-
1
-
-
0036051343
-
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
-
Abreu, J. G., Ketpura, N. I., Reversade, B., and De Robertis, E. M. (2002). Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat. Cell. Biol 4, 599-604.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 599-604
-
-
Abreu, J.G.1
Ketpura, N.I.2
Reversade, B.3
De Robertis, E.M.4
-
2
-
-
0347916881
-
Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists
-
Avsian-Kretchmer, O., and Hsueh, A. J. (2004). Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Mol. Enclocrinol. 18, 1-12.
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 1-12
-
-
Avsian-Kretchmer, O.1
Hsueh, A.J.2
-
3
-
-
0036399170
-
Extracellular regulation of BMP signaling in vertebrates: A cocktail of modulators
-
Balemans, W., and Van Hul, W. (2002). Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev. Biol. 250, 231-250.
-
(2002)
Dev. Biol.
, vol.250
, pp. 231-250
-
-
Balemans, W.1
Van Hul, W.2
-
4
-
-
0033966734
-
Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity
-
Baur, S. T., Mai, J. J., and Dymecki, S. M. (2000). Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development 127, 605-619.
-
(2000)
Development
, vol.127
, pp. 605-619
-
-
Baur, S.T.1
Mai, J.J.2
Dymecki, S.M.3
-
5
-
-
0037417787
-
Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization
-
Bernat, B., Pal, G., Sun, M., and Kossiakoff, A. A. (2003). Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proc. Natl. Acad. Sci. USA 100, 952-957.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 952-957
-
-
Bernat, B.1
Pal, G.2
Sun, M.3
Kossiakoff, A.A.4
-
6
-
-
0029834634
-
Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: Inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions
-
Blessing, M., Schirmacher, P., and Kaiser, S. (1996). Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J. Cell Biol. 135, 227-239.
-
(1996)
J. Cell Biol.
, vol.135
, pp. 227-239
-
-
Blessing, M.1
Schirmacher, P.2
Kaiser, S.3
-
7
-
-
0036069143
-
The 1.1 Å crystal structure of human TGF-β type II receptor ligand binding domain
-
Boesen, C. C., Radaev, S., Motyka, S. A., Patamawenu, A., and Sun, P. D. (2002). The 1.1 Å crystal structure of human TGF-β type II receptor ligand binding domain. Structure 10, 913-919.
-
(2002)
Structure
, vol.10
, pp. 913-919
-
-
Boesen, C.C.1
Radaev, S.2
Motyka, S.A.3
Patamawenu, A.4
Sun, P.D.5
-
9
-
-
0242668869
-
Bone morphogenetic proteins, their antagonists, and the skeleton
-
Canalis, E., Economides, A. N., and Gazzerro, E. (2003). Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr. Rev. 24, 218-235.
-
(2003)
Endocr. Rev.
, vol.24
, pp. 218-235
-
-
Canalis, E.1
Economides, A.N.2
Gazzerro, E.3
-
10
-
-
0032540358
-
Structural and functional analysis of the 1:1 growth hormone: Receptor complex reveals the molecular basis for receptor affinity
-
Clackson, T., Ultsch, M. H., Wells, J. A., and de Vos, A. M. (1998). Structural and functional analysis of the 1:1 growth hormone: receptor complex reveals the molecular basis for receptor affinity. J. Mol. Biol. 277, 1111-1128.
-
(1998)
J. Mol. Biol.
, vol.277
, pp. 1111-1128
-
-
Clackson, T.1
Ultsch, M.H.2
Wells, J.A.3
de Vos, A.M.4
-
11
-
-
0028916599
-
A hot spot of binding energy in a hormone-receptor interface
-
Clackson, T., and Wells, J. A. (1995). A hot spot of binding energy in a hormone-receptor interface. Science 267, 383-386.
-
(1995)
Science
, vol.267
, pp. 383-386
-
-
Clackson, T.1
Wells, J.A.2
-
12
-
-
0027132013
-
Comparison of a structural and a functional epitope
-
[Erratum published in J. Mol. Biol. 237 (1994), p. 513]
-
Cunningham, B. C., and Wells, J. A. (1993). Comparison of a structural and a functional epitope. J. Mol. Biol. 234, 554-563. [Erratum published in J. Mol. Biol. 237 (1994), p. 513]
-
(1993)
J. Mol. Biol.
, vol.234
, pp. 554-563
-
-
Cunningham, B.C.1
Wells, J.A.2
-
13
-
-
0027122245
-
Crystal structure of transforming growth factor-β2: An unusual fold for the superfamily
-
Daopin, S., Piez, K. A., Ogawa, Y., and Davies, D. R. (1992). Crystal structure of transforming growth factor-β2: an unusual fold for the superfamily. Science 257, 369-373.
-
(1992)
Science
, vol.257
, pp. 369-373
-
-
Daopin, S.1
Piez, K.A.2
Ogawa, Y.3
Davies, D.R.4
-
14
-
-
0026598960
-
Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
-
de Vos, A. M., Ultsch, M., and Kossiakoff, A. A. (1992). Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312.
-
(1992)
Science
, vol.255
, pp. 306-312
-
-
de Vos, A.M.1
Ultsch, M.2
Kossiakoff, A.A.3
-
15
-
-
0042825676
-
Solution structure and backbone dynamics of the TGFβ type II receptor extracellular domain
-
Deep, S., Walker, K. P., 3rd, Shu, Z., and Hinck, A. P. (2003). Solution structure and backbone dynamics of the TGFβ type II receptor extracellular domain. Biochemistry 42, 10126-10139.
-
(2003)
Biochemistry
, vol.42
, pp. 10126-10139
-
-
Deep, S.1
Walker III, K.P.2
Shu, Z.3
Hinck, A.P.4
-
16
-
-
0034652207
-
Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes
-
DiLeone, R. J., Marcus, G. A., Johnson, M. D., and Kingsley, D. M. (2000). Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes. Proc. Natl. Acad. Sci. USA 97, 1612-1617.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1612-1617
-
-
DiLeone, R.J.1
Marcus, G.A.2
Johnson, M.D.3
Kingsley, D.M.4
-
17
-
-
0029861824
-
Growth differentiation factor-9 is required during early ovarian folliculogenesis
-
Dong, J., Albertini, D. F., Nishimori, K., Kumar, T. R., Lu, N., and Matzuk, M. M. (1996). Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 383, 531-535.
-
(1996)
Nature
, vol.383
, pp. 531-535
-
-
Dong, J.1
Albertini, D.F.2
Nishimori, K.3
Kumar, T.R.4
Lu, N.5
Matzuk, M.M.6
-
18
-
-
0032873465
-
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
-
Duncan, M. R., Frazier, K. S., Abramson, S., Williams, S., Klapper, H., Huang, X., and Grotendorst, G. R. (1999). Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J. 13, 1774-1786.
-
(1999)
FASEB J.
, vol.13
, pp. 1774-1786
-
-
Duncan, M.R.1
Frazier, K.S.2
Abramson, S.3
Williams, S.4
Klapper, H.5
Huang, X.6
Grotendorst, G.R.7
-
19
-
-
0035065478
-
How does the mouse get its trunk?
