Antidiabetic and antioxidant properties of Ficus deltoidea fruit extracts and fractions

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Misbah, Hasni ^a   Aziz, Azlina Abdul ^a   Aminudin, Norhaniza ^b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Antioxidant; Diabetes; Ficus deltoidea; Phenolic; SDS PAGE; SELDI TOF MS

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ACARBOSE; ACETIC ACID ETHYL ESTER; ALPHA GLUCOSIDASE; AMYLASE; ANTIDIABETIC AGENT; ANTIOXIDANT; FERRIC ION; FICUS ANGUSTIFOLIA EXTRACT; FICUS KUNSTLERI EXTRACT; FLAVONOID; NITRIC OXIDE; PHENOL DERIVATIVE; PLANT EXTRACT; PROTEIN; SUGAR; SUPEROXIDE; UNCLASSIFIED DRUG; WATER;

ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; FICUS; FICUS ANGUSTIFOLIA; FICUS KUNSTLERI; FRACTIONATION; FRUIT; IC 50; IN VITRO STUDY; OXIDATION REDUCTION POTENTIAL; PHYTOCHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; SWINE; YEAST;

ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS; ENZYME INHIBITORS; FICUS; FLAVONOIDS; FRUIT; HUMANS; HYPOGLYCEMIC AGENTS; PLANT EXTRACTS; RATS;

EID: 84878217652     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-118     Document Type: Article

References (65)

