Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging

Journal of Physiology

Volumn 521, Issue 1, 1999, Pages 113-122

  Umemiya, Masashi ^a   Senda, Mariko ^a   Murphy, Timothy H ^b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CALCIUM ION; GLUTAMATE RECEPTOR; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; RECEPTOR SUBTYPE; CALCIUM;

ANIMAL CELL; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; EXCITATORY POSTSYNAPTIC POTENTIAL; IMAGING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE; SYNAPSE VESICLE; ACTION POTENTIAL AMPLITUDE; ANIMAL EXPERIMENT; CONTROLLED STUDY; EVENT RELATED POTENTIAL; EXTRACELLULAR MATRIX; FUNCTIONAL NEUROIMAGING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SYNAPTIC TRANSMISSION;

EID: 0033571189     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.00113.x     Document Type: Article

References (48)

1. ASZTELY, F., ERDEMLI, G. & KULLMANN, D. M. (1997). Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake. Neuron 18, 281-293.
2. BEAR, M. F. & MALENKA, R. C. (1994). Hynaptic plasticity: LTP and LTD. Current Opinion in Neurobiology 4, 389-399.
3. BEKKERS, J. M., RICHERSON, G. B. & STEVENS, C. F. (1990). Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices. Proceedings of the National Academy of Sciences of the USA 87, 5359-5362.
4. BEKKERS, J. M. & STEVENS, C. F. (1989). NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus. Nature 341, 230-233.
5. BEKKERS, J. M. & STEVENS, C. F. (1996). Cable properties of cultured hippocampal neurons determined from sucrose-evoked miniature EPSCs. Journal of Neurophysiology 75, 1250-1255.
6. CLEMENTS, J. D. & WESTBROOK, G. L. (1991). Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor. Neuron 7, 605-613.
7. DONG, H., O'BRIEN, R. J., FUNG, E. T., LANAHAN, A. A., WORLEY, P. F. & HUGANIR, R. L. (1997). GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386, 279-284.
8. DURAND, G. M., KOVALCHUK, Y. & KONNERTH, A. (1996). Long-term potentiation and functional synapse induction in developing hippocampus. Nature 381, 71-75.
9. EHLERS, M. D., MAMMEN, A. L., LAU, L. F. & HUGANIR, R. L. (1996). Synaptic targeting of glutamate receptors. Current Opinion in Cell Biology 8, 484-489.
10. FABER, D. S., YOUNG, W. S., LEGENDRE, P. & KORN, H. (1992). Intrinsic quantal variability due to stochastic properties of receptor-transmitter interactions. Science 258, 1494-1498.
11. FORTI, L., BOSSI, M., BERGAMASCHI, A., VILLA, A. & MALGAROLI, A. (1997). Loose-patch recordings of single quanta at individual hippocampal synapses. Nature 388, 874-878.
12. FRERKING, M., BORGES, S. & WILSON, M. (1995). Variation in GABA mini amplitude is the consequence of variation in transmitter concentration. Neuron 15, 885-895.
13. GOMPERTS, S. N., RAO, A., CRAIG, A. M., MALENKA, R. C. & NICOLL, R. A. (1998). Postsynaptically silent synapses in single neuron cultures. Neuron 21, 1443-1451.
14. HESSLER, N. A., SHIRKE, A. M. & MALINOW, R. (1993). The probability of transmitter release at a mammalian central synapse. Nature 366, 569-572.
15. ISAAC, J. T., NICOLL, R. A. & MALENKA, R. C. (1995). Evidence for silent synapses: implications for the expression of LTP. Neuron 15, 427-434.
16. JONAS, P. & SAKMANN, B. (1992). Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices. Journal of Physiology 455, 143-171.
17. JONAS, P. & SPRUSTON, N. (1994). Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology 4, 366-372.
18. KAMBOJ, S. & HUGANIR, R. L. (1998). Receptor clustering - activate to accumulate. Current Biology 8, R719-721.
19. KULLMANN, D. M. (1999). Excitatory synapses. Neither too loud nor too quiet. Nature 399, 111-112.
20. LIAO, D., HESSLER, N. A. & MALINOW, R. (1995). Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 375, 400-404.
21. LIAO, D., ZHANG, X., O'BRIEN, R., EHLERS, M. D. & HUGANIR, R. L. (1999). Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nature Neuroscience 2, 37-43.
