Strategies for the discovery and development of anti-diabetic drugs from the natural products of traditional medicines

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 16, Issue 2, 2013, Pages 207-216

  Chan, Stanley M H ^a   Ye, Ji Ming ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALBIFLORIN; ANTIDIABETIC AGENT; GLITAZONE DERIVATIVE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; METFORMIN; NATURAL PRODUCT; OXYMATRINE; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ANTIDIABETIC ACTIVITY; CHINESE MEDICINE; COMPUTER AIDED DESIGN; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; FLUID RETENTION; GENE EXPRESSION PROFILING; GLUCOSE TRANSPORT; HEART FAILURE; HUMAN; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID STORAGE; MOLECULARLY TARGETED THERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; REVIEW; SIDE EFFECT; TRADITIONAL MEDICINE; WEIGHT GAIN;

EID: 84878182322     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3t60g     Document Type: Review

References (50)

1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414(6865):782-7.
2. Moller DE. New drug targets for type 2 diabetes and the metabolic syndrome. Nature. 2001 Dec 13;414(6865):821-7.PubMed PMID: 11742415. Epub 2001/12/14. eng.
3. Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, et al. Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes. 2009 Mar;58(3):550-8. PubMed PMID: 19073774. Pubmed Central PMCID: 2646053.
4. Smyth S, Heron A. Diabetes and obesity: the twin epidemics. Nat Med. 2006 Jan;12(1):75-80. PubMed PMID: 16397575.
5. Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol. 2007 Jul;3(7):360-6. PubMed PMID: 17576417. Epub 2007/06/20. Eng
6. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 2005 Mar;4(3):206-20. PubMed PMID: 15729362. Epub 2005/02/25. eng.
7. Jiang H, Wu J, Zhang L, Liang W, Gao F, Du C, et al. Chemical biology in China takes on signal transduction. Nat Chem Biol. 2008 Sep;4(9):515-8. PubMed PMID: 18711374. Epub 2008/08/20. eng.
8. Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007 Sep 7;130(5):769-74. PubMed PMID: 17803898. Pubmed Central PMCID: 2507744. Epub 2007/09/07. eng.
9. Swinney DC, Anthony J. How were new medicines discovered? Nat Rev Drug Discov. 2011 Jul;10(7):507-19. PubMed PMID: 21701501. Epub 2011/06/28. eng.
10. Munos B. Lessons from 60 years of pharmaceutical innovation. Nat Rev Drug Discov. 2009 Dec;8(12):959-68. PubMed PMID: 19949401. Epub 2009/12/02. eng.
11. Flordellis CS, Manolis AS, Paris H, Karabinis A. Rethinking target discovery in polygenic diseases. Curr Top Med Chem. 2006;6(16):1791-8. PubMed PMID: 17017957. Epub 2006/10/05. eng.
12. Williams M. Systems and integrative biology as alternative guises for pharmacology: prime time for an iPharm concept? Biochem Pharmacol. 2005 Dec 5;70(12):1707-16. PubMed PMID: 16198319. Epub 2005/10/04. eng.
13. Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, et al. Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. PubMed PMID: 19255428. Pubmed Central PMCID: 2649954. Epub 2009/03/04. eng.
14. Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes. 2008 May;57(5):1414-8. PubMed PMID: 18285556.
15. Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol. 2008 Mar;15(3):263-73. PubMed PMID: 18355726. Epub 2008/03/22. eng.
16. Qiu BY, Turner N, Li YY, Gu M, Huang MW, Wu F, et al. High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Diabetes. 2010 Jan;59(1):256-65. PubMed PMID: 19833880. Pubmed Central PMCID: 2797930.
17. Zeng XY, Zhou X, Xu J, Chan SM, Xue CL, Molero JC, et al. Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds. Biochem Pharmacol. 2012 Sep 15;84(6):830-7. PubMed PMID: 22820245. Epub 2012/07/24. eng.
18. Govers R, Coster AC, James DE. Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway. Mol Cell Biol. 2004 Jul;24(14):6456-66. PubMed PMID: 15226445. Pubmed Central PMCID: 434240. Epub 2004/07/01. eng.
19. Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab. 2007 Apr;5(4):237-52. PubMed PMID: 17403369. Epub 2007/04/04. eng.
20. Sridhar MG, Vinayagamoorthi R, Arul S.V, Bobby Z, Selvaraj N. Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr. 2008 Apr;99(4):806-12. PubMed PMID: 17942003. Epub 2007/10/19. eng.
21. Tsai CH, Chen EC, Tsay HS, Huang CJ. Wild bitter gourd improves metabolic syndrome: a preliminary dietary supplementation trial. Nutr J. 2012;11:4. PubMed PMID: 22243626. Pubmed Central PMCID: 3311063. Epub 2012/01/17. eng.
22. Iseli TJ, Turner N, Zeng XY, Cooney GJ, Kraegen EW, Yao S, et al. Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKbeta. PLoS One. 2013;8(4):e62309. PubMed PMID: 23638033. Pubmed Central PMCID: 3636144.
23. Zhang Y, Li Y, Guo YW, Jiang HL, Shen X. A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases. Acta pharmacologica Sinica. 2009 Mar;30(3):333-45. PubMed PMID: 19262557.
24. Li Y, Tran VH, Duke CC, Roufogalis BD. Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes. Planta medica. 2012 Sep;78(14):1549-55. PubMed PMID: 22828920.
