Saturation in excitatory synapses of hippocampus investigated by computer simulations

Biological Cybernetics

Volumn 90, Issue 5, 2004, Pages 349-359

  Ventriglia, Francesco ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BROWNIAN MOVEMENT; COMPUTER SIMULATION; GAUSSIAN NOISE (ELECTRONIC); MATHEMATICAL MODELS; OPTIMIZATION; RANDOM PROCESSES; RECEPTION QUALITY; SATURATION (MATERIALS COMPOSITION);

ERROR-OPTIMIZATION; EXCITORY SYNAPSES; HIPPOCAMPUS; RECEPTOR SATURATION;

BIOMECHANICS;

ARTICLE; COMPARATIVE STUDY; COMPUTER SIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; PHYSIOLOGY; SYNAPSE;

COMPUTER SIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; SYNAPSES;

EID: 4344626475     PISSN: 03401200     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00422-004-0476-4     Document Type: Article

References (51)

1. Agmon N, Edelstein AL (1997) Collective binding properties of receptor arrays. Biophys J 72: 1582-1594
2. Armstrong N, Gouaux E (2000) Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 28: 165-181.
3. Armstrong N, Sun Y, Chen GQ, Gouaux E (1998) Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 395: 913-917
4. Auger C, Marty A (2000) Quantal currents at single-site central synapses. J Physiol 526: 3-11
5. Bartol TM Jr, Land BR, Salpeter EE, Salpeter MM (1991) Monte Carlo simulation of miniature end plate current generation in the vertebrate neuromuscular junction. Biophys J 59: 1290-1307
6. Bekkers JM, Richerson GB, Stevens CF (1990) Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices. Proc Natl Acad Sci USA 87: 5359-5362
7. Bruns D, Jahn R (1995) Real-time measurement of transmitter release from single synaptic vesicles. Nature 377: 62-65
8. Clements JD (1996) Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci 19: 163-171
9. Clements JD, Lester RA, Tong J, Jahr CE, Westbrook GL (1992) The time course of glutamate in the synaptic cleft. Science 258: 11498-11501
10. Colquhoun D, Jonas P, Sakmann B (1992) Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurons of rat hippocampal slices. J Physiol Lond 458: 261-287
11. Diamond JS, Jahr CE (1997) Transporters buffer synaptically released glutamate on a submillisecond time scale. J Neurosci 17: 4672-4687
12. Edelstein AL, Agmon N (1997) Brownian simulation of many-particle binding to a reversible receptor array. J Comput Phys 132: 260-275
13. Forti L, Bossi M, Bergamaschi A, Villa A, Malgaroli A (1997) Loosepatch recordings of single quanta at individual hippocampal synapses. Nature 388: 874-878
14. Gegelashvili G, Dehnes Y, Danbolt NC, Schousboe A (2000) The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms. Neurochem Int 37: 163-170
15. Gillespie DT (1996) The mathematics of Brownian motion and Johnson noise. Am J Phys 64: 225-240
16. Glavinovic MI (1999) Monte carlo simulation of vesicular release, spatiotemporal distribution of glutamate in synaptic cleft and generation of postsynaptic currents. Pflugers Arch 437: 462-470
17. Hanse E, Gustafsson B (2001) Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus. J Physiol 531:467-480
18. Holmes WR (1995) Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation. Biophys J 69: 1734-1747
19. Jahn K, Bufler J, Franke C (1998) Kinetics of AMPA-type glutamate receptor channels in rat caudate-putamen neurons show a wide range of desensitization but distinct recovery characteristics. Eur J Neurosci 10: 664-672
20. Jayaraman V, Keesey R, Madden DR (2000) Ligand-protein interactions in the glutamate receptor. Biochemistry 39: 8693-8697
21. Jonas P, Major G, Sakmann B (1993) Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J Physiol Lond 472 C: 615-663
22. Jonas P, Spruston N (1994) Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Curr Opin Neurobiol 4: 366-372
23. Kleinle J, Vogt K, Luscher HR, Muller L, Senn W, Wyler K, Streit J (1996) Transmitter concentration profiles in the synaptic cleft: an analytical model of release and diffusion. Biophys J 71: 2413-2426
24. Kruk PJ, Korn H, Faber DS (1997) The effects of geometrical parameters on synaptic transmission: a Monte Carlo simulation study. Biophys J 73: 2874-2890
