Effect of filaments within the synaptic cleft on the response of excitatory synapses simulated by computer experiments

BioSystems

Volumn 104, Issue 1, 2011, Pages 14-22

  Ventriglia, Francesco ^a  

^a CNR   (Italy)

Author keywords

25 C and 37 C; Computer simulation; Filaments; Hippocampal glutamate synapse; Synaptic response

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMIC ACID;

BRAIN; BROWNIAN MOTION; COMPUTER SIMULATION; DEVELOPMENTAL BIOLOGY; DIAMETER; EXPERIMENTAL STUDY; METABOLISM; MOLECULAR ANALYSIS; NUMERICAL MODEL; PHYSIOLOGICAL RESPONSE; TIMESCALE;

ARTICLE; ELECTROENCEPHALOGRAM; GEOMETRY; HUMAN; MATHEMATICAL MODEL; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SIMULATION; SYNAPSE;

EID: 79952312974     PISSN: 03032647     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biosystems.2010.12.008     Document Type: Article

References (42)

1. Agmon N., Edelstein A.L. Collective binding properties of receptor arrays. Biophys. J. 1997, 72:1582-1594.
2. Araç D., Boucard A.A., Ozkan E., Strop P., Newell E., Südhof T.C., Brunger A.T. Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 2007, 56:992-1003.
3. Armstrong N., Gouaux E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 2000, 28:165-181.
4. Attwell D., Iadecola C The neural basis of functional brain imaging signals. Trends Neurosci. 2002, 25:621-625.
5. Attwell D., Laughlin S.B. An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. 2001, 21:1133-1145.
6. Auger C., Marty A Quantal currents at single-site central synapses. J. Physiol. 2000, 526:3-11.
7. Betancur C., Sakurai T., Buxbaum J.D. The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders. Trends Neurosci. 2009, 32(7):402-412.
8. Carroll L.S., Owen M. Genetic overlap between autism, schizophrenia and bipolar disorder. Genome Med. 2009, 1:102.
9. Clarke D.D., Sokoloff L. Circulation and energy metabolism of the brain. Basic Neurochemistry 1999, 637-669. Lippincott-Raven, Philadelphia. G.J. Siegel, B.W. Agranoff, R.W. Albers, S.K. Fisher, M.D. Uhler (Eds.).
10. Clements J.D., Lester R.A., Tong J., Jahr C.E., Westbrook G.L. The time course of glutamate in the synaptic cleft. Science 1992, 258:11498-11501.
11. Forti L., Bossi M., Bergamaschi A., Villa A., Malgaroli A. Loose-patch recordings of single quanta at individual hippocampal synapses. Nature 1997, 388:874-878.
12. Gegelashvili G., Dehnes Y., Danbolt N.C., Schousboe A. The high-affinity glutamate transporters GLT1 GLAST, and EAAT4 are regulated via different signalling mechanisms. Neurochem. Int. 2000, 37:163-170.
13. Gillespie D.T. The mathematics of Brownian motion and Johnson noise. Am. J. Phys. 1996, 64:225-240.
14. Hanse E., Gustafsson B. Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus. J. Physiol. 2001, 531:467-480.
15. Ichimura T., Hashimoto P.H. Structural components in the synaptic cleft captured by freeze-substitution and deep etching of directly frozen cerebellar cortex. J. Neurocytol. 1988, 17:3-12.
16. Jonas P., Major G., Sakmann B. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J. Physiol. (London) 1993, 472 C:615-663.
17. Jonas P., Spruston N. Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Curr. Opin. Neurobiol. 1994, 4:366-372.
18. Kleppe I.C., Robinson H.P. Determining the activation time course of synaptic AMPA receptors from openings of colocalized NMDA receptors. Biophys. J. 1999, 77:1418-1427.
19. Levinson J.N., El-Husseini A. A crystal-clear interaction: relating neuroligin/neurexin complex structure to function at the synapse. Neuron 2007, 56:937-939.
