Collective binding properties of receptor arrays

Biophysical Journal

Volumn 72, Issue 4, 1997, Pages 1582-1594

  Agmon, Noam ^a   Edelstein, Arieh L ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; COMPUTER PROGRAM; EXCITATORY POSTSYNAPTIC POTENTIAL; MOLECULAR DYNAMICS; NEUROTRANSMITTER RELEASE; RECEPTOR BINDING; SYNAPTIC TRANSMISSION;

EID: 0030981988     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78805-2     Document Type: Article

References (63)

1. Agmon, N., and A. L. Edelstein. 1995. Geometric and many-particle aspects of transmitter binding. Biophys. J. 68:815-825.
2. Agmon, N., and A. Szabo. 1990. Theory of reversible diffusion-influenced reactions. J. Chem. Phys. 92:5270-5284.
3. Barbour, B., B. U. Keller, I. Llano, and A. Marty. 1994. Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells. Neuron. 12:1331-1343.
4. Bartol, T. M., Jr., B. R. Land, E. E. Salpeter, and M. M. Salpeter. 1991. Monte Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction. Biophys. J. 59:1290-1307.
5. Becker, O. M., M. Silverberg, and A. Ben-Shaul. 1990. Kinetically controlled aggregation in reactive adsorbate overlayers. Isr. J. Chem. 30:179-188.
6. Bekkers, J. M., and C. F. Stevens. 1989. NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus. Nature. 341:230-233.
7. Clements, J. D. 1996. Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci. 19:163-171.
8. Clements, J. D., R. A. J. Lester, G. Tong, C. E. Jahr, and G. L. Westbrook. 1992. The time course of glutamate in the synaptic cleft. Science. 258:1498-1501.
9. Clements, J. D., and G. L. Westbrook. 1991. Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor. Neuron. 7:605-613.
10. Diamond, J. S., and C. E. Jahr. 1995. Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC. Neuron. 15:1097-1107.
11. Eccles, J. C., and J. C. Jaeger. 1958. The relationship between the mode of operation and the dimensions of the junctional regions at synapses and motor-end-organs. Proc. R. Soc. Lond. B. 148:38-56.
12. Edelstein, A. L., and N. Agmon. 1993. Brownian dynamics simulations of reversible reactions in one dimension. J. Chem. Phys. 99:5396-5404.
13. Edelstein, A. L., and N. Agmon. 1995. Equilibration in reversible bimolecular reactions. J. Phys. Chem. 99:5389-5401.
14. Edelstein, A. L., and N. Agmon. 1997. Brownian-simulation of many-particle binding to a reversible receptor array. J. Comp. Phys. 132:000-000.
15. Edmonds, B., A. J. Gibb, and D. Colquhoun. 1995a. Mechanisms of activation of muscle nicotinic acetylcholine receptors and the time course of endplate currents. Annu. Rev. Physiol. 57:469-493.
16. Edmonds, B., A. J. Gibb, and D. Colquhoun. 1995b. Mechanisms of activation of glutamate receptors and the time course of excitatory synaptic currents. Annu. Rev. Physiol. 57:495-519.
17. Faber, D. S., W. S. Young, P. Legendre, and H. Korn. 1992. Intrinsic quantal variability due to stochastic properties of receptor-transmitter interactions. Science. 258:1494-1498.
18. Friboulet, A. and D. Thomas. 1993. Reaction-diffusion coupling in a structured system: application to the quantitative simulation of endplate currents. J. Theor. Biol. 160:441-455.
19. Giniatullin, R. A., R. N. Khazipov, and F. Vyskočil. 1993. A correlation between quantal content and decay time of endplate currents in frog muscles with intact cholinesterase. J. Physiol. (Lond.). 466:95-103.
20. Gogan, P., I. Schmiedel-Jakob, Y. Chitti, and S. Tyč-Dumont. 1995. Fluorescence imaging of local membrane electric fields during the excitation of single neurons in culture. Biophys. J. 69:299-310.
