Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Vinther, Tine N ^a,b   Norrman, Mathias ^a   Strauss, Holger M ^a   Huus, Kasper ^a   Schlein, Morten ^a   Pedersen, Thomas A ^a   Kjeldsen, Thomas ^a   Jensen, Knud J ^b   Hubálek, František ^a  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; DIMER; HUMAN INSULIN; INSULIN; INSULIN RECEPTOR; MONOMER;

ARTICLE; BINDING COMPETITION; BIOENGINEERING; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DISULFIDE BOND; HORMONE RECEPTOR INTERACTION; IN VITRO STUDY; INSULIN RESPONSE; MECHANICAL STRESS; MOLECULAR STABILITY; OLIGOMERIZATION; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; THERMOSTABILITY; ANIMAL; AREA UNDER THE CURVE; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SWINE; X RAY CRYSTALLOGRAPHY;

ANIMALS; AREA UNDER CURVE; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SUS SCROFA;

EID: 84857143448     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030882     Document Type: Article

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