25. Kullmann DM (2003) Silent synapses: what are they telling us about long-term potentiation? Philos Trans R Soc Lond B Biol Sci 358: 727-733
26. Liu G (2003) Presynaptic control of quantal size: kinetic mechanisms and implications for synaptic transmission and plasticity. Curr Opin Neurobiol 13: 324-331
27. Liu G, Choi S, Tsien RW (1999) Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptor at synapses in hippocampal cultures and slices. Neuron 22: 395-409
28. Longsworth LG (1953) Diffusion measurements at 25° of aqueous solutions of amino acids, peptides and sugars. J Am Chem Soc 75: 5705-5709
29. Mainen ZF, Malinow R, Svoboda K (1999) Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature 399: 151-155
30. McAllister AK, Stevens CF (2000) Nonsaturation of AMPA and NMDA receptors at hippocampal synapses. Proc Natl Acad Sci USA 97: 6173-6178
31. Montgomery JM, Pavlidis P, Madison DV (2001) Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation. Neuron 29: 691-701
32. Murphy TH, Baraban JM, Wier WG (1995) Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in postsynaptic output. Neuron 15: 159-168
33. Paas Y, Devillers-Thiery A, Teichberg VI, Changeux JP, Eisenstein M (2000) How well can molecular modelling predict the crystal structure: the case of the ligand-binding domain of glutamate receptors. Trends Pharmacol Sci 21:87-92
34. Palfrey HC, Artalejo CR (2003) Secretion: kiss and run caught on film. Curr Biol 13: R397-399
35. Poncer JC, Malinow R (2001) Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics. Nat Neurosci 4: 989-996
36. Reigada D, Diez-Perez I, Gorostiza P, Verdaguer A, Gomez de Aranda I, Pineda O, Vilarrasa J, Marsal J, Blasi J, Aleu J, Solsona C (2003) Control of neurotransmitter release by an internal gel matrix in synaptic vesicles. Proc NatI Acad Sci USA 100: 3485-3490
37. Rusakov DA, Kullmann DM (1998) Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake, and receptor activation. J Neurosci 18: 3158-3170
38. Schikorski T, Stevens CF (1997) Quantitative ultrastructural analysis of hippocampus excitatory synapses. J Neurosci 17: 5858-5867
39. Shupliakov O, Brodin L, Cullheim S, Ottersen OP, Storm-Mathisen J (1992) Immunogold quantification of glutamate in two types of excitatory synapse with different firing patterns. J Neurosci 12: 3789-3803
40. Stevens CF, Wang Y (1994) Changes in reliability of synaptic function as a mechanism for plasticity. Nature 371: 704-707
41. Stevens CF, Williams JH (2000) "Kiss and run" exocytosis at hippocampal synapses. Proc Natl Acad Sci USA 97: 12828-12833
42. Trommershauser J, Marienhagen J, Zippelius A (1999) Stochastic model of central synapses: slow diffusion of transmitter interacting with spatially distributed receptors and transporters. J Theor Biol 198: 101-120
43. Umemiya M, Senda M, Murphy TH(1999) Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging. J Physiol Lond 521(Pt 1) : 113-122
44. Uteshev VV, Pennefather PS (1996) A mathematical description of miniature postsynaptic current generation at central nervous system synapses. Biophys J 71: 1256-1266
45. Ventriglia F, Di Maio V (2000a) A Brownian simulation model of glutamate synaptic diffusion in the femtosecond time scale. Biol Cybern 83: 93-109
46. Ventriglia F, Di Maio V (2000b) A Brownian model of glutamate diffusion in excitatory synapses of Hippocampus. Biosystems 58: 67-74
47. Ventriglia F, Di Maio V (2002) Stochastic fluctuations of the synaptic function. Biosystems 67: 287-294
48. Ventriglia F, Di Maio V (2003a) Synaptic fusion pore structure and AMPA receptor activation according to Brownian simulation of glutamate diffusion. Biol Cybern 88: 201-209
49. Ventriglia F, Di Maio V (2003b) Stochastic fluctuations of the quantal EPSC amplitude in computer simulated excitatory synapses of hippocampus. Biosystems 71: 195-204
50. Ventriglia F, Di Maio V, Talamo O (1999) A model of synaptic diffusion by brownian simulation. In: Abstracts of the workshop on neural coding, 11-15 October 1999, Osaka, Japan, pp 5-7
51. Wahl LM, Pouzat C, Stratford KJ (1996) Monte Carlo simulation of fast excitatory synaptic transmission at a hippocampal synapse. J Neurophysiol 75: 597-608