Activation of ERM-family proteins via RhoA-ROCK signaling increases intestinal P-gp expression and leads to attenuation of oral morphine analgesia

Journal of Pharmaceutical Sciences

Volumn 102, Issue 3, 2013, Pages 1095-1105

  Kobori, Takuro ^a   Harada, Shinichi ^a   Nakamoto, Kazuo ^a   Tokuyama, Shogo ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

ABC transporters; Drug interactions; Efflux pumpus; Ileum; Intestinal epithelia; Membrane translocation; P glycoprotein

Indexed keywords

ETOPOSIDE; EZRIN; FASUDIL; MOESIN; MORPHINE; MULTIDRUG RESISTANCE PROTEIN; PROTEIN SERINE THREONINE KINASE; RADIXIN; RHO ASSOCIATED COILED COIL CONTAINING KINASE; RHO KINASE; ROSUVASTATIN; UNCLASSIFIED DRUG;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CYTOSOLIC FRACTION; ILEUM; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

EID: 84878126933     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23441     Document Type: Article

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