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Volumn 51, Issue 1, 2013, Pages 27-35

Lentiviral vector-mediated knockdown of Lrb in the arcuate nucleus promotes diet-induced obesity in rats

Author keywords

Leptin; Metabolism; Obesity; Receptors

Indexed keywords

INSULIN; LENTIVIRUS VECTOR; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; NUCLEAR FACTOR Y; SHORT HAIRPIN RNA; STAT3 PROTEIN;

EID: 84878033015     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-12-0212     Document Type: Article
Times cited : (15)

References (31)
  • 1
    • 40849085400 scopus 로고    scopus 로고
    • Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion
    • (doi:10.1210/en.2007-1018)
    • Augustine RA & Grattan DR 2008 Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology 149 1049-1055. (doi:10.1210/en.2007-1018)
    • (2008) Endocrinology , vol.149 , pp. 1049-1055
    • Augustine, R.A.1    Grattan, D.R.2
  • 2
    • 0033830448 scopus 로고    scopus 로고
    • Regulation of metabolism and body fat mass by leptin
    • (doi:10.1146/annurev.nutr.20.1.105)
    • Baile CA, Bella-Fera M & Martin RJ 2000 Regulation of metabolism and body fat mass by leptin. Annual Review of Nutrition 20 105-127. (doi:10.1146/annurev.nutr.20.1.105)
    • (2000) Annual Review of Nutrition , vol.20 , pp. 105-127
    • Baile, C.A.1    Bella-Fera, M.2    Martin, R.J.3
  • 3
    • 2342439732 scopus 로고    scopus 로고
    • Leptin signaling in the central nervous system and the periphery
    • (doi:10.1210/rp.59.1.305)
    • Bjorbaek C & Kahn BB 2004 Leptin signaling in the central nervous system and the periphery. Recent Progress in Hormone Research 57 305-331. (doi:10.1210/rp.59.1.305)
    • (2004) Recent Progress In Hormone Research , vol.57 , pp. 305-331
    • Bjorbaek, C.1    Kahn, B.B.2
  • 6
    • 15444366416 scopus 로고    scopus 로고
    • Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and supperessor of cytokine signaling 3
    • (doi:10.1210/me.2004-0353)
    • Dunn SL, Bjornholm M, Bates SH, Chen Z, Seifert M & Myers MG Jr 2005 Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and supperessor of cytokine signaling 3. Molecular Endocrinology 19 925-938. (doi:10.1210/me.2004-0353)
    • (2005) Molecular Endocrinology , vol.19 , pp. 925-938
    • Dunn, S.L.1    Bjornholm, M.2    Bates, S.H.3    Chen, Z.4    Seifert, M.5    Myers Jr., M.G.6
  • 10
    • 58149493406 scopus 로고    scopus 로고
    • Energy metabolism, fuel selection and body weight regulation
    • (doi:10.1038/ijo.2008.246)
    • Galgani J & Ravussin E 2008 Energy metabolism, fuel selection and body weight regulation. International Journal of Obesity 32 (Suppl 7). S109-S119. (doi:10.1038/ijo.2008.246)
    • (2008) International Journal of Obesity , vol.32 , Issue.SUPPL. 7
    • Galgani, J.1    Ravussin, E.2
  • 12
    • 0034801684 scopus 로고    scopus 로고
    • SOCS proteins: Negative regulators of cytokine signaling
    • (doi:10.1634/stemcells.19-5-378)
    • Krebs DL & Hilton DJ 2001 SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19 378-387. (doi:10.1634/stemcells.19-5-378)
    • (2001) Stem Cells , vol.19 , pp. 378-387
    • Krebs, D.L.1    Hilton, D.J.2
  • 14
    • 34547644682 scopus 로고    scopus 로고
    • Obesity reduced the gene expression of leptin receptors in hypothalamus and liver
    • (doi:10.1055/s-2007-981680)
    • Liu ZJ, Bian J, Liu J & Endoh A 2007 Obesity reduced the gene expression of leptin receptors in hypothalamus and liver. Hormone and Metabolic Research 39 489-494. (doi:10.1055/s-2007-981680)
    • (2007) Hormone and Metabolic Research , vol.39 , pp. 489-494
    • Liu, Z.J.1    Bian, J.2    Liu, J.3    Endoh, A.4
  • 15
    • 63349085149 scopus 로고    scopus 로고
    • Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene
    • (doi:10.1007/ s11684-009-0003-z)
    • Liu ZJ, Bian J, Wang YC, Zhao YL, Yan D & Wang XX 2009 Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene. Frontiers of Medicine in China 3 57-60. (doi:10.1007/ s11684-009-0003-z)
    • (2009) Frontiers of Medicine In China , vol.3 , pp. 57-60
    • Liu, Z.J.1    Bian, J.2    Wang, Y.C.3    Zhao, Y.L.4    Yan, D.5    Wang, X.X.6
  • 16
    • 80052535419 scopus 로고    scopus 로고
    • Lentiviral vectormediated knockdown of SOCS3 in the hypothalamus protects against the development of diet-induced obesity in rats. Diabetes
    • (doi:10.1111/j.1463-1326.2011. 01419.x)
