Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase

Planta Medica

Volumn 77, Issue 14, 2011, Pages 1575-1581

  Zhou, Dan Yang ^a   Du, Qiang ^b   Li, Ruo Ran ^c   Huang, Mao ^a   Zhang, Qian ^a   Wei, Guo Zhen ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

airway inflammation; asthma; grape seed proanthocyanidin extract; hyperresponsiveness; inducible nitric oxide synthase

Indexed keywords

ACETYLCHOLINE; BUDESONIDE; GAMMA INTERFERON; GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDIN EXTRACT; IMMUNOGLOBULIN E; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 13; INTERLEUKIN 4; OVALBUMIN; PROANTHOCYANIDIN; UNCLASSIFIED DRUG;

AIRWAY RESISTANCE; ALLERGIC ASTHMA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EOSINOPHIL COUNT; FEMALE; GOBLET CELL; LUNG LAVAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; EOSINOPHILS; FEMALE; GRAPE SEED EXTRACT; IMMUNOGLOBULIN E; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-13; INTERLEUKIN-4; LUNG; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED BALB C; NEUTROPHILS; NITRIC OXIDE SYNTHASE TYPE II; OVALBUMIN; PROANTHOCYANIDINS; RANDOM ALLOCATION; VITIS;

MURINAE; MUS; VITACEAE;

EID: 80053304241     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1270957     Document Type: Article

References (36)

