ATP activates regulatory T cells in vivo during contact hypersensitivity reactions

Journal of Immunology

Volumn 184, Issue 7, 2010, Pages 3408-3416

  Ring, Sabine ^a   Enk, Alexander H ^a   Mahnke, Karsten ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; 5' NUCLEOTIDASE; APYRASE; CD39 ANTIGEN; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTACT ALLERGY; CONTACT SENSITIZATION; CONTROLLED STUDY; IMMUNOPHENOTYPING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; BAGG ALBINO MOUSE; CONTACT DERMATITIS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

5'-NUCLEOTIDASE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, CD; APYRASE; DERMATITIS, CONTACT; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 77951636315     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901751     Document Type: Article

References (43)

1. Vignali, D. A., L. W. Collison, and C. J. Workman. 2008. How regulatory T cells work. Nat. Rev. Immunol. 8: 523-532.
2. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192: 1213-1222.
3. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
4. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
5. + regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
6. Collison, L. W., C. J. Workman, T. T. Kuo, K. Boyd, Y. Wang, K. M. Vignali, R. Cross, D. Sehy, R. S. Blumberg, and D. A. Vignali. 2007. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450: 566-569.
7. + regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue. Eur. J. Immunol. 36: 2981-2992.
8. + regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism. J. Allergy Clin. Immunol. 123: 1287-1296.
9. + Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232.
10. Deaglio, S., K. M. Dwyer, W. Gao, D. Friedman, A. Usheva, A. Erat, J. F. Chen, K. Enjyoji, J. Linden, M. Oukka, et al. 2007. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204: 1257-1265.
11. la Sala, A., D. Ferrari, S. Corinti, A. Cavani, F. Di Virgilio, and G. Girolomoni. 2001. Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses. J. Immunol. 166: 1611-1617.
12. Di Virgilio, F. 2007. Purinergic signalling in the immune system: a brief update. Purinergic Signal. 3: 1-3.
13. Willart, M. A., and B. N. Lambrecht. 2009. The danger within: endogenous danger signals, atopy and asthma. Clin. Exp. Allergy 39: 12-19.
14. Szymczak-Workman, A. L., C. J. Workman, and D. A. Vignali. 2009. Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress. J. Immunol. 182: 5188-5192.
15. Burnstock, G. 2006. Purinergic signalling - an overview. Novartis Found. Symp. 276: 26-48, discussion 48-57, 275-281.
16. Schenk, U., A. M. Westendorf, E. Radaelli, A. Casati, M. Ferro, M. Fumagalli, C. Verderio, J. Buer, E. Scanziani, and F. Grassi. 2008. Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels. Sci. Signal. 1: ra6.
17. Yip, L., T. Woehrle, R. Corriden, M. Hirsh, Y. Chen, Y. Inoue, V. Ferrari, P. A. Insel, and W. G. Junger. 2009. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J. 23: 1685-1693.
18. + regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int. Immunol. 19: 785-799.
19. + regulatory T cells. J. Immunol. 177: 6598-6602.
20. 7 and the inflammasome. Trends Pharmacol. Sci. 28: 465-472.
21. Idzko, M., H. Hammad, M. van Nimwegen, M. Kool, M. A. Willart, F. Muskens, H. C. Hoogsteden, W. Luttmann, D. Ferrari, F. Di Virgilio, et al. 2007. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat. Med. 13: 913-919.
22. Wilkin, F., X. Duhant, C. Bruyns, N. Suarez-Huerta, J. M. Boeynaems, and B. Robaye. 2001. The P2Y11 receptor mediates the ATP-induced maturation of human monocyte-derived dendritic cells. J. Immunol. 166: 7172-7177. (Pubitemid 32525589)
