RhoA/Rho kinase signaling in the spinal cord and diabetic painful neuropathy

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 1-4

  Ohsawa, Masahiro ^a   Kamei, Junzo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Diabetes mellitus; Neuron; Neuropathic pain; RhoA; Spinal cord

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; DIABETES MELLITUS; DIABETIC NEUROPATHY; ENZYME ACTIVATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPINAL CORD FUNCTION;

ANIMALS; DIABETIC NEPHROPATHIES; HUMANS; HYPERALGESIA; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 77955770157     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.07.007     Document Type: Article

References (50)

1. Behse F., Buchthal F., Carlsen F. Nerve biopsy and conduction studies in diabetic neuropathy. J. Neurol. Neurosurg. Psychiatry 1977, 40:1072-1082.
2. Billuart P., Winter C.G., Maresh A., Zhao X., Liqun L. Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway. Cell 2001, 107:195-207.
3. Brown M.J., Asbury A.K. Diabetic neuropathy. Ann. Neurol. 1984, 15:2-12.
4. Büyükafşar K., Yalçin I., Kurt A.H., Tiftik R.N., Sahan-Firat S., Aksu F. Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice. Eur. J. Pharmacol. 2006, 541:49-52.
5. Calcutt N.A., Li L., Yaksh T.L., Malmberg A.B. Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. Eur. J. Pharmacol. 1995, 285:189-197.
6. Chang J., Xie M., Shah V.R., Schneider M.D., Entman M.L., Wei L., Schwartz R.J. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc. Natl. Acad. Sci. USA 2006, 103:14495-14500.
7. Comelli F., Bettoni I., Colombo A., Fumagalli P., Giagnoni G., Costa B. Rimonabant, a cannabinoid CB1 receptor antagonist, attenuates mechanical allodynia and counteracts oxidative stress and nerve growth factor deficit in diabetic mice. Eur. J. Pharmacol. 2010, 637:62-69.
8. Danesh F.R., Sadeghi M.M., Amro N., Philips C., Zeng L., Lin S., Sahai A., Kanwar Y.S. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy. Proc. Natl. Acad. Sci. USA 2002, 99:8301-8305.
9. Dickinson P.J., Carrington A.L., Frost G.S., Boulton A.J. Neurovascular disease, antioxidants and glycation in diabetes. Diabetes Metab. Res. Rev. 2002, 18:260-272.
10. Fleming I.N., Elliot C.M., Exton J.H. Differential translocation of Rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor. J. Biol. Chem. 1996, 271:33067-33073.
11. Freshwater J.D., Svensson C.I., Malmberg A.B., Calcutt N.A. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Diabetes 2002, 51:2249-2255.
12. Goalstone M., Kamath V., Kowluru A. Glucose activates prenyltransferases in pancreatic islet beta-cells. Biochem. Biophys. Res. Commun. 2010, 391:895-898.
13. Gojo A., Utsunomiya K., Taniguchi K., Yokota T., Ishizawa S., Kanazawa Y., Kurata H., Tajima N. The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2007, 568:242-247.
14. Gong M.C., Fugihara H., Somlyo A.V., Somlyo A.P. Translocation of rhoA associated with Ca2+ sensitization of smooth muscle. J. Biol. Chem. 1997, 272:10704-10709.
15. Inoue M., Rashid M.H., Fujita R., Contos J.J., Chun J., Ueda H. Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat. Med. 2004, 10:712-718.
16. Kamei J., Ogawa M., Kasuya Y. Development of supersensitivity to substance P in the spinal cord of the streptozotocin-induced diabetic rats. Pharmacol. BiochemBehav. 1990, 35:473-475.
17. Kamei J., Ogawa Y., Ohhashi Y., Kasuya Y. Alterations in the potassium-evoked release of substance P from the spinal cord of streptozotocin-induced diabetic rats in vitro. Gen. Pharmacol. 1991, 22:1093-1096.
18. Kamei J., Hitosugi H., Kasuya Y. Effects of mexiletine on formalin-induced nociceptive responses in mice. Res. Commun. Chem. Pathol. Pharmacol. 1993, 80:153-162.
19. Kanda T., Wakino S., Homma K., Yoshioka K., Tatematsu S., Hasegawa K., Takamatsu I., Sugano N., Hayashi K., Saruta T. Rho-kinase as a molecular target for insulin resistance and hypertension. FASEB J. 2006, 20:169-171.
20. Kawamura H., Yokote K., Asaumi S., Kobayashi K., Fujimoto M., Maezawa Y., Saito Y., Mori S. High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 2004, 24:276-281.
21. Kolavennu V., Zeng L., Peng H., Wang Y., Danesh F.R. Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control. Diabetes 2008, 57:714-723.
22. Lee T.S., Saltsman K.A., Ohashi H., King G.L. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications. Proc. Natl Acad. Sci. USA 1989, 86:5141-5145.
