Growth and differentiation factor-5 (GDF-5) stimulates osteogenic differentiation and increases vascular endothelial growth factor (VEGF) levels in fat-derived stromal cells in vitro

Bone

Volumn 40, Issue 2, 2007, Pages 374-381

  Zeng, Qing ^a   Li, Xudong ^a   Beck, Gina ^a   Balian, Gary ^a   Shen, Francis H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Angiogenic activity of stromal cells; Fat derived stromal cells; GDF 5; Osteogenesis; VEGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; GROWTH DIFFERENTIATION FACTOR 5; MORPHOGEN; VASCULOTROPIN;

ADIPOSE TISSUE CELL; ANGIOGENESIS; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; EXTRACELLULAR MATRIX; FAT DERIVED STROMAL CELL; GENE EXPRESSION PROFILING; MINERALIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN FUNCTION; RAT; STROMA CELL;

ADIPOCYTES; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; MICE; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33846168436     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2006.09.022     Document Type: Article

References (45)

1. Ohgushi H., and Caplan A.I. Stem cell technology and bioceramics: from cell to gene engineering. J. Biomed. Mater. Res. 48 (1999) 913-927
2. Owen M. Marrow stromal stem cells. J. Cell. Sci. Suppl. 10 (1988) 63-76
3. Jaiswal N., Haynesworth S.E., Caplan A.I., and Bruder S.P. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell. Biochem. 64 (1997) 295-312
4. Wakitani S., Saito T., and Caplan A.I. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 18 (1995) 1417-1426
5. Yoo J.U., Barthel T.S., Nishimura K., Solchaga L., Caplan A.I., Goldberg V.M., et al. The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J. Bone Jt. Surg. Am. 80 (1998) 1745-1757
6. Shen F.H., Visger J., Balian G., Hurwitz S.R., and Diduch D.R. Systemically administered mesenchymal stromal cells tranduced with insulin-like growth factor-I localize to a fracture site and potentiate healing. J. Orthop. Traumatol. 16 9 (2002) 651-659
7. Shen F.H., Samartzis D., and An H.S. Cellular technologies in spinal fusions. Spine J. 5 (2005) 231S-239S
8. Im G.I., Kim D.Y., Shin J.H., Hyun C.W., and Cho W.H. Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow. J. Bone Jt. Surg. Am., Br. 83 (2001) 289-294
9. Toquet J., Rohanizadeh R., Guicheux J., Couillaud S., Passuti N., Daculsi G., et al. Osteogenic potential in vitro of human bone marrow cells cultured on macroporous biphasic calcium phosphate ceramic. J. Biomed. Mater. Res. 44 (1999) 98-108
10. Dennis J.E., Merriam A., Awadallah A., Yoo J.U., Johnstone B., and Caplan A.I. A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse. J. Bone Miner. Res. 14 (1999) 700-709
11. Rietze R.L., Valcanis H., Brooker G.F., Thomas T., Voss A.K., and Bartlett P.F. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 412 (2001) 736-739
12. Toma J.G., Akhavan M., Fernandes K.J., Barnabe-Heider F., Sadikot A., Kaplan D.R., et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat. Cell Biol. 3 (2001) 778-784
13. Young H.E., Steele T.A., Bray R.A., Hudson J., Floyd J.A., Hawkins K., et al. Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat. Rec. 264 (2001) 51-62
14. Zuk P.A., Zhu M., Mizuno H., Huang J., Futrell J.W., Katz A.J., et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 7 (2001) 211-228
15. Caplan A.I. Mesenchymal stem cells. J. Orthop. Res. 9 (1991) 641-650
16. Friedenstein A.J. Osteogenetic activity of transplanted transitional epithelium. Acta Anat. (Basel) 45 (1961) 31-59
17. Kuznetsov S.A., Krebsbach P.H., Satomura K., Kerr J., Riminucci M., Benayahu D., et al. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J. Bone Miner. Res. 12 (1997) 1335-1347
18. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 (1997) 71-74
19. Zeng Q., Li X., Balian G., and Shen F.H. GDF-5 stimulates osteogenic differentiation of fat-derived stromal cells in vitro. Spine J. 5 (2005) 175S
20. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., et al. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 13 (2002) 4279-4295
