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Volumn 15, Issue 1, 2013, Pages

The immune pathogenesis of scleroderma: Context is everything

Author keywords

Animal models; Immune; Interferon; Interleukin 13; Interleukin 33; Pathogenesis; Scleroderma; Systemic sclerosis; Toll like receptor 3

Indexed keywords

INTERLEUKIN 13;

EID: 84878346532     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-012-0297-8     Document Type: Article
Times cited : (38)

References (91)
  • 1
    • 0031736547 scopus 로고    scopus 로고
    • Biology of the scleroderma fibroblast
    • DOI 10.1097/00002281-199811000-00011
    • Strehlow D, Korn JH. Biology of the scleroderma fibroblast. Curr Opin Rheumatol. 1998;10(6):572-8. (Pubitemid 28508752)
    • (1998) Current Opinion in Rheumatology , vol.10 , Issue.6 , pp. 572-578
    • Strehlow, D.1    Korn, J.H.2
  • 2
    • 0032752728 scopus 로고    scopus 로고
    • The vascular perspective of systemic sclerosis: Of chickens, mice and men
    • Sgonc R. The vascular perspective of systemic sclerosis: of chickens, mice and men. Int Arch Allergy Immunol. 1999;120(3):169-76.
    • (1999) Int Arch Allergy Immunol. , vol.120 , Issue.3 , pp. 169-176
    • Sgonc, R.1
  • 3
    • 0025764287 scopus 로고
    • Autoimmunity as a secondary phenomenon in scleroderma (and so-called human adjuvant disease)
    • Stone OJ. Autoimmunity as a secondary phenomenon in scleroderma (and so-called human adjuvant disease). Med Hypotheses. 1991;34(2):127-30.
    • (1991) Med Hypotheses. , vol.34 , Issue.2 , pp. 127-130
    • Stone, O.J.1
  • 4
    • 78649502678 scopus 로고    scopus 로고
    • Immunotherapy of systemic sclerosis
    • Manno R, Boin F. Immunotherapy of systemic sclerosis. Immunotherapy. 2010;2(6):863-78.
    • (2010) Immunotherapy. , vol.2 , Issue.6 , pp. 863-878
    • Manno, R.1    Boin, F.2
  • 5
    • 73249152055 scopus 로고    scopus 로고
    • HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: A genome-wide association study in Koreans with replication in North Americans
    • Zhou X, Lee JE, Arnett FC, et al. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. Arthritis Rheum. 2009;60(12):3807-14.
    • (2009) Arthritis Rheum. , vol.60 , Issue.12 , pp. 3807-3814
    • Zhou, X.1    Lee, J.E.2    Arnett, F.C.3
  • 6
    • 77951765348 scopus 로고    scopus 로고
    • Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
    • Radstake TR, Gorlova O, Rueda B, et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet. 2010;42(5):426-9.
    • (2010) Nat Genet. , vol.42 , Issue.5 , pp. 426-429
    • Radstake, T.R.1    Gorlova, O.2    Rueda, B.3
  • 7
    • 79960934301 scopus 로고    scopus 로고
    • Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis
    • Allanore Y, Saad M, Dieude P, et al. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. PLoS Genet. 2011;7(7):e1002091.
    • (2011) PLoS Genet. , vol.7 , Issue.7
    • Allanore, Y.1    Saad, M.2    Dieude, P.3
  • 8
    • 84862789262 scopus 로고    scopus 로고
    • IRF5 polymorphism predicts prognosis in patients with systemic sclerosis
    • Sharif R, Mayes MD, Tan FK, et al. IRF5 polymorphism predicts prognosis in patients with systemic sclerosis. Ann Rheum Dis. 2012;71(7):1197-202.