    • Liu ZJ, Bian J, Zhao YL, Zhang X, Zou N & Li D 2011 Lentiviral vectormediated knockdown of SOCS3 in the hypothalamus protects against the development of diet-induced obesity in rats. Diabetes, Obesity & Metabolism 13 885-892. (doi:10.1111/j.1463-1326.2011. 01419.x)
    • (2011) Obesity & Metabolism , vol.13 , pp. 885-892
    • Liu, Z.J.1    Bian, J.2    Zhao, Y.L.3    Zhang, X.4    Zou, N.5    Li, D.6
  • 17
    • 0037038758 scopus 로고    scopus 로고
    • Reducing hypothalamic AGRP by RNA interference increases metabolic rat and decreases body weight with influencing food intake
    • (doi:10.1186/1471-2202-3-18)
    • Makimura H, Mizuno TM, Mastaitis JW, Agami R & Mobbs CV 2002 Reducing hypothalamic AGRP by RNA interference increases metabolic rat and decreases body weight with influencing food intake. BMC Neuroscience 3 18-23. (doi:10.1186/1471-2202-3-18)
    • (2002) BMC Neuroscience , vol.3 , pp. 18-23
    • Makimura, H.1    Mizuno, T.M.2    Mastaitis, J.W.3    Agami, R.4    Mobbs, C.V.5
  • 19
    • 0033756298 scopus 로고    scopus 로고
    • Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein down-regulation
    • (doi:10.1053/meta. 2000.17695)
    • Martin RL, Perex E, He Y, Dawson R Jr & Millard WJ 2000 Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein down-regulation. Metabolism 9 1479-1484. (doi:10.1053/meta. 2000.17695)
    • (2000) Metabolism , vol.9 , pp. 1479-1484
    • Martin, R.L.1    Perex, E.2    He, Y.3    Dawson Jr., R.4    Millard, W.J.5
  • 22
    • 39549089324 scopus 로고    scopus 로고
    • (doi:10.1146/annurev.physiol.70.113006.100707)
    • (doi:10.1146/annurev.physiol.70.113006.100707)
  • 23
    • 0034754985 scopus 로고    scopus 로고
    • Sexual dimorphism in relationship of serum leptin and relative weight for the standard in normal-weight, but not in overweight children as well as adolescents
    • (doi:10.1038/sj.ejcn.1601257)
    • Nakanishi T, Li R, Liu Z, Nakagawa MY & Ohzeki T 2001 Sexual dimorphism in relationship of serum leptin and relative weight for the standard in normal-weight, but not in overweight children as well as adolescents. European Journal of Clinical Nutrition 55 989-993. (doi:10.1038/sj.ejcn.1601257)
    • (2001) European Journal of Clinical Nutrition , vol.55 , pp. 989-993
    • Nakanishi, T.1    Li, R.2    Liu, Z.3    Nakagawa, M.Y.4    Ohzeki, T.5
  • 24
    • 0015697938 scopus 로고
    • Isolated removal of hypothalamic or other brain nuclei of the rat
    • (doi:10.1016/0006-8993(73)90290-4)
    • Palkovits M 1973 Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Research 59 449-450. (doi:10.1016/0006-8993(73)90290-4)
    • (1973) Brain Research , vol.59 , pp. 449-450
    • Palkovits, M.1
  • 28
    • 0842284789 scopus 로고    scopus 로고
    • Leptin effects on pancreatic b-cell gene expression and function
    • (doi:10.2337/diabetes.53. 2007.S152)
    • Seufert J 2004 Leptin effects on pancreatic b-cell gene expression and function. Diabetes 53 S152-S158. (doi:10.2337/diabetes.53. 2007.S152)
    • (2004) Diabetes , vol.53
    • Seufert, J.1
  • 29
    • 0034111722 scopus 로고    scopus 로고
    • Preperitoneal fat thickness in childhood obesity: Association with serum insulin concentration
    • (doi:10.1046/j.1442-200x. 2000.01197.x)
    • Tamura A, Mori T, Hara Y & Komiyama A 2000 Preperitoneal fat thickness in childhood obesity: association with serum insulin concentration. Pediatrics International 42 155-159. (doi:10.1046/j.1442-200x. 2000.01197.x)
    • (2000) Pediatrics International , vol.42 , pp. 155-159
    • Tamura, A.1    Mori, T.2    Hara, Y.3    Komiyama, A.4
  • 30
    • 2942628012 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    • (doi:10.1128/MCB.24.12.5434-5446.2004)
    • Ueki K, Kondo T & Kahn CR 2004 Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Molecular and Cellular Biology 24 5434-5446. (doi:10.1128/MCB.24.12.5434-5446.2004)
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 5434-5446
    • Ueki, K.1    Kondo, T.2    Kahn, C.R.3
  • 31
    • 0030669288 scopus 로고    scopus 로고
    • Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity
    • (doi:10.2337/diabetes.46.11.1782)
    • Widdowson PS, Upton R, Buckingham R, Arch J & Williams G 1997 Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes 46 1782-1785. (doi:10.2337/diabetes.46.11.1782)
    • (1997) Diabetes , vol.46 , pp. 1782-1785
    • Widdowson, P.S.1    Upton, R.2    Buckingham, R.3    Arch, J.4    Williams, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.