1. Teixeira CC, Rava CA, Da-Silva PM, Melchior R, Argenta R, Anselmi F, Almeida CR, Fuchs FD. Absence of antihyperglycemic effect of jambolan in experimental and clinical models. J Ethnopharmacol 2000, 71:343-347. 10.1016/S0378-8741(00)00185-9, 10904184.
2. Youn J, Park H, Cho K. Anti-hyperglycaemic activity of Commelina communis L.: inhibition of α-glucosidase. Diabetic Res Clin Prac 2004, 665:S149-S155.
3. Saito N, Sakai H, Sekihara H, Yajima Y. Effect of α-glucosidase inhibitor (voglibose), in combination with sulphonylureas, on glycaemic control in type 2 diabetes patients. J Int Med Res 1998, 26:219-232.
4. Bhandari MR, Jong-Anurakkhun N, Hong G, Kawabata J. α-glucosidase and α-amylase inhibitory activities of Napalese medicinal herb Pakhanbhed (Bergenia ciliata, Haw). Food Chem 2008, 106:247-252.
5. Rhabasa-Lhoret R, Chiasson JL. Glucosidase inhibitors. International Textbook of Diabetes Mellitus 2004, UK: John Wiley & Sons Ltd, Defronzo RA, Ferrannini E, Keen H, Zimmet P, 3, 1: 901-914.
6. Bonnefont-Rousselot D, Bastard JP, Jaudon MC, Delattre J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab 2000, 26:163-176.
7. Ceriello A. Oxidative stress and diabetes-associated complications. Endocr Pract 2006, 12:60-62.
8. Rains JL, Jain SK. Oxidative stress, insulin signaling and diabetes. Free Radic Biol Med 2011, 50:567-575. 10.1016/j.freeradbiomed.2010.12.006, 3557825, 21163346.
9. Pasupathi P, Rao YY, Faook J, Saravanan G, Bakthavathsalam G. Oxidative stress and cardiac biomarkers in patients with acute myocardial infarction. Eur J Sci Res 2009, 27:275-285.
10. Calabrese V, Mancuso C, Sapienza M, Puleo E, Calafato S, Cornelius C, Finocchiaro M, Mangiameli A, Di-Mauro M, Giuffrida Stella AM, Castellino P. Oxidative stress and cellular stress response in diabetic nephropathy. Cell Stress Chaperones 2007, 12:299-306. 10.1379/CSC-270.1, 2134792, 18229449.
11. Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetic potential. J Ethnopharmacol 2002, 81:81-100. 10.1016/S0378-8741(02)00059-4, 12020931.
12. Manickam M, Ramanathan M, Jahromi MA, Chansouria JP, Ray AB. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 1997, 60:609-610. 10.1021/np9607013, 9214733.
13. Panda S, Kar A. Apigenin (4′,5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. J Pharm Pharmacol 2007, 59:1543-1548. 10.1211/jpp.59.11.0012, 17976266.
14. Yoshikawa M, Wang T, Morikawa T, Xie H, Matsuda H. Bioactive Constituents from Chinese Natural Medicines XXIV Hypoglycemic Effects of Sinocrassula indica in Sugar-Loaded Rats and Genetically Diabetic KK-Ay Mice and Structures of New Acylated Flavonol Glycosides, Sinocrassosides A1, A2, B1, and B2. Chem Pharm Bull 2007, 55:1308-1315. 10.1248/cpb.55.1308, 17827753.
15. Dineshkumar B, Mitra A, Mahadevappa M. Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from murraya koenigii (rutaceae) leaves. Int J Phytomed 2010, 2:22-30.
16. Sharma B, Salunke R, Balomajumder C, Daniel S, Roy P. Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice. J Ethnopharmacol 2010, 127:457-462. 10.1016/j.jep.2009.10.013, 19837152.
17. Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, Chen T, Weiss HC, Gesing ER, Rowland A, James DE, Ye Y. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 2008, 15:263-273. 10.1016/j.chembiol.2008.01.013, 18355726.
18. Contreras C, Roman R, Perez C, Alarcon F, Zavala M, Perez S. Hypoglycemic activity of a new carbohydrate isolated from the roots of Psacalium peltatum. Chem Pharm Bull 2005, 53:1408-1410. 10.1248/cpb.53.1408, 16272722.
19. Farsi E, Shafaei A, Sook YH, Khadeer Ahamed BM, Mun FY, Idress HA, Zaini MA, Ismail Z. Correlation between enzymes inhibitory effects and antioxidant activities of standardized fractions of methanolic extract obtained from Ficus deltoidea leaves. Afr J Biotechnol 2011, 10:15184-15194.
20. Choo CY, Sulong NY, Man F, Wong TW. Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition. J Ethnopharmacol 2012, 142:776-781. 10.1016/j.jep.2012.05.062, 22683902.
21. Omar MH, Mullen W, Crozier A. Identification of proanthocyanidin dimers and trimers, flavone C-Glycosides, and antioxidants in Ficus deltoidea, a Malaysian herbal tea. J Agric Food Chem 2011, 59:1363-1369. 10.1021/jf1032729, 21261251.