    • (2012) Ann Rheum Dis. , vol.71 , Issue.7 , pp. 1197-1202
    • Sharif, R.1    Mayes, M.D.2    Tan, F.K.3
  • 9
    • 84863043315 scopus 로고    scopus 로고
    • A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations
    • Bossini-Castillo L, Martin JE, Broen J, et al. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Hum Mol Genet. 2012;21 (4):926-33.
    • (2012) Hum Mol Genet. , vol.21 , Issue.4 , pp. 926-933
    • Bossini-Castillo, L.1    Martin, J.E.2    Broen, J.3
  • 10
    • 84859935899 scopus 로고    scopus 로고
    • A multicenter study confirms CD226 gene association with systemic sclerosisrelated pulmonary fibrosis
    • Bossini-Castillo L, Simeon CP, Beretta L, et al. A multicenter study confirms CD226 gene association with systemic sclerosisrelated pulmonary fibrosis. Arthritis Res Ther. 2012;14(2):R85.
    • (2012) Arthritis Res Ther. , vol.14 , Issue.2
    • Bossini-Castillo, L.1    Simeon, C.P.2    Beretta, L.3
  • 11
    • 79952359835 scopus 로고    scopus 로고
    • A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort
    • Bossini-Castillo L, Broen JC, Simeon CP, et al. A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Ann Rheum Dis. 2011;70(4):638-41.
    • (2011) Ann Rheum Dis. , vol.70 , Issue.4 , pp. 638-641
    • Bossini-Castillo, L.1    Broen, J.C.2    Simeon, C.P.3
  • 13
    • 79960421272 scopus 로고    scopus 로고
    • The genetics of systemic sclerosis: An update
    • Romano E, Manetti M, Guiducci S, et al. The genetics of systemic sclerosis: an update. Clin Exp Rheumatol. 2011;29(2 Suppl 65): S75-86.
    • (2011) Clin Exp Rheumatol. , vol.29 , Issue.2 SUPPL. 65
    • Romano, E.1    Manetti, M.2    Guiducci, S.3
  • 14
    • 77957668307 scopus 로고    scopus 로고
    • Animal models of systemic sclerosis: Prospects and limitations
    • Beyer C, Schett G, Distler O, Distler JH. Animal models of systemic sclerosis: prospects and limitations. Arthritis Rheum. 2010;62(10):2831-44.
    • (2010) Arthritis Rheum. , vol.62 , Issue.10 , pp. 2831-2844
    • Beyer, C.1    Schett, G.2    Distler, O.3    Distler, J.H.4
  • 15
    • 79960908376 scopus 로고    scopus 로고
    • Capturing the heterogeneity in systemic sclerosis with genome-wide expression profiling
    • Sargent JL, Whitfield ML. Capturing the heterogeneity in systemic sclerosis with genome-wide expression profiling. Expert Rev Clin Immunol. 2011;7(4):463-73.
    • (2011) Expert Rev Clin Immunol. , vol.7 , Issue.4 , pp. 463-473
    • Sargent, J.L.1    Whitfield, M.L.2
  • 17
    • 49949114547 scopus 로고    scopus 로고
    • Molecular subsets in the gene expression signatures of scleroderma skin
    • Milano A, Pendergrass SA, Sargent JL, et al. Molecular subsets in the gene expression signatures of scleroderma skin. PLoS One. 2008;3(7):e2696.
    • (2008) PLoS One. , vol.3 , Issue.7
    • Milano, A.1    Pendergrass, S.A.2    Sargent, J.L.3
  • 18
    • 84859760888 scopus 로고    scopus 로고
    • Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies
    • Pendergrass SA, Lemaire R, Francis IP, et al. Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies. J Invest Dermatol. 2012;132 (5):1363-73.
    • (2012) J Invest Dermatol. , vol.132 , Issue.5 , pp. 1363-1373
    • Pendergrass, S.A.1    Lemaire, R.2    Francis, I.P.3
  • 19
    • 75649110070 scopus 로고    scopus 로고
    • Animal model of systemic sclerosis
    • Yamamoto T. Animal model of systemic sclerosis. J Dermatol. 2010;37(1):26-41.
