Effects of AMPARs trafficking and glutamate-receptors binding probability on stochastic variability of EPSC

BioSystems

Volumn 112, Issue 3, 2013, Pages 298-304

  Ventriglia, Francesco ^a   Di Maio, Vito ^a  

^a CNR   (Italy)

Author keywords

AMPA receptor trafficking; Computer simulation; Glutamate synaptic response; Variable binding probability

Indexed keywords

AMPA RECEPTOR; CHLORPHENIRAMINE MALEATE PLUS PHENYLEPHRINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

AMINO ACID; COMPUTER SIMULATION; EXPERIMENTAL STUDY; NUMERICAL MODEL; PROBABILITY; STOCHASTICITY;

ACTION POTENTIAL; ARTICLE; COMPUTER SIMULATION; DIFFUSION; EXCITATORY POSTSYNAPTIC POTENTIAL; GEOMETRY; PROBABILITY; RECEPTOR BINDING; STOCHASTIC MODEL; SYNAPSE;

EID: 84878242959     PISSN: 03032647     EISSN: 18728324     Source Type: Journal    
DOI: 10.1016/j.biosystems.2013.01.010     Document Type: Article

References (38)

1. Agmon N., Edelstein A.L. Collective binding properties of receptor arrays. Biophys. J. 1997, 72:1582-1594.
2. 2+ interactions. Neuron 2007, 56:992-1003.
3. Armstrong N., Gouaux E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 2000, 28:165-181.
4. Auger C., Marty A. Quantal currents at single-site central synapses. J. Physiol. 2000, 526:3-11.
5. Clements J.D., Lester R.A., Tong J., Jahr C.E., Westbrook G.L. The time course of glutamate in the synaptic cleft. Science 1992, 258:11498-11501.
6. Forti L., Bossi M., Bergamaschi A., Villa A., Malgaroli A. Loose-patch recordings of single quanta at individual hippocampal synapses. Nature 1997, 388:874-878.
7. Gegelashvili G., Dehnes Y., Danbolt N.C., Schousboe A. The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms. Neurochem. Int. 2000, 37:163-170.
8. Gillespie D.T. The mathematics of Brownian motion and Johnson noise. Am. J. Phys. 1996, 64:225-240.
9. Hanse E., Gustafsson B. Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus. J. Physiol. 2001, 531:467-480.
10. Ichimura T., Hashimoto P.H. Structural components in the synaptic cleft captured by freeze-substitution and deep etching of directly frozen cerebellar cortex. J. Neurocytol. 1988, 17:3-12.
11. Jonas P., Major G., Sakmann B. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J. Physiol. 1993, 472 C:615-663.
12. Jonas P., Spruston N. Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Curr. Opin. Neurobiol. 1994, 4:366-372.
13. Kleppe I.C., Robinson H.P. Determining the activation time course of synaptic AMPA receptors from openings of colocalized NMDA receptors. Biophys. J. 1999, 77:1418-1427.
14. Liu G. Presynaptic control of quantal size: kinetic mechanisms and implications for synaptic transmission and plasticity. Curr. Opin. Neurobiol. 2003, 13:324-331.
15. Liu G., Choi S., Tsien R.W. Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptor at synapses in hippocampal cultures and slices. Neuron 1999, 22:395-409.
16. Longsworth L.G. Diffusion measurements at 25°C of aqueous solutions of amino acids, peptides and sugars. J. Am. Chem. Soc. 1953, 75:5705-5709.
17. Mainen Z.F., Malinow R., Svoboda K. Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature 1999, 399:151-155.
18. Malinow R., Malenka R.C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 2002, 25:103-126.
19. Mayer M.L. Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation. Curr. Opin. Neurobiol. 2011, 21:283-290.
20. McAllister A.K., Stevens C.F. Nonsaturation of AMPA and NMDA receptors at hippocampal synapses. Proc. Natl. Acad. Sci. USA 2000, 97:6173-6178.
21. Murphy T.H., Baraban J.M., Wier W.G. Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in postsynaptic output. Neuron 1995, 15:159-168.
22. Nakagawa T. The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors. Mol. Neurobiol. 2010, 42:161-184.
23. Rabie H.R., Rong J., Glavinović M.I. Monte Carlo simulation of release of vesicular content in neuroendocrine cells. Biol. Cybern. 2006, 94:483-499.
24. Santos S.D., Carvalho A.L., Caldeira M.V., Duarte C.B. Regulation of AMPA receptors and synaptic plasticity. Neuroscience 2009, 158:105-125.
25. Schikorski T., Stevens C.F. Quantitative ultrastructural analysis of hippocampus excitatory synapses. J. Neurosci. 1997, 17:5858-5867.
26. Schwenk J., Harmel N., Brechet A., Zolles G., Berkefeld H., Müller C.S., Bildl W., Baehrens D., Hüber B., Kulik A., Klöcker N., Schulte U., Fakler B. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron 2012, 74:621-633.
27. Sobolevsky A.I., Rosconi M.P., Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 2009, 462:745-756.
28. Takumi Y., Matsubara A., Rinvik E., Ottersen O.P. The arrangement of glutamate receptors in excitatory synapses. Ann. N. Y. Acad. Sci. 1999, 868:474-482.
29. Tichelaar W., Safferling M., Keinnen K., Stark H., Madden D.R. The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly. J. Mol. Biol. 2004, 344:435-442.
30. Trommershäuser J., Titz S., Keller B.U., Zippelius A. Variability of excitatory currents due to single-channel noise, receptor number and morphological heterogeneity. J. Theor. Biol. 2001, 208:329-343.
31. Umemiya M., Senda M., Murphy T.H. Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging. J. Physiol. (London) 1999, 521(Pt 1):113-122.
32. Uteshev V.V., Pennefather P.S. A mathematical description of miniature postsynaptic current generation at central nervous system synapses. Biophys. J. 1996, 71:1256-1266.
33. Ventriglia F., Di Maio V. A Brownian simulation model of glutamate synaptic diffusion in the femtosecond time scale. Biol. Cybern. 2000, 83:93-109.
34. Ventriglia F., Di Maio V. Stochastic fluctuations of the quantal EPSC amplitude in computer simulated excitatory synapses of hippocampus. Biosystems 2003, 71:195-204.
35. Ventriglia F. Saturation in excitatory synapses of hippocampus investigated by computer simulations. Biol. Cybern. 2004, 90:349-359.
36. Ventriglia F. Effect of filaments within the synaptic cleft on the response of excitatory synapses simulated by computer experiments. BioSystems 2011, 104:14-22.
37. Wahl L.M., Pouzat C., Stratford K.J. Monte Carlo simulation of fast excitatory synaptic transmission at a hippocampal synapse. J. Neurophysiol. 1996, 75:597-608.
38. Zuber B., Nikonenko I., Klauser P., Muller D., Dubochet J. The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:19192-19197.