Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins

Biochemistry

Volumn 48, Issue 47, 2009, Pages 11283-11295

  Sajid, Waseem ^a   Holst, Patricia A ^a   Kiselyov, Vladislav V ^a   Andersen, Asser S ^b   Conlon, J Michael ^c   Kristensen, Claus ^b   Kjeldsen, Thomas ^b   Whittaker, Jonathan ^d   Chan, Shu J ^e   De Meyts, Pierre ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; BINDING KINETICS; BIOLOGICAL ACTIVITIES; BIOLOGICAL POTENCY; BIOLOGICAL PROPERTIES; DATA SUPPORT; GLUTINOSA; INSULIN ANALOGUES; INSULIN GENE; MITOGENIC PROPERTIES; RECEPTOR BINDING; SINGLE MUTATION; STRUCTURAL BASIS; STRUCTURAL EXPLANATION;

AMINES; AMINO ACIDS; BINDING ENERGY; BIOACTIVITY; ORGANIC ACIDS; PLANTS (BOTANY);

INSULIN;

INSULIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; HAGFISH; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; INSULIN BINDING; LAMPREY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; HAGFISHES; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; KINETICS; LAMPREYS; MITOGENS; MODELS, MOLECULAR; MUTATION; PHYLOGENY; RECEPTOR, INSULIN;

CHORDATA; HAGFISH; LAMPETRA AYRESII; LAMPETRA FLUVIATILIS; MYXINE GLUTINOSA; PETROMYZONTIDAE;

EID: 72749113530     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901269j     Document Type: Article

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