by socioeconomic factors in adolescence or familial effects?. Pediatrics 117 (2006) 714-721
18. Biro F.M., Khoury P., and Morrison J.A. Influence of obesity on timing of puberty. Int. J. Androl. 29 (2005) 272-277
19. Blennow K., Wallin A., Fredman P., Karlsson I., Gottfries C.G., and Svennerholm L. Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors. Acta Neurol. Scand. 81 (1990) 323-326
20. Bo M., Massaia M., Raspo S., Bosco F., Cena P., Molaschi M., and Fabris F. Predictive factors of in-hospital mortality in older patients admitted to a medical intensive care unit. J. Am. Geriatr. Soc. 51 (2003) 529-533
21. Borjesson-Hanson A., Edin E., Gislason T., and Skoog I. The prevalence of dementia in 95 year olds. Neurology 63 (2004) 2436-2438
22. Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl) 82 (1991) 239-259
23. Bray G.A., Fisler J., and York D.A. Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Front Neuroendocrinol. 11 (1990) 128-181
24. Brook R.D., Bard R.L., Rubenfire M., Ridker P.M., and Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am. J. Cardiol. 88 (2001) 1264-1269
25. Buchman A.S., Wilson R.S., Bienias J.L., Shah R.C., Evans D.A., and Bennett D.A. Change in body mass index and risk of incident Alzheimer disease. Neurology 65 (2005) 892-897
26. Chandola T., Deary I.J., Blane D., and Batty G.D. Childhood IQ in relation to obesity and weight gain in adult life: the National Child Development (1958) Study. Int. J. Obes. 30 (2006) 1422-1432
27. Chiang C.J., Yip P.K., Wu S.C., Lu C.S., Liou C.W., Liu H.C., Liu C.K., Chu C.H., Hwang C.S., Sung S.F., Hsu Y.D., Chen C.C., Liu S.I., Yan S.H., Fong C.S., Chang S.F., You S.L., and Chen C.J. Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan. Am. J. Geriatr. Psychiatry 15 (2007) 762-771
28. Cohen L.J., Simeon D., Hollander E., and Stein D.J. Obsessive-compulsive spectrum disorders. In: Hollander E., and Stein D.J. (Eds). Obsessive-Compulsive Disorders (1997), Marcel Dekker, Inc., New York 47-73
29. Cota D., Proulx K., and Seeley R.J. The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology 132 (2007) 2158-2168
30. Craft S. Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr. Alzheimer Res. 4 (2007) 147-152
31. Cunnane S.C., and Crawford M.A. Survival of the fattest: fat babies were the key to evolution of the large human brain. Comp. Biochem. Physiol. A, Mol. Integr. Physiol. 136 (2003) 17-26
32. Davidson T.L., Kanoski S.E., Walls E.K., and Jarrard L.E. Memory inhibition and energy regulation. Physiol. Behav. 86 (2005) 731-746
33. Delacourte A. Biochemical and molecular characterization of neurofibrillary degeneration in frontotemporal dementias. Dement Geriatr. Cogn. Disord. 10 Suppl. 1 (1999) 75-79
34. deLeon M.J., George A.E., Golomb J., Tarshish C., Convit A., Kluger A., Santi S., McRae T., Ferris S.H., Reisberg B., Ince C., Rusinek H., Bobinski M., Quinn B., Miller D.C., and Wisniewski H.M. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol. Aging 18 (1996) 1-11
35. DeMichele M., Panico S., Iannuzzi A., Celentano E., Ciardullo A.V., Galasso R., Sacchetti L., Zarrilli F., Bond G., and Rubba P. Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. Stroke 33 (2002) 2923-2928
36. Diaz V.A., Mainous III A.G., Koopman R.J., and Geesey M.E. Undiagnosed obesity: implications for undiagnosed hypertension, diabetes, and hypercholesterolemia. Fam. Med. 36 (2004) 639-644
37. Dubois B., Feldman H.H., Jacova C., Dekosky S.T., Barberger-Gateau P., Cummings J., Delacourte A., Galasko D., Gauthier S., Jicha G., Meguro K., O'Brien J., Pasquier F., Robert P., Rossor M., Salloway S., Stern Y., Visser P.J., and Scheltens P. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 6 (2007) 734-746