22. Adam Z, Khamis S, Ismail A, Hamid M. Ficus deltoidea: A potential alternative medicine for diabetes mellitus. Evidence-Based Complementary Altern Med 2012, 201(2):632763.
23. Armaghan S, Elham F, Khadeer BMH, Jamshid MAS, Idress HA, Ismail Z, Zaini MA. Evaluation of toxicological and standardization parameter and phytochemical investigation of Ficus deltoidea. Am J Biochem Mol Biol 2011, 1:237-243.
24. Adam Z, Hamid M, Ismail A, Khamis S. Effect of Ficus deltoidea aqueous extract on blood glucose level in normal and mild diabetic rats. Malaysian J Health Sci 2007, 5:9-16.
25. Aminudin N, Chung YS, Eue SC, Kang IN, Lee R. Blood glucose lowering effect of Ficus deltoidea aqueous extract. Malaysian J Sci 2007, 26:73-78.
26. Adam Z, Khamis S, Ismail A, Hamid M. Inhibitory properties of Ficus deltoidea on α-glucosidase activity. Res J Med Plant 2010, 4:61-75.
27. Sulaiman MR, Hussain MK, Zakaria ZA. Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. Fitoterapia 2008, 79:557-561. 10.1016/j.fitote.2008.06.005, 18672036.
28. Siti Fatimah Zahra MA, Mahmood AA, Hapipah MA, Suzita MN, Salmah I. Anti-ulcerogenic activity of aqueous extract of Ficus deltoidea against ethanol-induced gastric mucosal injury in rats. Res J Med Sci 2009, 3:42-46.
29. Hakiman M, Maziah M. Non enzymatic and enzymatic antioxidant activities in aqueous extract of different Ficus deltoidea accessions. J Med Plants Res 2009, 3:120-131.
30. Abdullah Z, Hussain K, Zhari I, Rasadah MA, Mazura P, Jamaludin F, Sahdan R. Evaluation of extracts of leaf of three Ficus deltoidea varieties for antioxidant activities and secondary metabolites. Pharmacogn Res 2009, 1:216-223.
31. Zakaria ZA, Hussain MK, Mohamad AS, Abdullah FC, Sulaiman MR. Anti-inflammatory activity of the aqueous extract of Ficus deltoidea. Biol Res Nurs 2012, 14:90-97. 10.1177/1099800410395378, 21278166.
32. Oh MJ, Abdul Hamid M, Ngadiran S, Seo YK, Sarmidi MR, Park CS. Ficus deltoidea (Mas cotek) extract exerted anti-melanogenic activity by preventing tyrosinase activity in vitro and by suppressing tyrosinase gene expression in B16F1 melanoma cells. Arch Dermatol Res 2011, 303:161-170. 10.1007/s00403-010-1089-5, 20981431.
33. Singleton UL, Rossi J. Colorimetry of total phenolics with phosphomolybdic-posphotungustic acid reagent. Am J Enol Vit 1965, 16:144.
34. DuBois MK, Gils JK, Hanniton PA, Robes, Smith F. Use of phenol reagent for the determination of total sugar. Anal Chem 1956, 28:350.
35. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.
36. Braca A, Tommasi ND, Bari LD, Pizza C, Politi M, Morelli I. Antioxidant principles from Bauhinia terapotensis. J Nat Prod 2001, 64:892-895. 10.1021/np0100845, 11473417.
37. Benzie IFF, Strain JJ. Ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal Biochem 1996, 239:70-76. 10.1006/abio.1996.0292, 8660627.
38. Nishikimi M, Appaji N, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 1972, 46:849-854. 10.1016/S0006-291X(72)80218-3, 4400444.
39. Sindhu RK, Griffin DH, Walton DC. Abscisic aldehyde is an intermediate in the enzymatic conversion of xanthoxin to abscisic acid in Phaseolus vulgaris L leaves. Plant Physiol 1990, 93:689-694. 10.1104/pp.93.2.689, 1062571, 16667524.
40. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685. 10.1038/227680a0, 5432063.
41. Lau BF, Aminudin N, Abdullah N. Comparative SELDI-TOF-MS profiling of low-molecular-mass proteins from Lignosus rhinocerus (Cooke) Ryvarden grown under stirred and static conditions of liquid fermentation. J Microbiol Methods 2011, 87:56-63. 10.1016/j.mimet.2011.07.005, 21801760.
42. Anam K, Widharna RM, Kusrini D. α-glucosidase inhibitor activity of Terminalia species. Int J Pharmacol 2009, 5:277-280.
43. Momo CEN, Fuh Ngwa A, Dongmo GIF, Oben JE. Antioxidant properties and α amylase inhibition of Terminalia superba Albizia sp., Cola nitida, Cola odorata and Harungana madagascarensis used in the management of diabetes in Cameroon. J Health Sci 2009, 55:732-738.
44. Oki T, Matsui O, Osajima Y. Inhibitory effect of alpha-glucosidase inhibitors varies according to its origin. J Agric Food Chem 1999, 47:550-553. 10.1021/jf980788t, 10563931.