21. Gutman, M., E. Nachliel, and S. Kiryati. 1992. Dynamic studies of proton diffusion in mesoscopic heterogeneous matrix. II. The interbilayer space between phospholipid membranes. Biophys. J. 63:281-290.
22. Harris, K. M. and D. M. D. Landis. 1986. Membrane structure at synaptic junctions in area CA1 of the rat hippocampus. Neuroscience. 19: 857-872.
23. Hartzell, H. C., S. W. Kuffler, and D. Yoshikami. 1975. Post-synaptic potentiation: interaction between quanta of acetylcholine at the skeletal neuromuscular synapse. J. Physiol. (Lond.). 251:427-463.
24. Holmes, W. R. 1995. Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation. Biophys. J. 69:1734-1747.
25. Ichimura, T., and P. H. Hashimoto. 1988. Structural components in the synaptic cleft captured by freeze-substitution and deep etching of directly frozen cerebellar cortex. J. Neurocytol. 17:3-12.
26. Isaacson, J. S., and B. Walmsley. 1995. Counting quanta: direct measurements of transmitter release at a central synapse. Neuron. 15:875-884.
27. Jonas, P., and N. Spruston. 1994. Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Curr. Opin. Neurobiol. 4:366-372.
28. Katz, B., and R. Miledi. 1973. The binding of acetylcholine to receptors and its removal from the synaptic cleft. J. Physiol. (Lond.). 231: 549-574.
29. Katz, B., and R. Miledi. 1979. Estimates of quantal content during "chemical potentiation" of transmitter release. Proc. R. Soc. Lond. B. 205:369-378.
30. Kleinle, J., K. Vogt, H.-R. Lüscher, L. Müller, W. Senn, K. Wyler, and J. Streit. 1996. Transmitter concentration profiles in the synaptic cleft: an analytical model of release and diffusion. Biophys. J. 71:2413-2426.
31. Kordaš, M. 1977. On the role of junctional cholinesterase in determining the time course of the end-plate current. J. Physiol. (Lond.). 270:133-150.
32. Korn, H., and D. S. Faber. 1991. Quantal analysis and synaptic efficacy in the CNS. Trends Neurosci. 14:439-445.
33. Land, B. R., W. V. Harris, E. E. Salpeter, and M. M. Salpeter. 1984. Diffusion and binding constants for acetylcholine derived from the falling phase of miniature endplate currents. Proc. Natl. Acad. Sci. USA. 81:1594-1598.
34. Land, B. R., E. E. Salpeter, and M. M. Salpeter. 1981. Kinetic parameters for acetylcholine interaction in intact neuromuscular junction. Proc. Natl. Acad. Sci. USA. 78:7200-7204.
35. Lester, R. A. J., J. D. Clements, G. L. Westbrook, and C. E. Jahr. 1990. Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature. 346:565-567.
36. Lester, R. A. J., and C. E. Jahr. 1992. NMDA channel behavior depends on agonist affinity. J. Neurosci. 12:635-643.
37. Lisman, J. E., and K. M. Harris. 1993. Quantal analysis and synaptic anatomy - integrating two views of hippocampal plasticity. Trends Neurosci. 16:141-147.
38. Longworth, L. G. 1953. Diffusion measurements, at 25°, of aqueous solutions of amino acids, peptides and sugars. J. Am. Chem. Soc. 75:5705-5709.
39. Magazanik, L. G., E. E. Nikolsky, and R. A. Giniatullin. 1984. End-plate currents evoked by paired stimuli in frog muscle fibres. Pflügers Arch. 401:185-192.
40. Magleby, K. L., and C. F. Stevens. 1972. A quantitative description of end-plate currents. J. Physiol. (Lond.). 223:173-197.
41. Magleby, K. L., and D. A. Terrar. 1975. Factors affecting the time course of decay of end-plate currents: a possible cooperative action of acetylcholine on receptors at the frog neuromuscular junction. J. Physiol. (Lond.). 244:467-495.