38. Elmquist J.K., and Flier J.S. Neuroscience. The fat-brain axis enters a new dimension. Science 304 (2004) 63-64
39. Enzinger C., Fazekas F., Matthews P.M., Ropele S., Schmidt H., Smith S., and Schmidt R. Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology 64 (2005) 1704-1711
40. Epel E., Jimenez S., Brownell K., Stroud L., Stoney C., and Niaura R. Are stress eaters at risk for the metabolic syndrome?. Ann. N. Y. Acad. Sci. 1032 (2004) 208-210
41. Faxen-Irving G., Basun H., and Cederholm T. Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders. Age Ageing 34 (2005) 136-141
42. Fewlass D.C., Noboa K., Pi-Sunyer F.X., Johnston J.M., Yan S.D., and Tezapsidis N. Obesity-related leptin regulates Alzheimer's Abeta. FASEB J. 18 (2004) 1870-1878
43. Finch C.E. Developmental origins of aging in brain and blood vessels: an overview. Neurobiol. Aging 26 (2005) 281-291
44. Flegal K.M. Epidemiologic aspects of overweight and obesity in the United States. Physiol. Behav. 86 (2005) 599-602
45. Ford E.S., Giles W.H., and Dietz W.H. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287 (2002) 356-359
46. Friedman J., and Halaas L. Leptin and the regulation of body weight in mammals. Nature 22 (1998) 763-770
47. Frisch R.E., and McArthur J.W. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 185 (1974) 949-951
48. Fulton S., Woodside B., and Shizgal P. Modulation of brain reward circuitry by leptin. Science 287 (2000) 125-128
49. Fulton S., Pissios P., Manchon R.P., Stiles L., Frank L., Pothos E.N., Maratos-Flier E., and Flier J.S. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51 (2006) 811-822
50. Gluckman P.D., and Hanson M. Mismatch: Why Our World No Longer Fits Our Bodies (2006), Oxford University Press, London
51. Gluckman P.D., Hanson M.A., and Pinal C. The developmental origins of adult disease. Matern Child Nutr. 1 (2005) 130-141
52. Goossens G.H., Blaak E.E., and van Baak M.A. Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders. Obes. Rev. 4 (2003) 43-55
53. Gottfredson L.S. Intelligence: is it the epidemiologists' elusive "fundamental cause" of social class inequalities in health?. J. Pers. Soc. Psychol. 86 (2004) 174-199
54. Gustafson D.R. Adiposity indices and dementia. Lancet Neurology 5 (2006) 713-720
55. Gustafson D.R., Rothenberg E., Blennow K., Steen B., and Skoog I. An 18-year follow up of overweight and risk for Alzheimer's disease. Arch. Intern. Med. 163 (2003) 1524-1528
56. Gustafson D., Lissner L., Bengtsson C., Björkelund C., and Skoog I. A 24-year follow-up of body mass index and cerebral atrophy. Neurology 63 (2004) 1876-1881
57. Gustafson D., Karlsson C., Skoog I., Rosengren L., Lissner L., and Blennow K. Mid-life adiposity factors relate to blood brain barrier integrity in late-life. J. Intern. Med. 262 (2007) 643-650
58. Hales C.N., Barker D.J., Clark P.M., Cox L.J., Fall C., Osmond C., and Winter P.D. Fetal and infant growth and impaired glucose tolerance at age 64. Br. Med. J. 303 (1991) 1019-1022
59. Halkjaer J., Holst C., and Sorensen T.I. Intelligence test score and educational level in relation to BMI changes and obesity. Obes. Res. 11 (2003) 1238-1245
60. Harvey J., Shanley L.J., O'Malley D., and Irving A.J. Leptin: a potential cognitive enhancer?. Biochem. Soc. Trans. 33 (2005) 1029-1032
61. Hayden K., Zandi P., Lyketsos C., Khachaturian A., Bastian L., Charoonruk G., Tschanz J., Norton M., Pieper C., Munger R., Breitner J., Welsh-Bohmer K., and Cache County Investigators. Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study. Alzheimer Dis. Assoc. Disord. 20 (2006) 93-100