-
Dunn, N. R., and Hogan, B. L. (2001). How does the mouse get its trunk? Nat. Genet. 27, 351-352.
-
(2001)
Nat. Genet.
, vol.27
, pp. 351-352
-
-
Dunn, N.R.1
Hogan, B.L.2
-
20
-
-
0032754669
-
Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation
-
Ebisawa, T., Tada, K., Kitajima, I., Tojo, K., Sampath, T. K., Kawabata, M., Miyazono, K., and Imamura, T. (1999). Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. J. Cell Sci. 112, 3519-3527.
-
(1999)
J. Cell Sci.
, vol.112
, pp. 3519-3527
-
-
Ebisawa, T.1
Tada, K.2
Kitajima, I.3
Tojo, K.4
Sampath, T.K.5
Kawabata, M.6
Miyazono, K.7
Imamura, T.8
-
21
-
-
0030989670
-
X-ray structure of glial cell-derived neurotrophic factor at 1.9 Å resolution and implications for receptor binding
-
Eigenbrot, C., and Gerber, N. (1997). X-ray structure of glial cell-derived neurotrophic factor at 1.9 Å resolution and implications for receptor binding. Nat. Struct. Biol. 4, 435-438.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 435-438
-
-
Eigenbrot, C.1
Gerber, N.2
-
22
-
-
0344423815
-
Distinct structural elements in GDNF mediate binding to GFRα1 and activation of the GFRα1-c-Ret receptor complex
-
Eketjall, S., Fainzilber, M., Murray Rust, J., and Ibanez, C. F. (1999). Distinct structural elements in GDNF mediate binding to GFRα1 and activation of the GFRα1-c-Ret receptor complex. EMBO J. 18, 5901-5910.
-
(1999)
EMBO J.
, vol.18
, pp. 5901-5910
-
-
Eketjall, S.1
Fainzilber, M.2
Murray Rust, J.3
Ibanez, C.F.4
-
23
-
-
0035105355
-
Three-dimensional structure of human follicle-stimulating hormone
-
Fox, K. M., Dias, J. A., and Van Roey, P. (2001). Three-dimensional structure of human follicle-stimulating hormone. Mol. Endocrinol. 15, 378-389.
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 378-389
-
-
Fox, K.M.1
Dias, J.A.2
Van Roey, P.3
-
24
-
-
0345426298
-
Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryo
-
Furthauer, M., Thisse, B., and Thisse, C. (1999). Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryo. Dev. Biol. 214, 181-196.
-
(1999)
Dev. Biol.
, vol.214
, pp. 181-196
-
-
Furthauer, M.1
Thisse, B.2
Thisse, C.3
-
25
-
-
0033917569
-
Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner
-
Galloway, S. M., McNatty, K. P., Cambridge, L. M., Laitinen, M. P., Juengel, J. L., Jokiranta, T. S., McLaren, R. J., Luiro, K., Dodds, K. G., Montgomery, G. W. et al. (2000). Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat. Genet. 25, 279-283.
-
(2000)
Nat. Genet.
, vol.25
, pp. 279-283
-
-
Galloway, S.M.1
McNatty, K.P.2
Cambridge, L.M.3
Laitinen, M.P.4
Juengel, J.L.5
Jokiranta, T.S.6
McLaren, R.J.7
Luiro, K.8
Dodds, K.G.9
Montgomery, G.W.10
-
26
-
-
0037012541
-
Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems
-
Garcia Abreu, J., Coffinier, C., Larrain, J., Oelgeschlager, M., and De Robertis, E. M. (2002). Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems. Gene 287, 39-47.
-
(2002)
Gene
, vol.287
, pp. 39-47
-
-
Garcia Abreu, J.1
Coffinier, C.2
Larrain, J.3
Oelgeschlager, M.4
De Robertis, E.M.5
-
27
-
-
0032559594
-
Oligomeric structure of type I and type II transforming growth factor β receptors: Homodimers form in the ER and persist at the plasma membrane
-
Gilboa, L., Wells, R. G., Lodish, H. F., and Henis, Y. I. (1998). Oligomeric structure of type I and type II transforming growth factor β receptors: homodimers form in the ER and persist at the plasma membrane. J. Cell Biol. 140, 767-777.
-
(1998)
J. Cell Biol.
, vol.140
, pp. 767-777
-
-
Gilboa, L.1
Wells, R.G.2
Lodish, H.F.3
Henis, Y.I.4
-
28
-
-
0034021776
-
Bone morphogenetic protein receptor complexes on the surface of live cells: A new oligomerization mode for serine/threonine kinase receptors
-
Gilboa, L., Nohe, A., Geissendorfer, T., Sebald, W., Henis, Y. I., and Knaus, P. (2000). Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. Mol. Biol. Cell 11, 1023-1035.
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 1023-1035
-
-
Gilboa, L.1
Nohe, A.2
Geissendorfer, T.3
Sebald, W.4
Henis, Y.I.5
Knaus, P.6
-
29
-
-
0037170462
-
Antagonism of activin by inhibin and inhibin receptors: A functional role for betaglycan
-
Gray, P. C., Bilezikjian, L. M., and Vale, W. (2002). Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan. Mol. Cell. Endocrinol. 188, 254-260.
-
(2002)
Mol. Cell Endocrinol.
, vol.188
, pp. 254-260
-
-
Gray, P.C.1
Bilezikjian, L.M.2
Vale, W.3
-
30
-
-
0032899751
-
Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase
-
Greenwald, J., Fischer, W. H., Vale, W. W., and Choe, S. (1999). Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase. Nat. Struct. Biol. 6, 18-22.
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 18-22
-
-
Greenwald, J.1
Fischer, W.H.2
Vale, W.W.3
Choe, S.4
-
31
-
-
0037351880
-
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly
-
Greenwald, J., Groppe, J., Gray, P., Wiater, E., Kwiatkowski, W., Vale, W., and Choe, S. (2003). The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol. Cell 11, 605-617.
-
(2003)
Mol. Cell
, vol.11
, pp. 605-617
-
-
Greenwald, J.1
Groppe, J.2
Gray, P.3
Wiater, E.4
Kwiatkowski, W.5
Vale, W.6
Choe, S.7
-
32
-
-
0030042590
-
Three-dimensional structure of recombinant human osteogenic protein 1: Structural paradigm for the transforming growth factor β superfamily
-
Griffith, D. L., Keck, P. C., Sampath, T. K., Rueger, D. C., and Carlson, W. D. (1996). Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor β superfamily. Proc. Natl. Acad. Sci. USA 93, 878-883.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 878-883
-
-
Griffith, D.L.1
Keck, P.C.2
Sampath, T.K.3
Rueger, D.C.4
Carlson, W.D.5
-
33
-
-
0037069653
-
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
-
Groppe, J., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A. N., Kwiatkowski, W., Affolter, M., Vale, W. W., Belmonte, J. C., and Choe, S. (2002). Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature 420, 636-642.