23. Massey A.R., Miao L., Smith B.N., Liu J., Kusaka I., Zhang J.H., Tang J. Increased RhoA translocation in renal cortex of diabetic rats. Life Sci. 2003, 72:2943-2952.
24. Mehta D., Rahman A., Malik A.B. Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J. Biol. Chem. 2001, 276:22614-22620.
25. Miao L., Calvert J.W., Tang J., Zhang J.H. Upregulation of small GTPase RhoA in the basilar artery from diabetic (mellitus) rats. Life Sci. 2002, 71:1175-1185.
26. Moomaw J., Casey P. Mammalian protein geranylgeranyltransferase: subunit composition and metal requirements. J. Biol. Chem. 1992, 267:17438-17443.
27. Mustafa S., Vasudevan H., Yuen V.G., McNeill J.H. Renal expression of arachidonic acid metabolizing enzymes and RhoA/Rho kinases in fructose insulin resistant hypertensive rats. Mol. Cell. Biochem. 2010, 333:203-209.
28. Naik J.S., Xiang L., Hester R.L. Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R154-R161.
29. Nakamura J., Koh N., Sakakibara F., Hamada Y., Hara T., Sasaki H., Chaya S., Komori T., Nakashima E., Naruse K., Kato K., Takeuchi N., Kasuya Y., Hotta N. Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats. J. Pharmacol. Exp. Ther. 1998, 287:897-902.
30. Nakayama A.Y., Harms M.B., Luo L. Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons. J. Neurosci. 2000, 20:5329-5338.
31. Nobes C.D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62.
32. Ohsawa M., Kamei J. Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice. Eur. J. Pharmacol. 1999, 372:221-228.
33. Ohsawa M., Mutoh J., Hisa H. Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord. Pain 2008, 134:285-292.
34. Peng F., Wu D., Gao B., Ingram A.J., Zhang B., Chorneyko K., McKenzie R., Krepinsky J.C. RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease. Diabetes 2008, 57:1683-1692.
35. Ramer L.M., Borisoff J.F., Ramer M.S. Rho-kinase inhibition enhances axonal plasticity and attenuates cold hyperalgesia after dorsal rhizotomy. J. Neurosci. 2004, 24:10796-10805.
36. Ramos K.M., Jiang Y., Svensson C.I., Calcutt N.A. Pathogenesis of spinally mediated hyperalgesia in diabetes. Diabetes 2007, 56:1569-1576.
37. Sauzeau V., Jeune H.L., Cario-Toumaniantz C., Smolenski A., Lohmann S.M., Chardin P., Pacaud P., Loirand G. Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J. Biol. Chem. 2000, 275:21722-21727.
38. Sawada N., Itoh H., Yamashita J., Doi K., Inoue M., Masatsugu K., Fukunaga Y., Sakaguchi S., Sone M., Yamahara K., Yurugi T., Nakao K. cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem. Biophys. Res. Commun. 2001, 280:798-805.
39. Scholz J., Woolf C.J. Can we conquer pain?. Nat. Neurosci. 2002, 5:1062-1067.
40. Schreibelt G., Kooij G., Reijerkerk A., van Doorn R., Gringhuis S.I., van der Pol S., Weksler B.B., Romero I.A., Couraud P.O., Piontek J., Blasig I.E., Dijkstra C.D., Ronken E., de Vries H.E. Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J. 2007, 21:3666-3676.
41. Takai Y., Sasali T., Matozaki T. Small GTP-binding proteins. Physiol. Rev. 2001, 81:153-208.
42. Tatsumi S., Mabuchi T., Katano T., Matsumura S., Abe T., Hidaka H., Suzuki M., Sasaki Y., Minami T., Ito S. Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS). Neuroscience 2005, 131:491-498.
43. The DCCT Research Group The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J. Med. 1993, 329:977-986.
44. Threadgill R., Bobb K., Ghosh A. Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42. Neuron 1997, 19:625-634.
45. Vicent D., Maratos-Flier E., Kahn C.R. The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. Mol. Cell. Biol. 2000, 20:2158-2166.
46. Vinik A.I., Park T.S., Stansberry K.B., Pittenger G.L. Diabetic neuropathies. Diabetologia 2000, 43:957-973.
47. Wang H.G., Lu F.M., Jin I., Udo H., Kandel E.R., De vente J., Walter U., Lohmann S.M., Hawkins R.D., Antonova I. Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins. Neuron 2005, 45:389-403.
48. Whiteside C.I. Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species. Curr. Hypertens. Rep. 2005, 7:148-154.
49. Woolf C.J., Salter M.W. Neuronal plasticity: increasing the gain in pain. Science 2000, 288:1765-1769.
50. Xie Z., Su W., Guo Z., Pang H., Post S.R., Gong M.C. Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells. Cardiovasc. Res. 2006, 69:491-501.