1. Kay A B. Asthma and inflammation. J Allergy Clin Immunol 1991 87 893-910
2. Lim K G., Mottram C. The use of fraction of exhaled nitric oxide in pulmonary practice. Chest 2008 133 1232-1242 (Pubitemid 351685531)
3. Ricciardolo F L., Nijkamp F P., Folkerts G. Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease. Curr Drug Targets 2006 7 721-735 (Pubitemid 43827268)
4. Korhonen R, Lahti A, Kankaanranta H, Moilanen E. Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy 2005 4 471-479 (Pubitemid 41052412)
5. Fernandes P D., Landgraf R G., Britto L R., Jancar S. Production of nitric oxide by airways neutrophils in the initial phase of murine asthma. Int Immunopharmacol 2007 7 96-102 (Pubitemid 44856392)
6. Islam T, Breton C, Salam M T., McConnell R, Wenten M, Gauderman W J., Conti D, Van Den Berg D, Peters J M., Gilliland F D. Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax 2010 65 139-145
7. Buhl R. Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. Allergy 2006 61 518-526
8. Hubbard R, Tattersfield A, Smith C, West J, Smeeth L, Fletcher A. Use of inhaled corticosteroids and the risk of fracture. Chest 2006 130 1082-1088 (Pubitemid 44583738)
9. Lasmar L, Camargos P, Champs N S., Fonseca M T., Fontes M J., Ibiapina C, Alvim C, Moura J A. Adherence rate to inhaled corticosteroids and their impact on asthma control. Allergy 2009 64 784-789
10. Rachelefsky G. Inhaled corticosteroids and asthma control in children: assessing impairment and risk. Pediatrics 2009 123 353-366
11. Nandakumar V, Singh T, Katiyar S K. Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Lett 2008 269 378-387
12. Ariga T. The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors 2004 21 197-201 (Pubitemid 40921854)
13. Bagchi D, Bagchi M, Stohs S J., Das D K., Ray S D., Kuszynski C A., Joshi S S., Pruess H G. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 2000 148 187-197 (Pubitemid 30621359)
14. Fine A M. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 2000 5 144-151 (Pubitemid 30226470)
15. Du Q, Chen Z, Zhou L F., Zhang Q, Huang M, Yin K S. Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma. Can J Physiol Pharmacol 2008 86 449-457 (Pubitemid 351948684)
16. Lee J J., Dimina D, Macias M P., Ochkur S I., McGarry M P., O'Neill K R., Protheroe C, Pero R, Nguyen T, Cormier S A., Lenkiewicz E, Colbert D, Rinaldi L, Ackerman S J., Irvin C G., Lee N A. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004 305 1773-1776 (Pubitemid 39249644)
17. Lee M Y., Ahn K S., Kwon O K., Kim M J., Kim M K., Lee I Y., Oh S R., Lee H K. Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model. Immunobiology 2007 212 647-654
18. Steudel W, Watanabe M, Dikranian K, Jacobson M, Jones R C. Expression of nitric oxide synthase isoforms (NOS II and NOS III) in adult rat lung in hyperoxic pulmonary hypertension. Cell Tissue Res 1999 295 317-329 (Pubitemid 29050264)
19. Miller M, Cho J Y., McElwain K, McElwain S, Shim J Y., Manni M, Baek J S., Broide D H. Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice. Am J Physiol Lung Cell Mol Physiol 2006 290 L162-L169
20. Katiyar S K. Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system. Mol Nutr Food Res 2008 52 (Suppl.1) S71-S76
21. Medoff B D., Thomas S Y., Luster A D. T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol 2008 26 205-232 (Pubitemid 351600375)
22. Lee S H., Choi S M., Sohn Y S., Kang K K., Yoo M. Effect of Oryza sativa extract on the progression of airway inflammation and remodeling in an experimental animal model of asthma. Planta Med 2006 72 405-410
23. Yang G, Volk A, Petley T, Emmell E, Giles-Komar J, Shang X, Li J, Das A M., Shealy D, Griswold D E., Li L. Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling. Cytokine 2004 28 224-232 (Pubitemid 39573497)
24. Moser R, Fehr J, Bruijnzeel P L. IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals. J Immunol 1992 149 1432-1438
25. Schleimer R P., Sterbinsky S A., Kaiser J, Bickel C A., Klunk D A., Tomioka K, Newman W, Luscinskas F W., Gimbrone Jr M A., McIntyre B W., Bochner B S. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol 1992 148 1086-1092
26. Sen C K., Bagchi D. Regulation of inducible adhesion molecule expression in human endothelial cells by grape seed proanthocyanidin extract. Mol Cell Biochem 2001 216 1-7 (Pubitemid 32142221)
27. Ma L, Gao H Q., Li B Y., Ma Y B., You B A., Zhang F L. Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation end products through activation of peroxisome proliferators-activated receptor gamma. J Cardiovasc Pharmacol 2007 49 293-298 (Pubitemid 46855123)
28. Barnes P J., Belvisi M G. Nitric oxide and lung disease. Thorax 1993 48 1034-1043 (Pubitemid 23319631)
29. Gaston B, Drazen J M., Loscalzo J, Stamler J S. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994 149 538-551 (Pubitemid 24069009)
30. Moon D O., Kim M O., Lee H J., Choi Y H., Park Y M., Heo M S., Kim G Y. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem Biophys Res Commun 2008 375 275-279
31. Hesslinger C, Strub A, Boer R, Ulrich W R., Lehner M D., Braun C. Inhibition of inducible nitric oxide synthase in respiratory diseases. Biochem Soc Trans 2009 37 886-891
32. Prado C M., Leick-Maldonado E A., Yano L, Leme A S., Capelozzi V L., Martins M A., Tibério I F. Effects of nitric oxide synthases in chronic allergic airway inflammation and remodeling. Am J Respir Cell Mol Biol 2006 35 457-465 (Pubitemid 44479728)
33. Houde V, Grenier D, Chandad F. Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens. J Periodontol 2006 77 1371-1379 (Pubitemid 44740593)
34. Bentivegna S S., Whitney K M. Subchronic 3-month oral toxicity study of grape seed and grape skin extracts. Food Chem Toxicol 2002 40 1731-1743 (Pubitemid 35284143)
35. Yamakoshi J, Saito M, Kataoka S, Kikuchi M. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chem Toxicol 2002 40 599-607 (Pubitemid 34310425)
36. Shao Z H., Vanden Hoek T L., Xie J, Wojcik K, Chan K C., Li C Q., Hamann K, Qin Y, Schumacker P T., Becker L B., Yuan C S. Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes. Cardiovasc Toxicol 2003 3 331-339 (Pubitemid 38056000)