BMP-14 deficiency inhibits long bone fracture healing: A biochemical, histologic, ond radiographic assessment

Journal of Orthopaedic Trauma

Volumn 19, Issue 9, 2005, Pages 629-634

  Chhabra, Anikar ^a   Zijerdi, David ^b   Zhang, Jianxin ^c   Kline, Alex ^d   Balian, Gary ^b   Hurwitz, Shephard ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b GEISINGER MEDICAL CENTER   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

BMP 14; Bone morphogenetic protein; CDMP 1; Fracture healing; GDF 5

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 14; GROWTH DIFFERENTIATION FACTOR 5; PROTEIN; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE RADIOGRAPHY; CELL PROLIFERATION; CHEMICAL ANALYSIS; CHONDROGENESIS; ENCHONDRAL OSSIFICATION; FRACTURE HEALING; HISTOLOGY; INTRAMEDULLARY NAILING; LONG BONE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; QUANTITATIVE ANALYSIS;

ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REMODELING; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; FRACTURE HEALING; GLYCOSAMINOGLYCANS; MICE;

EID: 27744442265     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.bot.0000177108.38461.9c     Document Type: Article

References (26)

1. Trippel SB, Coutts RD, Einhorn TA, et al. Growth factors as therapeutic agents. Instr Course Lect. 1996;78:1272-1286.
2. Bostrom MPG, Lane JM, Berberian WS, et al. Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing. J Orthop Res. 1995;13:357-367.
3. Joyce ME, Jingushi S, Scully SP, et al. Role of growth factors in fracture healing. Prog Clin Biol Res. 1991;365:391-416.
4. Day SM, Ostam RF, Chao EYS, et al. Orthopaedic Basic Science: Bone Injury, Regeneration, and Repair. Rosemont, IL: American Academy of Orthopaedic Surgeons; 2000.
5. Kloen P, Di Paola M, Borens O, et al. BMP signaling components are expressed in human fracture callus. Bone. 2003;33:362-371.
6. Kloen P, Doty SB, Gordon E, et al. Expression and activation of the BMP-signaling components in human fracture nonunions. J Bone Joint Surg Am. 2002;84:1909-1918.
7. Cheng H, Wei J, Phillips FM, et al. Osteogenic activity of the fourteen types of human bone morphogenic proteins (BMPs). J Bone Joint Surg Am. 2003;85:1544-1552.
8. Storm EE, Huynh TV, Copeland NG, et al. Limb alterations in brachypodism mice due to mutations in a new member of the TGF-beta superfamily. Nature. 1994;368:639-643.
9. Grunenberg H, Lee AJ. The anatomy and development of brachypodism in the mouse. J Embryol Exp Morphol. 1973;30:119-141.
10. Landauer W. Brachypodism: a recessive mutation of house mice. J Hered. 1952;43:293-298.
11. Storm EE, Kingsley DM. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development. 1996;122:3969-3979.
12. Francis-West PH, Abdeelfattah A, Chen P, et al. Mechanisms of GDF-5 action during skeletal development. Development. 1999;126:1305-1315.
13. Bak B, Andreassen TT. The effect of aging on fracture healing in the rat. Calcif Tissue Int. 1989;45:292-297.
14. Hiltunen A, Vuorio E, Aro HT. A standardized experimental fracture in the mouse tibia. J Orthop Res. 1993;11:305-312.
15. An Y, Friedman RJ, Parent T, Draughn RA. Production of a standard closed fracture in the rat tibia. J Orthop Trauma. 1994;8:111-115.
16. Bonnarens F, Einhorn TA. Production of a standard closed fracture in laboratory animal bone. J Orthop Res. 1984;2:97-101.
17. Devine MJ. Injected Bone Marrow Cells Localized to Fracture Callus in a Mouse Model. [master's thesis]. Charlottesville, VA: University of Virginia; 1999.
18. Devine MJ, Mierisch CM, Jang E, et al. Transplanted bone marrow cells localize to fracture callus in a mouse model. J Orthop Res. 2002;20:1232-1239.
19. Marino AA, Cullen JM, Reichmanis M, et al. Fracture healing in rats exposed to extremely low frequency electric fields. Clin Orthop. 1979;145:239-244.
20. Markley JT, Heiple KG, Chase SW, et al. The effect of reduced barometric pressure on fracture healing in rats. J Bone Joint Surg Am. 1967;49:903-914.
21. Kim YJ, Sah RL, Doong JY, Grodzinsky AJ. Fluorometric assay of DNA in cartilage expiants using Hoechst 33258. Anal Biochem. 1988;174:168-176.
22. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta. 1986;883:173-177.
23. Creemers LB, Jansen DC, van Veen-Reurings A, et al. Microassay for the assessment of low levels of Hydroxyproline. Biotechniques. 1997;22:656-658.
24. Merino R, Macias D, Ganan Y, et al. Expression and function of GDF-5 during digit skeletogenesis in the embryonic chick leg bud. Dev Biol. 1999;206:33-45.
25. Deckers MM, van Bezooijen RL, van der Horst G, et al. Bone morphogenetic progeins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology. 2002;143:1545-1553.
26. Yamashita H, Shimizu A, Nishitoh H, et al. Growth/differentiation factor-5 induces angiogenesis in vivo. Exp Cell Res. 1997;235:218-226.