    • (2010) J Dermatol. , vol.37 , Issue.1 , pp. 26-41
    • Yamamoto, T.1
  • 20
    • 77958061836 scopus 로고    scopus 로고
    • Animal models of scleroderma: Fresh insights
    • Artlett CM. Animal models of scleroderma: fresh insights. Curr Opin Rheumatol. 2010;22(6):677-82.
    • (2010) Curr Opin Rheumatol. , vol.22 , Issue.6 , pp. 677-682
    • Artlett, C.M.1
  • 21
    • 0020630583 scopus 로고
    • Chronic graft-versus-host disease (GVHD) as a model for scleroderma. I. Description of model systems
    • Jaffee BD, Claman HN. Chronic graft-versus-host disease (GVHD) as a model for scleroderma. I. Description of model systems. Cell Immunol. 1983;77(1):1-12. (Pubitemid 13135593)
    • (1983) Cellular Immunology , vol.77 , Issue.1 , pp. 1-12
    • Jaffee, B.D.1    Claman, H.N.2
  • 22
    • 67650908413 scopus 로고    scopus 로고
    • Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis
    • Fleming JN, Shulman HM, Nash RA, et al. Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis. PLoS One. 2009;4(7):e6203.
    • (2009) PLoS One. , vol.4 , Issue.7
    • Fleming, J.N.1    Shulman, H.M.2    Nash, R.A.3
  • 23
    • 1842783757 scopus 로고    scopus 로고
    • A Modified Model of Graft-Versus-Host-Induced Systemic Sclerosis (Scleroderma) Exhibits All Major Aspects of the Human Disease
    • DOI 10.1002/art.20160
    • Ruzek MC, Jha S, Ledbetter S, et al. A modified model of graftversus- host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease. Arthritis Rheum. 2004;50 (4):1319-31. (Pubitemid 38480843)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.4 , pp. 1319-1331
    • Ruzek, M.C.1    Jha, S.2    Ledbetter, S.3    Richards, S.M.4    Garman, R.D.5
  • 25
    • 84857229277 scopus 로고    scopus 로고
    • Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets
    • Greenblatt MB, Sargent JL, Farina G, et al. Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol. 2012;180(3):1080-94.
    • (2012) Am J Pathol. , vol.180 , Issue.3 , pp. 1080-1094
    • Greenblatt, M.B.1    Sargent, J.L.2    Farina, G.3
  • 26
    • 0033571072 scopus 로고    scopus 로고
    • Anti-TGF-b treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: A model for human scleroderma
    • McCormick LL, Zhang Y, Tootell E, Gilliam AC. Anti-TGF-b treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol. 1999;163:5693-9.
    • (1999) J Immunol. , vol.163 , pp. 5693-5699
    • McCormick, L.L.1    Zhang, Y.2    Tootell, E.3    Gilliam, A.C.4
  • 27
    • 78649448568 scopus 로고    scopus 로고
    • Gastroesophageal reflux incites interstitial lung disease in systemic sclerosis: Clinical, radiologic, histopathologic, and treatment evidence
    • ChristmannRB,WellsAU,CapelozziVL, SilverRM.Gastroesophageal reflux incites interstitial lung disease in systemic sclerosis: clinical, radiologic, histopathologic, and treatment evidence. Semin Arthritis Rheum. 2010;40(3):241-9.
    • (2010) Semin Arthritis Rheum. , vol.40 , Issue.3 , pp. 241-249
    • Christmann, R.B.1    Wells, A.U.2    Capelozzi, V.L.3    Silver, R.M.4
  • 28
    • 67650480995 scopus 로고    scopus 로고
    • Transforming growth factor beta as a therapeutic target in systemic sclerosis
    • Varga J, Pasche B. Transforming growth factor beta as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol. 2009;5 (4):200-6.
