Evaluation of the immunosuppressive activity of artesunate in vitro and in vivo

International Immunopharmacology

Volumn 16, Issue 2, 2013, Pages 306-312

  Li, Tan ^a   Chen, Hong ^a   Yang, Zhen ^a   Liu, Xiao Guang ^a   Zhang, Li Ming ^a   Wang, Huo ^a  

^a MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Artesunate; Immunosuppression; TGF ; Tregs Foxp3

Indexed keywords

ALLOANTIGEN; ARTESUNATE; MITOGENIC AGENT; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DELAYED HYPERSENSITIVITY; DRUG SAFETY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ANIMALS; ARTEMISININS; CELL PROLIFERATION; CELL SURVIVAL; DINITROFLUOROBENZENE; EAR; FORKHEAD TRANSCRIPTION FACTORS; HYPERSENSITIVITY, DELAYED; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SMAD2 PROTEIN; SMAD3 PROTEIN; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA;

EID: 84878304956     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.03.011     Document Type: Article

References (45)

1. A. Johnston, and D.W. Holt Immunosuppressant drugs - the role of therapeutic drug monitoring Br J Clin Pharmacol 52 2001 61 73
2. Y. Yin, Y. Sun, L. Gu, W. Zheng, F. Gong, and X. Wu Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells Eur J Pharmacol 651 1-3 2011 205 211
3. G.A. Balint Artemisinin and its derivatives, an important new class of antimalarial agents Pharmacol Ther 90 2001 261 265 (Pubitemid 32913479)
4. T. Efferth Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells Curr Drug Targets 7 2006 407 421 (Pubitemid 43744832)
5. M. Adjuik, A. Babiker, P. Garner, P. Olliaro, W. Taylor, and N. White Artesunate combinations for treatment of malaria: meta-analysis Lancet 363 2004 9 17 (Pubitemid 38076919)
6. H. Xu, Y. He, X. Yang, L. Liang, Z. Zhan, and Y. Ye Anti-malarial agent artesunate inhibits TNF-{alpha}-induced production of proinflammatory cytokines via inhibition of NF-{kappa}B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes Rheumatology 46 2007 920 926 (Pubitemid 47062496)
7. H. Chen, and H.I. Maibach Topical application of artesunate on guinea pig allergic contact dermatitis Contact Dermatitis 30 1994 280 282 (Pubitemid 24156850)
8. J. Zhang, J. Zhong, Z. Shi, and X. Dai Effects of lingdan and artesunate on T cell populations in human SLE Zhongguo Zhong Xi Yi Jie He Za Zhi 7 2002 489 491
9. S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono Regulatory T cells and immune tolerance Cell 133 2008 775 787 (Pubitemid 351707693)
10. E.M. Shevach Biological functions of regulatory T cells Adv Immunol 112 2011 137 176
11. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63 (Pubitemid 14203433)
12. T. Li, V.K. Wong, X.Q. Yi, Y.F. Wong, H. Zhou, and L. Liu Pseudolaric acid B suppresses T lymphocyte activation through inhibition of NF-kB signaling pathway and p38 phosphorylation J Cell Biochem 108 2009 87 95
13. T. Tsukatani, H. Suenaga, T. Higuchi, T. Akao, M. Ishiyama, and K. Ezoe Colorimetric cell proliferation assay for microorganisms in microtiter plate using water-soluble tetrazolium salts J Microbiol Methods 75 2008 109 116
14. R. Zhou, F. Zhang, P.L. He, W.L. Zhou, Q.L. Wu, and J.Y. Xu (5R)-5-Hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo Int Immunopharmacol 5 2005 1895 1903 (Pubitemid 41586228)
15. S. Motegi, H. Okazawa, Y. Murata, Y. Kanazawa, Y. Saito, and H. Kobayashi Essential roles of SHPS-1 in induction of contact hypersensitivity of skin Immunol Lett 121 2008 52 60
16. H. Niwa, T. Satoh, Y. Matsushima, K. Hosoya, K. Saeki, and T. Niki Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1-and/or Th17-mediated skin inflammation Clin Immunol 132 2009 184 194
17. J.X. Wang, W. Tang, L.P. Shi, J. Wan, R. Zhou, and J. Ni Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation Br J Pharmacol 150 2007 652 661 (Pubitemid 46355561)
18. T. Li, H. Chen, N. Wei, X. Mei, S. Zhang, and D.L. Liu Anti-inflammatory and immune-regulatory mechanisms of artemisinin on contact hypersensitivity in vivo Int Immunopharmacol 12 2012 144 150