23. Bles, N., M. Horckmans, A. Lefort, F. Libert, P. Macours, H. El Housni, F. Marteau, J. M. Boeynaems, and D. Communi. 2007. Gene expression profiling defines ATP as a key regulator of human dendritic cell functions. J. Immunol. 179: 3550-3558.
24. + T lymphocytes. Retrovirology 5: 30.
25. Schnurr, M., F. Then, P. Galambos, C. Scholz, B. Siegmund, S. Endres, and A. Eigler. 2000. Extracellular ATP and TNF-α synergize in the activation and maturation of human dendritic cells. J. Immunol. 165: 4704-4709.
26. Piccini, A., S. Carta, S. Tassi, D. Lasiglié, G. Fossati, and A. Rubartelli. 2008. ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way. Proc. Natl. Acad. Sci. USA 105: 8067-8072.
27. 7 receptors. J. Biol. Chem. 276: 125-132.
28. Atarashi, K., J. Nishimura, T. Shima, Y. Umesaki, M. Yamamoto, M. Onoue, H. Yagita, N. Ishii, R. Evans, K. Honda, and K. Takeda. 2008. ATP drives lamina propria T(H)17 cell differentiation. Nature 455: 808-812.
29. + regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors. J. Immunol. 175: 3075-3083.
30. Gu, B., L. J. Bendall, and J. S. Wiley. 1998. Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases. Blood 92: 946-951. (Pubitemid 28355478)
31. Aswad, F., and G. Dennert. 2006. P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes. Cell. Immunol. 243: 58-65.
32. 7 receptor: death or life? Purinergic Signal. 1: 219-227.
33. Idehara, K., G. Yamagishi, K. Yamashita, and M. Ito. 2008. Characterization and evaluation of a modified local lymph node assay using ATP content as a non-radio isotopic endpoint. J. Pharmacol. Toxicol. Methods 58: 1-10.
34. Mizumoto, N., M. E. Mummert, D. Shalhevet, and A. Takashima. 2003. Keratinocyte ATP release assay for testing skin-irritating potentials of structurally diverse chemicals. J. Invest. Dermatol. 121: 1066-1072.
35. Inoue, K., J. Hosoi, and M. Denda. 2007. Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes. J. Invest. Dermatol. 127: 362-371.
36. Dixon, C. J., W. B. Bowler, A. Littlewood-Evans, J. P. Dillon, G. Bilbe, G. R. Sharpe, and J. A. Gallagher. 1999. Regulation of epidermal homeostasis through P2Y2 receptors. Br. J. Pharmacol. 127: 1680-1686.
37. Seiffert, K., W. Ding, J. A. Wagner, and R. D. Granstein. 2006. ATPγS enhances the production of inflammatory mediators by a human dermal endothelial cell line via purinergic receptor signaling. J. Invest. Dermatol. 126: 1017-1027.
38. Wang, X., G. Arcuino, T. Takano, J. Lin, W. G. Peng, P. Wan, P. Li, Q. Xu, Q. S. Liu, S. A. Goldman, and M. Nedergaard. 2004. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat. Med. 10: 821-827.
39. Myrtek, D., and M. Idzko. 2007. Chemotactic activity of extracellular nucleotideson human immune cells. Purinergic Signal. 3: 5-11.
40. Wilkin, F., P. Stordeur, M. Goldman, J. M. Boeynaems, and B. Robaye. 2002. Extracellular adenine nucleotides modulate cytokine production by human monocyte-derived dendritic cells: dual effect on IL-12 and stimulation of IL-10. Eur. J. Immunol. 32: 2409-2417.
41. Kolosova, I. A., T. Mirzapoiazova, L. Moreno-Vinasco, S. Sammani, J. G. Garcia, and A. D. Verin. 2008. Protective effect of purinergic agonist ATPγS against acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L319-L324.
42. + T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses. J. Immunol. 181: 3861-3869.
43. Sitkovsky, M. V., and A. Ohta. 2005. The "danger" sensors that STOP the immune response: the A2 adenosine receptors? Trends Immunol. 26: 299-304.