The effect of two point mutations in GDF-5 on ectopic bone formation in a β-tricalciumphosphate scaffold

Biomaterials

Volumn 31, Issue 14, 2010, Pages 3878-3884

  Kasten, Philip ^a,b   Beyen, Ingo ^a   Bormann, Dirk ^c   Luginbühl, Reto ^d   Plöger, Frank ^e   Richter, Wiltrud ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c Institute for Material Science   (Germany)

^d Dr Robert Mathys Foundation   (Switzerland)

^e Biopharm GmbH   (Germany)

Author keywords

Beta tricalcium phosphate ceramic; GDF 5; Growth factor; Heterotopic bone formation; Mutation; Osteogenic differentiation

Indexed keywords

2-GROUP; BETA TRICALCIUM PHOSPHATE; BINDING AFFINITIES; BONE AREA; BONE FORMATION; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; ECTOPIC BONES; GROWTH FACTOR; HETEROTOPIC BONE; MICRO CT; OSTEOGENIC DIFFERENTIATION; OSTEOINDUCTIVITY; TWO-POINT; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; BIOACTIVITY; BONE; CERAMIC MATERIALS; COMPUTERIZED TOMOGRAPHY; ORGANIC ACIDS; PEPTIDES;

FACADES;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CALCIUM PHOSPHATE; GROWTH DIFFERENTIATION FACTOR 5; METHIONINE; MOLECULAR SCAFFOLD; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BONE REGENERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE FUNCTION; HETEROTOPIC OSSIFICATION; HISTOLOGY; MUTATIONAL ANALYSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; SCID MOUSE; WILD TYPE;

ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; CALCIUM PHOSPHATES; CHORISTOMA; ENZYME ACTIVATION; GROWTH DIFFERENTIATION FACTOR 5; HUMANS; MICE; MICE, SCID; OSTEOGENESIS; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; TISSUE SCAFFOLDS; X-RAY MICROTOMOGRAPHY;

MUS;

EID: 77649274205     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.01.109     Document Type: Article

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