-
(2002)
Nature
, vol.420
, pp. 636-642
-
-
Groppe, J.1
Greenwald, J.2
Wiater, E.3
Rodriguez-Leon, J.4
Economides, A.N.5
Kwiatkowski, W.6
Affolter, M.7
Vale, W.W.8
Belmonte, J.C.9
Choe, S.10
-
34
-
-
0031225015
-
Connective tissue growth factor: A mediator of TGF-β action on fibroblasts
-
Grotendorst, G. R. (1997). Connective tissue growth factor: a mediator of TGF-β action on fibroblasts. Cytokine Growth Factor Rev. 8, 171-179.
-
(1997)
Cytokine. Growth Factor Rev.
, vol.8
, pp. 171-179
-
-
Grotendorst, G.R.1
-
35
-
-
0036177334
-
Crystal structure of the human TβR2 ectodomain-TGF-β3 complex
-
Hart, P. J., Deep, S., Taylor, A. B., Shu, Z., Hinck, C. S., and Hinck, A. P. (2002). Crystal structure of the human TβR2 ectodomain-TGF-β3 complex. Nat. Struct. Biol. 9, 203-208.
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 203-208
-
-
Hart, P.J.1
Deep, S.2
Taylor, A.B.3
Shu, Z.4
Hinck, C.S.5
Hinck, A.P.6
-
36
-
-
0034460683
-
Identification of the ligand-binding site of the BMP type IA receptor for BMP-4
-
Hatta, T., Konishi, H., Katoh, E., Natsume, T., Ueno, N., Kobayashi, Y., and Yamazaki, T. (2000). Identification of the ligand-binding site of the BMP type IA receptor for BMP-4. Biopolymers 55, 399-406.
-
(2000)
Biopolymers
, vol.55
, pp. 399-406
-
-
Hatta, T.1
Konishi, H.2
Katoh, E.3
Natsume, T.4
Ueno, N.5
Kobayashi, Y.6
Yamazaki, T.7
-
37
-
-
0141833839
-
A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization
-
He, S., Jin, M. L., Worpel, V., and Hinton, D. R. (2003). A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch. Ophthalmol. 121, 1283-1288.
-
(2003)
Arch. Ophthalmol.
, vol.121
, pp. 1283-1288
-
-
He, S.1
Jin, M.L.2
Worpel, V.3
Hinton, D.R.4
-
38
-
-
0028838012
-
Dimerization of cell surface receptors in signal transduction
-
Heldin, C. H. (1995). Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223.
-
(1995)
Cell
, vol.80
, pp. 213-223
-
-
Heldin, C.H.1
-
39
-
-
0030183048
-
Ligand-induced dimerization of growth factor receptors: Variations on the theme
-
Heldin, C. H., and Ostman, A. (1996). Ligand-induced dimerization of growth factor receptors: variations on the theme. Cytokine Growth Factor Rev. 7, 3-10.
-
(1996)
Cytokine. Growth Factor Rev.
, vol.7
, pp. 3-10
-
-
Heldin, C.H.1
Ostman, A.2
-
40
-
-
0031438047
-
TGF-β signalling from cell membrane to nucleus through SMAD proteins
-
Heldin, C. H., Miyazono, K., and ten Dijke, P. (1997). TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
ten Dijke, P.3
-
41
-
-
0028291369
-
The types II and III transforming growth factor-β receptors form homo-oligomers
-
Henis, Y. I., Moustakas, A., Lin, H. Y., and Lodish, H. F. (1994). The types II and III transforming growth factor-β receptors form homo-oligomers. J. Cell Biol. 126, 139-154.
-
(1994)
J. Cell Biol.
, vol.126
, pp. 139-154
-
-
Henis, Y.I.1
Moustakas, A.2
Lin, H.Y.3
Lodish, H.F.4
-
42
-
-
8944220232
-
Transforming growth factor β1: Three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor β2
-
Hinck, A. P., Archer, S. J., Qian, S. W., Roberts, A. B., Sporn, M. B., Weatherbee, J. A., Tsang, M. L., Lucas, R., Zhang, B. L., Wenker, J., and Torchia, D. A. (1996). Transforming growth factor β 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor β2. Biochemistry 35, 8517-8534.
-
(1996)
Biochemistry
, vol.35
, pp. 8517-8534
-
-
Hinck, A.P.1
Archer, S.J.2
Qian, S.W.3
Roberts, A.B.4
Sporn, M.B.5
Weatherbee, J.A.6
Tsang, M.L.7
Lucas, R.8
Zhang, B.L.9
Wenker, J.10
Torchia, D.A.11
-
43
-
-
0030218004
-
Bone morphogenetic proteins in development
-
Hogan, B. L. (1996). Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 6, 432-438.
-
(1996)
Curr. Opin. Genet. Dev.
, vol.6
, pp. 432-438
-
-
Hogan, B.L.1
-
44
-
-
0039797251
-
Transforming growth factor β peptide antagonists and their conversion to partial agonists
-
Huang, S. S., Liu, Q., Johnson, F. E., Konish, Y., and Huang, J. S. (1997). Transforming growth factor β peptide antagonists and their conversion to partial agonists. J. Biol. Chem. 272, 27155-27159.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27155-27159
-
-
Huang, S.S.1
Liu, Q.2
Johnson, F.E.3
Konish, Y.4
Huang, J.S.5
-
45
-
-
0033524943
-
Crystal structure of the cytoplasmic domain of the type I TGFβ receptor in complex with FKBP12
-
Huse, M., Chen, Y. G., Massague, J., and Kuriyan, J. (1999). Crystal structure of the cytoplasmic domain of the type I TGFβ receptor in complex with FKBP12. Cell 96, 425-436.
-
(1999)
Cell
, vol.96
, pp. 425-436
-
-
Huse, M.1
Chen, Y.G.2
Massague, J.3
Kuriyan, J.4
-
46
-
-
0031860389
-
Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice
-
Katagiri, T., Boorla, S., Frendo, J. L., Hogan, B. L., and Karsenty, G. (1998). Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev. Genet. 22, 340-348.
-
(1998)
Dev. Genet.
, vol.22
, pp. 340-348
-
-
Katagiri, T.1
Boorla, S.2
Frendo, J.L.3
Hogan, B.L.4
Karsenty, G.5
-
47
-
-
2342516135
-
Molecular recognition of BMP-2 and BMP receptor IA
-
Keller, S., Nickel, J., Zhang, J. L., Sebald, W., and Mueller, T. D. (2004). Molecular recognition of BMP-2 and BMP receptor IA. Nat. Struct. Mol. Biol. 11, 481-488.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 481-488
-
-
Keller, S.1
Nickel, J.2
Zhang, J.L.3
Sebald, W.4
Mueller, T.D.5
-
48
-
-
0042681786
-
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins
-
Kim, M., Carman, C. V., and Springer, T. A. (2003). Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 301, 1720-1725.
-
(2003)
Science
, vol.301
, pp. 1720-1725
-
-
Kim, M.1
Carman, C.V.2
Springer, T.A.3
-
49
-
-
0027976891
-
What do BMPs do in mammals? Clues from the mouse short-ear mutation
-
Kingsley, D. M. (1994). What do BMPs do in mammals? Clues from the mouse short-ear mutation. Trends Genet. 10, 16-21.