20. Levy W.B., Baxter R.A. Energy-efficient neural codes. Neural Comput. 1996, 8:531-543.
21. Liu G., Choi S., Tsien R.W. Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptor at synapses in hippocampal cultures and slices. Neuron 1999, 22:395-409.
22. Longsworth L.G. Diffusion measurements at 25°C of aqueous solutions of amino acids, peptides and sugars. J. Am. Chem. Soc. 1953, 75:5705-5709.
23. Lucic V., Yang T., Schweikert G., Förster F., Baumeister W. Morphological characterization of molecular complexes present in the synaptic cleft. Structure 2005, 13:423-434.
24. Mainen Z.F., Malinow R., Svoboda K. Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature 1999, 399:151-155.
25. Mangia S., Giove F., Tkác1 I., Logothetis N.K., Henry P.-G., Olman C.A., Maraviglia B., Di Salle F., Ugurbil K. Metabolic and hemodynamic events following changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings. J. Cereb. Blood Flow Metab. 2009, 29(3):441-463.
26. McAllister A.K., Stevens C.F. Nonsaturation of AMPA and NMDA receptors at hippocampal synapses. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:6173-6178.
27. Murphy T.H., Baraban J.M., Wier W.G. Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in postsynaptic output. Neuron 1995, 15:159-168.
28. Niven J.E., Laughlin S.B. Energy limitation as a selective pressure on the evolution of sensory systems. J. Exp. Biol. 2008, 211(Pt 11):1792-1804.
29. Rabie H.R., Rong J., Glavinović M.I. Monte Carlo simulation of release of vesicular content in neuroendocrine cells. Biol. Cybern. 2006, 94:483-499.
30. Schikorski T., Stevens C.F. Quantitative ultrastructural analysis of hippocampus excitatory synapses. J. Neurosci. 1997, 17:5858-5867.
31. Shupliakov O., Brodin L., Cullheim S., Ottersen O.P., Storm-Mathisen J. Immunogold quantification of glutamate in two types of excitatory synapse with different firing patterns. J. Neurosci. 1992, 12:3789-3803.
32. Südhof T.C. Neuroligins and neurexins link synaptic function to cognitive disease. Nature 2008, 455:903-911.
33. Takumi Y., Matsubara A., Rinvik E., Ottersen O.P. The arrangement of glutamate receptors in excitatory synapses. Ann. N. Y. Acad. Sci. 1999, 868:474-482.
34. Trommershäuser J., Titz S., Keller B.U., Zippelius A. Variability of excitatory currents due to single-channel noise receptor number and morphological heterogeneity. J. Theor. Biol. 2001, 208:329-343.
35. Umemiya M., Senda M., Murphy T.H. Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging. J. Physiol. (London) 1999, 521(Pt 1):113-122.
36. Uteshev V.V., Pennefather P.S. A mathematical description of miniature postsynaptic current generation at central nervous system synapses. Biophys. J. 1996, 71:1256-1266.
37. Ventriglia F., Di Maio V. A Brownian simulation model of glutamate synaptic diffusion in the femtosecond time scale. Biol. Cybern. 2000, 83:93-109.
38. Ventriglia F., Di Maio V. Stochastic fluctuations of the quantal EPSC amplitude in computer simulated excitatory synapses of hippocampus. Biosystems 2003, 71:195-204.
39. Ventriglia F. Saturation in excitatory synapses of hippocampus investigated by computer simulations. Biol. Cybern. 2004, 90:349-359.
40. Wahl L.M., Pouzat C., Stratford K.J. Monte Carlo simulation of fast excitatory synaptic transmission at a hippocampal synapse. J. Neurophysiol. 1996, 75:597-608.
41. Wang R., Zhang Z. Energy coding in biological neural networks. Cogn. Neurodyn. 2007, 1(3):203-212.
42. Zuber B., Nikonenko I., Klauser P., Muller D., Dubochet J. The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:19192-19197.