    • (2009) Nat Rev Rheumatol. , vol.5 , Issue.4 , pp. 200-206
    • Varga, J.1    Pasche, B.2
  • 29
    • 65849445411 scopus 로고    scopus 로고
    • Connective tissue growth factor: Growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?
    • v8-9
    • Abraham D. Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc? Rheumatology (Oxford). 2008;47 Suppl 5:v8-9.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.SUPPL. , pp. 5
    • Abraham, D.1
  • 30
    • 69949153909 scopus 로고    scopus 로고
    • Role of PDGF in fibrotic diseases and systemic sclerosis
    • v2-4
    • Trojanowska M. Role of PDGF in fibrotic diseases and systemic sclerosis. Rheumatology (Oxford). 2008;47 Suppl 5:v2-4.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.SUPPL. , pp. 5
    • Trojanowska, M.1
  • 31
    • 65849500132 scopus 로고    scopus 로고
    • Endothelin and scleroderma lung disease
    • v25-6
    • Silver RM. Endothelin and scleroderma lung disease. Rheumatology (Oxford). 2008;47 Suppl 5:v25-6.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.SUPPL. , pp. 5
    • Silver, R.M.1
  • 34
    • 0037323940 scopus 로고    scopus 로고
    • Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6
    • DOI 10.1046/j.1365-2567.2003.01576.x
    • Bellinghausen I, Brand P, Bottcher I, et al. Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6. Immunology. 2003;108(2):167-76. (Pubitemid 36232866)
    • (2003) Immunology , vol.108 , Issue.2 , pp. 167-176
    • Bellinghausen, I.1    Brand, P.2    Bottcher, I.3    Klostermann, B.4    Knop, J.5    Saloga, J.6
  • 36
    • 80055068380 scopus 로고    scopus 로고
    • Nuocytes: Expanding the innate cell repertoire in type-2 immunity
    • Barlow JL, McKenzie AN. Nuocytes: expanding the innate cell repertoire in type-2 immunity. J Leukoc Biol. 2011;90(5):867-74.
    • (2011) J Leukoc Biol. , vol.90 , Issue.5 , pp. 867-874
    • Barlow, J.L.1    McKenzie, A.N.2
  • 37
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill DR, Wong SH, Bellosi A, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464(7293):1367- 70.
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1367-1370
    • Neill, D.R.1    Wong, S.H.2    Bellosi, A.3
  • 38
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • Moro K, Yamada T, Tanabe M, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature. 2010;463(7280):540-4.
    • (2010) Nature , vol.463 , Issue.7280 , pp. 540-544
    • Moro, K.1    Yamada, T.2    Tanabe, M.3
  • 39
    • 77954926597 scopus 로고    scopus 로고
    • Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    • Price AE, Liang HE, Sullivan BM, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci USA. 2010;107(25):11489-94.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.25 , pp. 11489-11494
    • Price, A.E.1    Liang, H.E.2    Sullivan, B.M.3
  • 41
    • 0038517976 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13 signaling connections maps
    • DOI 10.1126/science.1085458
    • Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD. Interleukin-4 and interleukin-13 signaling connections maps. Science. 2003;300(5625):1527-8. (Pubitemid 36686713)
    • (2003) Science , vol.300 , Issue.5625 , pp. 1527-1528
    • Kelly-Welch, A.E.1    Hanson, E.M.2    Boothby, M.R.3    Keegan, A.D.4
  • 42
    • 34548514010 scopus 로고    scopus 로고
    • IL-13 receptor isoforms: Breaking through the complexity
    • DOI 10.1007/s11882-007-0051-x
    • Tabata Y, Khurana Hershey GK. IL-13 receptor isoforms: breaking through the complexity. Curr Allergy Asthma Rep. 2007;7(5):338-45. (Pubitemid 47377322)
    • (2007) Current Allergy and Asthma Reports , vol.7 , Issue.5 , pp. 338-345
    • Tabata, Y.1    Hershey, G.K.K.2
  • 44
    • 0031903791 scopus 로고    scopus 로고
    • Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway
    • DOI 10.1093/intimm/10.8.1103
    • Murata T, Husain SR, Mohri H, Puri RK. Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway. Int Immunol. 1998;10(8):1103-10. (Pubitemid 28362684)
    • (1998) International Immunology , vol.10 , Issue.8 , pp. 1103-1110
    • Murata, T.1    Husain, S.R.2    Mohri, H.3    Puri, R.K.4
  • 49
    • 57249094020 scopus 로고    scopus 로고
    • IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis
    • 2013 e2001-2007
    • Fichtner-Feigl S, Young CA, Kitani A et al.: IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 2008, 135(6):2003-2013, 2013 e2001-2007.