21. Tholpady S.S., Katz A.J., and Ogle R.C. Mesenchymal stem cells from rat visceral fat exhibit multipotential differentiation in vitro. Anat. Rec. A. Discov. Mol. Cell. Evol. Biol. 272 (2003) 398-402
22. Hogan B.L. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10 (1996) 1580-1594
23. Samartzis D., Khanna N., Shen F.H., and An H.S. Update on bone morphogenetic proteins and their application in spine surgery. J. Am. Coll. Surg. 200 (2005) 236-248
24. Wozney J.M., and Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin. Orthop. Relat. Res. (1998) 26-37
25. Chang S.C., Hoang B., Thomas J.T., Vukicevic S., Luyten F.P., Ryba N.J., et al. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J. Biol. Chem. 269 (1994) 28227-28234
26. Francis-West P.H., Abdelfattah A., Chen P., Allen C., Parish J., Ladher R., et al. Mechanisms of GDF-5 action during skeletal development. Development 126 (1999) 1305-1315
27. Storm E.E., and Kingsley D.M. GDF5 coordinates bone and joint formation during digit development. Dev. Biol. 209 (1999) 11-27
28. Merino R., Macias D., Ganan Y., Economides A.N., Wang X., Wu Q., et al. Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud. Dev. Biol. 206 (1999) 33-45
29. Shimaoka H., Dohi Y., Ohgushi H., Ikeuchi M., Okamoto M., Kudo A., et al. Recombinant growth/differentiation factor-5 (GDF-5) stimulates osteogenic differentiation of marrow mesenchymal stem cells in porous hydroxyapatite ceramic. J. Biomed. Mater. Res. A 68 (2004) 168-176
30. Gerber H.P., Vu T.H., Ryan A.M., Kowalski J., Werb Z., and Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5 (1999) 623-628
31. Maes C., Stockmans I., Moermans K., Van L.R., Smets N., Carmeliet P., et al. Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J. Clin. Invest. 113 (2004) 188-199
32. Gruber R., Mayer C., Schulz W., Graninger W., Peterlik M., Watzek G., et al. Stimulatory effects of cartilage-derived morphogenetic proteins 1 and 2 on osteogenic differentiation of bone marrow stromal cells. Cytokine 12 (2000) 1630-1638
33. Puleo D.A. Dependence of mesenchymal cell responses on duration of exposure to bone morphogenetic protein-2 in vitro. J. Cell. Physiol. 173 (1997) 93-101
34. Yamaguchi A., Ishizuya T., Kintou N., Wada Y., Katagiri T., Wozney J.M., et al. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem. Biophys. Res. Commun. 220 (1996) 366-371
35. Reddi A.H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat. Biotechnol. 16 (1998) 247-252
36. Erlacher L., McCartney J., Piek E., ten D.P., Yanagishita M., Oppermann H., et al. Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. J. Bone Miner. Res. 13 (1998) 383-392
37. Chen D., Ji X., Harris M.A., Feng J.Q., Karsenty G., Celeste A.J., et al. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J. Cell Biol. 142 (1998) 295-305
38. Nishitoh H., Ichijo H., Kimura M., Matsumoto T., Makishima F., Yamaguchi A., et al. Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J. Biol. Chem. 271 (1996) 21345-21352
39. Gilboa L., Nohe A., Geissendorfer T., Sebald W., Henis Y.I., and Knaus P. Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. Mol. Biol. Cell 11 (2000) 1023-1035
40. Collin-Osdoby P. Role of vascular endothelial cells in bone biology. J. Cell. Biochem. 55 (1994) 304-309
41. Ferguson C., Alpern E., Miclau T., and Helms J.A. Does adult fracture repair recapitulate embryonic skeletal formation?. Mech. Dev. 87 (1999) 57-66
42. Glowacki J. Angiogenesis in fracture repair. Clin. Orthop. Relat. Res. (1998) S82-S89
43. Trueta J., and Amato V.P. The vascular contribution of osteogenesis: III. Changes in the growth cartilage caused by experimentally induced ischaemia. J. Bone Jt. Surg. 42B (1960) 571-587
44. Midy V., and Plouet J. Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts. Biochem. Biophys. Res. Commun. 199 (1994) 380-386
45. Zelzer E., McLean W., Ng Y.S., Fukai N., Reginato A.M., Lovejoy S., et al. Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development 129 (2002) 1893-1904