A growth and differentiation factor 5 (GDF-5) composite improves the healing of necrosis of the femoral head in a sheep model. Analysis of an animal model;Das wachstumsfaktorkomposit aus GDF-5 und mineralisiertem kollagen verbessert die ausheilung einer hüftkopfnekrose: Eine untersuchung im tiermodell

Orthopade

Volumn 33, Issue 1, 2004, Pages 68-75

  Simank, H G ^a   Herold, F ^a   Schneider, M ^a   Maedler, U ^b   Ries, R ^c   Sergi, C ^d  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Biopharm   (Germany)

^d ST MICHAEL'S HOSPITAL   (United Kingdom)

Author keywords

Collagen matrix; Growth factor composite; Necrosis of the femoral head

Indexed keywords

COLLAGEN; GROWTH DIFFERENTIATION FACTOR 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MATRIX; BONE MINERALIZATION; BONE REGENERATION; COMPOSITE GRAFT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMUR HEAD NECROSIS; HEALING; HISTOPATHOLOGY; MICRORADIOGRAPHY; NONHUMAN; SHEEP;

ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; CATTLE; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; FEMUR HEAD NECROSIS; MICRORADIOGRAPHY; SHEEP; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA;

EID: 1042290392     PISSN: 00854530     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00132-003-0541-z     Document Type: Article

References (29)

1. Arlet J (1992) Nontraumatic avascular necrosis of the femoral head. Past, present, and future. Clin Orthop 277: 12-21.
2. Arlet J, Ficat P (1968) Interêt de la mesure de la pression Intramedullaire dans le massif trochantérien chez l'homme en particulaire pour le diagnostic de l'ostéo-necrose fé moro-capitale. Rev Rhumat 35: 250-256
3. Conzenius MG, Brown TD, Zhang Y, Robinson RA (2002) A new animal model of femoral head necrosis: one that progresses to human-like mechanical failure. J Orthop Res 20/2: 303-309
4. Fairbank AC, Bhatia D, Jinnah RH, Hungerford DS (1995) Long-term results of core decompression for ischaemic necrosis of the femoral head. J Bone Joint Surg 77-B: 42-49
5. Gerhart TN, Kirker-Head CA, Vet MA et al. (1993) Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop Res 293: 317-326
6. Gold EW, Fox OD, Weissfeld S, Curtiss PH (1978) Corticosteroid-induced avascular necrosis: An experimental study on rabbits. Clin Orthop Rel Res 135: 272-280
7. Heldin, C.H. (1997) TGF-beta signaling from cell membrane to nucleus through 5MAD proteins. Nature 390: 465-471
8. Hofmann S, Kramer J, Leder K, Plenk H Jr, Engel A (1994) Die nichttraumatische Hüftkopfnekrose des Erwachsenen. Teil I: Pathophysiologie, Klinik und therapeutische Möglichkeiten. Radiologe 34/1: 1-10
9. Hötten G, Neidhardt H, Schneider C, Pohl J (1995) Cloning of a new member of the TGF-beta family: a putative new activin beta C chain. Biochem Biophys Res Commun 206/2: 608-613
10. Hungerford MW, Mont MA. (2000) Die potentielle Anwendung von Zytokinen und Wachstumsfaktoren bei der Behandlung der Osteonekrose. Orthopäde 29/5: 442-448
11. Kirker-Head CA, Gerhart TN, Schelling SH, Hennig GE, Wang E, Holtrop ME (1995) Long-term healing of bone using recombinant human bone morphogenetic protein 2. Clin Orthop 318: 222-230
12. Luyten FP (1997) Cartilage-derived morphogenetic protein-1. Int J Biochem Cell Biol 29/11: 1241-1244
13. Malizos KN; Soucacos PN; Beris AE (1995) Osteonecrosis of the femoral head. Hip salvaging with implantation of a vascularized fibular graft. Clin Orthop 314: 67-75
14. Manggold, Sergi C, Becker K, Lukoschek M, Simank HG (2002) A new animal model of femoral head necrosis induced by intraosseous injection of ethanol. Lab Anim 36/2: 173-180
15. Mankin HJ (1992) Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med 326: 1473-1479
16. Mazières B (1994) Bone Morphogenetic Proteins and Bone Necrosis: A Perspective. ARCO News 6: 3-5
17. Meyers MH (1983) Surgical treatment of osteonecrosis of the femoral head. Instr Course Lect 32: 260-265
18. Mont MA, Hungerford DS (1995) Non-traumatic avascular osteonecrosis of the femoral head. J Bone Joint Surg 77A: 459-474
19. Mont MA, Jones LC, Einhorn TA, Hungerford DS, Reddi AH (1998) Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors. Clin Orthop 355 (Suppl): 314-335
20. Ninomiya S (1989) An epidemiological survey of idiopathic avascular necrosis of the femoral head in Japan. Annual Report of Japanese Investigation Committee for Intractable Diseases. Tokyo, Ministry of Health and Welfare, 26
21. Schneider W, Breitenseher M, Engel A, Knahr K, Plenk H, Hofmann S (2000) Der Stellenwert der Bohr ung in der Behandlung der Hüftkopfnekrose. Orthopäce 29: 420-429
22. Scully SP, Rizk WAS, Seaber AV, Urbaniak JR (1995) Augmentation of subchondral bone formation in AVN with rhBMP-2. Trans Orthop Res Soc 20: 495
23. Seeherman HJ, Blake CA, Luppen CA, Bouxsein ML, Li J, Wozney JM (2000) RhBMP-2 stimulates remodelling and bone formation in a nonhuman primate core defect model. Transactions 25: 1042
24. Simank HG, Brocai DR, Brill C, Lukoschek M (2001) Comparison of results of core decompression and intertrochanteric osteotomy for nontraumatic osteonecrosis of the femoral head using Cox regression and survivorship analysis. J Arthroplasty 16: 790-794
25. Spiro RC, Liu L, Heidaran MA, Thompson AY, Ng CK, Pohl J, Poser JW (2000) Inductive activity of recombinant human growth and differentiation factor-5. Biochem Soc Trans 28/4: 362-368
26. Spiro RC, Thompson AY, Poser JW (2001) Spinal fusion with recombinant human growth and differentiation factor-5 combined with a mineralized collagen matrix. Anat Rec 263/4: 388-395
27. Tay BK, Le AX, Heilman M, Lotz J, Bradford DS (1998) Use of a collagen-hydroxyapatite matrix in spinal fusion. A rabbit model. Spine 23/21: 2276-2281
28. Urist MR (1965) Bone: Formation by autoinduction. Science 150: 893-899
29. Yamashita H, Shimuzu A, Kato M, Nishito H et al. (1997) Growth/differentiation factor 5 produces angiogenesis in vivo. Exp Cell Res 235: 218-226