    • (2008) Gastroenterology , vol.135 , Issue.6 , pp. 2003-2013
    • Fichtner-Feigl, S.1    Young, C.A.2    Kitani, A.3
  • 50
    • 30044449492 scopus 로고    scopus 로고
    • 1 production and fibrosis
    • DOI 10.1038/nm1332
    • Fichtner-Feigl S, Strober W, Kawakami K, et al. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGFbeta1 production and fibrosis. Nat Med. 2006;12(1):99-106. (Pubitemid 43050083)
    • (2006) Nature Medicine , vol.12 , Issue.1 , pp. 99-106
    • Fichtner-Feigl, S.1    Strober, W.2    Kawakami, K.3    Puri, R.K.4    Kitani, A.5
  • 51
    • 0031056613 scopus 로고    scopus 로고
    • Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis
    • Hasegawa M, Fujimoto M, Kikuchi K, Takehara K. Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. J Rheumatol. 1997;24(2):328-32. (Pubitemid 27104098)
    • (1997) Journal of Rheumatology , vol.24 , Issue.2 , pp. 328-332
    • Hasegawa, M.1    Fujimoto, M.2    Kikuchi, K.3    Takehara, K.4
  • 52
    • 65249173941 scopus 로고    scopus 로고
    • Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis
    • Fuschiotti P, Medsger Jr TA, Morel PA. Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis. Arthritis Rheum. 2009;60(4):1119-28.
    • (2009) Arthritis Rheum. , vol.60 , Issue.4 , pp. 1119-1128
    • Fuschiotti, P.1    Medsger Jr., T.A.2    Morel, P.A.3
  • 53
    • 80051816813 scopus 로고    scopus 로고
    • GATA-3 upregulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production
    • Medsger Jr TA, Ivanco DE, Kardava L, et al. GATA-3 upregulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production. Arthritis Rheum. 2011;63(6):1738-47.
    • (2011) Arthritis Rheum. , vol.63 , Issue.6 , pp. 1738-1747
    • Medsger Jr., T.A.1    Ivanco, D.E.2    Kardava, L.3
  • 54
    • 77249095292 scopus 로고    scopus 로고
    • Diagnosis and management of pulmonary hypertension in systemic sclerosis
    • Sweiss NJ, Hushaw L, Thenappan T, et al. Diagnosis and management of pulmonary hypertension in systemic sclerosis. Curr Rheumatol Rep. 2010;12(1):8-18.
    • (2010) Curr Rheumatol Rep. , vol.12 , Issue.1 , pp. 8-18
    • Sweiss, N.J.1    Hushaw, L.2    Thenappan, T.3
  • 55
    • 79958031292 scopus 로고    scopus 로고
    • Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension
    • Christmann RB, Hayes E, Pendergrass S, et al. Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum. 2011;63(6):1718-28.
    • (2011) Arthritis Rheum. , vol.63 , Issue.6 , pp. 1718-1728
    • Christmann, R.B.1    Hayes, E.2    Pendergrass, S.3
  • 57
    • 77957551169 scopus 로고    scopus 로고
    • Assessing microvascular changes in systemic sclerosis diagnosis and management
    • Cutolo M, Sulli A, Smith V. Assessing microvascular changes in systemic sclerosis diagnosis and management. Nat Rev Rheumatol. 2010;6(10):578-87.