62. Hinton E.C., Parkinson J.A., Holland A.J., Arana F.S., Roberts A.C., and Owen A.M. Neural contributions to the motivational control of appetite in humans. Eur. J. Neurosci. 20 (2004) 1411-1418
63. Hogan D.B., Ebly E.M., and Rockwood K. Weight, blood pressure, osmolarity, and glucose levels across various stages of Alzheimer's disease and vascular dementia. Dement. Geriatr. Cogn. Disord. 8 (1997) 147-151
64. Huda M.S., Wilding J.P., and Pinkney J.H. Gut peptides and the regulation of appetite. Obes. Rev. 7 (2006) 163-182
65. Jagust W., Harvey D., Mungas D., and Haan M. Central obesity and the aging brain. Arch. Neurol. 62 (2005) 1545-1548
66. Jerlhag E., Egecioglu E., Dickson S.L., Andersson M., Svensson L., and Engel J. Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward. Addict Biol. 11 (2006) 45-54
67. Johnson S.C., Schmitz T.W., Moritz C.H., Meyerand M.E., Rowley H.A., Alexander A.L., Hansen K.W., Gleason C.E., Carlsson C.M., Ries M.L., Asthana S., Chen K., Reiman E.M., and Alexander G.E. Activation of brain regions vulnerable to Alzheimer's disease: the effect of mild cognitive impairment. Neurobiol. Aging 27 (2006) 1604-1612
68. Katagiri H., Yamada T., and Oka Y. Adiposity and cardiovascular disorders: disturbance of the regulatory system consisting of humoral and neuronal signals. Circ. Res. 101 (2007) 27-39
69. Katzov H., Bennet A.M., Kehoe P., Wiman B., Gatz M., Blennow K., Lenhard B., Pedersen N.L., deFaire U., and Prince J.A. A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity. Human Mol. Genetics 13 (2004) 2647-2657
70. Kelley A.E. Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci. Biobehav. Rev. 27 (2004) 765-776
71. Kerrouche N., Herholz K., Mielke R., Holthoff V., and Baron J.C. 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis. J. Cereb. Blood Flow Metab. 26 (2006) 1213-1221
72. Kim J.M., Stewart R., Shin I.S., Kim S.W., Yang S.J., and Yoon J.S. Associations between head circumference, leg length and dementia in a Korean population. Int. J. Geriatr. Psychiatry 23 (2008) 41-48
73. Kind K.L., Moore V.M., and Davies M.J. Diet around conception and during pregnancy-effects on fetal and neonatal outcomes. Reprod. Biomed. Online 12 (2006) 532-541
74. Kirschbaum C., Pirke K.M., and Hellhammer D.H. The 'Trier Social Stress Test' - a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28 (1993) 76-81
75. Kishi T., and Elmquist J.K. Body weight is regulated by the brain: a link between feeding and emotion. Mol. Psychiatry 10 (2005) 132-146
76. Kivipelto M., Ngandu T., Fratiglioni L., Viitanen M., Kareholt I., Winblad B., Helkala E.L., Tuomilehto J., Soininen H., and Nissinen A. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch. Neurol. 62 (2005) 1556-1560
77. Knopman D.S., Edland S.D., Cha R.H., Petersen R.C., and Rocca W.A. Incident dementia in women is preceded by weight loss by at least a decade. Neurology 69 (2007) 739-746
78. Knowler W.C., Pettitt D.J., Bennett P.H., and Williams R.C. Diabetes mellitus in the Pima Indians: genetic and evolutionary considerations. Am. J. Phys. Anthropol. 62 (1983) 107-114
79. Lawlor D.A., Clark H., Davey Smith G., and Leon D.A. Childhood intelligence, educational attainment and adult body mass index: findings from a prospective cohort and within sibling-pairs analysis. Int. J. Obes. (Lond) 30 (2006) 1758-1765
80. Lawlor D.A., Clark H., Smith G.D., and Leon D.A. Intrauterine growth and intelligence within sibling pairs: findings from the Aberdeen children of the 1950s cohort. Pediatrics 117 (2006) e894-e902
81. Li C., Ford E.S., McGuire L.C., and Mokdad A.H. Increasing trends in waist circumference and abdominal obesity among US adults. Obesity (Silver Spring) 15 (2007) 216-224
