Synthesis and cytotoxic activities of new fatty acid esters of 20(S)-protopanaxadiol

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 66 C, Issue 5-6, 2011, Pages 199-204

  Li, Ning ^a,b   Huang, Yuan ^a   Xiao, Wan ^a   Liu, Jinping ^b   Li, Xian ^a   Li, Pingya ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

Cytotoxic Activities; Protopanaxadiol; Structure Activity Relationships

Indexed keywords

EID: 79959619034     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2011-5-601     Document Type: Article

References (12)

1. Akao T. (1992), Metabolic activation of crude drug components by intestinal bacterial enzymes. J. Med. Pharm. Soc. 9, 1-13.
2. Chen X., Zhou Q. L., and Wang B. X. (1999), The metabolism of ginsenoside Rb1 by intestinal bacteria. Acta Pharm. Sin. 34, 410-414.
3. Cui J. F., Byström S., Eneroth P., and Bjoerkhem I. (1994), Novel mechanism for oxidative cleavage of glycosidic bonds: evidence for an oxygen dependent reaction. J. Org. Chem. 59, 8251-8255.
4. Gao L. S., Li N., and Li X. (2007), Alkaline-degradation products of total ginsenosides from leaves and stems of Panax quinquefolium L. J. Shenyang Pharm. Univ. 27, 552-555.
5. Hasegawa H. (2004), Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J. Pharmacol. Sci. 95, 153-157.
6. Hasegawa H., Suzuki R., and Nagaoka T. (2002), Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol. Pharm. Bull. 25, 861-866.
7. Huang Y., Li N., Li X., Gao L. S., and Meng D. L. (2008), New dammarane type triterpene with cyclization at the side chain from oxidative alkaline-degradation products of PQS. Acta Pharm. Sin. 43, 277-280.
8. Hui Y. Z., Liu J. H., Yang Z. Q., Teng J. J., Xie H. Q., and Zhang J. (2005), The preparative methods of protopanaxadiol and protopanaxatriol. CN Patent 200410018038. 8 [P].
9. Jin W. R., Shi Q., Hong C. T., Cheng Y. Y., Ma Z. J., and Qu H. B. (2008), Cytotoxic properties of thiophenes from Echinops grijissi Hance. Phytomedicine 15, 768-774.
10. Li N., Gao L. S., Huang Y., and Li X. (2008), Two new oleoylated 20(S)-protopanaxadiol derivatives. Chin. J. Med. Chem. 18, 60.
11. Wang Y., Liu T. H., Wang W., and Wang B. X. (2001), Research on the transformation of ginsenoside Rg1 by intestinal flora. China J. Chin. Materia Medica 26, 188-189.
12. Zhang W. Y., Zheng Y. N., and Chen Q. C. (2005), Progress in the research of activity of antitumour of ginsenoside metabolite M1 and its fatty acid ester EM1. Renshen Yanjiu 2, 10-16.