    • (2010) Nat Rev Rheumatol. , vol.6 , Issue.10 , pp. 578-587
    • Cutolo, M.1    Sulli, A.2    Smith, V.3
  • 60
    • 84855382124 scopus 로고    scopus 로고
    • Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression
    • Broen JC, Dieude P, Vonk MC, et al. Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression. J Rheumatol. 2012;39(1):112-8.
    • (2012) J Rheumatol. , vol.39 , Issue.1 , pp. 112-118
    • Broen, J.C.1    Dieude, P.2    Vonk, M.C.3
  • 61
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999;103(6):779-88. (Pubitemid 29152623)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.6 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6    Zhang, Y.7    Elias, J.A.8
  • 62
    • 59949089656 scopus 로고    scopus 로고
    • Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling
    • Zheng T, Oh MH, Oh SY, et al. Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling. J Invest Dermatol. 2009;129(3):742-51.
    • (2009) J Invest Dermatol. , vol.129 , Issue.3 , pp. 742-751
    • Zheng, T.1    Oh, M.H.2    Oh, S.Y.3
  • 63
    • 11444270348 scopus 로고    scopus 로고
    • Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma
    • DOI 10.1159/000082331
    • Matsushita M, Yamamoto T, Nishioka K. Upregulation of interleukin-13 and its receptor in a murine model of bleomycininduced scleroderma. Int Arch Allergy Immunol. 2004;135 (4):348-56. (Pubitemid 40082202)
    • (2004) International Archives of Allergy and Immunology , vol.135 , Issue.4 , pp. 348-356
    • Matsushita, M.1    Yamamoto, T.2    Nishioka, K.3
  • 65
    • 0036787916 scopus 로고    scopus 로고
    • Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis
    • Belperio JA, Dy M, Burdick MD, et al. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2002;27(4):419-27.
    • (2002) Am J Respir Cell Mol Biol. , vol.27 , Issue.4 , pp. 419-427
    • Belperio, J.A.1    Dy, M.2    Burdick, M.D.3
  • 66
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: An immunologic functional perspective
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol. 2009;27:451-83.
    • (2009) Annu Rev Immunol. , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 68
    • 0037087365 scopus 로고    scopus 로고
    • IL-13-induced chemokine responses in the lung: Role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling
    • Zhu Z, Ma B, Zheng T, et al. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2002;168(6):2953-62. (Pubitemid 34211676)
    • (2002) Journal of Immunology , vol.168 , Issue.6 , pp. 2953-2962
    • Zhu, Z.1    Ma, B.2    Zheng, T.3    Homer, R.J.4    Lee, C.G.5    Charo, I.F.6    Noble, P.7    Elias, J.A.8
  • 69
    • 79958086613 scopus 로고    scopus 로고
    • Interleukin-33 biology with potential insights into human diseases
    • Palmer G, Gabay C. Interleukin-33 biology with potential insights into human diseases. Nat Rev Rheumatol. 2011;7(6):321-9.
    • (2011) Nat Rev Rheumatol. , vol.7 , Issue.6 , pp. 321-329
    • Palmer, G.1    Gabay, C.2
  • 71
    • 34848899012 scopus 로고    scopus 로고
    • IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex
    • Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007;179(4):2551-5.