45. Shai LJ, Masoko P, Mokgotho MP, Magano SR, Mogale AM. Yeast alpha glucosidase inhibitory and antioxidant activities of six medicinal plants collected in Phalaborwa, South Africa. South Afr J Bot 2010, 76:465-470.
46. Kim JS, Kwon CS, Son KH. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci Biotechnol Biochem 2000, 64:2458-2461. 10.1271/bbb.64.2458, 11193416.
47. Kim YM, Wang MH, Rhee HI. A novel alpha-glucosidase inhibitor from pine bark. Carbohydr Res 2004, 339:715-717. 10.1016/j.carres.2003.11.005, 15013410.
48. Schafer A, Hogger P. Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol®) effectively inhibit α-glucosidase. Diabetes Res Clin Pract 2007, 77:41-46. 10.1016/j.diabres.2006.10.011, 17098323.
49. Iwai K. Antidiabetic and antioxidant effects of polyphenols in brown alga Ecklonia stolonifera in genetically diabetic KK-Ay mice. Plant Foods Hum Nutr 2008, 63:163-169. 10.1007/s11130-008-0098-4, 18958624.
50. Gao H, Kawabata J. α-glucosidase inhibition of 6-hydroxyflavones. Part 3: synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors. Bioorg Med Chem 2005, 13:1661-1671. 10.1016/j.bmc.2004.12.010, 15698784.
51. Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 2005, 59:365-373. 10.1016/j.biopha.2005.07.002, 16081237.
52. Tchinda AT, Tchuendem MH, Khan SN, Omar I, Ngandeu F, Nkeng PEA, Choudhary IM. Antioxidant activity of the crude extract of the fruits of Pycnanthus angolensis and α-glucosidase inhibitory activity of its constituents. Pharmacologyonline 2008, 1:422-431.
53. Yao Y, Sang W, Zhou M, Ren G. Antioxidant and alpha-glucosidase inhibitory activity of colored grains in China. J Agric Food Chem 2010, 58:770-774. 10.1021/jf903234c, 19904935.
54. Wu N, Fu K, Fu YJ, Zu YG, Chang FR, Chen YH, Liu XL, Kong Y, Liu W, Gu CB. Antioxidant Activities of Extracts and Main Components of Pigeonpea [Cajanus cajan (L) Millsp] Leaves. Molecules 2009, 14:1032-1043. 10.3390/molecules14031032, 19305357.
55. Jain DP, Pancholi SS, Patel R. Synergistic antioxidant activity of green tea with some herbs. J Adv Pharm Technol Res 2011, 2:177-183. 10.4103/2231-4040.85538, 3217702, 22171315.
56. Carpenter A, Siggia S, Carter S. Separation and/or Concentration of phenolic materials from dilute aqueous solutions. Anal Chem 1976, 48:225-228.
57. Azevedo CR, Maciel FM, Silva LB, Ferreira AT, Da-Cunha M, Machado OL, Fernandes KV, Oliveira AE, Xavier-Filho J. Isolation and intracellular localization of insulin-like proteins from leaves of Bauhinia variegate. Braz J Med Biol Res 2006, 39:1435-1444. 10.1590/S0100-879X2006001100007, 17146556.
58. Yuan X, Gu X, Tang J. Purification and characterisation of a hypoglycemic peptide from Momordica Charantia L. Var abbreviata Ser. Food Chem 2008, 111:415-420.
59. Fenglin L, Qingwang L, Dawei G, Yong P, Caining F. Preparation and antidiabetic activity of polysaccharide from Portulaca oleracea L. Afr J Biotechnol 2009, 8:569-573.
60. Kim HM, Kang JS, Kim JY, Park SK, Kim HS, Lee YJ, Yun J, Hong JT, Kim Y, Han SB. Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse. Int Immunopharmacol 2010, 10:72-78. 10.1016/j.intimp.2009.09.024, 19811769.
61. Paul A, Raychaudhuri SS. Medicinal uses and molecular identification of two Momordica charantia varieties - a review. Electron J Biol 2010, 6:43-51.
62. Kim H, Choi H, Moon J, Kim Y, Mosaddik A, Cho S. Comparative antioxidant and antiproliferative activities of red and white pitayas and their correlation with flavonoid and polyphenol content. J Food Sci 2010, 76:C38-C45.
63. Razab A, Abdul Aziz A. Antioxidants from tropical herbs. Nat Prod Commun 2010, 5:441-445.
64. Sariburun E, Sahin S, Demir C, Turkben C, Uylaser V. Phenolic content and antioxidant activity of raspberry and blackberry cultivars. J Food Sci 2010, 75:C328-C335. 10.1111/j.1750-3841.2010.01571.x, 20546390.
65. Papale M, Pedicillo MC, Thatcher BJ, Di-Paolo S, Lo Muzio L, Bufo P, Rocchetti MT, Centra M, Ranieri E, Gesualdo L. Urinary profiling by SELDITOF/MS: monitoring of the critical steps in sample collection, handling and analysis. J Chromatogr B 2007, 856:205-213.