-
(1994)
Trends Genet.
, vol.10
, pp. 16-21
-
-
Kingsley, D.M.1
-
50
-
-
0034600953
-
BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II
-
Kirsch, T., Nickel, J., and Sebald, W. (2000a). BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. EMBO J. 19, 3314-3324.
-
(2000)
EMBO J.
, vol.19
, pp. 3314-3324
-
-
Kirsch, T.1
Nickel, J.2
Sebald, W.3
-
51
-
-
0034043106
-
Crystal structure of the BMP-2-BRIA ectodomain complex
-
Kirsch, T., Sebald, W., and Dreyer, M. K. (2000b). Crystal structure of the BMP-2-BRIA ectodomain complex. Nat. Struct. Biol. 7, 492-496.
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 492-496
-
-
Kirsch, T.1
Sebald, W.2
Dreyer, M.K.3
-
52
-
-
0034826931
-
Cooperativity of binding epitopes and receptor chains in the BMP/TGFβ superfamily
-
Knaus, P., and Sebald, W. (2001). Cooperativity of binding epitopes and receptor chains in the BMP/TGFβ superfamily. Biol. Chem. 382, 1189-1195.
-
(2001)
Biol. Chem.
, vol.382
, pp. 1189-1195
-
-
Knaus, P.1
Sebald, W.2
-
53
-
-
0028142801
-
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells
-
Koenig, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., and et al. (1994). Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol. Cell. Biol. 14, 5961-5974.
-
(1994)
Mol. Cell Biol.
, vol.14
, pp. 5961-5974
-
-
Koenig, B.B.1
Cook, J.S.2
Wolsing, D.H.3
Ting, J.4
Tiesman, J.P.5
Correa, P.E.6
Olson, C.A.7
Pecquet, A.L.8
Ventura, F.9
Grant, R.A.10
-
54
-
-
0038267120
-
Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity
-
Kusu, N., Laurikkala, J., Imanishi, M., Usui, H., Konishi, M., Miyake, A., Thesleff, I., and Itoh, N. (2003). Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J. Biol. Chem. 278, 24113-24117.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24113-24117
-
-
Kusu, N.1
Laurikkala, J.2
Imanishi, M.3
Usui, H.4
Konishi, M.5
Miyake, A.6
Thesleff, I.7
Itoh, N.8
-
55
-
-
0028239813
-
Crystal structure of human chorionic gonadotropin
-
Lapthorn, A. J., Harris, D. C., Littlejohn, A., Lustbader, J. W., Canfield, R. E., Machin, K. J., Morgan, F. J., and Isaacs, N. W. (1994). Crystal structure of human chorionic gonadotropin. Nature 369, 455-461.
-
(1994)
Nature
, vol.369
, pp. 455-461
-
-
Lapthorn, A.J.1
Harris, D.C.2
Littlejohn, A.3
Lustbader, J.W.4
Canfield, R.E.5
Machin, K.J.6
Morgan, F.J.7
Isaacs, N.W.8
-
56
-
-
0034010982
-
BMP-binding modules in chordin: A model for signalling regulation in the extracellular space
-
Larrain, J., Bachiller, D., Lu, B., Agius, E., Piccolo, S., and De Robertis, E. M. (2000). BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. Development 127, 821-830.
-
(2000)
Development
, vol.127
, pp. 821-830
-
-
Larrain, J.1
Bachiller, D.2
Lu, B.3
Agius, E.4
Piccolo, S.5
De Robertis, E.M.6
-
57
-
-
0035205079
-
Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling
-
Larrain, J., Oelgeschlager, M., Ketpura, N. I., Reversade, B., Zakin, L., and De Robertis, E. M. (2001). Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling. Development 128, 4439-4447.
-
(2001)
Development
, vol.128
, pp. 4439-4447
-
-
Larrain, J.1
Oelgeschlager, M.2
Ketpura, N.I.3
Reversade, B.4
Zakin, L.5
De Robertis, E.M.6
-
58
-
-
0035979253
-
Regulation of myostatin activity and muscle growth
-
Lee, S. J., and McPherron, A. C. (2001). Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci. USA 98, 9306-9311.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9306-9311
-
-
Lee, S.J.1
McPherron, A.C.2
-
59
-
-
0032188943
-
The interleukin-4 site-2 epitope determining binding of the common receptor γ chain
-
Letzelter, F., Wang, Y., and Sebald, W. (1998). The interleukin-4 site-2 epitope determining binding of the common receptor γ chain. Eur. J. Biochem. 257, 11-20.
-
(1998)
Eur. J. Biochem.
, vol.257
, pp. 11-20
-
-
Letzelter, F.1
Wang, Y.2
Sebald, W.3
-
60
-
-
0034704753
-
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
-
Lewis, K. A., Gray, P. C., Blount, A. L., MacConell, L. A., Wiater, E., Bilezikjian, L. M., and Vale, W. (2000). Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404, 411-414.
-
(2000)
Nature
, vol.404
, pp. 411-414
-
-
Lewis, K.A.1
Gray, P.C.2
Blount, A.L.3
MacConell, L.A.4
Wiater, E.5
Bilezikjian, L.M.6
Vale, W.7
-
61
-
-
0029008597
-
Human type II receptor for bone morphogenic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
-
Liu, F., Ventura, F., Doody, J., and Massague, J. (1995). Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol. Cell. Biol. 15, 3479-3486.
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 3479-3486
-
-
Liu, F.1
Ventura, F.2
Doody, J.3
Massague, J.4
-
62
-
-
0033548259
-
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
-
Livnah, O., Stura, E. A., Middleton, S. A., Johnson, D. L., Jolliffe, L. K., and Wilson, I. A. (1999). Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283, 987-990.
-
(1999)
Science
, vol.283
, pp. 987-990
-
-
Livnah, O.1
Stura, E.A.2
Middleton, S.A.3
Johnson, D.L.4
Jolliffe, L.K.5
Wilson, I.A.6
-
63
-
-
0033257926
-
Ubiquitin-dependent degradation of TGF-β-activated smad2
-
Lo, R. S., and Massague, J. (1999). Ubiquitin-dependent degradation of TGF-β-activated smad2. Nat. Cell Biol. 1, 472-478.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 472-478
-
-
Lo, R.S.1
Massague, J.2
-
64
-
-
0030972496
-
Positive and negative regulation of type II TGF-β receptor signal transduction by autophosphorylation on multiple serine residues
-
Luo, K., and Lodish, H. F. (1997). Positive and negative regulation of type II TGF-β receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J. 16, 1970-1981.
-
(1997)
EMBO J.
, vol.16
, pp. 1970-1981
-
-
Luo, K.1
Lodish, H.F.2
-
65
-
-
0032475884
-
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
-
Macias-Silva, M., Hoodless, P. A., Tang, S. J., Buchwald, M., and Wrana, J. L. (1998). Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem. 273, 25628-25636.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25628-25636
-
-
Macias-Silva, M.1
Hoodless, P.A.2
Tang, S.J.3
Buchwald, M.4
Wrana, J.L.5
-
66
-
-
0031685620
-
TGF-β signal transduction
-
Massague, J. (1998). TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 753-791
-
-
Massague, J.1
-
67
-
-
0034654497
-
Controlling TGF-β signaling
-
Massague, J., and Chen, Y. G. (2000). Controlling TGF-β signaling. Genes Dev. 14, 627-644.