    • (2007) J Immunol. , vol.179 , Issue.4 , pp. 2551-2555
    • Chackerian, A.A.1    Oldham, E.R.2    Murphy, E.E.3
  • 72
    • 67049158193 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    • Cayrol C, Girard JP. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA. 2009;106 (22):9021-6.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.22 , pp. 9021-9026
    • Cayrol, C.1    Girard, J.P.2
  • 73
    • 84857134135 scopus 로고    scopus 로고
    • IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
    • Lefrancais E, Roga S, Gautier V, et al. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci USA. 2012;109(5):1673-8.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.5 , pp. 1673-1678
    • Lefrancais, E.1    Roga, S.2    Gautier, V.3
  • 74
    • 84859378165 scopus 로고    scopus 로고
    • Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: In situ analysis using a novel Il-33- LacZ gene trap reporter strain
    • Pichery M, Mirey E, Mercier P, et al. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33- LacZ gene trap reporter strain. J Immunol. 2012;188(7):3488-95.
    • (2012) J Immunol. , vol.188 , Issue.7 , pp. 3488-3495
    • Pichery, M.1    Mirey, E.2    Mercier, P.3
  • 75
    • 78650226947 scopus 로고    scopus 로고
    • Interleukin-33: A novel mediator with a role in distinct disease pathologies
    • Kurowska-Stolarska M, Hueber A, Stolarski B, McInnes IB. Interleukin-33: a novel mediator with a role in distinct disease pathologies. J Intern Med. 2010;269(1):29-35.
    • (2010) J Intern Med. , vol.269 , Issue.1 , pp. 29-35
    • Kurowska-Stolarska, M.1    Hueber, A.2    Stolarski, B.3    McInnes, I.B.4
  • 76
    • 77949480323 scopus 로고    scopus 로고
    • The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis
    • Manetti M, Ibba-Manneschi L, Liakouli V, et al. The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis. Ann Rheum Dis. 2010;69(3):598-605.
    • (2010) Ann Rheum Dis. , vol.69 , Issue.3 , pp. 598-605
    • Manetti, M.1    Ibba-Manneschi, L.2    Liakouli, V.3
  • 77
    • 79959580694 scopus 로고    scopus 로고
    • Serum IL-33 levels are raised in patients with systemic sclerosis: Association with extent of skin sclerosis and severity of pulmonary fibrosis
    • Yanaba K, Yoshizaki A, Asano Y, et al. Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. Clin Rheumatol. 2011;30(6):825-30.
    • (2011) Clin Rheumatol. , vol.30 , Issue.6 , pp. 825-830
    • Yanaba, K.1    Yoshizaki, A.2    Asano, Y.3
  • 78
    • 80052510979 scopus 로고    scopus 로고
    • Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement
    • Manetti M, Guiducci S, Ceccarelli C, et al. Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement. Ann Rheum Dis. 2011;70(10):1876-8.
    • (2011) Ann Rheum Dis. , vol.70 , Issue.10 , pp. 1876-1878
    • Manetti, M.1    Guiducci, S.2    Ceccarelli, C.3
  • 79
    • 80052026760 scopus 로고    scopus 로고
    • Role of IL-33 in inflammation and disease
    • Miller AM. Role of IL-33 in inflammation and disease. J Inflamm (Lond). 2011;8(1):22.
    • (2011) J Inflamm (Lond) , vol.8 , Issue.1 , pp. 22
    • Miller, A.M.1
  • 81
    • 48449089903 scopus 로고    scopus 로고
    • IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells
    • Smithgall MD, Comeau MR, Yoon BR, et al. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. Int Immunol. 2008;20(8):1019-30.
    • (2008) Int Immunol. , vol.20 , Issue.8 , pp. 1019-1030
    • Smithgall, M.D.1    Comeau, M.R.2    Yoon, B.R.3
  • 82
    • 77949311799 scopus 로고    scopus 로고
    • IL-33 induces IL-13- dependent cutaneous fibrosis
    • Rankin AL, Mumm JB, Murphy E, et al. IL-33 induces IL-13- dependent cutaneous fibrosis. J Immunol. 2009;184(3):1526-35.
    • (2009) J Immunol. , vol.184 , Issue.3 , pp. 1526-1535
    • Rankin, A.L.1    Mumm, J.B.2    Murphy, E.3
  • 83
    • 31344473454 scopus 로고    scopus 로고
    • The bleomycin-induced scleroderma model: What have we learned for scleroderma pathogenesis?
