T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms

Chemical Research in Toxicology

Volumn 26, Issue 5, 2013, Pages 759-766

  Bell, Catherine C ^a   Faulkner, Lee ^a   Martinsson, Klara ^a   Farrell, John ^a   Alfirevic, Ana ^a   Tugwood, Jonathan ^b   Pirmohamed, Munir ^a   Naisbitt, Dean J ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; FAS LIGAND; GAMMA INTERFERON; GRANZYME B; HLA A11 ANTIGEN; HLA A3 ANTIGEN; HLA A31 ANTIGEN; HLA B57 ANTIGEN; HLA C ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; PERFORIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; CYTOKINE; HLA B ANTIGEN; HLA-B57 ANTIGEN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL DEATH; CELL PROLIFERATION; CIRCULAR DICHROISM; CYTOKINE RELEASE; GENE LOCUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MASS SPECTROMETRY; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; CELL CLONE; CELL LINE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION;

CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; CELL LINE; CELL PROLIFERATION; CLONE CELLS; CYTOKINES; DIDEOXYNUCLEOSIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HLA-B ANTIGENS; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877983147     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400060p     Document Type: Article

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