The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core

Journal of Structural Biology

Volumn 182, Issue 3, 2013, Pages 197-208

  Simone, Peter D ^a   Struble, Lucas R ^b   Kellezi, Admir ^a   Brown, Carrie A ^c   Grabow, Corinn E ^a   Khutsishvili, Irine ^d   Marky, Luis A ^a,b,d   Pavlov, Youri I ^a,b,e   Borgstahl, Gloria E O ^a,b,d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c WAYNE STATE COLLEGE   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

Author keywords

Genomic instability; Hydrophobic surfaces; Inosine triphosphate pyrophosphatase; Nucleotide pool; Protein stability; X ray crystallography

Indexed keywords

INORGANIC PYROPHOSPHATASE; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME STABILITY; ENZYME STRUCTURE; FIBROBLAST; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; THERMOSTABILITY;

CIRCULAR DICHROISM; ERYTHROCYTES; GENOMIC INSTABILITY; HETEROZYGOTE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MUTATION; NUCLEOTIDES; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; PYROPHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878122528     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2013.03.007     Document Type: Article

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