-
(2000)
Genes Dev.
, vol.14
, pp. 627-644
-
-
Massague, J.1
Chen, Y.G.2
-
68
-
-
0028179120
-
The TGF-β family and its composite receptors
-
Massague, J., Attisano, L., and Wrana, J. L. (1994). The TGF-β family and its composite receptors. Trends Cell Biol. 4, 172-178.
-
(1994)
Trends Cell Biol.
, vol.4
, pp. 172-178
-
-
Massague, J.1
Attisano, L.2
Wrana, J.L.3
-
69
-
-
0034644472
-
TGF-β signaling in growth control, cancer, and heritable disorders
-
Massague, J., Blain, S. W., and Lo, R. S. (2000). TGF-β signaling in growth control, cancer, and heritable disorders. Cell 103, 295-309.
-
(2000)
Cell
, vol.103
, pp. 295-309
-
-
Massague, J.1
Blain, S.W.2
Lo, R.S.3
-
70
-
-
0027251256
-
A structural superfamily of growth factors containing a cystine knot motif
-
McDonald, N. Q., and Hendrickson, W. A. (1993). A structural superfamily of growth factors containing a cystine knot motif. Cell 73, 421-424.
-
(1993)
Cell
, vol.73
, pp. 421-424
-
-
McDonald, N.Q.1
Hendrickson, W.A.2
-
71
-
-
0025986121
-
New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor
-
McDonald, N. Q., Lapatto, R., Murray-Rust, J., Gunning, J., Wlodawer, A., and Blundell, T. L. (1991). New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor. Nature 354, 411-414.
-
(1991)
Nature
, vol.354
, pp. 411-414
-
-
McDonald, N.Q.1
Lapatto, R.2
Murray-Rust, J.3
Gunning, J.4
Wlodawer, A.5
Blundell, T.L.6
-
72
-
-
0029943464
-
The crystal structure of TGF-β 3 and comparison to TGF-β 2: Implications for receptor binding
-
Mittl, P. R., Priestle, J. P., Cox, D. A., McMaster, G., Cerletti, N., and Grutter, M. G. (1996). The crystal structure of TGF-β 3 and comparison to TGF-β 2: implications for receptor binding. Protein Sci. 5, 1261-1271.
-
(1996)
Protein Sci.
, vol.5
, pp. 1261-1271
-
-
Mittl, P.R.1
Priestle, J.P.2
Cox, D.A.3
McMaster, G.4
Cerletti, N.5
Grutter, M.G.6
-
73
-
-
0035032914
-
Divergence and convergence of TGF-β/BMP signaling
-
Miyazono, K., Kusanagi, K., and Inoue, H. (2001). Divergence and convergence of TGF-β/BMP signaling. J. Cell Physiol. 187, 265-276.
-
(2001)
J. Cell Physiol.
, vol.187
, pp. 265-276
-
-
Miyazono, K.1
Kusanagi, K.2
Inoue, H.3
-
74
-
-
0033932667
-
TGF-β signaling by Smad proteins
-
Miyazono, K., ten Dijke, P., and Heldin, C. H. (2000). TGF-β signaling by Smad proteins. Adv. Immunol. 75, 115-157.
-
(2000)
Adv. Immunol.
, vol.75
, pp. 115-157
-
-
Miyazono, K.1
ten Dijke, P.2
Heldin, C.H.3
-
75
-
-
0141519291
-
A general approach for identifying distant regulatory elements applied to the Gdf6 gene
-
Mortlock, D. P., Guenther, C., and Kingsley, D. M. (2003). A general approach for identifying distant regulatory elements applied to the Gdf6 gene. Genome Res. 13, 2069-2081.
-
(2003)
Genome Res.
, vol.13
, pp. 2069-2081
-
-
Mortlock, D.P.1
Guenther, C.2
Kingsley, D.M.3
-
76
-
-
0035694910
-
Smad regulation in TGF-β signal transduction
-
Moustakas, A., Souchelnytskyi, S., and Heldin, C. H. (2001). Smad regulation in TGF-β signal transduction. J. Cell Sci. 114, 4359-4369.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 4359-4369
-
-
Moustakas, A.1
Souchelnytskyi, S.2
Heldin, C.H.3
-
77
-
-
0030795733
-
Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site
-
Muller, Y. A., Li, B., Christinger, H. W., Wells, J. A., Cunningham, B. C., and de Vos, A. M. (1997). Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc. Natl. Acad. Sci. USA 94, 7192-7197.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 7192-7197
-
-
Muller, Y.A.1
Li, B.2
Christinger, H.W.3
Wells, J.A.4
Cunningham, B.C.5
de Vos, A.M.6
-
78
-
-
0033178337
-
p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells
-
Nakamura, K., Shirai, T., Morishita, S., Uchida, S., Saeki-Miura, K., and Makishima, F. (1999). p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells. Exp. Cell Res. 250, 351-363.
-
(1999)
Exp. Cell Res.
, vol.250
, pp. 351-363
-
-
Nakamura, K.1
Shirai, T.2
Morishita, S.3
Uchida, S.4
Saeki-Miura, K.5
Makishima, F.6
-
79
-
-
0032979875
-
Molecular evolution of a developmental pathway: Phylogenetic analyses of transforming growth factor-β family ligands, receptors and Smad signal transducers
-
Newfeld, S. J., Wisotzkey, R. G., and Kumar, S. (1999). Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-β family ligands, receptors and Smad signal transducers. Genetics 152, 783-795.
-
(1999)
Genetics
, vol.152
, pp. 783-795
-
-
Newfeld, S.J.1
Wisotzkey, R.G.2
Kumar, S.3
-
80
-
-
0029831660
-
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5
-
Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S., and Miyazono, K. (1996). Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J. Biol. Chem. 271, 21345-21352.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 21345-21352
-
-
Nishitoh, H.1
Ichijo, H.2
Kimura, M.3
Matsumoto, T.4
Makishima, F.5
Yamaguchi, A.6
Yamashita, H.7
Enomoto, S.8
Miyazono, K.9
-
81
-
-
0037085287
-
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways
-
Nohe, A., Hassel, S., Ehrlich, M., Neubauer, F., Sebald, W., Henis, Y. I., and Knaus, P. (2002). The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J. Biol. Chem. 277, 5330-5338.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5330-5338
-
-
Nohe, A.1
Hassel, S.2
Ehrlich, M.3
Neubauer, F.4
Sebald, W.5
Henis, Y.I.6
Knaus, P.7
-
82
-
-
0029153741
-
Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors
-
Nohno, T., Ishikawa, T., Saito, T., Hosokawa, K., Noji, S., Wolsing, D. H., and Rosenbaum, J. S. (1995). Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J. Biol. Chem. 270, 22522-22526.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22522-22526
-
-
Nohno, T.1
Ishikawa, T.2
Saito, T.3
Hosokawa, K.4
Noji, S.5
Wolsing, D.H.6
Rosenbaum, J.S.7
-
83
-
-
0042829275
-
The pro-BMP activity of Twisted gastrulation is independent of BMP binding
-
Oelgeschlager, M., Reversade, B., Larrain, J., Little, S., Mullins, M. C., and De Robertis, E. M. (2003). The pro-BMP activity of Twisted gastrulation is independent of BMP binding. Development 130, 4047-4056.