25. Liu F, Dallas-Yang Q, Castriota G, Fischer P, Santini F, Ferrer M, et al. Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization. Biochem J. 2009 Mar 1;418(2):413-20. PubMed PMID: 19035854.
26. Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet. 2010 Jun 26;375(9733):2267-77. PubMed PMID: 20609972. Pubmed Central PMCID: 2995547. Epub 2010/07/09. eng.
27. Zeng XY, Wang YP, Cantley J, Iseli TJ, Molero JC, Hegarty BD, et al. Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice. PLoS One. 2012;7(7):e42115. PubMed PMID: 22860063. Pubmed Central PMCID: 3408432. Epub 2012/08/04. eng.214
28. Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, et al. IRS1-independent defects define major nodes of insulin resistance. Cell Metab. 2008 May;7(5):421-33. PubMed PMID: 18460333. Pubmed Central PMCID: 2443409. Epub 2008/05/08. eng.
29. Sampson ER, McMurray HR, Hassane DC, Newman L, Salzman P, Jordan CT, et al. Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery. Oncogene. 2012 Sep 10. PubMed PMID: 22964631. Epub 2012/09/12. Eng.
30. Jayaraman S, Patel A, Jayaraman A, Patel V, Holterman M, Prabhakar B. Transcriptome analysis of epigenetically modulated genome indicates signature genes in manifestation of type 1 diabetes and its prevention in NOD mice. PLoS One. 2013;8(1):e55074. PubMed PMID: 23383062. Pubmed Central PMCID: 3559426. Epub 2013/02/06. eng.
31. Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, et al. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med. 2011 Aug 17;3(96):96ra77. PubMed PMID: 21849665. Pubmed Central PMCID: 3502016. Epub 2011/08/19. eng.
32. Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, et al. Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med. 2011 Aug 17;3(96):96ra76. PubMed PMID: 21849664. Pubmed Central PMCID: 3479650. Epub 2011/08/19. eng.
33. Zhang A, Sun H, Wang P, Han Y, Wang X. Future perspectives of personalized medicine in traditional Chinese medicine: a systems biology approach. Complement Ther Med. 2012 Feb-Apr;20(1-2):93-9. PubMed PMID: 22305254. Epub 2012/02/07. eng.
34. Brennan AM, Mantzoros CS. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2006 Jun;2(6):318-27. PubMed PMID: 16932309. Epub 2006/08/26. eng.
35. Coleman DL, Hummel KP. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia. 1973 Aug;9(4):287-93. PubMed PMID: 4588246. Epub 1973/08/01. eng.
36. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1995 Dec;1(12):1311-4. PubMed PMID: 7489415. Epub 1995/12/01. eng.
37. Chen G, Lai X, Jiang Q, Chen F, Chen N, Huang H, et al. Cardiovascular disease (CVD) risk, insulin resistance and beta-cell function in prehypertension population of China. Atherosclerosis. 2011 Jul;217(1):279-85. PubMed PMID: 21501840. Epub 2011/04/20. eng.
38. Kobayashi K, Forte TM, Taniguchi S, Ishida BY, Oka K, Chan L. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism. 2000 Jan;49(1):22-31. PubMed PMID: 10647060. Epub 2000/01/26. eng.
39. Sacca R, Engle SJ, Qin W, Stock JL, McNeish JD. Genetically engineered mouse models in drug discovery research. Methods Mol Biol. 2010;602:37-54. PubMed PMID: 20012391. Epub 2009/12/17. eng.
40. Maffei M, Stoffel M, Barone M, Moon B, Dammerman M, Ravussin E, et al. Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes. 1996 May;45(5):679-82. PubMed PMID: 8621022. Epub 1996/05/01. eng.
41. Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, Concannon P. Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs. Diabetes. 1995 Aug;44(8):999-1001. PubMed PMID: 7622007. Epub 1995/08/01. eng.
42. Park SY, Cho YR, Kim HJ, Higashimori T, Danton C, Lee MK, et al. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes. 2005 Dec;54(12):3530-40. PubMed PMID: 16306372. Epub 2005/11/25. eng.
43. Ye JM, Iglesias MA, Watson DG, Ellis B, Wood L, Jensen PB, et al. PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly. Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E531-40. PubMed PMID: 12556350. Epub 2003/01/31. eng.
44. Chalkley SM, Hettiarachchi M, Chisholm DJ, Kraegen EW. Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats. Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1231-8. PubMed PMID: 12006352. Epub 2002/05/15. eng.
45. Mu J, Woods J, Zhou YP, Roy RS, Li Z, Zycband E, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes. 2006 Jun;55(6):1695-704. PubMed PMID: 16731832.
46. Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012 Mar 2;148(5):852-71. PubMed PMID: 22385956. Pubmed Central PMCID: 3294420. Epub 2012/03/06. eng.
47. Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev. 2007 Apr;87(2):507-20. PubMed PMID: 17429039. Epub 2007/04/13. eng.
48. Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep;118(9):2992-3002. PubMed PMID: 18769626. Pubmed Central PMCID: 2522344.Epub 2008/09/05. eng.
49. Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, et al. Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. PubMed PMID: 19805130. Pubmed Central PMCID: 2764908. Epub 2009/10/07. eng.
50. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 2006 Aug;55(8):2256-64. PubMed PMID: 16873688. Epub 2006/07/29. eng.