Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans

Journal of Molecular Biology

Volumn 392, Issue 3, 2009, Pages 602-613

  Stepchenkova, Elena I ^a,b   Tarakhovskaya, Elena R ^c   Spitler, Kathryn ^d   Frahm, Christin ^a   Menezes, Miriam R ^a   Simone, Peter D ^a   Kolar, Carol ^a   Marky, Luis A ^a   Borgstahl, Gloria E O ^a   Pavlov, Youri I ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

^c ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^d DRAKE UNIVERSITY   (United States)

Author keywords

base analogs; drug sensitivity; ITPA; nucleotide pools

Indexed keywords

6 N HYDROXYADENINE; INORGANIC PYROPHOSPHATASE; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; PROLINE; PURINE DERIVATIVE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; FIBROBLAST; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MUTANT; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; WILD TYPE;

BACTERIA (MICROORGANISMS);

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DRUG RESISTANCE; ENZYME STABILITY; FIBROBLASTS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PYROPHOSPHATASES;

EID: 69349100176     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.07.051     Document Type: Article

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