Enhanced reconstruction of long bone architecture by a growth factor mutant combining positive features of GDF-5 and BMP-2

Biomaterials

Volumn 34, Issue 24, 2013, Pages 5926-5936

  Kleinschmidt, Kerstin ^a,d   Ploeger, Frank ^b   Nickel, Joachim ^c   Glockenmeier, Julia ^a   Kunz, Pierre ^a   Richter, Wiltrud ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Biopharm GmbH   (Germany)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d Biologics and Immunology e Osteoarthritis   (Germany)

Author keywords

Angiogenesis; Bone mineral density; Bone morphogenetic protein; Growth factor; Invivo micro CT; Osteogenesis

Indexed keywords

ANGIOGENESIS; BONE MINERAL DENSITY; BONE MORPHOGENETIC PROTEINS; GROWTH FACTOR; IN-VIVO MICRO-CT; OSTEOGENESIS;

BINDING ENERGY; COMPUTERIZED TOMOGRAPHY; DEFECTS; STEM CELLS;

BONE;

ALKALINE PHOSPHATASE; ANGIOPOIETIN 1; BETA ACTIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; GROWTH DIFFERENTIATION FACTOR 5; GROWTH FACTOR; MUTANT PROTEIN; PROTEIN BB 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BONE DENSITY; BONE DEVELOPMENT; BONE MASS; BONE REGENERATION; CELL DIFFERENTIATION; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPERIMENTAL RABBIT; FEMALE; FOLLOW UP; FRACTURE HEALING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LONG BONE; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; MICROMORPHOLOGY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RADIUS; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

ADULT; AGED; ALKALINE PHOSPHATASE; ANIMALS; BONE DENSITY; BONE MARROW; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONY CALLUS; CELL DIFFERENTIATION; CELL LINE; ENZYME ACTIVATION; GROWTH DIFFERENTIATION FACTOR 5; HORSES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MIDDLE AGED; MUTANT PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS; PROTEIN BINDING; RABBITS; RADIUS;

EID: 84878104053     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.04.029     Document Type: Article

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