ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study of Japanese HCV virus patients

Gastroenterology

Volumn 139, Issue 4, 2010, Pages

  Ochi, Hidenori ^a,b   Maekawa, Toshiro ^a   Abe, Hiromi ^b   Hayashida, Yasufumi ^b   Nakano, Rikita ^c   Kubo, Michaki ^d   Tsunoda, Tatsuhiko ^d   Hayes, C Nelson ^a,b   Kumada, Hiromitsu ^e   Nakamura, Yusuke ^f   Chayama, Kazuaki ^a,b  

^a RIKEN   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^d RIKEN Center for Integrative Medical Sciences   (Japan)

^e TORANOMON HOSPITAL   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hemolysis; Side Effect; SNP

Indexed keywords

HEMOGLOBIN; INORGANIC PYROPHOSPHATASE; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; PEGINTERFERON ALPHA2B; RIBAVIRIN; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; ITPA PROTEIN, HUMAN;

ADULT; ANEMIA; ARTICLE; CHROMOSOME 20P; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; GENE MAPPING; GENE REPLICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE COUNT; AGED; CHEMICALLY INDUCED; GENETICS; MIDDLE AGED; TREATMENT OUTCOME; VIROLOGY;

ADULT; AGED; ANEMIA; ANTIVIRAL AGENTS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HEPATITIS C; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PYROPHOSPHATASES; RIBAVIRIN; TREATMENT OUTCOME;

EID: 77957346513     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.06.071     Document Type: Article

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