-
(2003)
Development
, vol.130
, pp. 4047-4056
-
-
Oelgeschlager, M.1
Reversade, B.2
Larrain, J.3
Little, S.4
Mullins, M.C.5
De Robertis, E.M.6
-
84
-
-
0037022121
-
Action range of BMP is defined by its N-terminal basic amino acid core
-
Ohkawara, B., Iemura, S., ten Dijke, P., and Ueno, N. (2002). Action range of BMP is defined by its N-terminal basic amino acid core. Curr. Biol. 12, 205-209.
-
(2002)
Curr. Biol.
, vol.12
, pp. 205-209
-
-
Ohkawara, B.1
Iemura, S.2
ten Dijke, P.3
Ueno, N.4
-
85
-
-
0033619255
-
Silencing of TGF-β signalling by the pseudoreceptor BAMBI
-
Onichtchouk, D., Chen, Y. G., Dosch, R., Gawantka, V., Delius, H., Massague, J., and Niehrs, C. (1999). Silencing of TGF-β signalling by the pseudoreceptor BAMBI. Nature 401, 480-485.
-
(1999)
Nature
, vol.401
, pp. 480-485
-
-
Onichtchouk, D.1
Chen, Y.G.2
Dosch, R.3
Gawantka, V.4
Delius, H.5
Massague, J.6
Niehrs, C.7
-
86
-
-
0030987103
-
Growth factors and diabetic retinopathy
-
Paques, M., Massin, P., and Gaudric, A. (1997). Growth factors and diabetic retinopathy. Diabetes Metab. 23, 125-130.
-
(1997)
Diabetes Metab.
, vol.23
, pp. 125-130
-
-
Paques, M.1
Massin, P.2
Gaudric, A.3
-
87
-
-
0033985464
-
TGF β-related pathways. Roles in Caenorhabditis elegans development
-
Patterson, G. I., and Padgett, R. W. (2000). TGF β-related pathways. Roles in Caenorhabditis elegans development. Trends Genet. 16, 27-33.
-
(2000)
Trends Genet.
, vol.16
, pp. 27-33
-
-
Patterson, G.I.1
Padgett, R.W.2
-
88
-
-
0032990886
-
Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells
-
Piek, E., Afrakhte, M., Sampath, K., van Zoelen, E. J., Heldin, C. H., and ten Dijke, P. (1999). Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells. J. Cell Physiol. 180, 141-149.
-
(1999)
J. Cell Physiol.
, vol.180
, pp. 141-149
-
-
Piek, E.1
Afrakhte, M.2
Sampath, K.3
van Zoelen, E.J.4
Heldin, C.H.5
ten Dijke, P.6
-
89
-
-
0141864365
-
Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis
-
Rebbapragada, A., Benchabane, H., Wrana, J. L., Celeste, A. J., and Attisano, L. (2003). Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis. Mol. Cell. Biol. 23, 7230-7242.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 7230-7242
-
-
Rebbapragada, A.1
Benchabane, H.2
Wrana, J.L.3
Celeste, A.J.4
Attisano, L.5
-
90
-
-
0031909665
-
Role of morphogenetic proteins in skeletal tissue engineering and regeneration
-
Reddi, A. H. (1998). Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat. Biotechnol. 16, 247-252.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 247-252
-
-
Reddi, A.H.1
-
91
-
-
0026575663
-
The BMP proteins in bone formation and repair
-
Rosen, V., and Thies, R. S. (1992). The BMP proteins in bone formation and repair. Trends Genet. 8, 97-102.
-
(1992)
Trends Genet.
, vol.8
, pp. 97-102
-
-
Rosen, V.1
Thies, R.S.2
-
92
-
-
0035254335
-
Type III TGF-β receptor-independent signalling of TGF-β2 via TβRII-B, an alternatively spliced TGF-β type II receptor
-
Rotzer, D., Roth, M., Lutz, M., Lindemann, D., Sebald, W., and Knaus, P. (2001). Type III TGF-β receptor-independent signalling of TGF-β2 via TβRII-B, an alternatively spliced TGF-β type II receptor. EMBO J. 20, 480-490.
-
(2001)
EMBO J.
, vol.20
, pp. 480-490
-
-
Rotzer, D.1
Roth, M.2
Lutz, M.3
Lindemann, D.4
Sebald, W.5
Knaus, P.6
-
93
-
-
0029985256
-
Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity
-
Ruppert, R., Hoffmann, E., and Sebald, W. (1996). Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity. Eur. J. Biochem. 237, 295-302.
-
(1996)
Eur. J. Biochem.
, vol.237
, pp. 295-302
-
-
Ruppert, R.1
Hoffmann, E.2
Sebald, W.3
-
94
-
-
0033582942
-
Crystal structure of human bone morphogenetic protein-2 at 2.7 Å resolution
-
Scheufler, C., Sebald, W., and Hulsmeyer, M. (1999). Crystal structure of human bone morphogenetic protein-2 at 2.7 Å resolution. J. Mol. Biol. 287, 103-115.
-
(1999)
J. Mol. Biol.
, vol.287
, pp. 103-115
-
-
Scheufler, C.1
Sebald, W.2
Hulsmeyer, M.3
-
95
-
-
0023686033
-
Signal transduction by allosteric receptor oligomerization
-
Schlessinger, J. (1988). Signal transduction by allosteric receptor oligomerization. Trends Biochem. Sci. 13, 443-447.
-
(1988)
Trends Biochem. Sci.
, vol.13
, pp. 443-447
-
-
Schlessinger, J.1
-
96
-
-
0028825543
-
Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?
-
Schlessinger, J., Lax, I., and Lemmon, M. (1995). Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors? Cell 83, 357-360.
-
(1995)
Cell
, vol.83
, pp. 357-360
-
-
Schlessinger, J.1
Lax, I.2
Lemmon, M.3
-
97
-
-
0026633842
-
An unusual feature revealed by the crystal structure at 2.2 Å resolution of human transforming growth factor-β 2
-
Schlunegger, M. P., and Grutter, M. G. (1992). An unusual feature revealed by the crystal structure at 2.2 Å resolution of human transforming growth factor-β 2. Nature 358, 430-434.
-
(1992)
Nature
, vol.358
, pp. 430-434
-
-
Schlunegger, M.P.1
Grutter, M.G.2
-
98
-
-
0642285636
-
The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly
-
Sebald, W., and Mueller, T. D. (2003). The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly. Trends Biochem. Sci. 28, 518-521.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 518-521
-
-
Sebald, W.1
Mueller, T.D.2
-
99
-
-
0037330644
-
Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes
-
Settle, S. H., Jr., Rountree, R. B., Sinha, A., Thacker, A., Higgins, K., and Kingsley, D. M. (2003). Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev. Biol. 254, 116-130.