82. Lissner L., Karlsson C., Lindroos A.K., Sjostrom L., Carlsson B., Carlsson L., and Bengtsson C. Birth weight, adulthood BMI, and subsequent weight gain in relation to leptin levels in Swedish women. Obes. Res. 7 (1999) 150-154
83. Luchsinger J.A., Patel B., Tang M.X., Schupf N., and Mayeux R. Measures of adiposity and dementia risk in elderly persons. Arch. Neurol. 64 (2007) 392-398
84. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1 (1995) 1155-1161
85. Matochik J.A., London E.D., Yildiz B.O., Ozata M., Caglayan S., DePaoli A.M., Wong M.L., and Licinio J. Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J. Clin. Endocrinol. Metab. 90 (2005) 2851-2854
86. McGavock J.M., Victor R.G., Unger R.H., and Szczepaniak L.S. Adiposity of the heart, revisited. Ann. Intern. Med. 144 (2006) 517-524
87. Medina J.M., and Tabernerno A. Lactate utilization by brain cells and its role in CNS development. J. Neurosci. Res. 79 (2005) 2-10
88. Milgram N.W., Siwak-Tapp C.T., Araujo J., and Head E. Neuroprotective effects of cognitive enrichment. Ageing Res. Rev. 5 (2006) 354-369
89. Miyasaka K., Hosoya H., Sekime A., Ohta M., Amono H., Matsushita S., Suzuki K., Higuchi S., and Funakoshi A. Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population. J. Neural. Transm. 113 (2006) 1279-1285
90. Newsome C.A., Shiell A.W., Fall C.H., Phillips D.I., Shier R., and Law C.M. Is birth weight related to later glucose and insulin metabolism?-A systematic review. Diabet. Med. 20 (2003) 339-348
91. Nourhashemi F., Deschamps V., Larrieu S., Letenneur L., Dartigues J.F., and Barberger-Gateau P. Body mass index and incidence of dementia: the PAQUID study. Neurology 60 (2003) 117-119
92. Olsson T., Nasman B., Rasmuson S., and Ahren B. Dual relation between leptin and cortisol in humans is disturbed in Alzheimer's disease. Biol. Psychiatry 44 (1998) 374-376
93. Ouchi Y., Yoshikawa E., Futatsubashi M., Okada H., Torizuka T., and Kaneko M. Activation in the premotor cortex during mental calculation in patients with Alzheimer's disease: relevance of reduction in posterior cingulate metabolism. Neuroimage 22 (2004) 155-163
94. Pan D.A., Lillioja S., Kriketos A.D., Milner M.R., Baur L.A., Bogardus C., Jenkins A.B., and Storlein L.H. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46 (1997) 983-988
95. Pannacciulli N., Del Parigi A., Chen K., Le D.S., Reiman E.M., and Tataranni P.A. Brain abnormalities in human obesity: a voxel-based morphometric study. Neuroimage 31 (2006) 1419-1425
96. Pannacciulli N., Le D.S., Chen K., Reiman E.M., and Krakoff J. Relationships between plasma leptin concentrations and human brain structure: a voxel-based morphometric study. Neurosci. Lett. 412 (2007) 248-253
97. Phillips D.I., Barker D.J., Hales C.N., Hirst S., and Osmond C. Thinness at birth and insulin resistance in adult life. Diabetologia 37 (1994) 150-154
98. Power D.A., Noel J., Collins R., and O'Neill D. Circulating leptin levels and weight loss in Alzheimer's disease patients. Dement Geriatr. Cogn. Disord. 12 (2001) 167-170
99. Qi Y., Takahashi N., Hileman S.M., Patel H.R., Berg A.H., Pajvani U.B., Scherer P.E., and Ahima R.S. Adiponectin acts in the brain to decrease body weight. Nat. Med. 10 (2004) 524-529
100. Qureshi A.I., Suri M.F., Guterman L.R., and Hopkins L.N. Ineffective secondary prevention in survivors of cardiovascular events in the US population: report from the Third National Health and Nutrition Examination Survey. Arch. Intern. Med. 161 (2001) 1621-1628
101. Rabkin S.W. Epicardial fat: properties, function and relationship to obesity. Obes. Rev. 8 (2007) 253-261
102. Richards M., Hardy R., Kuh D., and Wadsworth M.E. Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study. Br. Med. J. 322 (2001) 199-203