    • DOI 10.1007/s00403-005-0635-z
    • Yamamoto T. The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis? Arch Dermatol Res. 2006;297(8):333-44. (Pubitemid 43144264)
    • (2006) Archives of Dermatological Research , vol.297 , Issue.8 , pp. 333-344
    • Yamamoto, T.1
  • 84
    • 33745625865 scopus 로고    scopus 로고
    • Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients
    • DOI 10.1093/rheumatology/kei244
    • Tan FK, Zhou X, Mayes MD, et al. Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients. Rheumatology (Oxford). 2006;45(6):694-702. (Pubitemid 43985337)
    • (2006) Rheumatology , vol.45 , Issue.6 , pp. 694-702
    • Tan, F.K.1    Zhou, X.2    Mayes, M.D.3    Gourh, P.4    Guo, X.5    Marcum, C.6    Jin, L.7    Arnett Jr., F.C.8
  • 85
    • 33947154329 scopus 로고    scopus 로고
    • A macrophage marker, siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists
    • DOI 10.1002/art.22382
    • York MR, Nagai T, Mangini AJ, et al. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum. 2007;56(3):1010-20. (Pubitemid 46399451)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.3 , pp. 1010-1020
    • York, M.R.1    Nagai, T.2    Mangini, A.J.3    Lemaire, R.4    Van Seventer, J.M.5    Lafyatis, R.6
  • 86
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    • DOI 10.1038/35099560
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732-8. (Pubitemid 33009951)
    • (2001) Nature , vol.413 , Issue.6857 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 87
    • 77957940944 scopus 로고    scopus 로고
    • Poly(I:C) drives type i IFN- and TGFbeta-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis
    • Farina GA, York MR, Di Marzio M, et al. Poly(I:C) drives type I IFN- and TGFbeta-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010;130(11):2583-93.
    • (2010) J Invest Dermatol. , vol.130 , Issue.11 , pp. 2583-2593
    • Farina, G.A.1    York, M.R.2    Di Marzio, M.3
  • 88
    • 79951512704 scopus 로고    scopus 로고
    • DsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts
    • Farina G, York M, Collins C, Lafyatis R. dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts. Ann Rheum Dis. 2011;70(3):544-50.
    • (2011) Ann Rheum Dis. , vol.70 , Issue.3 , pp. 544-550
    • Farina, G.1    York, M.2    Collins, C.3    Lafyatis, R.4
  • 89
    • 58149149839 scopus 로고    scopus 로고
    • TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
    • Cavassani KA, Ishii M, Wen H, et al. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med. 2008;205(11):2609-21.
    • (2008) J Exp Med. , vol.205 , Issue.11 , pp. 2609-2621
    • Cavassani, K.A.1    Ishii, M.2    Wen, H.3
  • 90
    • 0029963412 scopus 로고    scopus 로고
    • Immunopathogenesis of systemic sclerosis
    • White B. Immunopathogenesis of systemic sclerosis. Rheum Dis Clin North Am. 1996;22(4):695-708. (Pubitemid 26396046)
    • (1996) Rheumatic Disease Clinics of North America , vol.22 , Issue.4 , pp. 695-708
    • White, B.1
  • 91
    • 0021154318 scopus 로고
    • Lymphocytes in the skin of patients with progressive systemic sclerosis: Quantification, subtyping, and clinical correlations
    • Roumm AD, Whiteside TL, Medsger Jr TA, Rodnan GP. Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations. Arthritis Rheum. 1984;27(6):645-53. (Pubitemid 14089474)
    • (1984) Arthritis and Rheumatism , vol.27 , Issue.6 , pp. 645-653
    • Roumm, A.D.1    Whiteside, T.L.2    Medsger Jr., T.A.3    Rodnan, G.P.4


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