-
(2003)
Dev. Biol.
, vol.254
, pp. 116-130
-
-
Settle Jr., S.H.1
Rountree, R.B.2
Sinha, A.3
Thacker, A.4
Higgins, K.5
Kingsley, D.M.6
-
100
-
-
0038682002
-
Mechanisms of TGF-β signaling from cell membrane to the nucleus
-
Shi, Y., and Massague, J. (2003). Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
101
-
-
0032915460
-
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
-
Solloway, M. J., and Robertson, E. J. (1999). Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126, 1753-1768.
-
(1999)
Development
, vol.126
, pp. 1753-1768
-
-
Solloway, M.J.1
Robertson, E.J.2
-
102
-
-
0036633294
-
TGF-β signaling from a three-dimensional perspective: Insight into selection of partners
-
Souchelnytskyi, S., Moustakas, A., and Heldin, C. H. (2002). TGF-β signaling from a three-dimensional perspective: insight into selection of partners. Trends Cell Biol. 12, 304-307.
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 304-307
-
-
Souchelnytskyi, S.1
Moustakas, A.2
Heldin, C.H.3
-
103
-
-
0027328343
-
The alphas, betas, and kinases of cytokine receptor complexes
-
Stahl, N., and Yancopoulos, G. D. (1993). The alphas, betas, and kinases of cytokine receptor complexes. Cell 74, 587-590.
-
(1993)
Cell
, vol.74
, pp. 587-590
-
-
Stahl, N.1
Yancopoulos, G.D.2
-
104
-
-
12244251384
-
Grebe dysplasia and the spectrum of CDMP1 mutations
-
Stelzer, C., Winterpacht, A., Spranger, J., and Zabel, B. (2003). Grebe dysplasia and the spectrum of CDMP1 mutations. Pediatr. Pathol. Mol. Med. 22, 77-85.
-
(2003)
Pediatr. Pathol. Mol. Med.
, vol.22
, pp. 77-85
-
-
Stelzer, C.1
Winterpacht, A.2
Spranger, J.3
Zabel, B.4
-
105
-
-
0030481707
-
Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family
-
Storm, E. E., and Kingsley, D. M. (1996). Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 122, 3969-3979.
-
(1996)
Development
, vol.122
, pp. 3969-3979
-
-
Storm, E.E.1
Kingsley, D.M.2
-
106
-
-
0032188942
-
Efficiency of signalling through cytokine receptors depends critically on receptor orientation
-
Syed, R. S., Reid, S. W., Li, C., Cheetham, J. C., Aoki, K. H., Liu, B., Zhan, H., Osslund, T. D., Chirino, A. J., Zhang, J. et al. (1998). Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature 395, 511-516.
-
(1998)
Nature
, vol.395
, pp. 511-516
-
-
Syed, R.S.1
Reid, S.W.2
Li, C.3
Cheetham, J.C.4
Aoki, K.H.5
Liu, B.6
Zhan, H.7
Osslund, T.D.8
Chirino, A.J.9
Zhang, J.10
-
107
-
-
0028332818
-
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
-
ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C. H., and Miyazono, K. (1994). Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J. Biol. Chem. 269, 16985-16988.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16985-16988
-
-
ten Dijke, P.1
Yamashita, H.2
Sampath, T.K.3
Reddi, A.H.4
Estevez, M.5
Riddle, D.L.6
Ichijo, H.7
Heldin, C.H.8
Miyazono, K.9
-
108
-
-
0029944441
-
Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors
-
ten Dijke, P., Miyazono, K., and Heldin, C. H. (1996). Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Curr. Opin. Cell Biol. 8, 139-145.
-
(1996)
Curr. Opin. Cell Biol.
, vol.8
, pp. 139-145
-
-
ten Dijke, P.1
Miyazono, K.2
Heldin, C.H.3
-
109
-
-
0030763771
-
Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
-
Thomas, J. T., Kilpatrick, M. W., Lin, K., Erlacher, L., Lembessis, P., Costa, T., Tsipouras, P., and Luyten, F. P. (1997). Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nat. Genet. 17, 58-64.
-
(1997)
Nat. Genet.
, vol.17
, pp. 58-64
-
-
Thomas, J.T.1
Kilpatrick, M.W.2
Lin, K.3
Erlacher, L.4
Lembessis, P.5
Costa, T.6
Tsipouras, P.7
Luyten, F.P.8
-
110
-
-
0345269804
-
Structures of an ActRIIB: Activin A complex reveal a novel binding mode for TGF-β ligand: Receptor interactions
-
Thompson, T. B., Woodruff, T. K., and Jardetzky, T. S. (2003). Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-β ligand:receptor interactions. EMBO J. 22, 1555-1566.
-
(2003)
EMBO J.
, vol.22
, pp. 1555-1566
-
-
Thompson, T.B.1
Woodruff, T.K.2
Jardetzky, T.S.3
-
111
-
-
0036944302
-
Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice
-
Turgeman, G., Zilberman, Y., Zhou, S., Kelly, P., Moutsatsos, I. K., Kharode, Y. P., Borella, L. E., Bex, F. J., Komm, B. S., Bodine, P. V., and Gazit, D. (2002). Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice. J. Cell Biochem. 86, 461-474.
-
(2002)
J. Cell Biochem.
, vol.86
, pp. 461-474
-
-
Turgeman, G.1
Zilberman, Y.2
Zhou, S.3
Kelly, P.4
Moutsatsos, I.K.5
Kharode, Y.P.6
Borella, L.E.7
Bex, F.J.8
Komm, B.S.9
Bodine, P.V.10
Gazit, D.11
-
112
-
-
0242668281
-
The BMP antagonist noggin regulates cranial suture fusion
-
Warren, S. M., Brunet, L. J., Harland, R. M., Economides, A. N., and Longaker, M. T. (2003). The BMP antagonist noggin regulates cranial suture fusion. Nature 422, 625-629.
-
(2003)
Nature
, vol.422
, pp. 625-629
-
-
Warren, S.M.1
Brunet, L.J.2
Harland, R.M.3
Economides, A.N.4
Longaker, M.T.5
-
113
-
-
0030030373
-
Complementation between kinase-defective and activation-defective TGF-β receptors reveals a novel form of receptor cooperativity essential for signaling
-
Weis Garcia, F., and Massague, J. (1996). Complementation between kinase-defective and activation-defective TGF-β receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J. 15, 276-289.
-
(1996)
EMBO J.
, vol.15
, pp. 276-289
-
-
Weis Garcia, F.1
Massague, J.2
-
114
-
-
0027346824
-
The molecular basis for growth hormone-receptor interactions
-
Wells, J. A., Cunningham, B. C., Fuh, G., Lowman, H. B., Bass, S. H., Mulkerrin, M. G., Ultsch, M., and deVos, A. M. (1993). The molecular basis for growth hormone-receptor interactions. Recent Prog. Horm. Res. 48, 253-275.
