Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways

Oncology Reports

Volumn 30, Issue 1, 2013, Pages 292-298

  Gao, Jian Li ^a,b   Lv, Gui Yuan ^a   He, Bai Cheng ^b,c   Zhang, Bing Qiang ^b,c   Zhang, Hongyu ^b,c   Wang, Ning ^b,d   Wang, Chong Zhi ^e   Du, Wei ^e,f   Yuan, Chun Su ^e   He, Tong Chuan ^b,c,e  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^c CHONGQING MEDICAL UNIVERSITY   (China)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF CHICAGO   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

Author keywords

20(S) protopanaxadiol; Colorectal cancer; Ginseng; Ginseng metabolites; Natural products; Signaling pathway

Indexed keywords

CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; GINSENG SAPONIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA; PROTOPANAXADIOL; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METABOLITE; MULTIPLE CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HETEROGRAFTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NF-KAPPA B; NUCLEAR PROTEINS; PANAX; PHOSPHOLIPID TRANSFER PROTEINS; PLANT EXTRACTS; SAPOGENINS; SIGNAL TRANSDUCTION;

EID: 84878179067     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2438     Document Type: Article

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