42. Matthews-Bellinger, J., and M. M. Salpeter. 1978. Distribution of acetylcholine receptors at frog neuromuscular junction with a discussion of some physiological implications. J. Physiol. (Lond.). 279:197-213.
43. Mennerick, S., and C. F. Zorumski. 1995. Presynaptic influence on the time course of fast excitatory synaptic currents in cultured hippocampal cells J. Neurosci. 15:3178-3192.
44. Nicholson, C., and J. M. Phillips. 1981. Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. J. Physiol. (Lond.). 321:225-257.
45. Otis, T. S., Y.-C. Wu, and L. O. Trussell. 1996. Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites. J. Neurosci. 16:1634-1644.
46. Parnas, H., M. Flashner, and M. E. Spira. 1989. Sequential model to describe the nicotinic synaptic current. Biophys. J. 55:875-884.
47. Patneau, D. K., and M. L. Mayer. 1990. Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J. Neurosci. 10:2385-2399.
48. Patneau, D. K., L. Vyklicky, Jr., and M. L. Mayer. 1993. Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J. Neurosci. 13:3496-3509.
49. Rice, M. E., G. A. Gerhardt, P. M. Hierl, G. Nagy, and R. N. Adams. 1985. Diffusion coefficients of neurotransmitters and their metabolites in brain extracellular fluid space. Neuroscience. 15:891-902.
50. Rosenberry, T. 1979. Quantitative simulation of endplate currents at neuromuscular junctions based on the reaction of acetylcholine with acetylcholine receptor and acetylcholinesterase. Biophys. J. 26:263-290.
51. Rossi, D. J., S. Alford, E. Mugnaini, and N. T. Slater. 1995. Properties of transmission at a giant glutamatergic synapse in cerebellum: the mossy fiber-unipolar brush cell synapse. J. Neurophysiol. 74:24-42.
52. Shoup, D., and A. Szabo. 1982. Role of diffusion in ligand binding to macromolecules and cell-bound receptors. Biophys. J. 40:33-39.
53. Silver, R. A., D. Colquhoun, S. G. Cull-Candy, and B. Edmonds. 1996. Deactivation and desensitization of non-NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells. J. Physiol. (Lond.). 493:167-173.
54. Silver, R. A., S. F. Traynelis, and S. G. Cull-Candy. 1992. Rapid-time course miniature and evoked excitatory currents at cerebellar synapses in situ. Nature. 355:163-166.
55. Takahashi, M., Y. Kovalchuk, and D. Attwell. 1995. Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses. J. Neurosci. 15:5693-5702.
56. Tang, C.-M., M. Margulis, Q.-Y. Shi, and A. Fielding. 1994. Saturation of postsynaptic glutamate receptors after quantal release of transmitter. Neuron. 13:1385-1393.
57. Tong, G., and C. E. Jahr. 1994. Block of glutamate transporters potentiates postsynaptic excitation. Neuron. 13:1195-1203.
58. Trussell, L. O., S. Zhang, and I. M. Raman. 1993. Desensitization of AMPA receptors upon multiquantal neurotransmitter release. Neuron. 10:1185-1196.
59. Uteshev, V. V., and P. S. Pennefather. 1996. A mathematical description of miniature postsynaptic current generation at central nervous system synapses. Biophys. J. 71:1256-1266.
60. Vyklicky, L., Jr., D. K. Patneau, and M. L. Mayer. 1991. Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainte receptors. Neuron. 7:971-984.
61. Wahl, L. M., C. Pouzat, and K. J. Stratford. 1996. Monte carlo simulations of fast excitatory synaptic transmission at the hipocampal synapse. J. Neurophysiol. 75:597-608.
62. Wathey, J. C., M. M. Nass, and H. A. Lester. 1979. Numerical reconstruction of the quantal event at nicotinic synapses. Biophys. J. 27:145-164.
63. Yamada, K. A., and C.-M. Tang. 1993. Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents. J. Neurosci. 13:3904-3915.