19. J. Golenser, J.H. Waknine, M. Krugliak, N.H. Hunt, and G.E. Grau Current perspectives on the mechanism of action of artemisinins Int J Parasitol 36 2006 427 441
20. Z.S. Yang, J.X. Wang, Y. Zhou, J.P. Zuo, and Y. Li Synthesis and immunosuppressive activity of new artemisinin derivatives. Part 2: 2-[12(beta or alpha)-dihydroartemisinoxymethyl(or 1′-ethyl)]phenoxyl propionic acids and esters Bioorg Med Chem 14 2006 8043 8049 (Pubitemid 44739994)
21. S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057
22. L. Lu, J. Ma, X. Wang, J. Wang, F. Zhang, and J. Yu Synergistic effect of TGF-beta superfamily members on the induction of Foxp3 + Treg Eur J Immunol 40 2010 142 152
23. S. Jun, J. Ochoa-Repáraz, D. Zlotkowska, T. Hoyt, and D.W. Pascual Bystander-mediated stimulation of proteolipid protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-β J Neuroimmunol 245 2012 39 47
24. T. Takimoto, Y. Wakabayashi, T. Sekiya, N. Inoue, R. Morita, and K. Ichiyama Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development J Immunol 185 2010 842 855
25. A. Barbarulo, P. Grazioli, A.F. Campese, D. Bellavia, G. Di Mario, and M. Pelullo Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription J Immunol 186 2011 6199 6206
26. T. Vial, and J. Descotes Immunosuppressive drugs and cancer Toxicology 185 2003 229 240 (Pubitemid 36173740)
27. S.J. Kaptein, T. Efferth, M. Leis, S. Rechter, S. Auerochs, and M. Kalmer The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo Antivir Res 69 2006 60 69 (Pubitemid 43152041)
28. B. Li, R. Zhang, J. Li, L. Zhang, G. Ding, and P. Luo Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-kappa B activation Int Immunopharmacol 8 3 2008 379 389
29. S.M. Steward-Tharp, Y.J. Song, R.M. Siegel, and J.J. O'Shea New insights into T cells biology and T cells-directed therapy for autoimmunity, inflammation, and immunosuppression Ann N Y Acad Sci 1183 2010 123 148
30. M. Rasool, and P. Varalakshmi Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: an in vivo and in vitro study Vascul Pharmacol 44 2006 406 410 (Pubitemid 43766670)
31. M. Rasool, and E.P. Sabina Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study J Nat Med 63 2009 169 175
32. K. Kobayashi, K. Kaneda, and T. Kasama Immunopathogenesis of delayed-type hypersensitivity Microsc Res Tech 53 2001 241 245 (Pubitemid 32467161)
33. L.B. Barradell, and Fitton A. Artesunate A review of its pharmacology and therapeutic efficacy in the treatment of malaria Drugs 50 1995 714 741
34. Y.Y. Wan, and R.A. Flavell Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression Nature 445 2007 766 770 (Pubitemid 46279706)
35. D.A. Horwitz, S.G. Zheng, and J.D. Gray Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other Trends Immunol 29 2008 429 435
36. M.O. Li, and R.A. Flavell TGF-beta master of all T cell trades Cell 134 2008 392 404
37. + regulatory T cells Nat Immunol 9 2008 632 640 (Pubitemid 351712634)
38. D.Q. Tran TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells J Mol Cell Biol 4 2012 29 37
39. R. Derynck, Y. Zhang, and X.H. Feng Smads: transcriptional activators of TGF-beta responses Cell 95 1998 737 740 (Pubitemid 29014453)
40. Y. Tone, K. Furuuchi, Y. Kojima, M.L. Tykocinski, M.I. Greene, and M. Tone Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer Nat Immunol 9 2008 194 202
41. S. Jana, P. Jailwala, D. Haribhai, J. Waukau, S. Glisic, and W. Grossman The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression Eur J Immunol 39 2009 2571 2583
42. L. Lu, J. Wang, F. Zhang, Y. Chai, D. Brand, and X. Wang Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells J Immunol 184 2010 4295 4306
43. S. Ring, A.H. Enk, and K. Mahnke ATP activates regulatory T cells in vivo during contact hypersensitivity reactions J Immunol 184 2010 3408 3416
44. K. Miyazono, S. Maeda, and T. Imamura Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins Oncogene 23 2004 4232 4237 (Pubitemid 38758589)
45. Q. Ruan, and Y.H. Chen Nuclear Factor-κB in immunity and inflammation: the Treg and Th17 connection Adv Exp Med Biol 946 2012 207 221