103. Richards M., Hardy R., Kuh D., and Wadsworth M.E. Birthweight, postnatal growth and cognitive function in a national UK birth cohort. Int. J. Epidemiol. 31 (2002) 342-348
104. Rich-Edwards J.W., Colditz G.A., Stampfer M.J., Willett W.C., Gillman M.W., Hennekens C.H., Speizer F.E., and Manson J.E. Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann. Intern. Med. 130 (1999) 278-284
105. Rosengren A., Skoog I., Gustafson D., and Wilhelmsen L. Body mass index, other cardiovascular risk factors, and hospitalization for dementia. Arch. Intern. Med. 165 (2005) 321-326
106. Ross M.G., Desai M., Khorram O., McKnight R.A., Lane R.H., and Torday J. Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease. Curr. Alzheimer Res. 4 (2007) 213-217
107. Saunders A.M., Strittmatter W.J., Schmechel D., George-Hyslop P.H.S., Pericak-Vance M.A., Joo S.H., Rosi B.L., Gusella J.F., Crapper-MacLachlan D.R., Alberts M.J., Hulette C., Crain B., Goldgaber D., and Roses A.D. Association of apolipoprotein E allele *4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43 (1993) 1467-1472
108. Savaskan E. The role of the brain renin-angiotensin system in neurodegenerative disorders. Curr. Alzheimer Res. 2 (2005) 29-35
109. Schokker D.F., Visscher T.L., Nooyens A.C., van Baak M.A., and Seidell J.C. Prevalence of overweight and obesity in the Netherlands. Obes. Rev. 8 (2007) 101-108
110. Schwartz M.W., Woods S.C., Porte D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
111. Selden N., Mesulam M.M., and Geula C. Human striatum: the distribution of neurofibrillary tangles in Alzheimer's disease. Brain Res. 648 (1994) 327-331
112. Shaw P., Lerch J.P., Pruessner J.C., Taylor K.N., Rose A.B., Greenstein D., Clasen L., Evans A., Rapoport J.L., and Giedd J.N. Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. Lancet Neurol. 6 (2007) 494-500
113. Shenkin S.D., Starr J.M., Pattie A., Rush M.A., Whalley L.J., and Deary I.J. Birth weight and cognitive function at age 11 years: the Scottish Mental Survey 1932. Arch. Dis. Child 85 (2001) 189-196
114. Shenkin S.D., Starr J.M., and Deary I.J. Birth weight and cognitive ability in childhood: a systematic review. Psychol. Bull. 130 (2004) 989-1013
115. Squire L.R., and Zola S.M. Ischemic brain damage and memory impairment: a commentary. Hippocampus 6 (1996) 546-552
116. Stewart R., Masaki K., Xue Q.L., Peila R., Petrovitch H., White L.R., and Launer L.J. A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch. Neurol. 62 (2005) 55-60
117. Strazzullo P., Iacone R., Iacoviello L., Russo O., Barba G., Russo P., D'Orazio A., Barbato A., Cappuccio F.P., Farinaro E., and Siani A. Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study. Ann. Intern. Med. 138 (2003) 17-23
118. Suwaidi J.A., Higano S.T., Holmes D.R., Lennon R., and Lerman A. Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J. Am. Coll. Cardiol. 37 (2001) 1523-1528
119. Szczepaniak L.S., Dobbins R.L., Metzger G.J., Sartoni-D'Ambrosia G., Arbique D., Vongpatanasin W., Unger R., and Victor R.G. Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn. Reson.Med. 49 (2003) 417-423
120. Tracy A.L., Jarrard L.E., and Davidson T.L. The hippocampus and motivation revisited: appetite and activity. Behav. Brain Res. 127 (2001) 13-23
121. Ukkola O., Ravussin E., Jacobson P., Perusse L., Rankinen T., Tschop M., Heiman M.L., Leon A.S., Rao D.C., Skinner J.S., Wilmore J.H., Sjostrom L., and Bouchard C. Role of ghrelin polymorphisms in obesity based on three different studies. Obes. Res. 10 (2002) 782-791
122. van Dam P.S., Aleman A., de Vries W.R., Deijen J.B., van der Veen E.A., de Haan E.H., and Koppeschaar H.P. Growth hormone, insulin-like growth factor I and cognitive function in adults. Growth Horm. IGF Res. 10 Suppl. B (2000) S69-S73
