Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 21, 2013, Pages 8656-8661

  Alazawi, William ^a   Heath, Helen ^a   Waters, Jennifer A ^a   Woodfin, Abigail ^a   O'Brien, Alastair J ^b   Scarzello, Anthony J ^c   Ma, Bin ^a   Lopez Otalora, Yolanda ^d   Jacobs, Michael ^b   Petts, Gemma ^e   Goldin, Robert D ^e   Nourshargh, Sussan ^a   Gamero, Ana M ^d   Foster, Graham R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

^d TEMPLE UNIVERSITY   (United States)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; STAT2 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE STORM; FEMALE; GENOTYPE; HEPATITIS; LETHALITY; MALE; MORTALITY; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; SEPSIS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; CYTOKINES; GENE EXPRESSION REGULATION; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; NF-KAPPA B; SEPSIS; STAT2 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTORS;

EID: 84878156394     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221652110     Document Type: Article

References (42)

1. Cohen J (2002) The immunopathogenesis of sepsis. Nature 420(6917): 885-891.
2. Namas R, et al. (2012) Sepsis: Something old, something new, and a systems view. J Crit Care 27(3):314.e1-314.e11.
3. Salomao R, et al. (2012) Bacterial sensing, cell signaling, and modulation of the immune response during sepsis. Shock 38(3): 227-242.
4. Remick DG, et al. (1990) Role of tumor necrosis factor-alpha in lipopolysaccharideinduced pathologic alterations. Am J Pathol 136(1): 49-60.
5. Thiemermann C, Vane J (1990) Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol 182(3): 591-595.
6. Hoshino K, et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162(7): 3749-3752.
7. Nagai Y, et al. (2002) Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 3(7): 667-672.
8. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S (1999) Unresponsiveness of MyD88- deficient mice to endotoxin. Immunity 11(1): 115-122.
9. Wiersinga WJ (2011) Current insights in sepsis: From pathogenesis to new treatment targets. Curr Opin Crit Care 17(5): 480-486.
10. Zhang S-Y, et al. (2007) Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses. Immunol Rev 220(1): 225-236.
11. Karaghiosoff M, et al. (2003) Central role for type I interferons and Tyk2 in lipopolysaccharide- induced endotoxin shock. Nat Immunol 4(5): 471-477.
12. Darnell JE, Jr., Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264(5164): 1415-1421.
13. Maher SG, Romero-Weaver AL, Scarzello AJ, Gamero AM (2007) Interferon: Cellular executioner or white knight? Curr Med Chem 14(12): 1279-1289.
14. Leung S, Qureshi SA, Kerr IM, Darnell JE, Jr., Stark GR (1995) Role of STAT2 in the alpha interferon signaling pathway. Mol Cell Biol 15(3): 1312-1317.
15. Hahm B, Trifilo MJ, Zuniga EI, Oldstone MBA (2005) Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity 22(2): 247-257.
16. Jones M, et al. (2005) Dengue virus inhibits α interferon signaling by reducing STAT2 expression. J Virol 79(9): 5414-5420.
17. Ramachandran A, Parisien J-P, Horvath CM (2008) STAT2 is a primary target for measles virus V protein-mediated α/β interferon signaling inhibition. J Virol 82(17): 8330-8338.
18. Nguyen VA, Gao B (2002) Expression of interferon alfa signaling components in human alcoholic liver disease. Hepatology 35(2): 425-432.
19. Mudter J, et al. (2005) Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. Am J Gastroenterol 100(1): 64-72.
20. Dellinger RP (2003) Cardiovascular management of septic shock. Crit Care Med 31(3): 946-955.
21. Angus DC, et al. (2001) Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 29(7): 1303-1310.
22. Thompson RD, et al. (2001) Platelet-endothelial cell adhesion molecule-1 (PECAM-1)- deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane. Blood 97(6): 1854-1860.
23. Kumasaka T, et al. (1996) Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice. J Clin Invest 97(10): 2362-2369.
24. Mahieu T, Libert C (2007) Should we inhibit type I interferons in sepsis? Infect Immun 75(1): 22-29.
25. Zhao W, Cha EN, Lee C, Park CY, Schindler C (2007) Stat2-dependent regulation of MHC class II expression. J Immunol 179(1): 463-471.
26. Sheehan KC, et al. (2006) Blocking monoclonal antibodies specific for mouse IFN-alpha/ beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection. J Interferon Cytokine Res 26(11): 804-819.
27. Génin P, Algarté M, Roof P, Lin R, Hiscott J (2000) Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors. J Immunol 164(10): 5352-5361.
28. Solt LA, May MJ (2008) The IkappaB kinase complex: Master regulator of NF-kappaB signaling. Immunol Res 42(1-3): 3-18.
29. Freudenberg MA, Salômao R, Sing A, Mitov I, Galanos C (1998) Reconciling the concepts of endotoxin sensitization and tolerance. Prog Clin Biol Res 397: 261-268.
30. Ghosn EEB, et al. (2010) Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc Natl Acad Sci USA 107(6): 2568-2573.
31. Henderson RB, Hobbs JAR, Mathies M, Hogg N (2003) Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102(1): 328-335.
32. Schuhmann KM, Pfaller CK, Conzelmann KK (2011) The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity. J Virol 85(7): 3162-3171.
33. Baltimore D (2011) NF-κB is 25. Nat Immunol 12(8): 683-685.
34. Ashall L, et al. (2009) Pulsatile stimulation determines timing and specificity of NFkappaB- dependent transcription. Science 324(5924): 242-246.
35. Covert MW, Leung TH, Gaston JE, Baltimore D (2005) Achieving stability of lipopolysaccharide- induced NF-kappaB activation. Science 309(5742): 1854-1857.
36. Bergmann M, Hart L, Lindsay M, Barnes PJ, Newton R (1998) IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathway. J Biol Chem 273(12): 6607-6610.
37. Zerfaoui M, et al. (2010) Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. J Immunol 185(3): 1894-1902.
38. Bhattacharya S, et al. (1996) Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature 383(6598): 344-347.
39. Mansell A, et al. (2006) Suppressor of cytokine signaling 1 negatively regulates Tolllike receptor signaling by mediating Mal degradation. Nat Immunol 7(2): 148-155.
40. Morrow AN, Schmeisser H, Tsuno T, Zoon KC (2011) A novel role for IFN-stimulated gene factor 3II in IFN-γ signaling and induction of antiviral activity in human cells. J Immunol 186(3): 1685-1693.
41. Müller U, et al. (1994) Functional role of type I and type II interferons in antiviral defense. Science 264(5167): 1918-1921.
42. Woodfin A, Voisin MB, Nourshargh S (2007) PECAM-1: A multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol 27(12): 2514-2523.