The role of pancreatic stellate cells in pancreatic cancer

Pancreatology

Volumn 13, Issue 2, 2013, Pages 106-109

  Erkan, Mert ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antifibrotic therapy; Fibrosis; Hypoxia; Pancreatic cancer; Stroma

Indexed keywords

GEMCITABINE; K RAS PROTEIN; RECOMBINANT HYALURONIDASE; SARIDEGIB;

CANCER CHEMOTHERAPY; CANCER SURVIVAL; CARCINOGENESIS; CELL DIFFERENTIATION; CONFERENCE PAPER; CYTOTOXICITY; EXTRACELLULAR MATRIX; GENE MUTATION; HOMEOSTASIS; HUMAN; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREATIC STELLATE CELL; PRIORITY JOURNAL; SURVIVAL TIME; TUMOR MICROENVIRONMENT;

EID: 84878015534     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2013.01.008     Document Type: Conference Paper

References (32)

1. Apte MV, Wilson JS. Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells. J Gastroenterol Hepatol 2012;27(Suppl. 2):69-74.
2. Erkan M, Reiser-Erkan C, Michalski CW, Kong B, Esposito I, Friess H, et al. The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance. Curr Mol Med 2012;12(3):288-303.
3. Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 2011;17:320-9.
4. Pierce GB. Teratocarcinoma: model for a developmental concept of cancer. Curr Top Dev Biol 1967;2:223-46.
5. Stevens LC. The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos. Dev Biol 1970; 21:364-82.
6. Dolberg DS, Bissell MJ. Inability of rous sarcoma virus to cause sarcomas in the avian embryo. Nature 1984;309:552-6. (Pubitemid 14109376)
7. Postovit LM, Seftor EA, Seftor RE, Hendrix MJ. A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells 2006;24:501-5. (Pubitemid 44464753)
8. Bussard KM, Boulanger CA, Booth BW, Bruno RD, Smith GH. Reprogramming human cancer cells in the mouse mammary gland. Cancer Res 2010; 70:6336-43.
9. Collins AL, Rock J, Malhotra L, Frankel WL, Bloomston M. Osteopontin expression is associated with improved survival in patients with pancreatic adenocarcinoma. Ann Surg Oncol 2012;19:2673-8.
10. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, et al. The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol 2008;6:1155-61.
11. Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, et al. Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol 2012;226(5):723-34.
12. Erkan M, Hausmann S, Michalski CW, Fingerle AA, Dobritz M, Kleeff J, et al. The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol Hepatol 2012;9(8):454-67.
13. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, et al. Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology 2007;132:1447-64. (Pubitemid 46627568)
14. Lohr M, Kloppel G, Maisonneuve P, Lowenfels AB, Luttges J. Frequency of k-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis. Neoplasia 2005;7:17-23. (Pubitemid 40209467)
15. Hruban RH, Maitra A, Goggins M. Update on pancreatic intraepithelial neoplasia. Int J Clin Exp Pathol 2008;1:306-16.
16. Ji B, Tsou L, Wang H, Gaiser S, Chang DZ, Daniluk J, et al. Ras activity levels control the development of pancreatic diseases. Gastroenterology 2009;137: 1072-82. 1082 e1071-1076.
17. Collins MA, Bednar F, Zhang Y, Brisset JC, Galban S, Galban CJ, et al. Oncogenic kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 2012;122:639-53.
18. Bernards R, Weinberg RA. A progression puzzle. Nature 2002;418:823. (Pubitemid 34966286)
19. Gatenby RA, Gillies RJ. A microenvironmental model of carcinogenesis. Nat Rev Cancer 2008;8:56-61.
20. Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer 2012;12:487-93.
21. Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, et al. Loss of bnip3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene 2005;24:4421-32. (Pubitemid 40961765)
22. Lu X, Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010;16:5928-35.
23. Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2013;62(1):112-20.
24. Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, et al. Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61.
25. Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012;21:418-29.
26. Erkan M, Hausmann S, Michalski CW, Schlitter AM, Fingerle AA, Dobritz M, et al. How fibrosis influences imaging and surgical decisions in pancreatic cancer. Front Physiol 2012;3:389.
27. Nielsen M, Thomsen JL, Primdahl S, Dyreborg U, Andersen JA. Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies. Br J Cancer 1987;56:814-9. (Pubitemid 18048359)
28. Sakr WA, Haas GP, Cassin BF, Pontes JE, Crissman JD. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J Urol 1993;150:379-85. (Pubitemid 23215874)
29. Reiser-Erkan C, Gaa J, Kleeff J. T1 pancreatic cancer with lymph node metastasis and perineural invasion of the celiac trunk. Clin Gastroenterol Hepatol 2008;6:e41-2.
30. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467:1114-7.
31. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
32. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, et al. Stellatum: current consensus and discussion on pancreatic stellate cell research. Gut 2012;61:172-8.