123. van Domburg P.H., and ten Donkelaar H.J. The human substantia nigra and ventral tegmental area. A neuroanatomical study with notes on aging and aging diseases. Adv. Anat. Embryol. Cell Biol. 121 (1991) 1-132
124. Vickers M.H., Breier B.H., Cutfield W.S., Hofman P.L., and Gluckman P.D. Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am. J. Physiol. Endocrinol. Metab. 279 (2000) E83-E87
125. Visscher T.L.S., Seidell J.C., Menotti A., Blackburn H., Nissinen A., Feskens E.J.M., and Kromhout D. Underweight and overweight in relation to mortality among men aged 40-59 and 50-69 years. The Seven Countries Study. Am. J. Epidemiol. 151 (2000) 660-666
126. Visser P.J., Verhey F.R.J., Hofman P.A.M., Scheltens P., and Jolles J. Medial temporal lobe atrophy predicts Alzheimer' disease in patients with minor cognitive impairment. J. Neurol. Neurosur. Psychiatr. 72 (2002) 491-497
127. Volkow N.D., and O'Brien C.P. Issues for DSM-V: should obesity be included as a brain disorder? Am. J. Psychiatry 164 (2007) 708-710
128. Volkow N.D., Fowler J.S., and Wang G.J. The addicted human brain: insights from imaging studies. J. Clin. Invest. 111 (2003) 1444-1451
129. Ward M.A., Carlsson C.M., Trivedi M.A., Sager M.A., and Johnson S.C. The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study. BMC Neurol. 5 (2005) 23-29
130. Welsh-Bohmer K.A., Hulette C., Schmechel D., Burke J., and Saunders A. Neuropsychological detection of preclinical Alzheimer's disease: results of a neuropathological series of 'normal' controls. In: Iqbal K., Sisodia S.S., and Winblad B. (Eds). Alzheimer's Disease: Advances in Etiology, Pathogenesis and Treatment (2001), John Wiley & Sons, New York 111-128
131. White H., Pieper C., Schmader K., and Fillenbaum G. Weight change in Alzheimer's disease. J. Am. Geriatr. Soc. 44 (1996) 265-272
132. White H., Pieper C., and Schmader K. The association of weight change in Alzheimer's disease with severity of disease and mortality: a longitudinal analysis. J. Am. Geriatr. Soc. 46 (1998) 1223-1227
133. Whitmer R.A., Gunderson E.P., Barrett-Connor E., Quesenberry Jr. C.P., and Yaffe K. Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. Br. Med. J. 330 (2005) 1360-1364
134. Whitmer R.A., Gunderson E.P., Quesenberry Jr. C.P., Zhou J., and Yaffe K. Body mass index in midlife and risk of Alzheimer disease and vascular dementia. Curr. Alzheimer Res. 4 (2007) 103-109
135. Whitmer, R.A., Gustafson, D.R., Barrett-Connor, E., Haan, M.N., Gunderson, E.P., Yaffe, K., in press. Central obesity and increased risk of dementia more than three decades later. Neurology [2008 Mar 26, Electronic publication ahead of print].
136. Wilding J.P. Neuropeptides and appetite control. Diabet. Med. 19 (2002) 619-627
137. Williams I.L., Wheatcroft S.B., Shah A.M., and Kearney M.T. Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 754-764
138. Wolfe W., and Maisto S. The relationship between eating disorders and substance use: moving beyond co-prevalence research. Clin. Psychol. Rev. 20 (2000) 617-631
139. Yki-Järvinen H., and Westerbacka J. Vascular actions of insulin in obesity. Int. J. Obes. Relat. Metab. Disord. 24 (2000) S25-S28
140. Yoon S.J., Pae C.U., Lee H., Choi B., Kim T.S., Lyoo I.K., Kwon D.H., and Kim D.J. Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population. Neurosci. Res. 53 (2005) 391-395
141. Zhang R., and Reisin E. Obesity-hypertension: the effects on cardiovascular and renal systems. J. Hypertens. 13 (2000) 1308-1314
142. Zhang Y., Proenca R., Maffel M., Barone M., Leopold L., and Friedman J. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432