-
(1993)
Recent Prog. Horm. Res.
, vol.48
, pp. 253-275
-
-
Wells, J.A.1
Cunningham, B.C.2
Fuh, G.3
Lowman, H.B.4
Bass, S.H.5
Mulkerrin, M.G.6
Ultsch, M.7
deVos, A.M.8
-
115
-
-
0037424231
-
Inhibin is an antagonist of bone morphogenetic protein signaling
-
Wiater, E., and Vale, W. (2003). Inhibin is an antagonist of bone morphogenetic protein signaling. J. Biol. Chem. 278, 7934-7941.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 7934-7941
-
-
Wiater, E.1
Vale, W.2
-
116
-
-
0029022221
-
GS domain mutations that constitutively activate T β R-I, the downstream signaling component in the TGF-β receptor complex
-
Wieser, R., Wrana, J. L., and Massague, J. (1995). GS domain mutations that constitutively activate T β R-I, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14, 2199-2208.
-
(1995)
EMBO J.
, vol.14
, pp. 2199-2208
-
-
Wieser, R.1
Wrana, J.L.2
Massague, J.3
-
117
-
-
10744221383
-
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
-
Winkler, D. G., Sutherland, M. K., Geoghegan, J. C., Yu, C., Hayes, T., Skonier, J. E., Shpektor, D., Jonas, M., Kovacevich, B. R., Staehling-Hampton, K. et al. (2003). Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 22, 6267-6276.
-
(2003)
EMBO J.
, vol.22
, pp. 6267-6276
-
-
Winkler, D.G.1
Sutherland, M.K.2
Geoghegan, J.C.3
Yu, C.4
Hayes, T.5
Skonier, J.E.6
Shpektor, D.7
Jonas, M.8
Kovacevich, B.R.9
Staehling-Hampton, K.10
-
118
-
-
0029860206
-
A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common β-chain is necessary and sufficient for high affinity binding and signaling by all three ligands
-
Woodcock, J. M., Bagley, C. J., Zacharakis, B., and Lopez, A. F. (1996). A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common β-chain is necessary and sufficient for high affinity binding and signaling by all three ligands. J. Biol. Chem. 271, 25999-26006.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25999-26006
-
-
Woodcock, J.M.1
Bagley, C.J.2
Zacharakis, B.3
Lopez, A.F.4
-
119
-
-
0028170226
-
Mechanism of activation of the TGF-Β receptor
-
Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., and Massague, J. (1994). Mechanism of activation of the TGF-Β receptor. Nature 370, 341-347.
-
(1994)
Nature
, vol.370
, pp. 341-347
-
-
Wrana, J.L.1
Attisano, L.2
Wieser, R.3
Ventura, F.4
Massague, J.5
-
120
-
-
85047689811
-
Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
-
Wu, X. B., Li, Y., Schneider, A., Yu, W., Rajendren, G., Iqbal, J., Yamamoto, M., Alam, M., Brunet, L. J., Blair, H. C. et al. (2003). Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J. Clin. Invest. 112, 924-934.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 924-934
-
-
Wu, X.B.1
Li, Y.2
Schneider, A.3
Yu, W.4
Rajendren, G.5
Iqbal, J.6
Yamamoto, M.7
Alam, M.8
Brunet, L.J.9
Blair, H.C.10
-
121
-
-
0033515443
-
Identification of two amino acids in activin A that are important for biological activity and binding to the activin type II receptors
-
Wuytens, G., Verschueren, K., de Winter, J. P., Gajendran, N., Beek, L., Devos, K., Bosman, F., de Waele, P., Andries, M., van den Eijnden van Raaij, A. J. et al. (1999). Identification of two amino acids in activin A that are important for biological activity and binding to the activin type II receptors. J. Biol. Chem. 274, 9821-9827.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9821-9827
-
-
Wuytens, G.1
Verschueren, K.2
de Winter, J.P.3
Gajendran, N.4
Beek, L.5
Devos, K.6
Bosman, F.7
de Waele, P.8
Andries, M.9
van den Eijnden van Raaij, A.J.10
-
122
-
-
0037023363
-
Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand
-
Xiong, J. P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L., and Arnaout, M. A. (2002). Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand. Science 296, 151-155.
-
(2002)
Science
, vol.296
, pp. 151-155
-
-
Xiong, J.P.1
Stehle, T.2
Zhang, R.3
Joachimiak, A.4
Frech, M.5
Goodman, S.L.6
Arnaout, M.A.7
-
123
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
-
Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., and Matsumoto, K. (1995). Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270, 2008-2011.
-
(1995)
Science
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
-
124
-
-
0033960316
-
The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
-
Yi, S. E., Daluiski, A., Pederson, R., Rosen, V., and Lyons, K. M. (2000). The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127, 621-630.
-
(2000)
Development
, vol.127
, pp. 621-630
-
-
Yi, S.E.1
Daluiski, A.2
Pederson, R.3
Rosen, V.4
Lyons, K.M.5
-
125
-
-
0035055352
-
Colocalization of noggin and bone morphogenetic protein-4 during fracture healing
-
Yoshimura, Y., Nomura, S., Kawasaki, S., Tsutsumimoto, T., Shimizu, T., and Takaoka, K. (2001). Colocalization of noggin and bone morphogenetic protein-4 during fracture healing. J. Bone Miner. Res. 16, 876-884.
-
(2001)
J. Bone Miner. Res.
, vol.16
, pp. 876-884
-
-
Yoshimura, Y.1
Nomura, S.2
Kawasaki, S.3
Tsutsumimoto, T.4
Shimizu, T.5
Takaoka, K.6
-
126
-
-
0037153157
-
The morphogenesis of feathers
-
Yu, M., Wu, P., Widelitz, R. B., and Chuong, C. M. (2002). The morphogenesis of feathers. Nature 420, 308-312.
-
(2002)
Nature
, vol.420
, pp. 308-312
-
-
Yu, M.1
Wu, P.2
Widelitz, R.B.3
Chuong, C.M.4
-
127
-
-
0033549789
-
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L., and Thomsen, G. H. (1999). A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400, 687-693.
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.5
-
128
-
-
0030598829
-
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
-
Zimmerman, L. B., De Jesus Escobar, J. M., and Harland, R. M. (1996). The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86, 599-606.
-
(1996)
Cell
, vol.86
, pp. 599-606
-
-
Zimmerman, L.B.1
De Jesus Escobar, J.M.2
Harland, R.M.3
-
129
-
-
0037165983
-
Induction of cachexia in mice by systemically administered myostatin
-
Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P., Esquela, A. F., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., and Lee, S. J. (2002). Induction of cachexia in mice by systemically administered myostatin. Science 296, 1486-1488.
-
(2002)
Science
, vol.296
, pp. 1486-1488
-
-
Zimmers, T.A.1
Davies, M.V.2
Koniaris, L.G.3
Haynes, P.4
Esquela, A.F.5
Tomkinson, K.N.6
McPherron, A.C.7
Wolfman, N.M.8
Lee, S.J.9
|