22. LIU, G., CHOI, S. & TSIEN, R. W. (1999). Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron 22, 395-409.
23. LIU, G. & TSIEN, R. W. (1995). Properties of synaptic transmission at single hippocampal synaptic boutons. Nature 375, 404-408.
24. MACKENZIE, P. J., KENNER, G. S., PRANGE, O., SHAYAN, H., UMEMIYA, M. & MURPHY, T. H. (1999). Ultrastructural correlates of quantal synaptic function at single CNS synapses. Journal of Neuroscience 19, RC13.
25. MAINEN, Z. F., MALINOW, R. & SVOBODA, K. (1999). Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature 399, 151-155.
26. MALENKA, R. C. (1994). Synaptic plasticity in the hippocampus: LTP and LTD. Cell 78, 535-538.
27. MALENKA, R. C. & NICOLL, R. A. (1997). Silent synapses speak up. Neuron 19, 473-476.
28. 2+ entry through the N-methyl-D-aspartate channel. Proceedings of the National Academy of Sciences of the USA 91, 8170-8174.
29. MIN, M. Y., RUSAKOV, D. A. & KULLMANN, D. M. (1998). Activation of AMPA, kainate, and metabotropic receptors at hippocampal mossy fiber synapses: role of glutamate diffusion. Neuron 21, 561-570.
30. MULLER, B. M., KISTNER, U., KINDLER, S., CHUNG, W. J., KUHLENDAHL, S., FENSTER, S. D., LAU, L. F., VEH, R. W., HUGANIR, R. L., GUNDELFINGER, E. D. & GARNER, C. C. (1996). SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron 17, 255-265.
31. 2+ responses. Nature 354, 73-76.
32. MURPHY, T. H., BARABAN, J. M. & WIER, W. G. (1995). Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in postsynaptic output. Neuron 15, 159-168.
33. MURPHY, T. H., BARABAN, J. M., WIER, W. G. & BLATTER, L. A. (1994). Visualization of quantal synaptic transmission by dendritic calcium imaging. Science 263, 529-532.
34. NUSSER, Z., LUJAN, R., LAUBE, G., ROBERTS, J. D., MOLNAR, E. & SOMOGYI, P. (1998). Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21, 545-559.
35. O'BRIEN, R. J., LAU, L. F. & HUGANIR, R. L. (1998). Molecular mechanisms of glutamate receptor clustering at excitatory synapses. Current Opinion in Neurobiology 8, 364-369.
36. PATNEAU, D. K. & MAYER, M. L. (1990). Structure - activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. Journal of Neuroscience 10, 2385-2399.
37. PETRALIA, R. S., ESTEBAN, J. A., WANG, Y. X., PARTRIDGE, J. G., ZHAO, H.-M., WENTHOLD, R. J. & MALINOW, R. (1999). Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nature Neuroscience 2, 31-36.
38. RAO, A., KIM, E., SHENG, M. & CRAIG, A. M. (1998). Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture. Journal of Neuroscience 18, 1217-1229.
39. ROSENMUND, C., CLEMENTS, J. D. & WESTBROOK, G. L. (1993). Nonuniform probability of glutamate release at a hippocampal synapse. Science 262, 754-757.
40. ROSENMUND, C. & WESTBROOK, G. L. (1993). Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 10, 805-814.
41. SCHILLER, J., SCHILLER, Y. & CLAPHAM, D. (1998). NMDA receptors amplify calcium influx into dendritic spines during associative preand postsynaptic activation. Nature Neuroscience 1, 114-118.
42. SILVER, R. A., TRAYNELIS, S. F. & CULL CANDY, S. G. (1992). Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ. Nature 355, 163-166.
43. SPRUSTON, N., JONAS, P. & SAKMANN, B. (1995). Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology 482, 325-352.
44. TONG, G., SHEPHERD, D. & JAHR, C. E. (1995). Synaptic desensitization of NMDA receptors by calcineurin. Science 267, 1510-1512.
45. WILDING, T. J. & HUETTNER, J. E. (1996). Antagonist pharmacology of kainate- and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid-preferring receptors. Molecular Pharmacology 49, 540-546.
46. WU, G., MALINOW, R. & CLINE, H. T. (1996). Maturation of a central glutamatergic synapse. Science 274, 972-976.
47. WU, G. Y. & CLINE, H. T. (1998). Stabilization of dendritic arbor structure in vivo by CaMKII. Science 279, 222-226.
48. ZHANG, S., EHLERS, M. D., BERNHARDT, J. P., SU, C. T. & HUGANIR, R. L. (1998). Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors. Neuron 21, 443-453.