Investigations on polyplex stability during the freezing step of lyophilization using controlled ice nucleation-the importance of residence time in the low-viscosity fluid state

Journal of Pharmaceutical Sciences

Volumn 102, Issue 3, 2013, Pages 929-946

  Kasper, Julia C ^a   Pikal, Michael J ^b   Friess, Wolfgang ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Cryoprotection; Freezing; Freezing drying; Lyophilization; Nanoparticles; Non viral gene delivery; Stabilization; Viscosity

Indexed keywords

HISTIDINE; ICE; POLYETHYLENEIMINE; SUCROSE;

ARTICLE; ATMOSPHERIC PRESSURE; CRYOPROTECTION; DIFFUSION COEFFICIENT; DRUG STABILITY; FREEZE DRYING; FREEZE THAWING; FREEZING; GENE TARGETING; GLASS TRANSITION TEMPERATURE; HEAT TRANSFER; LIQUID; MEAN RESIDENCE TIME; MOISTURE; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; VISCOSITY;

EID: 84878125146     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23419     Document Type: Article

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